In 1966 the genetic code is cracked by Marshall Nirenberg, Har Khorana and Severo Ochoa by demonstrating that when the 4 possible nucleotide bases are sequenced in groups of 3 to form a codon, they encode one of 20 amino acids. In time codons which signal the start and end of protein synthesis are deciphered. [1]

Messenger RNA (mRNA) genetic sequence codes for a string of specific amino acids which form and fold into a specific protein within the cell cytoplasm.