Ebola oubreak in West Africa – the catalyst for global R&D and regulatory preparedness

On March 23, 2014 the WHO release news of a rapidly evolving outbreak of Ebola virus disease (Ebola Hemorrhagic Fever) in forested areas south eastern Guinea, West Africa. At that date Ministry of Health (MoH) of Guinea were aware of 49 cases with 29 deaths, concluding a case fatality rate of an alarming 59%! The very next day on March 24, 2014 it was communicated "a total of 86 suspected cases in-cluding 59 deaths" providing a case fatality ratio of 69%! [1, 2, 3, 4, 6, 7] On July 31, 2015 it was reported the "World on the verge of an effective Ebola vaccine", where Phase III trials of developed of  VSV-EBOV were claimed to be " highly effective against Ebola", used in a "ring vaccination protocol".  The vaccine was developed by the Public Health Agency of Canada, then licensed to NewLink Genetics, and on November 24, 2014 to Merck & Co. [5]  The ring vaccination protocol provided an alternative to using a placebo! The vaccine trial design group "included Professor Donald A. Henderson of John Hopkins University, who led the WHO smallpox eradication effort by using the ring vaccination strategy". In 2003 the WHO stated: "The Ebola virus was..> READ MORE

First annual World Health Summit is held in Germany

The first annual World Health Summit (WHS) was held October 15-18, 2009 in Berlin, Germany.  The summit was initiated in March 2009 by the French and German governments, in partnership with Pfizer.  It is a "forum to bring together an international array of eminent researchers, physicians, and representatives of government, industry, and health care systems" for the "evolution of medicine". A welcome message in 2009 given by Australia's Prime Minister Mr Kevin Rudd.   [1, 2] The forum is to address those health related issues which challenge physicians, scientists, political leaders and those employed in the health care industry. "Among these are health-related consequences of climate change, international pandemic strategies, and the impact of the financial crisis on global health and health care." [3] The World Health Summit was founded by the President (2009-2020) Prof Dr Detlev Ganten, to coincide with the 300th anniversary of the Charité - Universitätsmedizin Berlin [home of Christen Drosten], to bring Germany back on the medical breakthrough's map and celebrate the likes of Robert Koch, Rudolf Virchow, von Behring and more who "greatly contributed to the advent of modern medicine." [7, 8] Each year in October a WHS is held. The M8 Alliance of Academic..> READ MORE

SARS spike protein vaccine in ferrets warns “extra caution” if trialled in humans

In a paper published November 15, 2004, ferrets were vaccinated with an experimental vaccine of recombinant modified vaccinia virus Ankara (rMVA) (a cowpox virus vector) which expressed the SARS-CoV spike (S) protein - the target antigen. Upon challenge, 14 days after booster dose, the vaccinated ferrets "developed a more rapid and vigorous neutralizing antibody response" (in 3 days) compared to the unvaccinated, first time exposed to SARS-CoV virus, control animals who took 7 days to develop neutralizing antibodies. Vaccine manufactures consider antibody titres, that is the measure of an immune response, to be "an essential feature" for determining an effective prophylactic vaccine or "protection potential" - generating antibodies is a measure of  vaccine "protection" or "efficacy". However is it really?  When challenged with SARS-CoV virus via intranasal route, the vaccinated ferrets exhibited a "strong inflammatory response" in their liver causing "severe hepatitis", which was noted as "mild" in the unvaccinated animals. The paper notes:  "It is known that neutralizing antibodies induced by the S protein of feline infectious peritonitis virus (also a coronavirus) often lead to accelerated infection by the mechanism of antibody-dependent enhancement of virus infectivity" The "neutralizing activity [IgG] was detected in sera collected from all three ferrets..> READ MORE

Mosquito vector for malaria confirmed

On August 20, 1897, while in Secunderabad, India, Ronald Ross made his landmark discovery that malaria parasites were found in the stomach tissue of an anapheline mosquito which he was dissecting,  The insect had been feeding for 4 days prior on the blood of a malarious patient.  He went on to demonstrate that the malaria parasite is transmitted from infected birds to healthy ones through the bite of a mosquito, a finding that suggested the disease’s mode of transmission to humans, and for which he received the 1902 Nobel Prize in Medicine "for his work on malaria, by which he has shown how it enters the organism and thereby has laid the foundation for successful research on this disease and methods of combating it".  Ross was knighted 1911. [1, 3, 4, 5] On August 10, 1899 Major Ross published in Nature that it is now confirmed certain species of mosquito transmit the malaria parasite. His results being accepted by Dr. Laveran, the discoverer of the parasites of malaria and others. [8, 9] Ross concluded: "It may therefore be finally accepted as a fact that malaria is communicated by the bites of some species of mosquito... Hence it follows that, in..> READ MORE

US Army receives SARS-CoV-2 sample, grows master stock and created humanised animal models

In February 2020, U.S. Army Medical Research Institute of Infectious Diseases (USAMRIID) scientists at Fort Detrick, received a sample of SARS-CoV-2 from the Centers for Disease Control and Prevention (CDC)." It came from a patient in Washington State, one of the first COVID-19 cases identified in the United States."  [1] USAMRIID first grew the virus and prepared a master stock used in "testing diagnostics, vaccines and treatments."  They then "turned their attention to developing animal models that represent the disease course of COVID-19 in humans. Animal model development is essential to the process of getting a medical product licensed for human use, and it is one of USAMRIID’s core capabilities" "Small animal models, like, rodents allow for early investigation of the disease process and preliminary testing of potential vaccines and treatments. This work builds the foundation for additional studies and helps to determine which products should advance for further testing" "USAMRIID has developed two small animal models, the ACE2 mouse and the Syrian hamster...[The] ACE2 mice have the same receptor used by SARS-CoV-2 to enter human cells, making them a suitable model of infection, and Syrian hamsters appear to show signs of developing protective immunity when re-exposed to the virus...> READ MORE

Gates Foundation Dumps mRNA Shares in Q3 of 2021 at Huge Profit

By November 15, 2021 the Bill & Melinda Gates Foundation (BMGF) had sold off 86% of their share holding in BioNTech at massive, untaxable profit. The foundation purchased the shares in September 2019. [1, 2, 3] In November of 2021, Bill Gates, after dumping his stocks, "shockingly declared that “we need a new way of doing the vaccines.”...“We didn’t have vaccines that block transmission,” Gates said, contradicting all of his previous interviews in which he continuously claimed the shots were safe and significantly block transmission." [1]
Gene Therapy
Posted inPublic Health Vaccines

Gene Therapy

The definition of "Gene Therapy" appears to mean different things to different bodies. This page is an attempt to log definitions and understand the evolution of "gene therapy" from the context of how designated "gene therapy" products (i.e. Moderna and…
18 April 2024Posted inPublic Health, Vaccines

Public Health agencies cannot force a treatment on it’s citizens

According to Dr Dave Martin, in the The United States, since 1905, the Public Health Policy says that the State public health agencies are entitled to do police powers on public health if they can disrupt infection or transmission.  There is NO police power that has ever been granted, in any circumstance, for any reason, for a medical treatment. [1] A therapy is something that only disrupts the severity of a disease (symptoms in the recipient), and not the infection or transmission rate of the pathogent that is believed to cause the disease. [This data point need statutory links]