The Vaccine Act of 1813 was an Act of the Twelfth Congress of the United States to encourage vaccination against smallpox. It was passed  February 27, 1813.  On the back of a 1821 outbreak of smallpox in North Carolina, the act was repealed May 4, 1822 handing the authority to regulate vaccines back to the states.  This Act was the first federal law concerning consumer protection and pharmaceuticals. [1, 2]