Sodium chlorite (NaClO2) + an acid forms a chemical reaction which releases chlorine dioxide gas.
This gas readily dissolves in water, which forms the solution that has been called Chlorine Dioxide Solution (CDS)

During the early days of the pandemic chlorine dioxide was misrepresented as bleach, following a comment by President Trump, where it has been assumed he was referring to Chlorine dioxide, but that is not clear. Bleach, is an alkaline inorganic chemical compound, chemically known as Sodium hypochlorite (NaClO), which is a powerful cleaning agent, it is not a therapeutic, but is useful for surface cleansing – such as bench tops.

Chlorine dioxide, is used as a whitening agent, or a bleach, in the process of manufacturing paper, but it needs to be at very high concentrations of 5%, and at temperatures around 60^oC and at low acidic pH range. Contrary to chlorine dioxide for human use, which is orders of magnitude lower concentrations of 0.000003-0.02% solution, such as use in water disinfection. – REF

Typically chlorine dioxide is consumed in the range of 10-100 parts per million – REF

While chlorine dioxide has “chlorine” in its name, its chemistry is radically different from that of chlorine.
As we all learned in high school chemistry, we can mix two compounds and create a third that bears little resemblance to its parents.

…Chlorine and chlorine dioxide are both oxidising agents (electron receivers). However, chlorine has the capacity to take in two electrons, whereas chlorine dioxide can absorb five. This means that, mole for mole, ClO₂ is 2.6 times more effective than chlorine.

…chlorine dioxide will not react with many organic compounds, and as a result ClO₂ does not produce environmentally dangerous chlorinated organics.

Scotmas

This page on chlorine dioxide is overdue to be launched, but inspired by it’s mention by Dr Pierre Kory who recently wrote an article documenting it’s censorship, all stemming from a comment made by President Trump on April 23, 2020.

During the early days of 2020, after Vitamin C was censored, I came across mention of chlorine dioxide. It has a fascinating long history in the miraculous treatment of malaria, driven by the work and discovery by Jim Humble, but this has been highly controversial and censored.

• Andreas Kalker provides more information of CDS – HERE
  • Books – ARCHIVE
• Dr Andreas Kalker on Substack – HERE
  • How to make CDS – WATCH
  • CDS vs MMS – READ, ARCHIVE
  • Dioxipedia – READ, CREDIT
• The Universal Antidote Documentary (As claimed by NASA!) – WATCH, References – PDF
• Complete CD propaganda playlist – HERE, CREDIT
• The late Jim Humble books and website – HERE

This page will document the Chlorine dioxide timeline as best as I can capture links. Use it for your own research and education, helping to understand the many more aspects of the pandemic

Links in reverse chronological order

This page will be updated from time to time

2025

January 27, 2025 – Pierre Kory’s Medical Musings: The History and Therapeutic Mechanisms Of Chlorine Dioxide –READ

• Chlorine dioxide was discovered over 200 years ago. It’s use has steadily expanded into many industries and therapeutic applications despite a near global regulatory blockade on clinical research.

January 12, 2025 – Andreas Kalcker Substack: CDS: A Solution for mRNA Vaccine Damage – A Critical Perspective – READ

2024

December 28, 2024 – Pierre Kory’s Medical Musings Bolivia’s Use Of Chlorine Dioxide Led To The Best Outcomes In South America – READ

December 28, 2024 – Dr Andreas Kalker Substack: CDS, the mechanism of action – READ

• “Chlorine dioxide (ClO₂) operates through a distinctive mechanism that distinguishes it from other disinfectants. When introduced to water, it dissolves as an ion, generating a negative charge surrounding the water molecule, particularly in the presence of salts. This negative charge successfully neutralizes the positively charged proteins present in viruses, leading to their deactivation. Moreover, chlorine dioxide can penetrate the outer shell of encapsulated viruses when in its gaseous state.”

December 27, 2024 – Dr Andreas Kalker: What is CDS [Chlorine Dioxide Solution]? The facts and the overview – READ

• “Based on the opinions of more than 5,000 doctors connected with the international COMUSAV organization, CDS is considered one of the most important medical breakthroughs of the last hundred years.”
• See within article links to 32 PEER-Reviewed Publications on CDS in Humans and Related

December 26, 2024 – Pierre Kory Medical Musings : Trump’s “Bleach” Conference Alluded To The Antidote For Future Pandemics – Globally ridiculed for his comments, Trump was erroneously thought to be referring to chlorine dioxide, a treatment nationally deployed by Bolivia which led to the best outcomes in South America. – READ

• “This is the first post in a series I plan on doing on chlorine dioxide, a broad and powerful anti-microbial and disinfectant that is, contrary to the propaganda surrounding it, safe for human ingestion at therapeutic doses. I promise that what you will come to learn (especially in later posts) will massively impact your ability to protect your health, especially in regards to any future pandemics that may arise from bioweapons research…”
• “…not only [is chlorine dioxide] an extremely safe and highly effective treatment for Covid, but it also works against a diverse and likely complete array of pathogenic organisms.”
• “…chlorine dioxide is under a seemingly impenetrable global research blockade by the FDA and other regulatory authorities that follow FDA’s lead”

July 19, 2024 – Snopes: Trump Didn’t Tell People to ‘Inject Bleach’ for COVID-19. But Here’s What He Did Say – Trump’s confusing remarks near the start of the coronavirus pandemic were revived during the 2024 presidential campaign – READ

June 3, 2024 – US Environmental Protection Agency (EPA): Chlorine dioxide Results – Acute Exposure Guideline Levels (AEGL) Program – READ, Chlorine dioxide AEGL Technical Support Document (2007) latest update – PDF

• National Primary Drinking Water Regulations – Chlorine Dioxide Maximum Contaminant Level Goal (MCLG) is 0.8 mg/L – READ
  • “Units are in milligrams per liter (mg/L) unless otherwise noted. Milligrams per liter are equivalent to parts per million (PPM)” – REF

February 26, 2024 – WCH | Better Way Today: Transforming Health and Sanitation with Chlorine Dioxide Solution – WATCH

2023

October 7, 2023 – CBS News: Florida man, sons sentenced to years in prison after being convicted of selling bleach as fake COVID-19 cure – READ, CREDIT

2023 – Bloomberg: How US Authorities Tracked Down the ‘Miracle Cure’ to Colombia: Deadly Cure Podcast – READ

October 6, 2023 – DOJ: Leaders of “Genesis II Church of Health and Healing,” who sold toxic bleach as fake “Miracle” cure for COVID-19 and other serious diseases, sentenced to more than 12 years in federal prison – READ, website – HERE

September 1, 2024 – MMS founder Jim Humble passes away aged 90 – READ, ARCHIVE

July 21, 2023 – FDA Press Release: Leader of “Genesis II Church of Health and Healing,” Who Sold Toxic Bleach as Fake “Miracle” Cure for COVID-19 and Other Serious Diseases, Guilty of Conspiracy to Defraud the United States- READ, ARCHIVE

July 20, 2023 – ABC 7: ‘Church of Bleach’ family found guilty of selling fake COVID-19 cure through online church – WATCH, READ, CREDIT

• “A Florida man and his three sons were convicted on federal fraud charges for marketing a poisonous bleach concoction as a cure for 95% of the world’s diseases, including COVID-19″ !
• Mark Grenon, 65, and his sons, 37-year-old Jonathan, 35-year-old Joseph and 29-year-old Jordan, were all charged with conspiring to defraud the U.S. and deliver misbranded drugs.”

July 20, 2023 – Bradenton Herald: Father, 3 sons face Miami trial on charges of peddling industrial cleaner as ‘miracle’ cure – READ

July 17, 2023 – Bradenton Herald: Florida family behind ‘church’ that sold bleach as a COVID cure goes to trial this week – READ

• “The Grenons caught the eye of federal agents during the COVID-19 pandemic when they began promoting MMS as a cure for the virus. At the time, many unproven and dangerous cures for COVID-19 were circulating social media….In April 2020, federal authorities sent the Grenons a warning letter ordering them to stop sales of MMS.”

June 29, 2023 – Natural News: Study finds that chlorine dioxide destroys gender-bender herbicide atrazine in water – READ

2022

July 28, 2022 – Florida DOJ: Leader of “Genesis II Church of Health and Healing,” Who Sold Toxic Bleach as Fake “Miracle” Cure for Covid-19 and Other Serious Diseases, Extradited from Colombia to the United States – READ

• Links to FDA page first launched (conveniently): Aug 12, 2019: FDA: Danger: Don’t Drink Miracle Mineral Solution or Similar Products – The FDA warns you not to drink sodium chlorite products such as Miracle Mineral Solution. These products can make you sick. – READ, ARCHIVE

April 25, 2022 – Charlie Ward: JACK KIDDS CANCEROUS MOLE TREATED WITH CHLORINE DIOXIDE (MMS) INCREDIBLE – WATCH

March 11, 2022 – Stew Peters Show: Call In From Columbia Prison: Missionary Family Arrested For Curing Chlorine Dioxide – WATCH

2021

December 28, 2021 – COMUSAV (World Health and Life Coalition) U.S.A. Presents Anti-inoculation A.I. Protocol (Chlorine Dioxide Solution) – WATCH

November 18, 2021 – Updated CDS COVID-19 protocols – [English/Spanish/German/French] – READ

August 23, 2021 – International Journal of Medicine: The chlorine dioxide controversy: A deadly poison or a cure for COVID-19? – READ

• Fact: “over 500 U.S public water treatment plants add chlorine dioxide to the water full time and as many as 900 use it either part time or seasonally. Safety levels of orally ingested doses have been well established and are far above therapeutic dosing ranges, period.” – CREDIT

July 1, 2021 – Cedars Sinai: Reduced Viral Loads Seen in COVID-19 Patients Treated With (Ultra violet) UVA Light – READ, CREDIT, AMD: The Evidence Putting Light Inside the Body Is A Miraculous Therapy – ARCHIVE

June 8, 2021 – Stew Peter Network: EXCLUSIVE! Doctor Has Cured Thousands of COVID Patients (using chlorine dioxide), Issues Strong Warning About Jab – w/ Doctor Manuel Aparicio – WATCH

April 23, 2021 – Uproxx Trends: One Year Later, People Are Still In Disbelief About Trump’s ‘Craziest And Most Surreal’ Press Conference – READ

April 5, 2021 – Curious Human Productions: The doctor said there was nothing that could be done. Boy were they wrong! – WATCH

• This video shows in pictures, the progression of the healing of an “incurable skin lesion”, in 55 days using Chlorine Dioxide and DMSO, it was gone!

April 1, 2021 – Molecular and Genetic Medicine: Determination of the Effectiveness of [oral] Chlorine Dioxide in the Treatment of COVID-19 – Eduardo et al – READ, PDF

• “Conclusion: Chlorine dioxide is effective in the treatment of COVID19 and the mechanisms of action by which it acts to achieve it are proposed in this work. We recommend doing more research. We recommend conducting double-blind studies and delving into studies of toxicological safety and therapeutic efficacy of chlorine dioxide in pathologies of epidemiological impact in the near future.”

March 11, 2021 – Message from Jim Humble to the Bolivian Chlorine Dioxide Conference – WATCH

January 30, 2021 – DOCUMENTARY: The Universal Antidote – The science and story of Chlorine Dioxide – WATCH, CREDIT

2020

May 12, 2020 – Time Magazine: Accidental Poisonings Increased After President Trump’s Disinfectant Comments – READ

• “What’s key is what happened in the weeks that followed Trump’s controversial and widely debunked comments—and there does appear to have been a rise in accidental poisonings thereafter.”
• “In January, February and March of 2020, accidental poisonings with household disinfectants were up 5%, 17% and 93% respectively over the same months in 2019.” Before Trump’s press conference, and due to surface cleaning and produce cleaning promoted by health authorities!!!

April 27, 2020 – Bradenton ‘church’ promotes drinking bleach to cure COVID-19. They recommended it to Trump – ARCHIVE

• “A Bradenton-based organization that promotes drinking industrial-grade bleach as a cure for COVID-19 and other diseases and conditions has been ordered to stop sales of its “Miracle Mineral Solution.”
• A temporary injunction filed on April 17 in the U.S. District Court for the Southern District of Florida names Genesis, which is operated from a residence in the 2000 block of Garden Lane in Bradenton, as well as Mark Grenon, Joseph Grenon, Jordan Grenon and Jonathan Grenon, as defendants.”
• “While the Environmental Protection Agency has approved the use of chlorine dioxide for water treatment in amounts of up to .8 milligrams per liter, the agent is present at dramatically higher, unsafe levels in MMS, according to health officials.”

April 24, 2020 – Time Magazine: Trump’s Comment on Disinfectant Prompts Experts to Warn Against Inhaling Bleach to Kill Coronavirus – READ

• “…President Donald Trump seemed to suggest that sunlight or disinfectant might help unlock potential cures for the coronavirus.”

April 24, 2020 – Popular Science: Drinking, bathing in, or injecting yourself with bleach can be deadly—and it won’t cure COVID-19 – No matter what anyone says. – READ

April 24, 2020 – Uproxx: Lysol And Others React To Trump’s Suggestion That Injecting Disinfectant Might Cure Coronavirus – READ

April 24, 2020 – Washington Post: Trump claims controversial comment about injecting disinfectants was ‘sarcastic’ – ARCHIVE

April 24, 2020 – NY Times: Trump’s Suggestion That Disinfectants Could Be Used to Treat Coronavirus Prompts Aggressive Pushback – ARCHIVE

April 24, 2020 – NBC: ‘It’s irresponsible and it’s dangerous’: Experts rip Trump’s idea of injecting disinfectant to treat COVID-19 – READ

April 23, 2020 – Trump White House: Remarks by President Trump, Vice President Pence, and Members of the Coronavirus Task Force in Press Briefing – WATCH, READ

• many interpreted Trump as speaking about chlorine dioxide. The media took “injecting bleach” for a ride following Trump’s comments. Trump was also referring to Ultra violet light, UVA therapy

“We’re also testing disinfectants readily available. We’ve tested bleach, we’ve tested isopropyl alcohol on the virus, specifically in saliva or in respiratory fluids. And I can tell you that bleach will kill the virus in five minutes; isopropyl alcohol will kill the virus in 30 seconds, and that’s with no manipulation, no rubbing — just spraying it on and letting it go.”

[following a question]

“It wouldn’t be through injection. We’re talking about through almost a cleaning, sterilization of an area. Maybe it works, maybe it doesn’t work. But it certainly has a big effect if it’s on a stationary object.”

President Donald Trump mentions “bleach”

April 21, 2020 – Livesceince: Poison control sees spike in calls for cleaner, disinfectant accidents amid COVID-19 pandemic – up 20% compared to last year – READ

• “The report cannot prove for certain that the rise is due to people’s cleaning efforts to prevent COVID-19, but it does show “a clear temporal association with increased use of these products,” the authors said.” [nothing to do with Trump!, as this article is before his comment]
• March 18, 2020: Here’s how long the coronavirus will last on surfaces, and how to disinfect those surfaces – ARCHIVE, following March 11, 2020 PREPRINT

April 21, 2020 – The Guaridan: US orders group to stop selling bleach ‘miracle cure’ for coronavirus – READ

April 17, 2020 – CBS: Feds go after self-described church in Florida selling bleaching agent as cure for COVID-19 – READ

April 17, 2020 – US DOJ – Justice Department Seeks to End Illegal Online Sale of Industrial Bleach Marketed as “Miracle” Treatment for COVID-19 – Court Orders Defendants to Stop Operating Website Selling Unlawful Bleach Product for Coronavirus Treatment – ARCHIVE, CREDIT

• “The Food and Drug Administration requested the injunction after a previous warning and request to stop sales sent to the organization were met with outright refusal.”

April 17, 2020 – FDA News Release: Coronavirus (COVID-19) Update: Federal judge enters temporary injunction against Genesis II Church of Health and Healing, preventing sale of Chlorine Dioxide Products Equivalent to Industrial Bleach to Treat COVID-19 – Agency Continues Effort to Protect Public Health from Fraudulent and Potentially Harmful Products – ARCHIVE

April 8, 2020 – FDA Press Release: Coronavirus (COVID-19) Update: FDA Warns Seller Marketing Dangerous Chlorine Dioxide Products that Claim to Treat or Prevent COVID-19 – Agency Continues Effort to Protect Public Health from Fraudulent and Harmful Products. – READ, CREDIT

• The FDA has received reports of people experiencing serious adverse events after drinking chlorine dioxide products…The FDA is not aware of any scientific evidence supporting the safety or effectiveness of “Miracle Mineral Solution” products, despite claims that the solution has antimicrobial, antiviral and antibacterial properties. “
• [To wit, know that Jim Humble and Mark Grenon, two of the most well known “pioneers” of using chlorine dioxide either as chlorine dioxide (CDS) or it’s alternative formulation called Miracle Mineral Solution (MMS) had been treating many tens of thousands of patients in Africa and South and Central America since 1996. In 2010, they formed an entity called the Genesis Church For Health And Healing, thinking that as a church, they would be immune from regulatory attack. In a way, they were, that is, until April 8, 2020, when suddenly the FDA went after them with a “warning letter”] Why now, an not anytime in the past 10 years?- REF
• WARNING LETTER to Genesis 2 Church RE: Unapproved and Misbranded Products Related to Coronavirus Disease 2019 (COVID-19) – LETTER, ARCHIVE
  • “FDA has observed that the website https://newg2sacraments.org offers Miracle Mineral Solution (MMS) (chlorine dioxide)^[2] for sale in the United States and that this product is intended to cure, mitigate, treat, prevent, or diagnose Coronavirus and/or COVID-19 in people”
  • “…Based on our review, MMS is an unapproved new drug sold in violation of section 505(a) of the Federal Food, Drug, and Cosmetic Act (FD&C Act), 21 U.S.C. § 355(a). Furthermore, this product is a misbranded drug under section 502(f)(1) of the FD&C Act, 21 U.S.C. § 352(f)(1).  …”

April 7, 2020 – Project Camelot: Forbidden Health re CV and CDS w/ Andreas Kalker – WATCH

April 2, 2020 – How to make CDS ? with Andreas Kalcker (caution not to be confused with bleach) – WATCH

2019

August 12, 2019 – FDA: Danger: Don’t Drink Miracle Mineral Solution or Similar Products – The FDA warns you not to drink sodium chlorite products such as Miracle Mineral Solution. These products can make you sick. – READ, ARCHIVE [curious timing of launching this web page!]

• “Websites selling Miracle Mineral Solution describe the product as a liquid that is 28 percent sodium chlorite in distilled water. Product directions instruct people to mix the sodium chlorite solution with a citric acid, such as lemon or lime juice, or another acid before drinking. In many instances, the sodium chlorite is sold with a citric acid “activator.” When the acid is added, the mixture becomes chlorine dioxide, a powerful bleaching agent.“
• “Both sodium chlorite and chlorine dioxide are the active ingredients in disinfectants and have additional industrial uses. They are not meant to be swallowed by people.” [Yet chlorine dioxide is added to drining water, and swallowed every day by millions!]
• This “warning” was used a few months later, cited by FDA Commissioner Stephen M. Hahn, M.D, to stop MMS being used for COVID-19 – READ

May 23, 2019 – The Guardian: British man arrested on suspicion of giving bleach-based ‘cure’ to Ugandans – Sam Little arrested after Guardian exposed massive distribution network of MMS in Uganda that was being supervised by US pastor – READ, though later released.” – REF

• “The US mission, an outpost of the US embassy in Kampala, issued a public statement saying that it was aware of reports that MMS was being distributed by an American pastor in the country and stating: “We strongly condemn the distribution of this substance, which is extremely dangerous and is NOT a cure for any disease.””
• “After the Guardian story appeared Baldwin took down the website of his “Global Healing” ministry as well as his personal Facebook page where MMS – which he called “healing water” – was promoted. He told a local New Jersey newspaper that he was being “demonized” by people who do not understand the science behind natural medicines but went on to insist such medicines could cure the world’s deadliest diseases.”

May 18, 2019 – The Guardian: US pastor runs network giving 50,000 Ugandans bleach-based ‘miracle cure’ – READ, CREDIT

• Group led by Robert Baldwin and part-funded by Sam Little claims toxic fluid will eradicate HIV/Aids and other diseases.
• 5 days after this Gardian article Sam Little was arrested

March 2019? – G2Church: THIS VIDEO GOT US THROWN OFF YOUTUBE! NEW STUDY! Malaria cured in 4 hours with MMS Miracle mineral solution! – ARCHIVE, CREDIT

2017

November 18, 2017 – Scotmas Group: Chlorine Dioxide in Municipal Drinking Systems – WATCH, CREDIT

• Chlorine Dioxide is an extremely safe and cost effective alternative to Chlorine. Scotmas are leading the way in implementing Chlorine Dioxide for a number of municipal water disinfection projects around the world.

October 9, 2017 – Jim Humble, at 85 years old, announces retirement from the Genesis II Church of Health and Healing. Though not retiring from MMS – READ

• “I started the Genesis II Church along with Mark Grenon. I have seen the sacraments (MMS and other things) of the Church save many lives and overcome much suffering, and this has brought a great deal of joy to my life. But now, along with my retirement, Mark Grenon is head of the Genesis II Church of Health and Healing.”

March 22, 2017 – Int. J. Environ. Res. Public Health: Efficacy and Safety Evaluation of a Chlorine Dioxide Solution by Ma et al – READ, CREDIT

• “A ClO₂ concentration of up to 40 ppm in drinking water did not show any toxicity in a subchronic oral toxicity test….”

2016

2016 – The Universal Antidote: Quantum Leap Documentary – The Universal Antidote Lost Documentaries Series – WATCH, CREDIT

• “… interviews with Mark Grenon, testimonials from people cured of various diseases, and some other interesting historical details….This video series is made as an attempt to preserve this information for the historical record.”

October 29, 2016 – ‘Bionic Woman’ actress [ Lindsay Wagner] says substance known as MMS worked for her – WATCH, CREDIT

• “This kind of positive testimonial is common and there are thousands of them online in both written form and as videos on Youtube (now removed) —a fact that is rarely if ever given any light on mainstream news.” – REF

October 29, 2016 – ABC News: ‘Church of Bleach‘: ABC News confronts founder of Genesis II Church – by an undercover Eyewitness News producer – WATCH, CREDIT (remember its not bleach!)

• Jim Humble responds to the ABC News 20/20 Program of October 29, 2016 – “Not one of these programs made even a single attempt to be fair and balanced. It was all about MMS being a scam, etc.”- READ

2013

May 15, 2013 – The International Federation of Red Cross and Red Crescent Societies (IFRC) : IFRC strongly dissociates from the claim of a ‘miracle’ solution to defeat malaria – ARCHIVE, CREDIT

2012

December 2012 – Leo Koehof, an associate of Jim Humble, together with the eager Uganda Red Cross with the International Red Cross and Water Reference Center all came together to perform a clinical trial on malaria using chlorine dioxide solution or Miracle Mineral Solution ( MMS). 154 malaria victims were treated and cured, to the surprise of the Red Cross staff. The Red Cross refused to announce the results. READ, CREDIT,

• July 1, 2013 – LEAKED: Proof the Red Cross Cured 154 Malaria Cases with MMS – YouTube – DELETED, ARCHIVE, WATCH, BACKUP, MMS Wiki – ARCHIVE
  • Mustaque Abdullah, a Ugandan videographer eventually posted his own video of the trial. However it was largely buried on Youtube with little public notice. – Inconveniently this video documents the trial that the Red Cross assisted with but now “dissociates” with!
  • “This video finally proves that the Red Cross did a field test showing malaria was cured using MMS (sodium chlorite+activating acid producing chlorine dioxide) with a 100% success rate in 154 cases within 24-48 hours. This formerly hidden video was kept from the public for over 5 months until recently discovered. [2013]” Youtube has deleted the video, but Internet Archives has captured a copy.

2012 – The Universal Antidote Lost Documentary Series: Straight Talk on MMS- Kerri Rivera (Autism) – WATCH, CREDIT

• “Thousands of children have recovered from Autism using Chlorine Dioxide as the foundation of a recovery program.”

2011

2011 – Documentary footage shot in 2011: Straight Talk on MMS – Chlorine Dioxide – with Andreas Kalcker – WATCH, CREDIT

• Andreas plans to travel the world and talk to experts about MMS

2008

November 2008 – Project Camelot: Interview w/ Jim Humble, the man behind MMS: Miracle Mineral Supplement – READ, BACKUP, WATCH, YouTube DELETED

• Jim Humble’s website – ARCHIVE

2008 – Part 1 Lost Documentary Series – Understanding MMS – WATCH, CREDIT

• “Understanding MMS and was produced in 2008 and contains original footage of Jim Humble, testimonials from physicians and patients, and some other interesting historical details.

2007

2007 – US Environmental Protection Agency (EPA): Chlorine dioxide Results – Acute Exposure Guideline Levels (AEGL) Program – Chlorine dioxide AEGL Technical Support Document- PDF, SOURCE

• “The major use of chlorine dioxide is that of chemical pulp bleaching. Other uses include drinking water disinfection, the bleaching of textiles, flour, cellulose, leather, fats, oils, and beeswax; taste and odor control of water; as an oxidizing agent; and the in manufacture of chlorite salts”

2007 – Daniel Smith founded Project Green Life (PGL) around 2007 as “an alternative health association that made the first professional grade MMS (Master Mineral Solution)  ~ making it available in over 160 countries between 2007 and 2011” – READ

March 12, 2007 – WikiLeaks | The Global Intelligence Files: Chlorine Dioxide – cancer-toxins-pathogens cleanse – READ, noted SOURCE

2004

2004 – Multi Billion Dollar company EcoLab purchased Alcide – and human use research and application of Chlorine dioxide seems to have stopped – REF

• Watch chlorine dioxide killing bacteria – ARCHIVE

1996

1996 – Jim Humble stumbles upon the application of Chlorine Dioxide for the treatment of malaria while leading a mining expedition through the South American jungle – REF

• Jim had Stabilised oxygen on hand, which is Sodium Chlorite, that was used to purify water. He gave some to his sick men, who were thought to have been struck with malaria. In contact with stomach acids, chlorine dioxide would have been produced. The men recovered quickly.

1993

1993 – At aged 66, the founder of chlorine dioxide, Howard Alliger, founded a new company that in 2004 would become Frontier Pharmaceutical – READ, CREDIT

• “with the goal of creating and commercializing products to deliver the benefits of chlorine dioxide in easily usable and shelf stable formulas.”
• “When hearing the words “chlorine dioxide” you probably think of chlorine bleach, a harsh chemical used in the backyard pool. Both are oxidizing agents with strong disinfecting properties, but have little else in common…chlorine dioxide offers numerous health benefits without the toxicity concerns of chlorine bleach.” – READ
• An Overall View of ClO2, by Howard Alliger – PDF

1988

August 1988 – SPINOFF by NASA – NASA proclaimed a patented chlorine dioxide product called Alcide to to be “A Universal Antidote” – (page 118) PDF, (CREDIT, Interactive Reference Guidebook – REF)

• “The special properties of the Alcidem formulation, which has been approved by U.S. regulatory authorities, enable it to destroy mold and fungus, as well as bacteria and viruses, with minimal harm to humans, animals or plants. This allows use of the product to disinfect and deodorize auto air conditioners without removing them and without any lingering toxicity.”

1983

1983 – Spinoff by NASA – titled “A Multipurpose Compound” – (pg 87) PDF, CREDIT

• “The University of Massachusetts Department of Animal Sciences, Amherst, Massachusetts is conducting a year-long test of products that might be the answer to effective treatment and prevention of the disease, specially-formulated derivatives of an unusual basic compound known as Alcide^TM. Manufactured by Alcide Corporation, Westport, Connecticut, the Alcide compound has killed all tested bacteria, virus and fungi shortly after contact, with minimal toxic effect on humans or animals.” [Chlorine dioxide is a biocide – REF]
• “The exceptional properties of the Alcide compound were discovered by Howard Alliger of Heat Systems-Ultrasonics, Plainview, New York. It was originally developed as a fast-acting liquid sterilizer for disinfecting ultrasonic cleaning tanks. On a day in 1978 when he was bothered by a skin irritation on his hands, Alliger nonetheless proceeded with a tank disinfecting job, saturating his hands with Alcide compound. By day’s end, he discovered the skin irritation had disappeared. Recognizing the potential of a compound that apparently had uses far beyond tank sterilization, Alliger performed initial experiments to test its efficacy against bacteria, virus and fungi. Results were sufficiently promising that Alliger teamed with fellow inventor Elliott J. Siff to develop, market and license the compound; they are, respectively, chairman and president of the company.”

1976

1976 – US Patent US4084747A: Germ killing composition and method by Howard Alliger – READ, CREDIT

• Howard Alliger discovers chlorine dioxide in his search for a sterilising compound – REF, CREDIT

• He patented the chemical process and called it Alcide
• He formed a company called Alcide Corporation, then took it public in 1983 – following multiple other patents. “For reasons unknown, Howard soon sold his share of the company and parted ways” signing a no-compete agreement! – REF

1811

1811 – Chlorine dioxide is first discovered by Sir Humphrey Davy – (History of ClO₂) REF, CREDIT

The post Chlorine Dioxide & CDS first appeared on Totality of Evidence.

I will also capture other articles of interest relating to DMSO as they come to my attention. Helping us all do our own research.

Articles in reverse chronological order

2024

November 1, 2024 – AMWD: How DMSO Cures Eye, Ear, Nose, Throat and Dental Disease – Many of those “incurable” conditions respond remarkably to DMSO – READ

October 28, 28, 2024 – AMWD: The FDA’s War Against DMSO and America – The Forgotten History That Led to the FDA Again and Again Keeping the Things We Most Desperately Need Away From Us – READ

October 21, 2-024 – AMWD: How DMSO Treats “Incurable” Autoimmune and Contractile Disorders – The decades of research that could have prevented an immense amount of human suffering – READ

October 13, 2024 – AMWD: The Remarkable History and Safety of DMSO – Please share your experiences with DMSO with the readers here! – READ

September 30, 2024 – AMWD: DMSO is a Miraculous Therapy for Chronic Pain and Musculoskeletal Injuries – The decades of evidence DMSO revolutionizes the practice of medicine – READ

September 15, 2024 – AMWD: DMSO Could Save Millions From Brain and Spinal Injury – The decades of evidence showing DMSO revolutionizes the care of many “untreatable” circulatory and neurologic conditions – READ

2019

November 2, 2019 – Thy Principles: The Unbelievable Health Benefits of DMSO | Everything You Need to Know – WATCH

1980

March 24, 1980 – Hearing before the Select Committee on Aging, House of Representatives: DMSO: New Hope for Arthritis? – PDF, CREDIT

• “Sadly, despite the incredibly compelling testimony presented at the hearing, a subsequent Senate subcommittee hearing being held over the drug’s status with the FDA on July 31, 1980, the former governor of Alabama being treated with it and a champion of DMSO becoming the Secretary of Health and Human Services in 1985, the FDA never relented, and DMSO remains a forgotten side of medicine,” – AMWD – REF

March 1980 – 60 Minutes: The Riddle of DMSO – WATCH

The post Dimethyl sulfoxide (DMSO) first appeared on Totality of Evidence.

“Molnupiravir is the oral prodrug of beta-D-N4-hydroxycytidine (NHC), a ribonucleoside that has shown antiviral activity against SARS-CoV-2 in vitro and in clinical trials. NHC uptake by viral RNA-dependent RNA-polymerases results in viral mutations and lethal mutagenesis.” – REF

LAGEVRIO (molnupiravir) (MK-4482) is an investigational, orally administered nucleoside analog that inhibits the replication of SARS-CoV-2. It is a prodrug of beta-D-N4-hydroxycytidine (NHC), a ribonucleoside that has shown antiviral activity against SARS-CoV-2 in vitro and in clinical trials. NHC uptake by viral RNA-dependent RNA-polymerases results in viral mutations and lethal mutagenesis.” – REF

Interim phase III trial results, released by MSD via press release on October 1, 2021 conclude molnupiravir reduced the risk of admission to hospital or death by around 50% in non-hospitalised adults who had mild to moderate COVID-19 and were at risk of poor outcomes.

The Phase 3 clinical trial, referred to as the MOVe-OUT study, looked at the “treatment of non-hospitalized patients with laboratory-confirmed COVID-19 and at least one risk factor associated with poor disease outcomes”.

On November 4, 2021, the UK’s Medicines and Healthcare products Regulatory Agency (MHRA) was the first to authorise molnupiravir with the trade name Lagevrio, for the treatment of mild to moderate COVID-19 in adults with at least one risk factor for severe illness. The reasoning being to reduce symptom severity and ease pressure on the National Health Service over winter.

• Merck’s Molnupiravir – WEBSITE
• Merck’s product pipeline – HERE
• NIH Therapeutic Management of Non-hospitalized Adults With COVID-19 – READ, ARCHIVE
• Running analysis of all Molnupiravir studies for COVID-19 – HERE

Molnupiravir links in reverse chronological order

2023

July 3, 2023 – BMJ Open: Platform adaptive trial of novel antivirals for early treatment of COVID-19 In the community (PANORAMIC): protocol for a randomised, controlled, open-label, adaptive platform trial of community novel antiviral treatment of COVID-19 in people at increased risk of more severe disease – Gbinige and Chris Butler et al – READ, CV19 analysis – READ, Prof Butler was also chief investigator for ivermectin trial, comment by Dr Kory – HERE

2022

December 22, 2022 – The Lancet: Molnupiravir plus usual care versus usual care alone as early treatment for adults with COVID-19 at increased risk of adverse outcomes (PANORAMIC): an open-label, platform-adaptive randomised controlled trial – Christopher Butler et al – READ, CREDIT

• Amazingly high enrolment with “26,411 patient RCT in the UK, showing faster recovery but no significant difference in hospitalization/death or transmission. Improved recovery may be in part due to the open label design with self-reported symptomatic data. Viral load initially declined more quickly, but was higher at 14 days.” – CV19 analysis – READ

October 17, 2022 – SSRN Pre-Print: Molnupiravir Plus Usual Care Versus Usual Care Alone as Early Treatment for Adults with COVID-19 at Increased Risk of Adverse Outcomes (PANORAMIC): Preliminary Analysis from the United Kingdom Randomised, Controlled Open-Label, Platform Adaptive Trial by Butler et al – READ, PDF

October 11, 2022 – MedPage: Authorized COVID Antiviral Fails to Cut Hospitalization Risk — Recovery moderately faster with molnupiravir, but risks may outweigh benefit – READ

October 11, 2022 – BMJ: Covid-19: Antiviral purchased by UK government does not lower risk of hospital admission, trial shows by Jacqui Wise – READ

• “Molnupiravir, a covid-19 antiviral drug bought by the UK government in the amount of 2.23 million doses, is no better than placebo at lowering the risks of death and hospital admission, a pivotal UK trial has found.”

October 8, 2022 – Observational Study not randomised: Real-world effectiveness of molnupiravir and nirmatrelvir plus ritonavir against mortality, hospitalisation, and in-hospital outcomes among community-dwelling, ambulatory patients with confirmed SARS-CoV-2 infection during the omicron wave in Hong Kong: an observational study by Wong et al – READ

October 6, 2022 – Merck PRESS RELEASE: Merck and Ridgeback Biotherapeutics Provide Update on New Clinical and Non-Clinical Studies of LAGEVRIO (molnupiravir) – READ

September 25, 2022 – UK NHS – COVID-19 Therapeutics: Antivirals and neutralising-monoclonal antibodies (AVs and nMABs): Non-hospitalised treatments – NATIONAL SUMMARY – EXCEL, ARCHIVE

• “Only 13 944 of the UK’s 2.23 million doses of molnupiravir have been administered outside clinical trials in the UK, according to NHS data up to the week ending 25 September 2022” – REF
• “The NHS has used less than 1% of the antiviral treatments it ordered, and it is not clear how the other 99% will be used before they pass their expiry dates,” said Hill.

August 2022 – Annals of Internal Medicine: Effect of Molnupiravir on Biomarkers, Respiratory Interventions, and Medical Services in COVID-19 – A Randomized, Placebo-Controlled Trial by Johnson et al – READ

June 7, 2022 – Merck PRESS REALEASE: Merck and Ridgeback Announce New Data For Investigational LAGEVRIO (molnupiravir) From Phase 3 MOVe-OUT Study – READ

April 1, 2022 – Merck PRESS RELEASE: Merck and Ridgeback to Present Data Demonstrating That Treatment With LAGEVRIO (molnupiravir) Was Associated With More Rapid Elimination of Infectious SARS-CoV-2 Than Placebo – READ

March 31, 2022 – Update on Progress of LAGEVRIO (molnupiravir) Supply and Access Strategy – PDF
As of March 31, 2022, we have committed to providing approximately 10 million courses of LAGEVRIO (molnupiravir) through nearly 40 supply and purchase agreements.

March 9, 2022 – The Conversation: Molnupiravir: why are there potential safety issues around this COVID antiviral? – READ

February 8, 2022 – TGA Regulatory Decision Notice: Australian Public Assessment Report (AusPAR): Molnupiravir- ARCHIVE

February 24, 2022 – NIH COVID-19 Treatment Guidelines – Molnupiravir – READ, ARCHIVE

Feburary 19, 2022 – Merck PRESS RELEASE: Merck and Ridgeback Statement on Clinical Trial of Hetero’s Generic Molnupiravir – In India a Global Efforts to Accelerate Access to Molnupiravir – READ – July 2021 clinical trial in india – READ

February 10, 2022 – NEJM: Molnupiravir for Oral Treatment of Covid-19 in Nonhospitalized Patients – Bernal et al – (MOVeOUT study group) – READ

February 8, 2022 – Merck PRESS RELEASE: Merck and Ridgeback Announce That 3.1 Million Courses of Molnupiravir, an Investigational Oral Antiviral COVID-19 Medicine, Have Been Supplied to the U.S. Government for Use in the United States – READ

February 3, 2022 – Merck PRESS RELEASE: Merck Announces Fourth-Quarter and Full-Year 2021 Financial Results – READ

• “Merck will have shipped more than 4 million courses of therapy to more than 25 countries, including approximately 3 million courses to the U.S. Government as part of its procurement agreement.”

January 28, 2022 – Merck PRESS RELEASE: Merck and Ridgeback’s Molnupiravir, an Investigational Oral Antiviral COVID-19 Medicine, Demonstrated Activity Against Omicron Variant in In Vitro Studies – READ

January 20, 2022 – TGA: TGA provisionally approves two oral COVID-19 treatments, molnupiravir (LAGEVRIO) and nirmatrelvir + ritonavir (PAXLOVID) – READ

January 18, 2022 – TGA provisionally approves Merck Sharp & Dohme (Australia) Pty Ltd’s oral COVID-19 treatment, LAGEVRIO (molnupiravir) – READ, TGA Documents molnupiravir – READ

January 18, 2022 – Merck PRESS RELEASE”: Merck and Ridgeback Announce Supply Agreement with UNICEF for Molnupiravir – READ

2021

December 30, 2021 – NIH: The COVID-19 Treatment Guidelines Panel’s Statement on Therapies for High-Risk, Nonhospitalized Patients With Mild to Moderate COVID-19 – ARCHIVE

• “As a mutagenic ribonucleoside antiviral agent, there is a theoretical risk that molnupiravir will be metabolized by the human host cell and incorporated into the host DNA, leading to mutations”
• “The FDA concluded that, based on the available genotoxicity data and the 5-day duration of treatment, molnupiravir has a low risk for genotoxicity.”
• “In the MOVe-OUT trial, molnupiravir reduced the rate of hospitalization or death by 30% compared to placebo.”

December 24, 2021 – Merck PRESS RELEASE: Merck and Ridgeback’s Molnupiravir, an Investigational Oral Antiviral COVID-19 Treatment, Receives Special Approval for Emergency in Japan – READ

December 23, 2021 – Merck PRESS RELEASE: Merck and Ridgeback’s Molnupiravir Receives U.S. FDA Emergency Use Authorization for the Treatment of High-Risk Adults With Mild to Moderate COVID-19 – READ, FDA Fact Sheet – PDF, Merck Fact Sheet – READ

December 23, 2021 – FDA NEWS RELEASE: Coronavirus (COVID-19) Update: FDA Authorizes Additional Oral Antiviral for Treatment of COVID-19 in Certain Adults – READ,
FDA FACT SHEET FOR HEALTHCARE PROVIDERS: EMERGENCY USE AUTHORIZATION FOR MOLNUPIRAVIR – PDF

December 22, 2021 – Fox News: Ingraham Angle: Dr Stephen Smith and Dr Harvey Risch – 10 of the review committee on molmupiravir voted it down. This is a drug that makes the virus mutate like crazy and could create mutant strains across the world – ARCHIVE

December 22, 2021 – Merck PRESS RELEASE: Merck and Ridgeback Announce U.K. Government to Purchase Additional 1.75 Million Courses of Molnupiravir – READ

December 16, 2021 – Merck PRESS RELEASE: Merck and Ridgeback Announce Publication of Phase 3 Study of Molnupiravir, an Investigational Oral Antiviral COVID-19 Treatment, in the New England Journal of Medicine – READ
fully published Feb 10, 2022 – STUDY

November 17, 2021 – Merck PRESS RELEASE: Merck and Ridgeback to Present Phase 3 Data for Molnupiravir, an Investigational Oral COVID-19 Antiviral Medicine, at American Society of Tropical Medicine and Hygiene (ASTMH) 2021 Annual Meeting – READ

November 4, 2021 – BMJ: Covid-19: UK becomes first country to authorise antiviral molnupiravir – ” temporary authorisation” – READ

November 4, 2021 – Merck PRESS RELEASE: Merck and Ridgeback’s Molnupiravir, an Oral COVID-19 Antiviral Medicine, Receives First Authorization in the World – READ

November 4, 2021 – UK’s MHPA: Regulatory approval of Lagevrio (molnupiravir) – READ

November 4, 2021 – UK MHRA PRESS RELEASE: First oral antiviral for COVID-19, Lagevrio (molnupiravir), approved by MHRA – The antiviral was found to be safe and effective following a stringent review of the available evidence – READ

October 25, 2021 – BMJ: Covid-19: UK stockpiles two unapproved antiviral drugs for treatment at home – Molnupiravir & PF-07321332/ritonavir (Paxlovid) – READ

October 25, 2021 – Merck PRESS RELEASE: Merck and Ridgeback Announce Initiation of a Rolling Review by the European Medicines Agency for Molnupiravir – READ

October 11, 2021 – Merck PRESS RELEASE: Merck and Ridgeback Announce Submission of Emergency Use Authorization Application to the U.S. FDA for Molnupiravir… Submissions to Regulatory Agencies Worldwide Underway – READ

October 7, 2021 – TK News by Matt Taibbi Substack: The Cult of the Vaccine – The tone of the coverage on molnupiravir turned within a day – READ, WATCH

• i.e. NY Times & Fauci – “A pill that could potentially treat Covid-19 is a ‘game-changer,’ but experts are emphasizing that it’s not an alternative to vaccinations.” – WATCH

October 5, 2021 – Dr James Lyons-Weiler Substack: The Extraordinary Hypocrisy of Molnupiravir – The Representation of Merck’s Molnupiravir as a “Game Changer” Only Underscores a Bias – And Merck Has Other Data It Is Not Sharing – READ

• “Merck and NIH allowed 14.1% of people in the control arms to develop severe COVID-19 and die with no treatment. None. Just placebo. How did the NIH and the FDA let this happen in the face of the evidence of efficacy of early treatment? How could they?”

October 4, 2021 – News: Brand new oral Covid-19 treatment bound for Australian shores – Australians will soon have access to a brand new Covid treatment after Scott Morrison announced the purchase of 300,000 courses of the new drug – Molnupiravir – READ

October 4, 2021 – BMJ: Covid-19: Molnupiravir reduces risk of hospital admission or death by 50% in patients at risk, MSD reports – READ

October 2, 2021 – CNN: Covid-19 antiviral pill could be a game changer, but vaccines are still America’s way out of the pandemic, experts say – READ

October 1, 2021 – Associated Press: Merck Antiviral Pill’s Clinical Trial Success Is ‘Good News,’ Fauci Says – but stressed that vaccines remained the best tool to prevent infections. – WATCH

October 1, 2021 – NPR: A pill can reduce deaths by half in new coronavirus patients, company says – READ

October 1, 2021 – Merck PRESS RELEASE: Merck and Ridgeback’s Investigational Oral Antiviral Molnupiravir Reduced the Risk of Hospitalization or Death by Approximately 50 Percent Compared to Placebo for Patients with Mild or Moderate COVID-19 in Positive Interim Analysis of Phase 3 Study – READ – Based on 762 patients, 385 in the treatment group.

September 1, 2021 – Merck PRESS RELEASE: Merck and Ridgeback Biotherapeutics Announce Initiation of Pivotal Phase 3 MOVe-AHEAD Study Evaluating Molnupiravir for Post-Exposure Prophylaxis of COVID-19 Infection – Study Now Enrolling Participants Who Live in the Same Household as Someone With Symptomatic, Laboratory-Confirmed COVID-19 – READ

August 11, 2021 – Nature Structural & Molecular Biology: Mechanism of molnupiravir-induced SARS-CoV-2 mutagenesis – By Kabinger et al – READ

• “Molnupiravir increases the frequency of viral RNA mutations and impairs SARS-CoV-2 replication in animal models and in humans.”

August 1, 2021 – The Journal of Infectious Diseases: β-d-N4-hydroxycytidine Inhibits SARS-CoV-2 Through Lethal Mutagenesis But Is Also Mutagenic To Mammalian Cells by Zhou, Ralph Baric et al – READ, READ

July 12, 2021 – Merck PRESS RELEASE: Interim Results from Phase 2/3 Studies of Molnupiravir, an Investigational Oral Antiviral Therapeutic for Mild to Moderate COVID-19, Presented at the European Congress of Clinical Microbiology & Infectious Diseases (ECCMID) – READ

June 9, 2021 – Merck PRESS RELEASE: Merck Announces Supply Agreement with U.S. Government for Molnupiravir, an Investigational Oral Antiviral Candidate for Treatment of Mild to Moderate COVID-19 – READ

April 15, 2021 – Merck PRESS RELEASE: Merck and Ridgeback Biotherapeutics Provide Update on Progress of Clinical Development Program for Molnupiravir, an Investigational Oral Therapeutic for the Treatment of Mild-to-Moderate COVID-19 – READ

March 6, 2021 – Merck PRESS RELEASE: Ridgeback Biotherapeutics and Merck Announce Preliminary Findings from a Phase 2a Trial of Investigational COVID-19 Therapeutic Molnupiravir – READ

January 25, 2021 – Merck PRESS RELEASE”: Merck Discontinues Development of SARS-CoV-2/COVID-19 Vaccine Candidates; Continues Development of Two Investigational Therapeutic Candidates – READ

2020

November 23, 2020 – Merck PRESS RELEASE: Merck to Acquire OncoImmune – READ

• OncoImmune’s lead product is CD24Fc, a first-in-class recombinant fusion protein that targets the innate immune system – Clinical Trial – READ, Study history – READ

October 5, 2020 – Clinical Trails: Efficacy and Safety of Molnupiravir (MK-4482) in Hospitalized Adult Participants With COVID-19 (MK-4482-001) – Sponsor MSD – READ – “Terminated (Business reasons)”, last updated on August 16, 2022!

• “For Business Reasons” is not a scientific or medical reason to terminate the study.” – SUBSTACK

October 5, 2020 – Clinical Trails: Efficacy and Safety of Molnupiravir (MK-4482) in Non-Hospitalized Adult Participants With COVID-19 (MK-4482-002) – READ

The post Molnupiravir first appeared on Totality of Evidence.

TGA: PAXLOVID: nirmatrelvir 150 mg tablet and ritonavir 100 mg tablet blister composite pack.

ClinicalTrials.gov: Evaluation of Protease Inhibition for COVID-19 in Standard-Risk Patients (EPIC-SR) – HERE

People take paxlovid after they contract COVID-19 (lab confirmed PCR positive) intending to lessen symptoms and lower the chance for hospitalisation. Event for people who have been vaccinated or boosted!

According to the CDC: “Paxlovid is a prescription oral antiviral drug that reduces the risk of hospitalisation and death for patients with mild-to-moderate COVID-19 who are at risk of disease progression and severe illness. Treatment should be initiated as soon as possible and within 5 days of symptom onset among persons eligible to receive the treatmetn under the EUA.” [This timing sounds a lot like what Dr Zelenko was recommending for HCQ+zinc in early 2020]

A full treatment course of paxlovid involves taking 30 pills during a 5 day period @ approx USD$529/treatment
(Hydroxychloroquine plus zinc treatment would be far less than $20!)

FDA Fact Sheet for Paxlovid – HERE
Pfizer: How a Coronavirus Protease Inhibitor Works to Fight COVID-19 – READ
Pfizer Press Releases on Paxlovid – HERE

Paxlovid info in reverse chronological order

2023

July 7, 2023 – Dr McCullough | Courageous Discourse Substack: FDA Grants Paxlovid Full Approval but Patients Prefer Ivermectin-Based Multidrug Protocols- Three Years of COVID-19 Home Regimens Have Greater Public Confidence than Government Recommended Monotherapy – READ & WATCH

• “Emily Harris, writer for JAMA reported on June 7, 2023, that the US FDA fully approved Paxlovid for the acute ambulatory treatment of COVID-19. Paxlovid is dosed from a bubble pack: 2 tabs nirmatrelvir 300 mg plus 1 tab ritonavir 100 mg taken every 12 hours for 5 days. In the video I remind you that the CDC has a public health advisory on Paxlovid rebound or prolongation of the syndrome. Additionally, I review the issue of drug-drug interactions while taking Paxlovid.’

June 5, 2023Australia Department of Health: Protecting Older Australians – COVID-19 Update 2 June 2023 – READ, ARCHIVE

• COVID-19 Oral antiviral treatments – “Continued strong uptake of oral antiviral medications remain important in residential aged care settings. The oral antivirals Lagevrio® and Paxlovid® are available through the Pharmaceutical Benefits Scheme (PBS) for all people aged 70 years or older.”

February 22, 2023 – The Guardian: Labor MP calls on government to widen Covid anti-viral eligibility in Australia – Lagevrio and Paxlovid – READ, The drugs are “taken to reduce Covid symptoms after infection” – [isn’t that what the vaccine is meant to do?]

2022

October 27, 2022 – Clinial Trials Gov: SARS CoV-2 Viral Persistence Study (PASC) – Study of Long COVID-19 (PASC) – Paxlovid – READ, ARCHIVE, NIH – SOURCE

• “The Paxlovid trial, which is expected to begin in 2023, is part of the NIH-funded RECOVER project – Researching COVID to Enhance Recovery” – REF

October 24, 2022 – The Highwire: URGENT WARNING ON USE OF PAXLOVID – Paxlovid became the first antiviral approved for Covid from the FDA over a year ago. Now, urgent warnings of severe drug interactions with several common heart, statin and immunosuppressive medications have come to light – WATCH, FULL

October 17, 2022 – Jack C Askins MD Substack: PAXLOVID AND UNINFORMED CONSENT – Disregarding oaths and ethics – READ

• “In 40 years of writing prescriptions, I have never seen a drug with that many drug interactions and potential incompatibilities. The lengthy list of interactions represents 35 categories of drugs (not 35 drugs, but 35 categories of drugs).”

August 24, 2022 – USA Today (AP): Paxlovid, Pfizer’s COVID pill, showed no measurable benefit in adults 40 to 65, study says – re the results from a 109,000-patient Israeli study – READ, Daily Beast – READ, CREDIT

August 6, 2022 – BPR: Basement Biden still testing positive after 15 days and 4 Pfizer shots. Hmmm? [taking paxlovid & multi-jabbed]- READ, SOURCE

August 6, 2022 – Dr Malone Substack: Paxlovid Escape Mutations? – President Biden’s two and a half-week Covid-19 marathon – READ

July 31, 2022 – NBC News: Biden tests positive for Covid again, has Paxlovid rebound and no symptoms, doctor says – READ

July 30, 2022 – pResident Biden is” “rebound” COVID positive observed in a small percentage of patients treated with PAXLOVID” the White House reports, he was negative for 2 days – READ

July 29, 2022 – The Highwire Ep 278 – PAXLOVID PLAN BYPASSES DOCTORS – Dr. Pierre Kory, discusses the dangers of Paxlovid. – WATCH, FULL

July 22, 2022 – America Out Load with Dr McCullough: Vaccinated Pounded by Paxlovid Rebound – READ & LISTEN

July 21, 2022 – Bannons War Room: Dr Robert Malone: The Treatment of Joe Biden re Paxlovid problems at time of trials – WATCH, Effects of Paxlovid – WATCH

July 21, 2022 – Rebel News: NYC giving Pfizer’s Paxlovid away for free to any New Yorker who tests positive for COVID, forking millions of dollars worth of taxpayer funds to Pfizer – READ

July 14, 2022 – The Highwire Episode 276 – It Gave Fauci ‘Rebound’: What’s Going to Happen If We Keep Prescribing Paxlovid? – Dr Richard Urso – EXCERPT

July 13, 2022 – Just the News: Study finds COVID already mutating around Paxlovid, as FDA circumvents doctors to prescribe – The FDA’s expansion of the emergency use authorization (EUA) for Pfizer’s COVID-19 antiviral pill could play a role in accelerating mutations of SARS-CoV-2, new research suggests. – READ

• The FDA’s expansion of the emergency use authorization (EUA) for Pfizer’s COVID-19 antiviral pill could play a role in accelerating mutations of SARS-CoV-2, new research suggests.
• Last week, the FDA authorized state-licensed pharmacists to circumvent doctors by directly prescribing Paxlovid…
• “Apparently, someone in government decided that there wasn’t enough Paxlovid being prescribed” seven months after its approval, Philadelphia cardiologist Anish Koka wrote skeptically in his newsletter this week. 
• The pill was initially submitted to treat people who balked at COVID vaccination, but the FDA approved it for “mild-to-moderate” infections in people at high risk of developing severe COVID, as young as 12, regardless of vaccination status. “
• The COVID rebound phenomenon wasn’t disclosed in Pfizer’s peer-reviewed paper on the nirmatrelvir trial, only showing up in the FDA’s EUA documents, Koka said. …”98% of placebo recipients not developing severe COVID”.

“Pfizer will make $20 billion+ from this drug, and they still have not provided a positive randomized trial in vaccinated people,“

Vinay Prasad epidemiologist (July 8, 2022)

July 10, 2022 – Anish Koka substack – Pharmacists Can Now Prescribe Paxlovid. Good idea? – READ

July 4, 2022 – Preprint: SARS-CoV-2 3CLpro mutations confer resistance to Paxlovid (nirmatrelvir/ritonavir) in a VSV-based, non-gain-of-function system , Heilmann et al – PDF

June 30, 2022 – PRESS RELEASE: Pfizer Announces Submission of New Drug Application to the U.S. FDA for PAXLOVID – for individuals at high risk for progression to severe illness from COVID-19 – READ

June 30, 2022 – New York Times: New York City Will Offer Paxlovid at Mobile Testing Sites, a First in the U.S. – READ

–

“New York City is creating the first mobile testing units in the United States that will allow people who test positive for the coronavirus to immediately receive for free the antiviral treatment Paxlovid” REASON: “help address concerns over inequities in distributing antiviral treatments.”

June 14, 2022 – Pfier: Pfizer Reports Additional Data on PAXLOVID Supporting Upcoming New Drug Application Submission to U.S. FDA – READ

• “just a handful of hospitalizations or deaths separated placebo recipients from those who took Paxlovid, including in a vaccinated subgroup. The drugmaker characterized the benefits as “non-significant.”” – source
• ERGO: Paxlovid trial stopped for lack of efficacy in standard risk patients. Coronavirus can find multiple ways to evade COVID-19 drug – Dr Malone – source

June 6, 2022 – PRESS RELEASE: Pfizer to Invest $120 Million to Produce COVID-19 Oral Treatment in the U.S – PAXLOVID. – READ

June 2, 2022 – Epoch Times Facts Matter – CDC Issues Warning on Pfizer’s Covid Pills, Alerts Issued For “Covid Rebound” and Positive Viral PCR Tests – WATCH

• Watch above as Roman Balmokov takes you through Paxlovid’s story, what it is and how it works. He notes that before EUA was issued the Biden administration payed $5.3 billion contract with Pfizer upfront agreeing to 10million tmt courses of the pills working out to $529/treatment.
• COVID-19 rebound [feeling sick, the thing the drug was meant to prevent!] did not represent reinfection with SARS-CoV-2 or the development of resistance to Paxlovid – this was something known from the clinical trials.

May 24, 2022 – CDC issues an advisory warning: COVID-19 Rebound After Paxlovid Treatment – HERE

May 9, 2022 – Medicine with Dr Moran: Pfizer cashing in on COVID Drug Paxlovid- Was it helpful for VP Harris? Is Pfizer being Transparent? – WATCH

May 4, 2022 – John Campbell looks at Paxlovid evidence? – WATCH

April 29, 2022 – PRESS RELEASE: Pfizer Shares Top-Line Results from Phase 2/3 EPIC-PEP Study of PAXLOVID for Post-Exposure Prophylactic Use – READ (Evaluation of Protease Inhibition for COVID-19 in Post-Exposure Prophylaxis = EPIC-PEP)

April 14, 2022 – NEJM: Oral Nirmatrelvir for High-Risk, Nonhospitalized Adults with Covid-19 – Hammond et al – PAPER

• “Nirmatrelvir is an orally administered severe acute respiratory syndrome coronavirus 2 main protease (M^pro) inhibitor with potent pan–human-coronavirus activity in vitro.” – this is the clinical trail that FDA EUA was based when Delta variant was in circulation.

March 22, 2022 – PRESS RELEASE: Pfizer to Supply UNICEF up to 4 Million Treatment Courses of Novel COVID-19 Oral Treatment for Low- and Middle-Income Countries – READ

March 21, 2022 – Precision vaccinations: What is Paxlovid’s Absolute and Relative COVID-19 Risk Reduction – READ

March 9, 2022 – PRESS RELEASE: Pfizer Initiates Phase 2/3 Study of Novel COVID-19 Oral Treatment in Pediatric Participants – PAXLOVID (nirmatrelvir [PF-07321332] tablets and ritonavir tablets) is the first oral therapy specifically designed to combat COVID-19 to be evaluated in a pediatric clinical study – READ

January 19, 2022 – Epoch Times: Australia Approves Novavax COVID-19 Vaccine and New COVID Oral Drug Treatments (Paxlovid and Lagevrio) – READ

• TGA has also approved the first anti-viral pills, Pfizer’s Paxlovid and Merck Sharp & Dohme’s Lagevrio but stressed that they are not a substitute for vaccinations….The pills are designed to prevent a patient’s condition from progressing to a more severe stage and work by interfering with the virus’s ability to multiply within the patient’s body.

January 20, 2022 – Australia’s Therapeutic Goods Administration (TGA): TGA provisionally approves two oral COVID-19 treatments, molnupiravir (LAGEVRIO) and nirmatrelvir + ritonavir (PAXLOVID) – READ

January 18, 2022 – Pfizer press release: Pfizer Shares In Vitro Efficacy of Novel COVID-19 Oral Treatment Against Omicron Variant – READ

January 18, 2022 – Australia’s Therapeutic Goods Administration (TGA): TGA provisionally approves Pfizer Australia Pty Ltd’s COVID-19 treatment nirmatrelvir + ritonavir (PAXLOVID) – READ, Provisional treatments, TGA summary on Paxlovid, axlovid regulatory documents – HERE

• “The decision has been made on the basis of short term efficacy and safety data. Continued approval of this indication depends on the efficacy and safety data from ongoing clinical trials and post-market assessment.”

January 4, 2022 – PRESS RELEASE: Pfizer to Provide U.S. Government with an Additional 10 Million Treatment Courses of its Oral Therapy to Help Combat COVID-19 – READ

2021

December 22, 2021 – PFIZER PRESS RELEASE: Pfizer Receives U.S. FDA Emergency Use Authorization for Novel COVID-19 Oral Antiviral Treatment – PAXLOVID (nirmatrelvir [PF-07321332] tablets and ritonavir tablets) – READ

December 22, 2021 – FDA EUA press release: Coronavirus (COVID-19) Update: FDA Authorizes First Oral Antiviral for Treatment of COVID-19 – LINK, FDA FACT SHEET –

December 14, 2021 – Pfizer press release: Pfizer Announces Additional Phase 2/3 Study Results Confirming Robust Efficacy of Novel COVID-19 Oral Antiviral Treatment Candidate in Reducing Risk of Hospitalization or Death – READ Data not delivered 5 month later – WATCH

November 5, 2021 – PRESS RELEASE: Pfizer’s Novel COVID-19 Oral Antiviral Treatment Candidate Reduced Risk of Hospitalization or Death by 89% in Interim Analysis of Phase 2/3 EPIC-HR Study – 28 day study – READ

November 2021 – TGA: PAXLOVID by Pfizer was Accepted for evaluation For treatment of COVID-19 – LINK, SCREENSHOT,

5 October 2021 -TGA grants “Provisional Determination” for Paxlovid, this authorises the drug to move through the Provisional Approval assessment process – READ

2020

October 2020 – Journal of Clinical Pharmacy and Therapeutics: QTc prolongation during antiviral therapy in two COVID‐19 patients by Zhu et al – READ lopinavir/ritonavir, CREDIT

• “In fact, Lopinavir/ritonavir (Paxlovid), used to treat Covid, has an established QT prolongation effect like HCQ, but since warnings about drug-drug interactions are well-publicized and Paxlovid is dispensed under physician/pharmacist supervision, reported cardiac adverse events are uncommon, avoiding cardiac and other safety concerns. ” – (2024) REF

The post Paxlovid by Pfizer first appeared on Totality of Evidence.

Vitamin D levels correlate strongly with SARS-CoV-2 infection severity,
with a theoretical point of zero mortality at approximately 50 ng/mL D3 – REF

Vitamin D administration results in a decreased risk of death and ICU admission.– REF

Overview on Vitamin D

This one hour presentation by Dr Michael F. Holick – a compelling overview of the power of vitamin D.

As temperature goes down (so too does the sunshine)

An interesting look at a time-laps video below showing as the US temperature drops (LEFT) the COVID-19 cases seem to follow along to some degree. When temperature decreases the tendency to stay outside reduces as well as the availability of sunshine hours decreases.

Dr Horick writes “when the angle of the sunlight (zenith angle) reaching the Earth’s surface is very oblique (ie, early morning, late afternoon, and winter), sunlight must pass through more ozone, which efficiently absorbs the previtamin D₃-producing UVB photons, and thus very few, if any, reach the earth’s surface. Because the zenith angle is dependent on time of day, season of the year, and latitude, those factors have a dramatic effect on the cutaneous [skin] production of vitamin D₃“

Dr Joe Prendergast & and Dr Liz Lipski on Vitamin D

Vitamin D is really a hormone. The whole immune system would become measurably stronger by a factor of 3-5 times, probalby better than any vaccines, for any virus. – Dr Prendergast – circa 2007

“57% of us a vitamin D deficient”, 92% of people with high pigmented skin are vitamin D deficient, making one more susceptible to colds and flu, amongst other things – Dr Liz Lipski 2008

[Vitamin D] has antimicrobial, antiviral activity

Dr Shiva March 2020 presentation

Vitamin D references in reverse chronological order

2025

February 15, 2025 – Doc Malik Honest Health Podcast #300 – Angus Dalgleish – IMPORTANT -mRNA “vaccines” and Public Health Lies – WATCH

• 4000 patients in pancreatic cancer chemo trials – show they won’t respond to chemotherapy if they have a low vitamin D level, and thousands of International Units of Vit D3 is needed not the 400IU RDI – EXCERPT

2024

May 30, 2024 -The Highwire Ep 374 – Perilous Protocols – FULL, Are Lithium and Vitamin D the missing keys to mental health and long-COVID (spike induced) brain fog? w/ Dr Michael Nehls – EXCERPT, WATCH

2023

Novmeber 30, 2023 – The Highwire Ep 348: The 500 Billion Dollar Man – Dr Eric Nepute – WATCH, FULL

• Sued by the government for $508 Billion for recommending Vitamin D and Zinc for COVID-19 – he stood his ground and didn’t cave. Listen to his story

November 12, 2023 – Dr John Campbell: The Great Biological Reset – interview w/ Professor David Anderson – WATCH, BACKUP, WATCH June 5, 2024 followup – WATCH

• BOOK: Vitamin D3 and the Great Biology Reset – A journey from global D-deficiency and Lab-leaked viruses, to Nuclear Vaccines from the Gates of Hell- by Prof David Coussmaker Anderson w/ Dr David Stuart Grimes – WEBSITE, (download digital edition for free)

November 2, 2023 – Dr Ian Brighthope Substack: Vitamin D supplementation for optimum levels by Dr John Piesse – READ

September 27, 2023 – FLCCC Stories: Adess Singh Requested That a Campaign To Boost the Vitamin D Levels of the People of Punjab Be Undertaken Right Away – WATCH, CREDIT

August 21, 2023 – WHH General Assembly Meeting #100: Professor David Anderson: The Central and Unique Role of Vitamin D in Health – WATCH, READ,

• In 2020, Dr Anderson realised the COVID-19 crisis was compounded by D3 deficiency
• He is now calling for a Great Biology Reset to restore Vitamin D and natural immunity to the centre stage of medicine as an antidote to Big Pharma, which he says exploits Vitamin D-deficiency to make money.

May 15, 2023 – Dr John Campbell: Vitamin D doses – reasearch shows we are likely under dosed – WATCH

• January 4, 2019 – The Journal of Steroid Biochemistry and Molecular Biology: Daily oral dosing of vitamin D3 using 5000 TO 50,000 international units a day in long-term hospitalized patients: Insights from a seven year experience – McCullough et al – READ

February 9, 2023 – The Highwire Ep 306: NEW STUDY SHOWS MASKS DON’T WORK AGAINST ILLNESS, BUT WHAT DOES? – also more studies now show both vitamin D and exercise as cheap, empowering and extremely effective strategies against COVID – WATCH, FULL

February 2, 2023 – Dr John Campbell: Vitamin D, now conclusive – WATCH, STUDY

January 16, 2023 – Pharmaceuticals (Basel): Protective Effect of Vitamin D Supplementation on COVID-19-Related Intensive Care Hospitalization and Mortality: Definitive Evidence from Meta-Analysis and Trial Sequential Analysis [TSA] by Argano et al- READ, The Highwire – WATCH

• “We searched four databases on 20 September 2022. Two reviewers screened the randomized clinical trials (RCTs) and assessed the risk of bias, independently and in duplicate. The pre-specified outcomes of interest were mortality and ICU admission. …only five RCTs were found to be suitable for our analysis.” [no money to be made from Vitamin D research!]
• Vitamin D administration results in a decreased risk of death and ICU admission
• The results of the meta-analyses and respective TSAs suggest a definitive association between the protective role of vitamin D and ICU hospitalization.

2022

November 11, 2022 – Gateway Pundit: “I Humbly Risk It All Because I Know God Is In Control” – Dr. Eric Nepute told people to take vitamin D and zinc and the government is suing him for doing so – READ, TGP’s Joe Hoft Interviews Dr. Eric Nepute, the First Person Charged Under COVID False Claims Law – WATCH

October 25, 2022 – Annals of Internal Medicine: Vitamin D Deficiency Increases Mortality Risk in the UK Biobank – A Nonlinear Mendelian Randomization Study by Sutherland et al – READ

• “Our study supports a causal relationship between vitamin D deficiency and mortality.”

October 11, 2021 – Nutrients: COVID-19 Mortality Risk Correlates Inversely with Vitamin D3 Status, and a Mortality Rate Close to Zero Could Theoretically Be Achieved at 50 ng/mL 25(OH)D3: Results of a Systematic Review and Meta-Analysis – Borsche et al – READ, CREDIT

• “Much research shows that blood calcidiol (25(OH)D3) levels correlate strongly with SARS-CoV-2 infection severity.
• Regression suggested a theoretical point of zero mortality at approximately 50 ng/mL D3.
• “The datasets provide strong evidence that low D3 is a predictor rather than just a side effect of the infection. Despite ongoing vaccinations, we recommend raising serum 25(OH)D levels to above 50 ng/mL to prevent or mitigate new outbreaks due to escape mutations or decreasing antibody activity.”

September 26, 2022 – Dr Simon substack: Why Vitamin D is essential for a better Quality of Life – causal-loop diagrams to understand the metabolic pathways of vitamin D – READ

July 22, 2022 – Dr Brad Stanfield: When Exactly You Must Have a Vitamin D Test – WATCH

June 3, 2022 – Frontline Flash Daily Dose: ‘Why Is No One Talking About Vitamin D?’ with Dr. Peterson Pierre – The vitamin D group in the RCT of frontline workers had 4 x lower infection of COVID-19 – WATCH, ARTICLE

Published June 2022 – Archives of Medical Research: Efficacy and Safety of Vitamin D Supplementation to Prevent COVID-19 in Frontline Healthcare Workers. A Randomized Clinical Trial – Villasis-Keever et al – HERE

May 24, 2022 – Epoch Times: COVID-19 Is Treatable and Preventable With Vitamin D: Dr. Robert Malone – READ, WATCH

There are virtually no deaths from this disease [COVID-19] in people who have vitamin D levels in their blood above 50ng/mL [nanograms per millilitre].

Dr Robert Malone

May 8, 2022 – Dr Malone Substack: Preventable Deaths and D3 – The Ugly History of Vitamin D3 and Fauci’s pro-Vaccine Bias – READ

April 26, 2022 – Epoch Times: Vitamin D Supplementation Is Effective in Preventing COVID-19, Study Suggests – READ

April 11, 2022 – Archives of Medical Research: Efficacy and Safety of Vitamin D Supplementation to Prevent COVID-19 in Frontline Healthcare Workers. A Randomized Clinical Trial – Villasis-Keever et al – READ

April 7, 2022 – Dr John Campbell – Vitamin D Supplements for Prevention of Covid-19 or other Acute Respiratory Infections – WATCH

March 21, 2022 – Zdr Varst | Slovenian Journal of Public Health: COVID-19 and Vitamin D- a Systematic Review – Jordan et al – READ

• “Vitamin D supplementation might play an important role in protecting from acute respiratory infections like the SARS CoV2, and in high-risk individuals with COVID 19 from progressing to critical clinical condition and reducing mortality.”

February 17, 2022 – Orthomolecular: It’s Official: Vitamin D Reduces the Incidence of Autoimmunity – And a brief review of the growing body of knowledge of vitamin D – READ

January 9, 2022 – Orthomolecular Medicine News: Top Vitamin D Papers in 2021
Benefits ignored at a time they are most needed – READ

2021

December 28, 2021 – DarkHorse Podcast: Bret Weinstein Speaks with Gruff Davies and Linda Benskin on the subject of Vitamin D as a preventative measure for Covid – WATCH, BACKUP, LISTEN

December 22, 2021 – Paper: Vitamin D Status and SARS-CoV-2 Infection and COVID-19 Clinical Outcomes – READ

December 20, 2021 – There has been ZERO deaths from vitamins – READ

December 5, 2021 – CCCA: Vitamin D3 and COVID-19: A Brief for Family Physicians in Patients by Dr. Kanji Nakatsu, Ph.D. and Dr. Niel Karrow, Ph.D. – READ, PDF

October 14, 2021 – Nutrients: COVID-19 Mortality Risk Correlates Inversely with Vitamin D3 Status, and a Mortality Rate Close to Zero Could Theoretically Be Achieved at 50 ng/mL 25(OH)D3: Results of a Systematic Review and Meta-Analysis by Borsche et al – READ

• Regression suggested a theoretical point of zero mortality at approximately 50 ng/mL vitamin D3

August 13, 2021 – According to this new study, 84.4% of COVID-19 patients investigated had a vitamin D deficiency – TWEET, READ

May 18, 2021 – What’s Up Canada | Doctor Talks Part 6: Linda M. Rapson MD: Outpatient Treatment, “Host Resistance” with vitamin D – WATCH

March 15, 2021 – Wiener klinische Wochenschrift: Strong correlation between prevalence of severe vitamin D deficiency and population mortality rate from COVID-19 in Europe – Pugach et al – READ

• “The authors recommend universal screening for vitamin D deficiency, and further investigation of Vitamin D supplementation in randomized control studies, which may lead to possible treatment or prevention of COVID-19”

January 15, 2021 – Orthomolecular Medicine News: A Health Crisis Exposed by the COVID Pandemic- understanding the immune system – READ

January 10, 2021 – Orthomolecular Medicine News: Top 25 Vitamin D Publications in 2020 – READ

January 3, 2021 – MedCram: If You Get COVID 19: Optimize Immune System (Vitamin D, Monoclonal Antibodies, NAC, Quercetin etc.) – Professor Roger Seheult, MD gives practical strategies for combatting COVID-19 – WATCH, ARCHIVE

2020

December 22, 2020 – Gent Side: More than 130 experts have signed an open letter urging Boris Johnson to incorporate Vitamin D as part of the coronavirus strategy – READ

• The letter was sent to Boris Johnson and health Secretary Mike Hancock on Monday the 21st of December, advising that healthy adults should increase their daily vitamin D intake to 2,000 – 4000 international units (IU) during the pandemic.

December 17, 2020 – Public Health England | Scientific Advisory Committee on Nutrition (SACN) – NICE guideline: COVID-19 rapid guideline: vitamin D – PDF, ARCHIVE, READ

• “They stressed that everyone should consider taking a supplement containing 10 micrograms (400 units) of vitamin D daily between October and early March, when people in the UK do not make enough vitamin D from sunlight.” [Low dose!]

December 17, 2020 – National Institute for Health and Care Excellence (NICE UK) [NG187]: Vitamin D for COVID-19- [A] Evidence reviews for the use of vitamin D supplementation as prevention of COVID-19 – READ, ARCHIVE, PDF

• These evidence reviews were developed by Centre for Guidelines Methods and Economics Team

• This review aims to assess if vitamin D supplementation can prevent SARS CoV2 infection and subsequent COVID-19. It has been hypothesised that vitamin D is involved in the body’s immune response and could mitigate the inflammatory response.
• “No evidence relevant to the protocol was found for this question”

December 17, 2020 – Frontiers in Pharmacology: COVID-19 Disease and Vitamin D: A Mini-Review – Boulkrane et al – READ

• “Vitamin D is well-known to play a significant role in maintaining the immune health of an individual.” [SERIOUSLY, why not give it to the at risk then as a precautionary measure?]
• “Moreover, it induces antimicrobial peptide expression that can decrease viral replication and regulate the levels of pro-inflammatory/anti-inflammatory cytokines.”
• “We suggest that supplementation of subjects at high risk of COVID-19 with vitamin D (1.000 to 3.000 IU)…”[Too low for high risk?]
• “To verify this proposal, double-blind placebo-controlled trials and large-scale intervention and prevention studies using vitamin D₃ are needed.” [Volunteers anyone!!!!]

November 27, 2020 – Nutrients: Vitamin D Insufficiency May Account for Almost Nine of Ten COVID-19 Deaths: Time to Act. Comment on: “Vitamin D Deficiency and Outcome of COVID-19 Patients – Brenner & Schottker – READ

• “Evidence from observational studies is accumulating, suggesting that the majority of deaths due to SARS-CoV-2 infections are statistically attributable to vitamin D insufficiency and could potentially be prevented by vitamin D supplementation
• “these results imply that 87% of COVID-19 deaths may be statistically attributed to vitamin D insufficiency and could potentially be avoided by eliminating vitamin D insufficiency.”

November 7, 2020 – The UK Telegraph: Vitamin D to be delivered to millions of vulnerable people to help protect them from Covid – Ministers draw up plans for four-month supplies to go to care home residents and clinically extremely vulnerable people in England – READ

October 16, 2020 – Daily Mail: Now Matt Hancock [UKs Health Secretary] says you SHOULD take vitamin D to boost your overall health amid mounting evidence it can protect against Covid-19 – U-turned on previous comments it has ‘no impact’ on Covid-19 – READ

• The about face “comes after scientists and MPs lambasted Mr Hancock for ‘ignoring’ the increasing number of studies which show vitamin D is linked with better Covid-19 outcomes. Several studies have shown people with a vitamin D deficiency, which is common in Britain, are more likely to catch the coronavirus, get seriously ill or die.”
• A row on the benefits of vitamin D came to a head two weeks ago when Matt Hancock wrongly told the House of Commons in September that a Government-funded ‘trial’ investigating it showed it did not ‘appear to have any impact’. 

October 1, 2020 – Daily Mail: Since the Covid-19 epidemic started multiple studies have repeatedly shown a link to Vitamin D deficiency yet when Matt Hancock was asked about it he WRONGLY said a British study had found the opposite. Is he ignorant or incompetent? – READ

September 21, 2020 – UK House of Commons: UK Health Secretary Matt Hancock says trials of Vitamin D against COVID-19 are negative – WATCH, CREDIT, does an about face within a month.

December 23, 2020 – Orthomolecular Medicine News: Do the Math: “MATH+” Saves Lives – READ

September 17, 2020 – The Highwire: FAUCI TOUTS VITAMINS FOR COVID?! – WATCH

September 14, 2020 – Dr Shiva explains the mode of action of Vitamin D – WATCH

September 14, 2020 – Best Life: The 2 Vitamins Dr. Fauci Says You Should Take to Boost Immunity – Vitamin C & D – READ

September 12, 2020 – Insider: Fauci says that he takes vitamin D and C supplements and that they can lessen ‘your susceptibility to infection’ – READ

September 12, 2020 – Interview with Actress Jennifer Garner – WATCH, The supplement Dr. Fauci takes to help keep his immune system healthy – ARTICLE, The Highwire – WATCH

“If you are deficient in vitamin D, that does have an impact on your susceptibility to infection. So I would not mind recommending, and I do it myself taking vitamin D supplements,”

September 1, 2020 – Tiffany Haddish interviews Dr. Fauci about COVID-19 – WATCH

• “Fauci said in clinical studies most “so-called” immune-boosting supplements didn’t really help people unless they had some sort of a deficiency. In fact, a lot of these herbs “either do nothing, or, if you take too much of them, they harm you,””
• 2 days later paper shows Vit D deficiency increases risk of COVID-19 – READ

September 8, 2020 – Uni Chicago News: Vitamin D deficiency may raise risk of getting COVID-19, study finds – READ

June 29, 2020 – NICE UK: COVID-19 rapid evidence summary: vitamin D for COVID-19 – Evidence summary [ES28] – ARCHIVE

June 18, 2020 – The Royal Society | preprint: Vitamin D and COVID-19: This rapid review of the science of Vitamin D and COVID-19 from the Royal Society is provided to assist in the understanding of COVID-19. – READ

June 9, 2020 – Orthomolecular Medicine News: The role of vitamin D in reducing risk of COVID-19: a brief survey of the literature – READ

April 28, 2020 – MeRxiv pre print: Vitamin D insufficiency is prevalent in severe COVID-19 – Lau et al – READ

April 2, 2020 – MDPI | Nutrients: Evidence that Vitamin D Supplementation Could Reduce Risk of Influenza and COVID-19 Infections and Deaths – Grant et al – READ

March 29, 2020 – Dr Shiva Ayyadurai, PhD: How Vitamin D Destroys FOR YOU. A Molecular Systems Understanding. – WATCH

The virus is not what actually kills you. It is the over reaction of a weakened and dysfunctional immune system.”

Dr Shiva

• Vitamin D has many modes of action. When it comes to acute respiratory infections vitamin D supports the creation of cathelicidins, which are anti-microbial peptides (AMPs) – which destroy viruses by attacking their membranes – Dr Shiva explains this mode of action of the vitamin D
• Macrophages (primary white blood cells) are part of your innate immune system. There are two types of macrophages – M1 – Pro-inflammatory which support anti-microbial properties and M2 Anti-inflammatory which supports tissue repair
• PAPER: March 18, 2019 – Nature: Cathelicidins PMAP-36, LL-37 and CATH-2 are similar peptides with different modes of action by Scheenstra et al – READ
  • “…almost all cathelicidins show, in simple media, direct antimicrobial activity against many different bacteria, viruses, fungi, and parasites.”
• Macrophages secrete antimicrobial peptides (AMPs) of which one is Cathelicidin AMPs or CAMPs, which are critical to the antimicrobial immune response activity. Vitamin Di is essential for generating CAMPs – EXCERPT

March 23, 2020 – Fox News – Former CDC Chief Dr. Tom Frieden: Coronavirus infection risk may be reduced by Vitamin D – WATCH

March 23, 2020 – Dr Shiva sends letter to President Trump with science-based immune boost protocol, with Vitamin C & D being critical – TIMELINE, LETTER

March 17, 2020 – International Society for Orthomolecular Medicine (ISOM) recommends nutrition support for curing and treating new coronavirus infections – WATCH, ISOM for COVID-19 – HERE, Basic tmt first steps – READ

February 11, 2020 – Immune Network: Vitamin D-Cathelicidin Axis: at the Crossroads between Protective Immunity and Pathological Inflammation during Infection by Chung et al – READ, (For context see Dr Shiva’s presentation March 2020 above)

• “we discuss recent findings that demonstrate how the vitamin D-cathelicidin pathway regulates autophagy machinery, protective immune defenses, and inflammation, and contributes to immune cooperation between innate and adaptive immunity”

2019

March 18, 2019 – Nature: Cathelicidins PMAP-36, LL-37 and CATH-2 are similar peptides with different modes of action by Scheenstra et al – READ, Dr Shiva – CREDIT

• “…almost all cathelicidins show, in simple media, direct antimicrobial activity against many different bacteria, viruses, fungi, and parasites.”

2018

October 1, 2018 – Orthomolecular Medicine News – Vitamin D acceptance delayed by Big Pharma following the Disinformation Playbook – READ

June 2018 – Journal Steroid Biochemistry and Molecular Biology: In vivo response of the human epigenome to vitamin D: A Proof-of-principle study – Carlberg et al – READ

2017

February 2017 – BMJ: Vitamin D supplementation to prevent acute respiratory tract infections: systematic review and meta-analysis of individual participant data by Martineau et al – READ, Dr Shiva – CREDIT

• “Conclusions Vitamin D supplementation was safe and it protected against acute respiratory tract infection overall. Patients who were very vitamin D deficient and those not receiving bolus doses experienced the most benefit”

February 13, 2017 – Orthomolecular Medicine News – The Top 18 Vitamin D Papers in 2015-2016 – READ

2016

April 22, 2016 – Biogena Academy Vienna: The D-Lightful Vitamin for Health – presentation by Dr. Michael F. Holick, Boston University Medical Center – Important information and facts about the vitamin D – WATCH

• [From the comments under this video] “I am a 66 year old obese type 2 diabetic who was vitamin D deficient, my doctor put me on 1000 units a day and I was still deficient I went to 5000 units a day and I was still deficient I then went to 10,000 units a day and I am just within the normal range….You have opened my eyes to the importance of vit D supplementation!”

February 5, 2016 – Keio Journal of Medicine: Vitamin D Deficiency with High Intact PTH Levels is More Common in Younger than in Older Women: A Study of Women Aged 39-64 Years by Miyamoto et al – READ, PDF, CREDIT

• Study by Keio University showed that more than 70% of people had suboptimal (20-29 ng/mL) levels or were deficient (<20 ng/mL) in vitamin D – REF

2014

December 9, 2014 – Uni California TV: Vitamin D for Public Health: Integrating Sunshine, Supplements and Measurements for Optimal Health – presentation by Michael F. Holick, PhD MD, Boston University Medical Center – WATCH, SOURCED

2013

January 17, 2013 – Orthomolecular Medicine News: Vitamin D is Now the Most Popular Vitamin – READ

2010

June 2010 – PLOS One: Serum 25-Hydroxyvitamin D and the Incidence of Acute Viral Respiratory Tract Invections in Healthy Adults by Sabetta et al –READ, CREDIT, [38 ng/ml is the tipping point]

• “Conclusions/significance: Maintenance of a 25-hydroxyvitamin D serum concentration of 38 ng/ml or higher should significantly reduce the incidence of acute viral respiratory tract infections and the burden of illness caused thereby, at least during the fall and winter in temperate zones.
• The findings of the present study provide direction for and call for future interventional studies examining the efficacy of vitamin D supplementation in reducing the incidence and severity of specific viral infections, including influenza, in the general population and in subpopulations with lower 25-hydroxyvitamin D concentrations, such as pregnant women, dark skinned individuals, and the obese.”

May 2010 – American Journal of Clinical Nutrition: Randomized trial of Vitamin D supplementation to prevent seasonal influenza A in schoolchildren – Urashima et al (Japan) – READ, READ, CREDIT

• First of its kind trial. ” From December 2008 through March 2009, we conducted a randomized, double-blind, placebo-controlled trial comparing vitamin D(3) supplements (1200 IU/d) with placebo in schoolchildren.”
• Conclusion: This study suggests that vitamin D(3) supplementation during the winter may reduce the incidence of influenza A, especially in specific subgroups of schoolchildren.”

2008

March 2, 2008 – Dr Liz Lipski – Essential Information About Vitamin D – WATCH

• Mental institution patients were supplemented with vitamin D, as they were discovered to be deficient. The year a flu epidemic went through that hospital, these supplemented patients avoided getting sick! Vitamin D has anti-viral properties – EXCERPT
• The mechanism with which our body makes vitamin D from sunlight exposure: The skill cells make Cholecalciferol (Vitamin D3) from sunlight, this then goes to our liver to make 25-dihydroxyvitamin D3, which our kidneys then converted this to the active form of vitamin D, that’s actually a hormone. Optimal kidney function is essential. – EXCERPT
• Check your vitamin D level: 25-Hydroxyvitamin D [25(OH)D] is the active metabolite form that should be measured in the blood to determine vitamin D status – levels of 32 is minimal, optimal is 45-70 ng/mL – EXCERPT, REF
• 25-Hydroxyvitamin D [25(OH)D] is the metabolite that should be measured in the blood to determine vitamin D status
• On a sunny day your body can make thousands of units of vitamin D per 15-30 minute exposure without sunscreen – EXCERPT
• Vitamin D2 (Ergocalciferol) – is kind of a “fake” vitamin D – EXCERPT
• Vitamin D sun lamps are also available [I didn’t know that, if true should our aged care facilities have these?]

2007

July 16, 2007 – NEJM | Review Article: Vitamin D Deficiency by Michael F. Holick, M.D., Ph.D. – READ, via Researchgate – READ, Dr Holick – WEBSITE

2006

September 7, 2006 – Cambridge Uni Press: Epidemic influenza and vitamin D – Cannell et al – READ

2004

September 2004 – Continuing Medical Education: The clinical importance of Vitamin D (Cholecalciferol): A paradigm shift with implications for all healthcare providers by John Cannell et al – READ,

• “With the discovery of vitamin D receptors in tissues other than the gut and bone—especially the brain, breast, prostate, and lymphocytes—and the recent research suggesting that higher vitamin D levels provide protection from diabetes mellitus, osteoporosis, osteoarthritis, hypertension, cardiovascular disease, metabolic syndrome, depression, several autoimmune diseases, and cancers of the breast, prostate, and colon, we can now utilize vitamin D for a wider range of preventive and therapeutic applications to maintain and improve our patients’ health” [italic added]
• “Vitamin D is an endogenous, naturally occurring, photochemically-produced steroidal molecule with essential functions in systemic homeostasis and physiology, including modulation of calcium metabolism, cell proliferation, cardiovascular dynamics, immune/inflammatory balance, neurologic function, and genetic expression.”
• Current daily supplementation recommendations of 200–600 IU are insufficient

• “…many cells and tissues of the body have the ability to metabolize vitamin D, we should not be surprised that vitamin D plays a role in the function of these cells”

March 2004 – American J. Clinical Nutrition: Vitamin D: importance in the prevention of cancers, type 1 diabetes, heart disease, and osteoporosis – Holick – READ, [This has been know since 2004 for high risk groups, elderly and the obese, yet no vit D supplementation was recommended for prevention of COVID-19 symptom escalation in 2020 – i.e. to Flatten the Curve]

• “The elderly are at risk for vitamin D deficiency because of poor dietary vitamin D intake and decreased exposure to sunlight.”
• Healthy adults 18-29 y of age can also be vitamin D deficient – depending on their exposure to sun
• Obesity is often associated with vitamin D deficiency…it is efficiently deposited in the large body fat stores and is not bioavailable”
• UVB radiation above 290 nm …is responsible for producing previtamin D₃ in the skin.
• “…when the angle of the sunlight (zenith angle) reaching the Earth’s surface is very oblique (ie, early morning, late afternoon, and winter), sunlight must pass through more ozone, which efficiently absorbs the previtamin D₃-producing UVB photons, and thus very few, if any, reach the earth’s surface. Because the zenith angle is dependent on time of day, season of the year, and latitude, those factors have a dramatic effect on the cutaneous production of vitamin D₃“

2004 – The Vitamin D Council: Vitamin D Toxicity – ARCHIVE

• “Articles about vitamin D are beginning to appear everywhere. For years, most of us wrongly assumed we had enough if we drank a little milk and took a multivitamin pill. Now, headlines around the world are reporting most of us are deficient and those deficiencies are causing numerous illnesses.” – REF

• “Vitamin D is safe when used in the doses nature uses”

• “Most of us make about 20,000 units of vitamin D after about 20 minutes of summer sun. This is about 100 times more vitamin D than the government says you need every day.” – REF
• International Vitamin D Workshops have been conducted since 1973 – ARCHIVE

2002

December 28, 2002 – British J Nutrition: Vitamin D in preventive medicine: are we ignoring the evidence? – Zittermann A. – READ, PDF

• “There is mounting evidence for a pivotal role of vitamin D in the immune system“
• “Macrophages represent the first unspecific defence line of the immune system. Calcitriol increases the activity of lysosomal enzymes in macrophages and facilitate cytotoxic activity by enhancing the rate of phagocytosis.”
• “Data relating infectious diseases to vitamin D status are scanty. However, there is some evidence from epidemiological data for a link between low vitamin D status and an increased risk for infections.”

The post Vitamin D first appeared on Totality of Evidence.

[Sept 2024 – Note that this page was not started as a timeline, unlike other pages, so many of the pre 2023 data points are not complete but are still being populated. This Sept 9,2024 article HERE , provides an excellent summary of what happened with HCQ, along with comments by Dr Malone HERE]

So why is hydroxychloroquine suddenly “dangerous”?

Some facts to consider about HCQ:

• Chloroquine and HCQ are listed as an essential medicine by the WHO.
• HCQ is relatively less “toxic” than Chloroquine when you look at the potential side effect profile.
• The patents for both Chloroquine and it’s derivative HCQ have expired, which means they can be manufactured generically, which in turn means cheaply.
• Hydroxychloroquine has been on the FDA’s list of approved drugs since 1955
• In 2005 an in vitro study of Chloroquine on SARS virus showed prohibitive viral properties when used early.
  August 22, 2005 – Viroolgy Journal: Chloroquine is a potent inhibitor of SARS coronavirus infection and spread – Vincent et al – READ
• In malaria prone countries, HCQ can be bought over the counter – no doctor’s script necessary.  In CDC fact sheet they recommend purchase before and deems it safe for adults and children, except those prone to psoriasis.
• HCQ acts as an ionophore, meaning it opens up a transport channel for zinc to enter the cell and it is the zinc that stops viral replication.
• A 200mg oral dose of hydroxychloroquine has a half life of 537 hours or 22.4 days in blood, longer in plasma.
• Experts agree that “chloroquine has a small toxic to therapeutic margin“, meaning the right dose is effective, too high and it is toxic, even fatal.
• In Taiwan December 2020 a manufacturing plant that makes the precursor to HCQ was damaged, and in May 2020, possibly 2 other plants that also make or store magnesium stearate were also damaged.  Coincidence?
• Since 1968 very few deaths attributed to hydroxychloroquine

Fact, if an effective early treatment was “found” for COVID-19:

• The pandemic would be over
• States of Emergency would no longer be ‘justifiable’
• Experimental vaccine’s would not be necessary or justifiable
• Emergency Use Authorisation or Provisional Registrations of vaccines would need to be stopped
• Vaccine manufacturers would loose hundreds of billions of dollars in profits.

Other questions to consider:

• Is HCQ a potential, broadspectrum anti-viral, in particular when used in combination with zinc?
• If HCQ is safe for adults, children and pregnant women for weekly treatment for malaria, they why is the same/similar dose suddenly “dangerous” in the middle of a pandemic, as a demonstrated effective early treatment measure?
• Why did health authorities design clinical trials for HCQ in late stage, hospitalised patients only, and at rates in excess of that used by frontline doctors for early treatment?
• If a broad spectrum anti-viral medication was “discovered” what would this do to the profitability of the vaccine industry?
• What would happen to the childhood vaccination program?
• Do you think Big Pharma and it’s “soldiers” would do everything they can to stop such information from coming to light?
• What tools do Big Pharma have to control the narrative?  Media? Lobby groups? Health authorities? Grant funding? Medical journal funding?

These are all questions to ponder as you dive into this controversial topic.  The greater number of people who know this information, the quicker a corrections can be made – assuming they do something about it!

HCQ and COVID-19

As the COVID-19 pandemic took hold in early 2020, some key doctors highlighted the life saving benefits of the HCQ drug for treating the symptoms of COVID-19 as well as potentially reducing the replication of the disease agent SARS-CoV-2.

We’ve capture their story here, along with the science and the mode of action this drug has against this virus.  We’ll also look at the focus of the clinical trials that the “expert medical authorities” conducted using HCQ, and how they determined that the drug failed to be beneficial and was deemed to be potentially dangerous.  There is so much to unravel for this drug and its controversy.

In the mean time if you want an excellent summary read this article from Jun 2020:  How a False Hydroxychloroquine Narrative Was Created

HCQ Timeline

In March 2020, Australia’s Clive Palmer through his foundation donated 32,900,000 doses of HCQ to the people of Australia, because of the positive information coming from independent doctors, virologists and scientists.

For an excellent timeline of event surrounding HCQ the Palmer Foundation website has been keeping track of since April 2020, below we’ll share our own discoveries of which there will be overlaps.  It appears the general public is not aware of much of this information.

This web page will be updated, it is set up to build the story in chronological order.

Scroll to the bottom of this page for the most recent videos

Dr Vladimir Zelenko’s Story

Zelenko “discovers” HCQ combination as an effective treatment for COVID-19

This story is a movie in the making.  Dr Vladimir Zelenko is a family doctor for around 30,000 residents in New York area.  He himself was suffering with cancer, undergoing treatment and surgery during the pandemic.  He claims to have never worn a mask while with his patients (many coming to him with COVID-19 symptoms) and he takes his prophylaxis treatment daily to protect himself against contracting the disease – by late 2020 he as yet hasn’t contracted COVID-19 but has assisted many hundreds of patients through the disease process, with only 2 hospitalisations, and 2 deaths, one with late stage cancer (as of end 2020).

It is highly recommended you listen to his story (below) yourself as he shares how he discovered HCQ + Zinc + Azithromycin combination for the treatment of his patients who came to him presenting with COVID-19 symptoms.  Listen to what he says and compare that to trials the “authorities” designed that  “proved” the drug to be “ineffective”.

Since the media won’t show you this, you’ll have to discover it for yourself.

Dr Zelenko share’s his treatment protocol for COVID-19

This video was first aired 2 July 2020 on The Highwire  which has since been deleted from YouTube.  Below is a part of this episode that features Dr Zelenko.

The Zelenko Protocol

Zelenco Protocol information with publication links and links to more videos

The Zelenko Protocol

Find the Zelenko Protocol here, the whole purpose is to prevent symptoms from escalating and preventing hospitalisation.

Dr Zelenko mentions virologist Professor Didier Raoult from France.  Over time as these two doctors communicated and they refined their treatment, Dr Raoult started to use zinc in combination, and thus decreased his dosage of hydroxychloroquine.

Watch Medcram episode 34 explaining the mechanisms of zinc with an ionophore such as choloroquine, referenced by Dr Z.

www.VladamirZelenkoMD.com

Dr Zelenko’s Letter to President Trump

In March 2020 Dr Zelenko wrote a letter to President Trump to inform him about his success with the hydroxychloroquine combination treatment protocol for the COVID-19 pandemic.  Just as an aside it was claimed by the media that Trump owned shares in Sanofi, one of the companies that makes the generic drug, but that was taken out of context and thus fake news.

Video has been removed:
President Trump On Using Dr. Vladimir Zelenko’s Hydroxychloroquine Protocol
https://www.youtube.com/watch?v=92pDKwloEEk

What the media didn’t tell you

An informative interview with Dr Zelenko

Dr Zelenko’s interview with the Corona Investigation Committee July22, 2021 – Session 62

Interesting statement by Dr Zelenko: “I’ve noticed, what ever the FDA decides, the rest of the world follows”.   Why this is interesting is that our TGA does refer to international regulatory bodies to assist in making recommendations and decisions.

He talks about how HCQ went from being available to everyone under Executive Order to being thwarted by FDA/HHS EUA for use in hospital settings only – the one setting it was never going to work in based on existing experience!

“In America, any drug that’s FDA approved can be used off-label for any reason” stated Dr Zelenco (within registered dose rates)

Combination treatment has provided the best results

The combination of HCQ with Zinc, is more effective than either used alone.  Zinc needs an ionophore to help it get into the cells, once in there it works to block the replication of the virus by inhibiting an enzyme called RNA-dependent RNA polymerase also called RNA replicase (see video below).
In addition, HCQ has multiple modes of action (see Dr Shiva video below) but when used in combination with zinc there is a synergistic effect.  Zinc is the bullet, HCQ (an ionophore) is the gun or the delivery tool.

Alternative Ionophores

If HCQ is not available Quercetin and EGCG (green tea extract) are also efficient zinc ionophores as discussed by Dr Zelenko.  All the front line doctors have stated, you need to get in early, the moment symptoms appear.

How Zinc and an ionophore work together

The paper referenced in this video: “Zn(2+) inhibits coronavirus and arterivirus RNA polymerase activity in vitro and zinc ionophores block the replication of these viruses in cell culture”.

Early treatment is key to the success with HCQ

The medical establishment (clinical trials) and media choose ONLY TO FOCUS  on advanced disease (hospitalisation) where HCQ  has demonstrated to offers little if any benefit based on front line experience.  The trials are designed to fail from the outset – timing, dose, used alone, not in combination.  This is not conspiracy, this is fact.

Early treatment is where all the front line doctors are having success in preventing hospitalisation.  But strangely this information is being censored.

The health establishment are doing garbage science.

April 16, 2020 – Unbreaking Science with Dr James Lyons-Weiler: Coronavirus: Mortality Rates, Hidden Information, Witheld Drugs w/ Meryl Nass, MD – withholding hydroxychloroqine early treatment – WATCH

HCQ: How It Works, benefits and side effects

Dr Shiva extracts the information from the scientific literature

Multiple mechanisms of action of hydryoxychloroqine against coronavirus:

1. Inhibits virus entry into the cell by inhibiting the viral particle binding to ACE2 receptor, this leads to reduced viral entry into the cell (Vincent et. al. 2005 CDC)
2. Inhibits viral replication of RNA via inhibition of RdRP in coronavirus.
3. Inhibits viral assembly
4. Inhibits new particle transport out of the cell
5. It acts as an ionophore for zinc, allowing zinc access into the cell, which in turn stops viral replication.

(note: Remdezivir, which is still under patent and costs around USD $3000 per dose, only inhibits viral replication, meaning one mode of action)

Mode of Action and Side Effects of HCQ

Dr Zelenko discusses COVID-19 outpatient management with Dr Been

American Front Line Doctor’s Summit

The summit videos were deleted from YouTube and web host provide deleted their site within 24 hours!

Massive censorship of Frontline Doctors led by Dr Simone Gold, where she and many other front line professionals shared their experience and treatment success stories along with other literature based presentations to help get the word out about all things COVID-19 related.  Their YouTube video’s and website was taken down by the hosting company (Square.com) within 24 hours of the summit – unheard of censorship.

But they have a new site here.  With their COVID-19 treatment’s page here and video page here including their Summit on July 27, 2020 covering many topics including hydroxychloroquine.

Doctor’s experience with HCQ:

Dr Anthony Cardillo explains that in his ER, they’ve found that HCQ really only works in combination with zinc.

Dr Zelenko has published his studies to share with everyone.  This was on the original Frontline Doctors website

Dr Simone Gold – White Paper on HCQ

The heart of the “problem”

Cardiologist at Mayo Clinic in March 2020 claim QT issues with hydroxychloroquine.  Why wait for now to raise this issue, when the drug has been handed out effectively like candy for malaria prevention to adults and children? Why now?

Then comes the VA Study

On 21st April 2020, the paper titled “Outcomes of hydroxychloroquine usage in United States veterans hospitalized with Covid-19” was published.  This is refereed to as the VA Study.

The media then grabbed hold of it’s conclusions and began to shout higher mortality rates with hydroxychloroquine (1, 2) or Fox news claiming HCQ has no benefit.  Though what they don’t tell you is it is an observational study who’s conclusions have not been put into context.

That is HCQ was use on patients who’s immune system was already shot, they were hospitalised in ICU on ventilators, it was not a randomised trial, the study didn’t report the doses of the drugs used, plus 30% of the control group received a treatment that itself could help reduce mortality.  Plus one of the authors Scott Sutton received funding from the Remdezivir manufacture Gilead.  So a case of bad science, conflicts of interest and another attack on a drug that still has potential as an early treatment!

Then on 24th April 2020, the FDA cautioned the use of HCQ due to the risk of heart rhythm problems – but only for COVID-19 suspected patients, not for Lupus or RA or for malaria treatment!

French virologist, Dr Didier Raoult responds to the flawed VA study here.

Del Bigtree unpacks the FDA and the two factions of the HCQ

(that YouTube deleted)

Laura Ingram on US Fox News reports on this VA study

Dr Raoult’s study

Dr Patrice Harris the President of the American Medical Association claimed on CNN in April 2020 that there was no evidence to support the use of hydroxychloroquine for COVID-19.  Understanding at this time, the front line doctors were successfully accumulating thousands of case studies, they’re using rates that are commonly used for malaria, they’re using it at the first sign of symptoms for at risk patients, and they are successfully preventing patients from having to go to hospital.

Fraudulent Peer Reviewed Lancet Study

Published on 22nd May 2020, the Lancet published a damning paper looking at 96,000 patients, and concluding the HCQ group were dying at high rates and with more heart related complications! –

The “…study did not examine the QT interval but instead directly analysed the risk of clinically significant ventricular arrythmias. We showed an independent association of the use of either hydroxychloroquine or chloroquine with the occurrence of de-novo ventricular arrhythmias. We also note that the hazard of de-novo ventricular arrhythmias increased when the drugs were used in combination with a macrolide” [such as azithromyicin].

On 25 May 2020, this lancet study gave justification for the World Health Organisation to temporarily pause it’s SOLIDARTY trials on HCQ.  A fraudulent, supposedly peer reviewed study caused the WHO, in the middle of a pandemic, to stop trials because of the heart problems supposedly caused by hydroxychloroquine.

But then two weeks later on the 4th June, 2020 after doctors and scientist started questioning this peer reviewed scientific paper it was retracted by The Lancet  and the US based company Surgisphere [1] that allegedly collected the data for this study from all over the world, including Australia, was completely fake!

WHO then resumed it’s study of HCQ.

Then on 15th June 2020 the FDA revokes the EUA for the use of HCQ and CQ to treat COVID-19 and referenced the already retracted lanced paper and refers to it as evidence for their decision!  So the FDA reference fraudulent science as evidence to not use a potentially life saving early treatment drug.

A second paper associated with Surgisphere has also been retracted from another peer review journal.

Australia’s TGA used Lancet study as a reason to restrict hydroxychloroquine in Australia

How much damage did these fraudulent study do to the HCQ treatment narrative?

Who else has lost faith in the “authorities”?

Clinical trials appear set-up to fail

Must read overview by Dr Meryl Ness “WHO and UK trials use potentially lethal hydroxychloroquine dose–according to WHO consultant” – HERE

August 13, 2020 – Unbreaking Science: Dr. Meryl Nass on lethal doses used in the HCQ trials – 2400 mg (2.4 mg) of HCQ is a lethal dose. So why did key studies of HCQ use 6 times the normal dose and when 35% increase mortality occur in hospitalized (late-stage) patients did the cease the trial instead of reduce the dose? – WATCH

All HCQ clinical trials designed by “medical experts” focused on late stage COVID-19, contrary to what was experienced in the field.

The key to HCQ’s success is treating the patient early and using the drug in low dose, with zinc.  Yet the international “safety and efficacy” clinical trails were designed to use the drug as a stand alone (without zinc), and in exceedingly high doses plus only in hospitalised patients.  In this setting the virus has finished its replication, and the symptoms have escalated, beyond what the drug could hope to benefit. This is contrary to the way the front line doctors are using the drug, and are achieving a high degree of success.

This is shown when you read the paper from the RECOVERY trial published November 2020 where it states in the discussion “Hydroxychloroquine has been proposed as a treatment for Covid-19 largely on the basis of its in vitro SARS-CoV-2 antiviral activity and on data from observational studies reporting effective reduction in viral loads.”

If these health officials that designed the large scale international clinical trials heard the doctors in the field they would know that the antiviral affects of HCQ have been shown not to be enough when used alone, that it is when used with zinc that the best results are had.

Its almost as though the trials were designed to fail!

The dose rate between therapeutically effective and that of being toxic, is small for chloroquine, and likely too hydroxychloroquine.  In the frail and already sick and weakened hospitalised COVID-19 patients, how would these trial doses of HCQ make them fair?

This graph below shows the relative dose of HCQ between various treatments up to 10 days of use based on the table above.   As you can see the early treatment protocol dosage is within the common Malaria and Arthritis treatment rates, where as two of the trials conducted in sick hospitalised patients were at toxic and possibly lethal doses!

HCQ Key clinical trials list:

• WHO – SOLIDARITY trial protocol
  Published – interim
• Oxford University – the RECOVERY trial
  Published here
• NIH – ORCHID study
  Published here
• Henry Ford Health System HCQ study
  Published here

Compare this to early treatment protocol doses

•  Zelenko Protocol, Out-patient (not hospital) for only moderate to high risk patients – combination treatment zinc, azitromycin + HCC
  (200mg x twice daily for 5-7 days = 400mg in first 24 hrs, cummulative 2000mg – 2800mg in 5 to 7 days respectively, max 400mg/day)

These studies above have been highlighted because these are what the Australian Therapeutic Goods Administration specifically referred to when they claimed the data shows “ no more effective than standard care in treating patients with COVID-19″.  Standard care should start at the GP’s office and not in hospital!  HCQ has performed poorly in clinical trials because it was used too late, in high doses and alone, not as a combination drug treatment.

Further still, based on these late stage clinical trials, the health officials and regulatory agencies deemed all use of HCQ ineffective and potentially dangerous!
If an early treatment was found the pandemic would be over and a vaccine would not be necessary, or at least mandating couldn’t be justified.

Australia’s TGA’s position on HCQ

The TGA claim use restrictions due to supply issues, yet the Palmer Foundation stocked us up in April 2020 with nearly 33 million doses, on top of what we already had in stock.

24 March 2020 – New restrictions on prescribing hydroxychloroquine for COVID-19

26 August 2020 – Amendments to the new restrictions on prescribing hydroxychloroquine for COVID-19

In this amemdment the National COVID-19 Clinical Evidence Taskforce  (NCCET) recommended against the use of hydroxychloroquine for the treatment of COVID-19.

Their media release states: “Taskforce Executive Director, Associate Professor Julian Elliott said the evidence indicates that hydroxychloroquine is potentially harmful and no more effective than standard care in treating patients with COVID-19.”  further “The pooled results show the drug does not reduce mortality, or shorten the amount of time a sick person spends in hospital. It also exposes them to side effects including cardiactoxicity.”

We are more than a year into this pandemic and they have not completed an early combination treatment study with HCQ, zinc and azithromycin or similar broad spectrum antibiotic.  “There are ongoing prevention trials investigating the use of hydroxychloroquine to reduce the risk of contracting COVID-19″ and they’ll get back to us.  Will they be in combination, and why so long?

Update: Dr Fauci’s emails have been sourced under FOI request

Dr Anthony Fauci, head of US NIAID in late May 2021 had about 3,200 of his January to June 2020 emails released under the Freedom of Information Act (FOIA), and they reveal much about what he knew.

On February 29, 2020 he was copied in on a high priority email to the vice president regarding the potential use of the cheap drug hydroxychloroquine to prophylax high risk patients.  The email even quoted the safe use rate of up to 6.5 mg/kg, a rate which Fauci’s NIH clinical trials exceeded, they used a one-dose-fits-all rate, but more importantly they used it in hospitalised patients when it was too late to be effective, and they knew it.

This is important for Australia, because our TGA referenced Fauci’s NIH ORCHID study as a “supporting” reason for them to make a blanket statement to NOT recommend hydroxychloroquine here in Australia even for it’s demonstrated benefit of early use with zinc.

Read Fauci’s email from February 2020

Articles and websites relating to HCQ

Medical Misinformation, Part 1: Hydroxychloroquine, 30 April 2020

NY Doctor Proved Everyone Wrong About Hydroxychloroquine – article by State of the Nation, a retrospective look at Dr Zelenko’s plea for truth

Tracking: HCQ studies for COVID-19: Real-time meta analysis for 245 studies and counting, and CV19-HCQ

WHO SOLIDARITY and UK RECOVERY trials use potentially lethal hydroxychloroquine dose, article by Meryl Nass, MD

COVID-19 and Coronavirus Resource Center

Countries in RED: DO NOT use or have LIMITED use of HCQ

More from Dr Zelenko and other doctors on HCQ

For the record.

April 2021 Part 1 of 4

Part 2 of 4
Part 3 of 4
Part 4 of 4

Interview with Dr Mercola

July 16, 2021

Dr Zelenko Interviewed by the Corona Investigation Committee

July 22, 2021

https://youtube.com/watch?v=XO4BmDEE8zw%3Fstart%3D18252

Corona Investigation committee interview – Session 62 Watch @4:45:50

Dr Zelenko nominated for the Presidential Medal of Freedom & Nobel Prize

August 2021

August 14, 2021 – Stew Peters: Dr. Zev Zelenko SLAYS Globalists, Exposes “Global Genocidal Event” – WATCH,

September 2, 2021 – Stew Peters: Dr. Zev Zelenko COVID Genocide “Very Nefarious, Sinister Purpose” WATCH

Dr Zelenko exposes how Dr Rick Bright (BARDA) sabotaged early COVID-19 treatment with HCQ, killing masses

September 2021 – Dr Zelenko exposes how Dr Rick Bright’s Very Bad move sabotaged early Covid treatment killing masses – WATCH

Hydroxychloroquine data points in reverse chronological order

Note this timeline is not complete and only started in this format approx 202. It continues to be updated.

2024

September 24, 2024 – PLOS Medicine: Evaluation of hydroxychloroquine or chloroquine for the prevention of COVID-19 (COPCOV): A double-blind, randomised, placebo-controlled trial – Schilling et al – READ, Craig Kelly – CREDIT, University of Oxford ClinicalTrials.gov NCT04303507

• “In this large placebo-controlled, double-blind randomised trial, HCQ and CQ were safe and well tolerated in COVID-19 chemoprevention, and there was evidence of moderate protective benefit in a meta-analysis including this trial and similar RCTs. ….. they [Hydroxychloroquine & Chloroquine] could have been deployed with benefit earlier, and they might have value in future pandemics…

September 9, 2024 – Brownstone Institute: Trump’s 63 Million Doses of Hydroxychloroquine Could Have Been Great for America by David Gortler, Pharm. D – READ

• Dr Robert Malone: What Happened to Trump’s 63 Million Doses of Hydroxychloroquine? – CREDIT

June 4, 2024 – Gateway Pundit: KILLER FAUCI: On March 16, 2020, Dr. Fauci Received Email Cheering Hydroxychloroquine Treatment of COVID in China – 4 Days Later He Publicly Rebuked President Trump at WH Presser For Suggesting It a Valid COVID Treatment – READ

March 31, 2024 – Meryl Nass: “How a false hydroxychloroquine narrative was created, and more”–republishing because we must never forget this evidence of a terrible crime – our-de-force paper on the 50+ ways HCQ was suppressed during 2020 – READ

March 26, 2024 – Broken Truth: Didier Raoult Francesoir Interview – Woodcock and Q Fever Treatment – WATCH, An explosive interview with Dr Didier Raoult reveals a possible motive behind the FDA acting commissioner’s refusal to discuss Coxiella Burnetti. READ

February 20, 2024 – Broken Truth presents documentary: Epidemic of Fraud – the coverup story of hydroxychloroquine – WATCH, READ, Press READ

February 2024 – Biomedicine & Pharmacotherapy: Deaths induced by compassionate use of hydroxychloroquine during the first COVID-19 wave: an estimate by Pradelle et al – READ

• The Latest Attempts to Discredit Hydroxychloroquine as a Treatment for COVID-19 – READ

I challenge the authors of this study to send me 1 out of the supposed 17000 people who died from HCQ…

We are all tired of Egocentric maniacs running our lives and allowing articles like this one with a conclusion that says “ Although our “estimates are limited by their imprecision” Who in their right mind published a conclusion like this? I give this paper a ZERO.

Dr Sabine Hazen

January 16, 2024 – Meryl Nass Substack: Here is the evidence (from 2004-2014) that our governments tried to kill us by restricting HCQ. WHY? Hydroxychloroquine doesn’t kill people unless you overdose. But it does kill coronaviruses.
This is critically important evidence that our governments deliberately harmed us by suppressing this drug. – READ

January 4, 2024 – Politico: Hydroxychloroquine could have caused 17,000 deaths during Covid, study finds – ARCHIVE, CREDIT

• “Nearly 17,000 people may have died after taking hydroxycholoroquine during the first wave of Covid-19, according to a study by French researchers.” – [Another HCQ “study” retracted[
• RETRACTED Biomedicine & Pharmacotherapy: Deaths induced by compassionate use of hydroxychloroquine during the first COVID-19 wave: An estimate by Pradelle et al – READ, ARCHIVE, RETRACTED – READ

2023

December 15, 2023 – Bannons War Room: Episode 3251: Censorship In Peer Review Journals w/ Dr Steven Hatfill – a COVID-19 pandemic advisor to the Trump Administration – WATCH, EXCERPT

• December 2023 – Journal of American Physicians and Surgeions: The COVID Debacle: Merging Criminal Law and Medical Science for Accountability by Steven Hatfill – READ, PDF, EXCERPT
• Robert Kadlac helped acquire 62 million doses of hydroxychloroquine, FDA’s Janet Woodcock thwarted it’s use – EXCERPT
• mRNA vaccines should not have happened because there were safe early treatment options – EXCERPT

November 3, 2023 – Epoch Times: Hydroxychloroquine Associated With Lower COVID-19 Mortality: Study – The French study included 30,202 patients – READ, Vigilant Fox – CREDIT

• People who received hydroxychloroquine were less likely to die than those who did not – 0.8% vs 4.8%

“This study represents the largest single-center study evaluating HCQ-AZ in the treatment of COVID-19. Similarly, to other large observational studies, it concludes that HCQ would have saved lives,”

Dr. Didier Raoult

September 24, 2023 – Gateway Pundit: Mayo Clinic Website Now Says Hydroxychloroquine CAN Be Used to Treat COVID-19 Patients, Previously Claimed It Was Not Effective – READ

• May Sep 2023: “Hydroxychloroquine may be used to treat coronavirus (COVID-19) in certain hospitalized patients.” – ARCHIVE,
  • The webpage was deleted in 2 days – HERE, but has been live since 2014! – ARCHIVES

• Mayo Oct 2021: “Using this medicine alone or with other medicines (eg, azithromycin) may increase your risk of heart rhythm problems (eg, QT prolongation, ventricular fibrillation, ventricular tachycardia). Hydroxychloroquine should only be used for COVID-19 in a hospital or during clinical trials. Do not take any medicine that contains hydroxychloroquine unless prescribed by your doctor“.- ARCHIVE, Also READ

July 27, 2023 – Meryl Nass Substack: Treating COVID-19 in 2023 and update on HCQ & Ivermectin – READ

April 4, 2023 – Pre Print: Early Treatment with Hydroxychloroquine and Azithromycin: A ‘Real-Life’ Monocentric Retrospective Cohort Study of 30,423 COVID-19 Patients – Million & Didier Raoult et al – READ

• “retrospective study from France (30,000+ patients) has found that HCQ + Azithromycin was REDUCING DEATHS by 71% when given early and by 45% when given in hospital – before they banned it” CREDIT SpeedOfScience in comments

March 15, 2023 – United Australia Party (UAP) hosts Australian Covid Vaccines & Effects Tour – Clive Palmer introduction and speaks about his HCQ donation to Australia – WATCH, Palmer’s HCQ donation to Australia – TIMELINE

2022

2021

June 13, 2021 – Hydroxychloroquine: Just the facts and a Follow the Money investigation by Sharyl Attkisson – READ

• “…two new studies that show the inexpensive drug works. A new study in MedRxiv found that hydroxychloroquine and zinc increased Covid-19 survival by almost three times. And a recent study published in the Journal of The Association of Physicians of India also found hydroxychloroquine is an effective treatment for Covid-19.”

June 10, 2021 – The US Sun: Hydroxychloroquine drug touted by Trump as Covid treatment can increase survival rates by 200%, study finds – READ

June 10, 2021 – Fox News | Ingraham Angle: Ingraham: Fauci ‘routinely’ acted against science – “Study: 100K lives could have been saved” with using HCQ – WATCH, FULL

June 9, 2021 – The Washington Times: Follow the money: Big Pharma, Dr. Fauci and the death of hydroxychloroquine – The $2.45 million Gilead spent in the first quarter of 2020 lobbying the federal government was well spent – READ

• “HCQ is cheap (costing under $10 for the course of a COVID-19 treatment), well-understood by physicians having been prescribed for more than 80 years, and can be taken orally. Yet, Dr. Anthony Fauci and others at the National Health Institute of Allergy and Infectious Diseases preferred remdesivir, a proprietary, intravenous drug manufactured by Gilead Sciences, costing about $3,500 per treatment, with unknown side effects.”

June 1, 2021 – Fox News | The Ingraham Angle – Dr Stephen Smith, Fauci on variants nad Dr Scott Atlas – ARCHIVE, We could have saved 100K lives – EXCERPT

April 13, 2021 – Rounding the Earth w/ Mathew Crawford: How to Rig Research: Surgisphere Part I – READ

A lot of the observations that took Surgisphere down were me emailing other people, or writing in forums, under names other than my own.

Mathew Crawford – REF

February 26, 2021 – The Lancet: Hydroxychloroquine with or without azithromycin for treatment of early SARS-CoV-2 infection among high-risk outpatient adults: A randomized clinical trial – Johnson et al – READ [NO ZINC?, ], Clinical Trial # NCT04354428 – READ, trial HISTORY

• “The COVID-19 Early Treatment Study was funded by the Bill & Melinda Gates Foundation (INV-017062) through the COVID-19 Therapeutics Accelerator….”
• “placebo” was vitamin C (1000mg/day1, then 500mg/day) and folic acid – so not inert placebo! -clinical trial – ARCHIVE
• HCQ 400 mg orally twice on Day 1 [800mg total], followed by 200 mg orally twice daily [400mg/day] ( for an additional 9 days

February 22, 2021 – The Guardian: Melbourne doctors under review for promoting discredited Covid treatment – Covid Medical Network doctors – READ,

• References peer reviewd paper in Reviews in Cardiovascular Medicine: Multifaceted highly targeted sequential multidrug treatment of early ambulatory high-risk SARS-CoV-2 infection (COVID-19) by McCullough et al – ARCHIVE, READ

2020

December 30, 2020 – Reviews in Cardiovascular Medicine: Multifaceted highly targeted sequential multidrug treatment of early ambulatory high-risk SARS-CoV-2 infection (COVID-19) by McCullough et al – ARCHIVE, READ (and image source)

December 20, 2020 – Taiwan News: Pharmaceutical factory on fire after explosion: 2 injured – makers of HCQ precursor – READ, worlds second largest HCQ supplier – SOURCE

• “Liberty Times reported that the factory produces hydroxychloroquine APIs, and is the world’s second largest HCQ raw material supplier.“

December 2020 – International Journal of Antimicrobial Agents: COVID-19 outpatients: early risk-stratified treatment with zinc plus low-dose hydroxychloroquine and azithromycin: a retrospective case series study – by Derwand, Zelenko et al – READ, TWEET

October 1, 2020 – The Scientist: The Surgisphere Scandal: What Went Wrong? – READ, CREDIT

August 30, 2020 – COVID-19 Real-Time Learning Network (sponsored by CDC grant): Hydroxychloroquine – information for doctors, links to “evidence” – ARCHIVE

• Explore the many references to clinical trials in HOSPITAL settings
• “One RCT suggests increased risk of QT prolongation among patients treated with HCQ+AZ compared to those not receiving HCQ” still hospitalised – July 23, 2020 – READ

July 2, 2020: Science: One U.K. trial is transforming COVID-19 treatment. Why haven’t others delivered more results? – trial design (hospital use in large doses) rules out HCQ by authorities – READ

June 17, 2020 – WHO: World Health Organization announces it was dropping hydroxychloroquine from the Solidarity trial – REF

• “Update (June 18): The World Health Organization announced yesterday that it was dropping hydroxychloroquine from the Solidarity trial after new data suggest the drug is ineffective as a COVID-19 treatment or prophylaxis.” – REF

June 17, 2020 – CNN: US stockpile stuck with 63 million doses of hydroxychloroquine …now that the US Food and Drug Administration has revoked permission for the drug to be distributed to treat coronavirus patients – READ, CREDIT

June 15, 2020 – CNN: FDA revokes authorization of drug Trump touted – ARCHIVE

• “Doctors can continue to legally prescribe the drugs off-label, as they can with any drug that’s approved for other conditions. The FDA’s emergency use authorization for hydroxychloroquine and chloroquine was narrow in scope, applying only to hospitalized Covid-19 patients and only to drugs donated to the Strategic National Stockpile.” !

June 15, 2020 – FDA: FDA cautions against use of hydroxychloroquine or chloroquine for COVID-19 outside of the hospital setting or a clinical trial due to risk of heart rhythm problems – Does not affect FDA-approved uses for malaria, lupus, and rheumatoid arthritis [!!!] – READ, CNN- CREDIT

• FDA July 1, 2020 Update: “A summary of the FDA review of safety issues with the use of hydroxychloroquine and chloroquine to treat hospitalized patients with COVID-19 is now available.” – PDF

June 15, 2020 – FDA LETTER from Denise M. Hinton, Chief Scientists FDA to Gary Disbrow, Deputy Assistant Secretary of BARDA – PDF, ARCHIVE, CNN – CREDIT

• This letter in response to BARDA requesting the FDA “revoke the Emergency Use Authorization (EUA) for emergency use of oral formulations of chloroquine phosphate (CQ) and hydroxychloroquine sulfate (HCQ) to be distributed from the Strategic National Stockpile (SNS) issued on March 28, 2020”
• Letter has “Attachment: Memorandum Explaining Basis for Revocation of Emergency Use Authorization for Emergency Use of Chloroquine Phosphate and Hydroxychloroquine Sulfate”

June 15, 2020 – FDA: Coronavirus (COVID-19) Update: FDA Revokes Emergency Use Authorization for Chloroquine and Hydroxychloroquine [but the product is still licensed!]- READ, ARCHIVE, FDA letter – PDF, Wired – ARTICLE

• “…the FDA determined that chloroquine and hydroxychloroquine are unlikely to be effective in treating COVID-19 for the authorized uses in the EUA.” – off-label use (which is legal) does not require EUA for a licensed product!
• “Additionally, in light of ongoing serious cardiac adverse events and other potential serious side effects, the known and potential benefits of chloroquine and hydroxychloroquine no longer outweigh the known and potential risks for the authorized use. This is the statutory standard for issuance of an EUA.”
• The Emergency Use Authorization (EUA) for HCQ was issued on March 28, 2020
• “Today’s request to revoke is based on new information, including clinical trial data results, that have led BARDA to conclude that this drug may not be effective to treat COVID-19 [Coronavirus Disease 2019] and that the drug’s potential benefits for such use do not outweigh its known and potential risks.”
• CNN: FDA revokes authorization of drug Trump touted – ARCHIVE

June 13, 2020 – The Lancet | Comment: Expression of concern: Hydroxychloroquine or chloroquine with or without a macrolide for treatment of COVID-19: a multinational registry analysis – by The Lancet Editors – READ

• To “alert readers to the fact that serious scientific questions have been brought to our attention. We will update this notice as soon as we have further information.”

June 8, 2020 – Science: Who’s to blame? These three scientists are at the heart of the Surgisphere COVID-19 scandal – Author partnership on coronavirus papers is “completely bizarre” and should have been a red flag, former journal editor says – READ (presents overview of authors) – Regading the RETRACTED Lancet Study

• Mehra “provided the kind of gravitas that can fast-track papers to leading journals.”
• Amit Patel (co-author) had introduced Mehra to Sapan Desai, a vascular surgeon and founder of Surgisphere, the tiny company that supplied the data.
• Mehra received compensation from Triple-Gene [3GTx.com], a gene therapy company Patel co-founded [and Clinical Director] to develop cardiovascular treatments.
  • “Triple-Gene LLC is a clinical stage cardiovascular gene therapy company and majority owned subsidiary of Precigen Inc. (NASDAQ: PGEN).” – REF

June 7, 2020 – STAT News: Researcher involved in retracted Lancet study has faculty appointment terminated, as details in scandal emerge – READ, Amit Patel – TWEET, The only author to be “punished” – CREDIT

• University of Utah has “mutually agreed” to terminate the [unpaid adjunct appointment with the Department of Biomedical Engineering] faculty appointment of Amit Patel,..who appears to have played a key role in involving a little-known company that has ignited a firestorm of controversy.”

June 5, 2020 – Oxford University RECOVERY Trial: PRESS Statement from the Chief Investigators of the Randomised Evaluation of COVid-19 thERapY (RECOVERY) Trial on hydroxychloroquine : No clinical benefit from use of hydroxychloroquine in hospitalised patients with COVID-19 – READ, This statement was used by WHO to help justify shutting down HCQ – CREDIT

• “‘On Thursday 4 June, in response to a request from the UK Medicines and Healthcare Products Regulatory Agency (MHRA), the independent Data Monitoring Committee conducted a further review of the data. Last night, the Committee recommended the chief investigators review the unblinded data on the hydroxychloroquine arm of the trial.
• ‘We have concluded that there is no beneficial effect of hydroxychloroquine in patients hospitalised with COVID-19. We have therefore decided to stop enrolling participants to the hydroxychloroquine arm of the RECOVERY Trial with immediate effect. We are now releasing the preliminary results as they have important implications for patient care and public health. “
• Trial primary endpoint was 28-day mortality for hospitalised COVID-19 patients. “There was also no evidence of beneficial effects on hospital stay duration or other outcomes.”…‘These data convincingly rule out any meaningful mortality benefit of hydroxychloroquine in patients hospitalised with COVID-19″

‘Hydroxychloroquine and chloroquine have received a lot of attention and have been used very widely to treat COVID patients despite the absence of any good evidence. The RECOVERY Trial has shown that hydroxychloroquine is not an effective treatment in patients hospitalised with COVID-19. Although it is disappointing that this treatment has been shown to be ineffective, it does allow us to focus care and research on more promising drugs.” [remdesivir?]

Peter Horby, Professor of Emerging Infectious Diseases and Global Health in the Nuffield Department of Medicine, University of Oxford, and Chief Investigator for the RECOVERY HCQ trial

June 4, 2020 – MedScape: Two Journals Retract Studies on HCQ, Heart Disease in COVID-19 – READ, TIMELINE

• “The Lancet announced today [June 4, 2020] that it has retracted a highly cited study that suggested hydroxychloroquine may cause more harm than benefit in patients with COVID-19. Hours later, the New England Journal of Medicine announced that it had retracted a second article by some of the same authors, also on heart disease and COVID-19.”

June 4, 2020 – NY Times: Two Huge Covid-19 Studies Are Retracted After Scientists Sound Alarms -The reports, published in two leading journals, were retracted after authors could not verify an enormous database of medical records – READ (Hydroxychloroquine is not mentioned in the title, read down to find it!), Med City News – READ

• “Both studies were led by a professor at Harvard, and both depended on a huge international database of patient medical records that few experts had ever heard of.”
• “On Wednesday, after the journals [NEJM & The Lancet] noted concerns about the studies, the World Health Organization announced that it would resume trials of the medications”!

“It is now clear to me that in my hope to contribute to this research during a time of great need, I did not do enough to ensure that the data source was appropriate for this use…For that, and for all the disruptions — both directly and indirectly — I am truly sorry.”

Dr. Mandeep Mehra, lead author of the two studies, said in a statement to The New York Times.

June 4, 2020 – The Guardian: Surgisphere: governments and WHO changed Covid-19 policy based on suspect data from tiny US company – READ

• “Surgisphere, whose employees appear to include a sci-fi writer and adult content model, provided database behind Lancet and New England Journal of Medicine hydroxychloroquine studies”

June 4, 2020 – Med City News: Randomized trial shows hydroxychloroquine doesn’t prevent Covid-19 as questions arise about earlier study – A randomized, placebo-controlled trial published in NEJM found the malaria drug was not effective as a post-exposure prophylaxis against coronavirus disease. However, questions have arisen about data used in a large observational study about the drug published last month – READ

• Uni Minnesota trial “data showed that 11.8% of participants who received hydroxychloroquine developed Covid-19, compared with 14.3% who received a vitamin pill as a placebo….the result did not reach statistical significance…there is no way to rule out whether the result was due to chance alone.” Thus it was concluded no difference.
• Note COVID-19 was self reported by patient and not PCR confirmed [as far as I can tell] the trial objective was to “to prevent disease” i.e. any symptoms, not hospitalisation or death!
• “The study provides the most definitive evidence yet that hydroxychloroquine is not effective against Covid-19.”

June 3, 2020 – University of Minnesota: University of Minnesota Trial Shows Hydroxychloroquine Has No Benefit Over Placebo in Preventing COVID-19 – READ, ARCHIVE, CREDIT, Trial used by WHO to stop HCQ – REF

• June 3, 2020 – NEJM: A Randomized Trial of Hydroxychloroquine as Postexposure Prophylaxis for Covid-19 – Boulware et al – READ, Clinical Trial NCT04308668 – READ [No PCR confirmatory testing done, huge doses used]
  • “We conducted a randomized, double-blind, placebo-controlled trial across the United States and parts of Canada testing hydroxychloroquine as postexposure prophylaxis….We enrolled 821 asymptomatic participants”
  • Treatment dose “hydroxychloroquine (800 mg once, followed by 600 mg in 6 to 8 hours, then 600 mg daily for 4 additional days)” [High dose rate and without zinc, contrary to those finding success]. “The primary outcome was the incidence of either laboratory-confirmed Covid-19 or illness compatible with Covid-19 within 14 days.”
  • “The incidence of new illness compatible with Covid-19 did not differ significantly between participants…” [So they DIDN’T PCR test to confirm that an “illness” was COVID-19???] BUT
• “40% of trial participants taking hydroxychloroquine developed non-serious side effects — predominantly nausea, upset stomach or diarrhea.” [Maybe because to the excessive dosage they prescribed!! Normal dose 200-400mg/day, they gave a huge dose of 1400mg on day 1, and 3 times normal daily dose (200mg) on days 2-5]
• “However, the trial [even with excessive doses] found no serious side effects or cardiac complications from taking hydroxychloroquine”
• The WHO use this Boulware et al study to further justify dropping HCQ from their clinical trials because” the study found “the drug did not prevent people exposed to SARS-CoV-2 from becoming sick” [yet the study looked at COVID-19 (self assessed symptoms) not SARS-CoV-2 (the virus, which would require PCR confirmatory testing)] – The Scientist – REF

May 30, 2020 – The Scientist: Disputed Hydroxychloroquine Study Brings Scrutiny to Surgisphere – READ, CREDIT

• “Scientists have raised questions about the dataset published in The Lancet last week that triggered the suspension of clinical trials around the world—and about Surgisphere Corporation, the company behind the study.”

May 28, 2020 – The Guaridan: Questions raised over hydroxychloroquine study which caused WHO to halt trials for Covid-19 – Exclusive: Australian researchers query origin of data used for Lancet study, but stress there is no evidence drug is a safe or effective treatment – READ

May 28, 2020 – Zenodo: An open letter to Mehra et al and The Lancet (Richard Horton (editor) – Concerns regarding the statistical analysis and data integrity – by James Watson on behalf of 201 signatories – READ, PDF, CREDIT

• “This impact has led many researchers around the world to scrutinize in detail the [Lancet] publication in question. This scrutiny has raised both methodological and data integrity concerns.” – 10 concerns listed

May 27, 2020 – CNN: Fauci: Science shows hydroxychloroquine is not effective as a coronavirus treatment – ARCHIVE

“The scientific data is really quite evident now about the lack of efficacy for it,”…[ there’s likelihood of] “adverse events with regard to cardiovascular.”

Dr Anthony Fauci told CNN’s Jim Sciutto on “Newsroom”

• “Fauci.. is the first Trump administration official to say the drug is not effective in treating the virus based on scientific data.” [in hospitalised patients, not where the drug is being used by frontline doctors!]

May 27, 2020 – CNN: France halts use of hydroxychloroquine on Covid-19 patients – READ

• “French Health Ministry revoked its authorization for the drug to be given to those with coronavirus…suggest a link between the use of hydroxychloroquine and “cardiac toxicity,” particularly when used in combination with the azithromycin…”
• “Some context: The announcement comes after the World Health Organization (WHO) on Monday said it had temporarily halted the study of hydroxychloroquine as a potential Covid-19 treatment in its Solidarity Trial, due to safety concerns” [Based on The Lancet, soon-after RETRACTED fraudulent paper]

Our data has very convincingly shown that across the world in a real-world population that this drug combination, whichever way you slice it or dice it, does not show any evidence of benefit, and in fact is immutably showing a signal of grave harm

Dr. Mandeep Mehra, CNN passed this off as a direct quote – REF, more powerful than that quoted by TIME –HERE (See May 22, 2020)

May 27, 2020 – The Scientist: WHO Halts Hydroxychloroquine Testing Over Safety Concerns – based on The Lancet study – READ,

May 26, 2020 – The Guardian: Australian hydroxychloroquine trial to treat Covid-19 under review after WHO safety concern – READ

• “The AustralaSian Covid-19 trial (Ascot) has been recruiting patients in more than 70 hospitals in every state and territory, and 11 hospitals in New Zealand.”
• “Meanwhile, the Therapeutic Goods Administration granted former federal politician Clive Palmer a contract to import 1m doses of the drug [hydroxychloroquine] to add to the national medical stockpile.”

May 26, 2020 – The Guaridian: WHO halts hydroxychloroquine trial for coronavirus amid safety fears- READ

May 25, 2020 – Medical News: Zero benefit of Hydroxychloroquine or Chloroquine in COVID-19, says extensive study – READ

May 25, 2020 – CNN: WHO temporarily pauses hydroxychloroquine study due to safety concerns – READ

• WHO Director-General Tedros Adhanom Ghebreyesus said during a media briefing in Geneva – the decision was made after The Lancet observational study was published where the “authors reported that among patients receiving the drug, when used alone or with a macrolide, they estimated a higher mortality rate”

May 25, 2020 – WHO Director-General’s opening remarks at the media briefing on COVID-19 – 25 May 2020 – READ, ARCHIVE

• “The Executive Group has implemented a temporary pause of the hydroxychloroquine arm within the Solidarity Trial while the data is reviewed by the Data Safety Monitoring Board.”…”I wish to reiterate that these drugs [HCQ & CQ] are accepted as generally safe for use in patients with autoimmune diseases or malaria”

May 22, 2020 – CNN: Sales of drug touted by Trump have been soaring – READ,

• “Amid the growing public attention on the medication, its sales doubled from March 2019 to more than $50 million in March [2020]”
• Following FDA’s “caution”…more than 830,000 prescriptions for the drug were filled for the generic and name-brand version of the drug, Plaquenil, in March – up from roughly 460,000 prescriptions written during the same time last year….The IQVIA data did not yet include April figures and did not capture prescriptions administered to patients in nursing homes through long-term care pharmacies or at hospitals.”
• FDA aware of reports of “serious heart-related adverse events and death in patients with COVID-19” taking HCQ or CQ. [Why are all the arthritis (adults and children up to 400mg/day) and malaria (400mg/week) patients taking the drug on a daily basis, not suffring the same alleged concern?]

May 22, 2020 – Forbes: All The Times Trump Has Promoted Hydroxychloroquine – A TIMELINE- (NOTE this article references The Lancet study, but they’ve not updated their article since then to reflect the The Lancet RETRACTED that fraudulent paper) – READ, ARCHIVE

May 22, 2020 – Time Magazine: Large Study Finds No Benefit — and Potential Harm — in Using Hydroxychloroquine for COVID-19 – ARCHIVE, MD Edge – READ,

• “…scientists in the U.S. and Switzerland report on an analysis of more than 96,000 people hospitalized with confirmed COVID-19 in 671 hospitals on six continents. Nearly 15,000 patients were treated…”
• ““However we sliced and diced the data, the results were identical,” says Dr. Mandeep Mehra, chair of cardiovascular medicine at Brigham and Women’s Hospital and professor of medicine at Harvard Medical School, who led the study. “There was no evidence of benefit, and a consistent signal of harm — and in particular, harm linked to heart rhythm disturbances.”…“Why would you risk harm when there is so much consistent data showing lack of benefit [with hydroxychloroquine]?”
• “In fact, as the evidence continues to suggest that hydroxychloroquine may not provide much benefit, and instead might increase the risk of harm to the heart, Mehra says doctors may shift from considering hydroxychloroquine to other drugs being studied as COVID-19 treatments, like remdesivir. Studies indicate that remdesivir, an antiviral that has not yet been approved to treat any disease, may help people with COVID-19 to recover faster..”

May 22, 2020 – The Lancet: Hydroxychloroquine or chloroquine with or without a macrolide for treatment of COVID-19: a multinational registry analysis by Prof Mandeep Mehra (Brigham and Women’s Hospital & Harvard), Sapan Desai (founder and chief executive of Surgisphere Corporation, Chicago, IL, USA) et al – ARCHIVE, now RETRACTED – READ, Brigham’s PRESS RELEASE – READ

“However we sliced and diced the data, the results were identical,… “There was no evidence of benefit, and a consistent signal of harm — and in particular, harm linked to heart rhythm disturbances.””

Dr. Mandeep Mehra, chair of cardiovascular medicine at Brigham and Women’s Hospital and professor of medicine at Harvard Medical School, who led the study

• “The data [a mammoth private database of patient medical records] came from a company called Surgisphere, which claims to have granular patient-level information shared by 1,200 hospitals and health facilities on six continents.” – REF
• “Critics were quick to point out anomalies in both pieces of research, including implausible findings that should have been detected during the peer review process — like the registry’s apparent inclusion of a large number of Covid-19 cases very early on in the pandemic, even in Africa, where few hospitals have electronic health records….Many researchers were astonished to find out that such a database could exist, or that the gathering and analysis of tens of thousands of medical records on multiple continents could have been carried out so quickly.” – REF
• “Dr. Desai vigorously defended the Surgisphere database, saying that he was “all for transparency” but was bound to secrecy by contractual agreements with the hundreds of hospitals that are his clients, and therefore could not show anyone the raw data from his registry..”…”until February, [2020, Desai] worked as a vascular surgeon at Northwest Community Hospital in Arlington Heights, Ill.” – REF
• June 8, 2020 – Science: Who’s to blame? These three scientists are at the heart of the Surgisphere COVID-19 scandal -Author partnership on coronavirus papers is “completely bizarre” and should have been a red flag, former journal editor says – READ

May 19, 2020 – FDA: Pharmacovigilance Memorandum for Hydroxychloroquine and Chloroquine for All adverse events in the setting of COVID-19 from the FDA Adverse Event Reporting System (FAERS) – PDF, an “uncharacteristically brief 15-page safety review memorandum of HCQ” – CREDIT

• Brownstone: “a methodologically questionable report criticizing HCQ’s safety. The FDA’s narrative was based on preliminary and time-compartmentalized findings, and not a reflection of historical safety or based on the appropriate clinical use of HCQ dosing, prescribing, timing, and duration. The FDA then seemed to label its findings as conclusive, figuratively slamming the door shut on the consideration of new findings.” – REF
• “According to its uncharacteristically brief 15-page safety review memorandum of HCQ published on May 19, 2020, the FDA considered data from the National Poison Data System (NPDS) which means it seems to have included the use of non-pharmaceutical-grade and/or self-administered HCQ and/or overdose data in its clinical evaluation. “
• “…Table 6 only contained around 256 applicable adverse event reports [possibly associated with HCQ/CQ] over a five-month period in the entire world when administered for Covid-19″ With doses “anywhere from 2x to 6x the recommended maximum maintenance dose of HCQ for any clinical indication per FDA and manufacturer’s dosing recommendations.” Also “it did not appear to investigate or report patient weights”
• “92 of the 109 serious cardiac cases (84%) reported concomitant use of at least one other medication that prolongs the QT interval.”…”In other words, the FDA included well-known, clinically unsound, long-established, drug-drug interactions, contraindicated uses, and/or prescribing errors in denigrating HCQ’s safety.”
• And so many more oversights by this FDA’s report – REF

May 19, 2020 – CNN: Trump says he is taking hydroxychloroquine though health experts question its effectiveness – ARCHIVE

• Trump consulted his Whitehouse doctor
• “The admission was a dramatic development in Trump’s attempts to promote hydroxychloroquine as a treatment for coronavirus, which began earlier in the outbreak and has been met with resistance from medical professionals”

May 18, 2020 – Med City News: Report: VA still using hydroxychloroquine for Covid-19; mounting data indicate no effect …Meanwhile, two large studies from hospitals in the New York City area indicated that the drug did not improve rates of mortality among hospitalized patient – READ

May 16, 2020 – AP: VA says it won’t stop use of unproven drug on vets for now – READ, CREDIT

May 14, 2020 – The Guardian: Drug imported for Covid-19 trials won’t be given to Australians who need it for other conditions – Clive Palmer bought millions of doses of hydroxychloroquine – READ, Palmer Foundation – READ

• 33 million doses of hydroxichloroquine imported by Palmer and made freely available to Australias national stockpile – TIMELINE
• Clive Palmer’s donation – WATCH, he tells his story 2024 – WATCH

May 11, 2020 – Politico: Hydroxychloroquine shows no benefit against coronavirus in N.Y. study – READ, CNN – ARCHIVE, The JAMA STUDY

• “University at Albany looked at 1,438 patients with coronavirus who were admitted to 25 New York City area hospitals.” [Not pre-hospitalisation!]
• HCQ+azithromycin “…the patients who took the drug combination were more than twice as likely to suffer cardiac arrest during the course of the study. Heart issues are a known side effect of hydroxychloroquine.”

May 11, 2020 – JAMA: Association of Treatment With Hydroxychloroquine or Azithromycin With In-Hospital Mortality in Patients With COVID-19 in New York State by Rosenberg et al – PAPER, READ

May 7, 2020 – NEJM: Observational Study of Hydroxychloroquine in Hospitalized Patients with Covid-19 – Geleris et al – READ, Large study finds no benefit from hydroxychloroquine in Covid-19- CREDIT

• Study in New York-Presbyterian Hospital—Columbia University Irving Medical Center, – Of 1446 consecutive patients, 70 patients were intubated, died, or discharged within 24 hours after presentation and were excluded from the analysis.
• Hydroxychloroquine dose – 600mg twice on day 1 (total 1200mg), then 400 mg daily for a median of 5 days. Started 24-48 hrs upon admittance to hospital. “Hydroxychloroquine-treated patients were more severely ill at baseline than those who did not receive hydroxychloroquine”

May 6, 2020 – Med City News: The eye-popping allegations in ousted BARDA Director Rick Bright’s whistleblower complaint – READ

• “In the complaint, Bright alleges that he faced retaliation after resisting efforts to promote broad use of hydroxychloroquine and chloroquine on the basis of their safety problems and lack of scientific support for such use…”
• April 23, 2020 – Ex-BARDA director says he was ousted for questioning hydroxychloroquine for Covid-19 – READ

May 5, 2020 – Washington Post: Ousted vaccine official alleges he was demoted for prioritizing ‘science and safety’ – Rick Bright says in a whistleblower complaint that he resisted pressure from HHS leaders to make ‘potentially harmful’ antimalarial drugs more widely available – READ, COMPLAINT

• Biomedical Advanced Research and Development Authority (BARDA) Director Rick Bright alleged he was demoted due to his resistance to Trump’s promotion of the unproven drug

May 1, 2020 – FDA issued EUA for the patented, more expensive competitor drug remdesivir – REF

April 30, 2020 – The Highwire Ep 161: CORONAVIRUS: A NATION DIVIDED – segment on Chloroquine vs. Remdesivir – WATCH, FULL

April 28, 2020 – James Todaro MD on Twitter: The Italian Society of Rheumatology studied 65,000 patients on longterm hydroxychloroquine for RA and Lupus. – Only 20 patients tested positive for COVID-19, No ICU, no deaths – This is a 90% reduction in infection rate compared to the rest of Italy – No Archive, READ, Gateway Pundit – READ The Highwire – WATCH

April 28, 2020 The Italian – ARTICLE

• “primary care doctors and general practitioners contacted during this research, many have admitted – under their breath – to use the drug [hydroxychloroquine] as a “prophylaxis”, …Health professionals who are in close contact with contagious patients take the drug in advance, precisely to decrease the probability of contracting the infection.”
• Italian Society of Rheumatology (SIR) questioned 1,200 rheumatologists throughout Italy to collect statistics on infections. Out of 65,000 chronic rheumatoid patients (Lupus and Rheumatoid Arthritis), who systematically take Plaquenil / hydroxychloroquine, only 20 patients tested positive for the virus. Nobody died, nobody is in intensive care, according to the data collected so far.

April 28, 2020 – Fox News: Ingraham Angle: Infectious disease expert slams study that panned hydroxychloroquine as COVID-19 treatment: ‘It’s a sham‘ – WATCH

• Dr. Stephen Smith – the study published last week indicating the antimalarial drug hydroxychloroquine showed no benefit [and potentially harmful] for coronavirus patients in U.S. veterans hospitals was a “sham.” [the VA STUDY]
• A New study by French doctor Didier Raoult show correct way to use HCQ

April 24, 2020 – PRESS RELEASE: FDA cautions against use of hydroxychloroquine or chloroquine for COVID-19 outside of the hospital setting or a clinical trail due to risk of heart rhythm problems – Does not affect FDA-approved used for malaria, lupus and rheumatoid arthritis – READ, ARCHIVE, The Highwire – WATCH

April 22, 2020 – Fox News: COVID-19 treatment hydroxychloroquine showed no benefit, more deaths in VA virus study – READ (see paper below)

April 21, 2020 – University of Melbourne: Clinical trial into two potential COVID-19 treatments commences – AustralaSian COVID-19 Trial (ASCOT) – READ, CREDIT

• “Laboratory tests have shown that lopinavir/ritonavir, which is currently used to treat HIV, and hydroxychloroquine, used to treat arthritis and prevent and treat malaria, can stop SARS-CoV-2, the virus that causes COVID-19, in its tracks.”
• “A clinical trial aimed at testing the effectiveness and safety of two existing drugs in patients hospitalised with COVID-19 has opened at the first site, the Royal Melbourne Hospital.
• “The aim of ASCOT is to test whether using these drugs will prevent patients deteriorating to the point of needing a ventilator in the intensive care unit (ICU),” said Associate Professor Steven Tong

April 21, 2020 – PrePrint : Outcomes of hydroxychloroquine usage in United States veterans hospitalized with Covid-19 by Magagnoli et al – READ, PDF , The Highwire – WATCH

• This was NOT a randomised study, and had other flaws such administering the drug to only the severely ill and those ventilated – too late to be effective, yet they concluded it increased mortality!
• The dosages for either drug are NOT even listed!
• 31% of the “control” group received azithromycin!
• Dr Stephen Smith calls this study “a sham”!
• Pharma-backed mainstream media picked up on this studies “conclusions” and used it to disqualify HCQ as a treatment, and the unsuspecting public, and healthcare community simply believe them

April 17, 2020 – Int J of Antimicrobial Agents: Can post-exposure prophylaxis for COVID-19 be considered as one of outbreak response strategies in long-term care hospitals? by Lee et al – READ
Post-exposure prophylaxis using hydroxychloroquine was provided to 211 persons, Disease development was successfully prevented without severe adverse events.

April 2, 2020 – Fox News | Ingraham Angle: Dr. Stephen Smith on effectiveness of hydroxychloroquine: ‘I think this is the beginning of the end of the pandemic’ – WATCH

March 31, 2020 – Washington Post: FDA authorizes widespread use of unproven drugs to treat coronavirus, saying possible benefit outweighs risk – READ

March 30, 2020: KHN: FDA Approves Emergency Use Of Malaria Drug Trump Touted Despite Scant Evidence That It Works – READ, and this on March 27 – HERE

March 29, 2020 – HHS: HHS accepts donations of medicine to Strategic National Stockpile as possible treatments for COVID-19 patients – 30 million doses of hydroxychloroquine sulfate donated by Sandoz and and one million doses donated by Bayer Pharmaceuticals – ARCHIVE

March 28, 2020 – The Register: Remember that clinical trial, promoted by President Trump, of a possible COVID-19 cure? So, so, so many questions… – Scientists pull coronavirus treatment study apart after rushed publication – ARCHIVE

March 28, 2020 – LA Times: Doctors and experts warn of the risks of using malaria drugs to treat COVID-19 – heart rhythm QT interval – READ, what is QT interval – READ

• “An article published this week in the Mayo Clinic Proceedings warns that both drugs could prompt dangerous and potentially deadly heart arrhythmias in the 3 million people worldwide who have a congenital cardiac condition — called long QT syndrome — that can cause the heart to beat erratically and lead to sudden death.” – Mayo Clinic preprint – PDF, Long QT syndrome – READ
• [Yet it’s ok to take for malaria!]

March 27, 2020 – Gateway Pundit: HUGE! Second French Study by Dr. Raoult finds Hydroxychloroquine and Azithromycin Helped EVERY PATIENT in Study Group of 80 Minus One – READ

March 27, 2020 – Fox News | The Ingraham Angle: Dr. Stephen Smith on effectiveness of hydroxychloroquine: ‘I think this is the beginning of the end of the pandemic’ – with Dr. Stephen Smith & Dr. Amesh Adalja – TRANSCRIPT

March 26, 2020: Newsday: Cuomo limits prescriptions for two drugs to active virus cases – READ, Dr Oz lift ban – READ

• An executive order issued by Gov. Andrew Cuomo limits prescriptions of hydroxychloroquine and chloroquine to only COVID-19 patients in state-approved clinical trials…

March 25, 2020 – Tech Startups: Doctor Vladimir Zelenko: I treated 350 coronavirus patients with 100% success using Hydroxychloroquine Sulfate – READ, Mar. 28, 2020 that number rose to 699 – READ

March 24, 2020 – FDA Drug Safety Communication on Hydroxychloroquine begins – READ

• FDA cautions against use of hydroxychloroquine or chloroquine for COVID-19 outside of the hospital setting or a clinical trial due to risk of heart rhythm problems – PDF

March 24, 2020 – NBC News: Man dies after taking chloroquine in an attempt to prevent coronavirus – A husband and wife in Arizona took chloroquine phosphate, an ingredient of fish parasite killers rather than the anti-malaria medication, following the President’s recommendation. The man died soon after ingesting the toxic chemical. His spouse was left in a critical condition. – READ

March 24, 2020 – Time Magazine: President Trump Called Hydroxychloroquine a ‘Game Changer,’ But Experts Warn Against Self-Medicating With the Drug. Here’s What You Need to Know – ORIGINAL, READ, Article archives – HERE

• “For the past few weeks President Trump has continually expressed great confidence in the promise of a new COVID-19 therapy involving two drugs—azithromycin and hydroxychloroquine”…
• “But in those few days, a few people [2, husband and wife who took fish tank cleaner – not hydroxychloroquine] who began self medicating with the drugs in an effort to prevent COVID-19 [misleading] have died, and others have been hospitalized. These tragedies have raised questions about the safety of the drug combo [from fish tank cleaner!!!], and how valid they are as a possible solution to treating COVID-19.”

“What do you have to lose? Take it,” … “I really think they should take it. But it’s their choice. And it’s their doctor’s choice or the doctors in the hospital. But hydroxychloroquine. Try it, if you’d like.”

President Trump – White House briefing April 4, 2020 (Time article updated, but not acknowledged in date)

March 23, 2020 – Time Magazine: Arizona Man Dies After Taking Chemical in Coronavirus Treatment Touted by President Trump – ARCHIVE

• “A Phoenix-area man has died and his wife was in critical condition after the couple took chloroquine phosphate, an additive used to clean fish tanks…It’s unclear if the couple took it specifically because of COVID-19″,
• Now Banner Poison and Drug Information Center “is warning everyone to avoid self-medicating”

March 21, 2020 – President Trump on Twitter re HYDROXYCHLOROQUINE & AZITHROMYCIN – TWEET, ARCHIVE

March 20, 2020 – AP FACT CHECK: Trump falsely claims drug approval for virus – READ

• “Technically, doctors can already prescribe the drug to patients with COVID-19, a practice known as off-label prescribing.”
• “Drug trials typically require hundreds or thousands of patients and, even when accelerated, take weeks or months to complete”
  • [This is deceptive, as HCQ has already gone through those safety trials before registration, and has an established 60 year risk profile for the doses used by the frontline doctors, so such huge trials “safety” trials are not required and is misleading to state this]
• “no FDA-approved therapeutics or drugs to treat, cure or prevent COVID-19”
• [Note during the pandemic the media the word “approved” instead of the correct phrase “Emeregency Use Authroised” – yet they attack Trump for saying apporved for and EUA “indication” approval – The drug is already registered – but BARDA got in and killed that EUA – WATCH]

March 20, 2020 – NBC News: Trump, promoting unproven drug treatments, insults NBC reporter at coronavirus briefing – READ

March 20, 2020 – ABC News: Chloroquine, an old malaria drug, may help treat novel coronavirus, doctors say – READ

• FDA approves compassionate use of chloroquine – President Donald Trump held a teleconference with state governors on Thursday at FEMA headquarters and discussed possible treatments for coronavirus.
• “The way that it worked against SARS was by preventing of the attachment of the virus to the cells. Chloroquine interfered with the attachment to that receptor on the cell membrane surface,” Horovitz said. “So it’s disrupting a lock and key kind of mechanism of attachment.”

March 20, 2020 – International Journal of Antimicrobial Agents: Hydroxychloroquine and azithromycin as a treatment of COVID-19: results of an open-label non-randomized clinical trial by Gautret and Didier Raoult et al – READ, Preprint – READ

• “However, [this] study was too small to be of significance, and there was no control group of patients to compare the outcome of the drugs.” – REF [reminder the FDA/ACIP considered 8 mice enough to justify injecting an experimental “vaccine”]

March 19, 2020 – President Trump mentions chloroquine/hydroxychloroquine as a potential treatment for COVID-19 based on feedback he had received from doctors using it on the frontline – WATCH,
Tony Fauci said “no” to being effective for COVID-19! – READ

March 18, 2020 – Cell Discovery: Hydroxychloroquine, a less toxic derivative of chloroquine, is effective in inhibiting SARS-CoV-2 infection in vitro – Liu et al – READ

March 11, 2020 – MedCram: Coronavirus Epidemic Update 34: US Cases Surge, Chloroquine & Zinc Treatment Combo, Italy Lockdown – WATCH, Korea using HCQ – EXCERPT

March 10, 2020 – J Critical Care: A systematic review on the efficacy and safety of chloroquine for the treatment of COVID-19 – Cortegiani et al – READ

• “There are more than 20 ongoing clinical trials in China and more scheduled to start in England, Thailand, South Korea and the United States” – REF

February 18, 2020 – Clinical Trials Arena: Coronavirus: Chloroquine yields positive data in covid-19 trial – Early data from clinical trials being performed in China has revealed that chloroquine phosphate could help treat the new coronavirus disease, Covid-19 – READ, WATCH

• Chloroquine was selected after screening thousands of existing drugs

February 11, 2020 (received as preprint) – International Journal of Antimicrobial Agents: Chloroquine for the 2019 novel coronavirus SARS-CoV-2 – Colson, Didier Raoult et al – READ, READ

2017

2019 – CDC: Medicines for the Prevention of Malaria While Traveling – Hydroxychloroquine (Plaquenil) – Brochure – PDF

• CDC promotes use of Hydroxychloroquine as safe and “a relatively well tolerated medicine.”
• The CDC in referencing the long-term use of HCQ for chronic disease treatments states “HCQ can be prescribed to adults and children of all ages. It can also be safely taken by pregnant women and nursing mothers.”

2014

October 1, 2014 – PLOS: Chloroquine is a zinc ionophore – Xue et al – READ, WATCH

2003

November 2003 – The Lancet | Infectious Disease: Effects of chloroquine on viral infections: an old drug against today’s diseases – Savarino et al – READ, CREDIT

• Chloroquine is a 9-aminoquinoline known since 1934…”Chloroquine/hydroxychloroquie can impair the replication of several viruses by interacting with the endosome-mediated viral entry or the late stages of replication of enveloped viruses”
• “Chloroquine has been shown to inhibit different viruses requiring a pH-dependent step for entry”
  • 2021- “Influenza hemagglutinin (HA) is a viral membrane bound protein that plays a critical role in the viral life cycle by mediating entry into target cells” – PAPER
  • May 2023 – pH-dependent endocytosis mechanisms for influenza A and SARS-coronavirus – PAPER
• “ Of particular interest for human pathology is the report that chloroquine inhibits uncoating of the hepatitis A virus, thus blocking its entire replication cycle”

October 30, 2003 – Antimicrobial Agents and Chemotherapy : Effect of zinc salts on respiratory syncytial virus replication by Suara et al – READ, The Highwire – CREDIT

1994

1994 – BOOK: Vaccines and world health : science, policy, and practice by Faul F. Basch (1994) – (Borrow online) – READ, Credit Dr Judy Wilyman – Vaccination – HERE

• “The Effect of Infection-Controlling Drugs on the Immune Response to Vaccines” – Chloroquine can inhibit the antibody production to vaccine antigens! – READ

The post Hydroxychloroquine first appeared on Totality of Evidence.

Budesonide works…since mid 2020!

To alleviate COVID-19 symptoms, and reduce hospitalisation by 90%

Symptoms of difficulty breathing were overcome using Budesonide

Those of us who have been following the COVID-19 trail from it’s inception have come across many front line doctors “screaming” out about about how they have successfully assisted their patients presenting with symptoms attributed to the disease called COVID-19. These EARLY intervention treatments have prevented the disease process from escalating and thus preventing hospitalisation.  Early treatment was focus of many front line emergency doctors and GP’s.

Finding an Early Treatment to Prevent Hospitalisation Means The Pandemic is OVER!

This is IMPORTANT because if a successful EARLY TREATMENT for COVID-19 is found then this “pandemic” is over!  How many COVID-19 patients died before they reached hospital?

Stabilising patients and preventing hospitalisation was the focus of front line doctors, where in the emergency room breathing issues was a consistent symptom Dr Bartlett came across.

So these doctors hit the books, prayed and searched for ways to relieve symptoms using existing tools to relieve symptoms, and Dr Bartlett found one.

The Budesonide story is one you need to know about

Nebulised Budesonide was “discovered” early in the pandemic (March 2020) to address the breathing issues that many patients presented with in the United States – the country that was said to be hardest hit by COVID-19 deaths!  If early symptoms weren’t addressed then patients could escalate to a cytokine storm of inflammatory chemicals leading to the need for ICU hosptilisation.

Budesonide is a 25 year old drug, it’s used by many millions of people every day to treat their asthma, its been used on babies through to fragile elderly without any trouble.

“When you use budesonide, it’s almost like putting a wet blanket over a fire.  It decreases the release of those inflammatory chemicals, and that buys time for the bodies immune system to kill off the virus.”
Dr Richard Bartlett, MD

Information about this potentially life saving, cheap and symptom reducing product was censored and belittled by the media and the “authorities”.  You really have to ask why?  This drug is a known product with a vast history of scientific literature and known potential side effects (which are few) – that appeared to remedy a problem in the beginning of a “pandemic”.

“…I am heartened that a relatively safe, widely available and well studied medicine such as an inhaled steroid [budesonide] could have an impact on the pressures we are experiencing during the pandemic.”
Professor Mona Bafadhel of Nuffield Department of Medicine, University of Oxford

Repurposing an existing, off-patent, cheap drug was not part of the “solution” they wanted us to know about.  Remember from the outset the “experts” said we won’t get out of this without a vaccine?  How did they know this?  Wasn’t this meant to be a new disease?

West Texas Doctor Richard Bartlett MD reported great success with his protocol in treating COVID-19 patients when treatment began early, rather than when patients start having difficulties. Early treatment is common in virtually all illnesses including common flu BUT no early treatment has been suggested as part of any protocol for COVID-19.  This should concern everyone.  Did this suggested avoidance of any early intervention by the “medical establishment” in the USA contribute to their “high” death numbers attributed to COVID-19?

Thankfully Front line doctors didn’t listen to everything their “medical experts” had to say!

Oxford University Clinical Trials Prove Budesonide Works

Well now, March 2021, there are clinical trials to prove that budesonide works to curb the symptoms of COVID-19, preventing hospitalisation and the escalation of the disease process.  According to Dr Bartlett, the emergency medicine doctor who “discovered” this treatment, the Oxford trials had to be cut short because the treated group (versus the control group with no budesonide) were clearly helped with the drug, they couldn’t ethically hold it back from the untreated group.  Imagine how many people struggling to breath over the past 10-12 months could have been assisted, prevented from hospitalisation and maybe saved?

You can read more about budesonide at this website budesonideworks.com and find links to the medical literature.
Click here to go direct to the early phase 2 study done by Oxford early 2021.
Click here for Case study Report by Dr Richard Bartlett and Alexandria Watkins

Dr Bartlett talks about the Oxford trial (March 2021)

Watch Video Testimony by Dr Richard Bartlett

Following is a collection of video’s about Budesonide.  These are not easy to find on YouTube, and may at some point get taken down.  We’ll try to put links to alternate channels below too in case these go down.

Following are some of the interviews that Dr Richard Bartlett an Emergency Medicine Doctor from Texas, gave early on in the pandemic to try to get this information out.  These are just a small segment of what is out there, at this stage they appear to still be up on YouTube.

Take the time to watch at least this first video.

July 2020 – Dr Bartlett’s Story of Budesonide Discovery

Panic Porn; Dr. Richard Bartlett; Independence Day Brilliance 7.2.20
YouTube Channel: America Can We Talk
Published: July 3, 2020

August 2020:  Dr. Richard Bartlett on inhaled steroid Budesonide and Covid-19

YouTube Channel: Drbeen Medical Lectures

June 2020:  The “Silver Bullet” For COVID-19 – Dr Richard Bartlett

July 2020: Dr. Richard Bartlett on inhaled steroid Budesonide and Covid-19

Trying Everything to get the word out

Dr Bartlett was getting heavily censored from the monopoly platforms, that he made contact with the Documentary creators of Out Of Shadows, and put a POWERFUL 9 minute, downloadable video on their homepage to help spread the word of hope.  In this video you will hear him describes how his interviews were heard by other hospital staff in other states and they employed the treatment strategy and emptied an ICU in 48 hours!

March 2021: Oxford Trial of Budesonide

Articles in reverse chronological order

2023

May 11, 2023 – The Highwire Ep 319: Awakening – Dr Richard Bartlett is back – ‘SILVER BULLET’ PROTOCOL FOR COVID VALIDATED TWO YEARS AFTER ATTACKED – WATCH, FULL

• With in hours of treatment people can breathe

April 18, 2023 – Med Express: Oral fluvoxamine plus budesonide found to cut severe disease in COVID-19 – PDF, Medical News – READ

• May 5, 2023 – McCullough Substack: Oral Fluvoxamine Plus Inhaled Budesonide Reduced Prolonged ER Stays or Hospitalization for Acute COVID-19 – Underpowered Multicenter Trial Confirms Expected Signal of Benefit Especially in Vaccinated Patients – READ

April 18, 2023 – Annals of Internatl Medicine: Oral Fluvoxamine With Inhaled Budesonide for Treatment of Early-Onset COVID-19 – A Randomized Platform Trial – Reis et al – READ

2021

August 10, 2021 – The Lancet – Inhaled budesonide for COVID-19 in people at high risk of complications in the community in the UK (PRINCIPLE): a randomised, controlled, open-label, adaptive platform trial – Yu et al (Oxford Uni trial) – READ, READ2, Dr Bartlett – WATCH,

• Science direct lists more budesonide trials – HERE

April 12, 2021 – Pre Print: Inhaled budesonide for COVID-19 in people at higher risk of adverse outcomes in the community: interim analyses from the PRINCIPLE trial – PRINCIPLE Collaborative Group – Yu et al – READ, REF, Published Aug 10, 2021 in The Lancet.

April 9, 2021 – The Lancet: Inhaled budesonide in the treatment of early COVID-19 (STOIC): a phase 2, open-label, randomised controlled trial – Ramakrishnan et al – READ

February 9, 2021 – Oxford University News: Common asthma treatment reduces need for hospitalisation in COVID-19 patients, study suggests – READ, BBC – READ, Yahoo – READ, Guardian – READ

• “The STOIC study found that inhaled budesonide given to patients with COVID-19 within seven days of the onset of symptoms also reduced recovery time.”
• “With at-home patients still often feeling seriously unwell, scientists from the University of Oxford found inhaling budesonide twice a day for two weeks speeds up an individual’s self-reported recovery by 72 hours.” – REF

February 8, 2021 – Preprint: Inhaled budesonide in the treatment of early COVID-19 illness: a randomised controlled trial – Oxford universtity authors – Ramakrishnan et al – READ, now published The Lancet – READ

• 90% of hospitalisations can be prevented – WATCH

2020

November 27, 2020 – The Oxford PRINCIPLE Trial: Inhaled corticosteroids to be investigated as a possible treatment for Covid-19 in national PRINCIPLE Trial – READ, ARCHIVE, Results – ARCHIVE, The Lancet – READ

• Platform Randomised trial of INterventions against COVID-19 In older peoPLE (PRINCIPLE) – ARCHIVE
• Inhaled budesonide is an inexpensive, safe and commonly prescribed treatment for asthma and COPD. It is the fourth medication to be tested in PRINCIPLE.
• “Led by the University of Oxford, the Platform Randomised trial of Interventions against Covid-19 In older peoPLE (PRINCIPLE) Trial is evaluating treatments that can help people aged over 50 recover more quickly from Covid-19 illness and prevent the need for hospital admission. The study has so far recruited more than 2100 volunteers from across the UK.”

2016

June 4, 2016 – BMC Pulmonary Medicine: Budesonide ameliorates lung injury induced by large volume ventilation – Ju et al – READ., CREDIT

• Cytokines are shut down with budesonide – REF

The post Budesonide first appeared on Totality of Evidence.

Ivermectin is said, by many expert research doctor’s, to be one of the most promising drugs for the treatment and prevention of COVID-19 symptoms.  There are years of safety data on ivermectin to back up the safety of the dosage being used, yet the authorities continue to put up road blocks to it’s use for COVID-19.

Safety and efficacy of ivermectin has been demonstrated by in depth literature searches, data analysis, and field experience.  It works.  It stops hospitalisations of COVID-19 cases.  The benefits have been shown to greatly outweigh any risk associated with the years old medication.

The main manufacturer of ivermectin, a now off-patent product is Merck, and in February 2021 they released a statement warning of it’s use.  What they neglected to disclose was they were applying for emergency use authorisation for a new product, which if ivermectin was “demonstrated” to be successful, then an EUA for a new product couldn’t be justified, and profits will be lost.

On this page we have aggregated some key videos and links to information about Ivermectin for use as a prophylaxis or early treatment for COVID-19. If this product was demonstrated (which it has been) to be successful in preventing hospitalistion for COVID-19 disease, then the vaccines cannot be coerced or mandated and a State of Emergency would no longer exist.  Vaccine manufactures would have to take back liability for their product, they will no longer be protected under EUA or Provisional Registration for their brand new technology vaccines.

• COVID-19 Critical Care: Totality of Evidence for Ivermectin – 2022 – PDF

• Doctors work with Ivermectin:
  • Dr Pierre Kory – HERE
  • Dr Paul Marik – HERE
  • Dr Tess Lawrie – HERE

Three mini-documentaries on ivermectin

If ivermectin was shown to be an effective treatment for COVID-19 then there could be no emergency use authorisation for the new technology, experimental, gene therapy COVID-19 vaccines.

“Public health was built on an obsessive global vaccination policy, which ivermectin would have threatened“

Dr Pierre Kory

Ivermectin was first brought to the public’s attention in late 2020

Dr Pierre Kory’s testimony at US Senate Committee Hearing for Early Treatments for COVID-19

The public became aware of ivermectin as a potential early treatment for COVID-19 when Dr Pierre Kory gave a presentation to the US senate committee on December 8th, 2020.  This US government testimony video was deleted from YouTube within 10 days after 5 million views.

This link is how the mainstream media outlets label this doctor “anti-vaccine”, which in actual fact he does promote vaccination. But in this instance he is promoting early treatment to save lives based on his experience and that of his colleagues at FLCCC and globally.

US Senate Testimony

December 8, 2020

Bitchute video Here
Archive of original vimeo video

Dr Kory is Chief Medical Officer of the Front Line COVID-19 Critical Care Alliance (FLCCC), a team of specialist critical care doctors who spend their days treating patients and wading through scientific literature.  Their website contains a wealth of information, including more videos and tutorials.

They have been fighting to get this life saving information out, but the authorities refuse to listen.

Timeline of Ivermectin

The Palmer Foundation has put together a timeline of Ivermectin, and keep this up to date with the latest information on Ivermectin.

The science of ivermectin for COVID-19 – meta data

September 2021 – TGA restrict ivermectin in Australia, based on advisory committee’s advice, who looked at international in-hospital use! Not early treatment. Remember it is drug companies that sponsor registration submissions, off-patent drugs are not cost effective for pharma to sponsor.

COVID-19 Patient Management with Dr Paul Marik

Dr Paul Marik leads the team at FLCCC and together they developed a treatment protocol called MATH+ Protocol

July 16, 2020

Webinar on Ivermectin for COVID-19

April 15, 2021

****Lots of gems in this presentation******.  Get your notebook ready

Interview of Dr Pierre Kory with Dr John Campbell – Part 1

April 25, 2020  – Steroids and anticoagulants

Interview of Dr Pierre Kory with Dr John Campbell – Part 2

April 25, 2020  – Ivermectin

Part 2 – Archive here and here .   YouTube deleted part 2

Interview with Dr James Lyons Weiler

January 16, 2021 [Sorry no archive!]

Independent Meta Analysis of Ivermectin Data

DarkHorse Podcast with Tess Lawrie & Bret Weinstein. 
July 17, 2021

Tess Lawrie is an MD and PHD, external analyst for the World Health Organization, and an expert in analysis of medical evidence.  Learn about quadruple randomised control trials.

Joe Rogan Experience Podcast with Dr Pierre Kory and Bret Weinstein

Listen to just under 3 hours of discussion of all things ivermectin relevant to COVID-19 response.
June 2021 – LISTEN

The Evidence for Ivermectin

Ivermectin is a globally registered drug which has been prescribed more than 4 BILLION times, and suddenly it is “dangerous”- WATCH

June 2, 2021 – AJT: Ivermectin for Prevention and Treatment of COVID-19 Infection: A Systematic Review, Meta-analysis, and Trial Sequential Analysis to Inform Clinical Guidelines, Bryant, A & Lawrie, T et al- READ

Open Letter by U.S. Doctors: JAMA Ivermectin Study Is Fatally Flawed – READ

The Global Disinformation Campaign Against Ivermectin

Dr Pierre Kory is documenting all things Ivermectin on his substack (2022) – Read “The Global Disinformation Campaign Against Ivermectin, “The Fix” – Chapter 1″ – HERE

A patients story treating Omicron with Ivermectin – HERE

Random links to ivermectin

This above is but a small snap-shot of ivermectin, it’s exhausting trying to keep up with everything. From time to time I may post something new here – in no particular order.

• Ivermectin: enigmatic multifaceted ‘wonder’ drug continues to surprise and exceed expectations
• FLCCC Alliance: Videos & Tutorials on Ivermectin – link
• Swiss Policy Research – Ivermectin summary – link
• South African-born Dr Paul Marik: the pioneer for ivermectin use against Covid-19 – video
• Maria Bartiromo with Pierre Kory & Senator Ron Johnson 9 Jan 2022 – video
• Dr. Pierre Kory of the FLCCC Alliance on the Therapeutic Value of Ivermectin in Treatment of COVID – video
• Lab experiments show anti-parasitic drug, Ivermectin, eliminates SARS-CoV-2 in cells in 48 hours – Monash University and Tweet and video
• Dr. Pierre Kory Talks Covid-19, Ivermectin and the FLCCC | Podcast E43 -Nov 2020
• Dr Lee Merritt on The Highwire – video
• Ivermectin timeline – on Palmer Foundation website
• What is ivermectin and how does it work? – video
• The First International Ivermectin for Covid Conference – April 2021 – The BIRD group – tweet – video
• Dr Thomas Borody – Australia – video
• NIH claim “insufficient data” to support ivermectin – link
• Full Senate hearing for Early Treatments – December 2020 – link
• Tess Lawrie’s review and meta-analysis: “Ivermectin reduces the risk of death from COVID-19” – link
• Ivermectin has been used to alleviate symptoms post COVID-19 vaccination – watch before & after
• The Case for Ivermectin in Australia – by the Honorable MP Craig Kelly – 22 June 2021 – watch
• The Story Of Ivermectin And COVID-19 – watch
• Joe Rogan takes ivermectin – the real story – not horse dewormer! – watch
• Dr. Robert Malone on Ivermectin – American Though Leaders – Sept 2021 – watch
• Scientist Alleges Deception in NIH’s Non-Recommendation of Ivermectin – UncoverDC Sept 2021
• Doctor defends ‘80 clinical studies’ showing ivermectin ‘89% effective’ at preventing COVID – April 2021 – link
• Dr. Harvey Risch: Hydroxychloroquine, Ivermectin, and Other Therapeutics Highly Effective in Early COVID Treatment – Nov 2021 – American Though Leaders – link
• Jan 2022 – Japan – Ivermectin effective on Omicron – article

Ivermectin data points in reverse chronological order

This is not a complete list, much of the information above needs to be added in when time permits.

For the best information on ivermectin
visit Dr Pierre Kory & Dr Paul Marik pages
C19 Group Ivermectin analysis – HERE

2024

August 27, 2024 – Project Veritas: BREAKING: DOJ Lawyer ADMITS FDA War Against Ivermect*n was a Mistake, Abuse of Authority, After Doctors Sue Government and Win – TWEET, READ

August 25, 2024 – Dr Altman Substack: EXPLOSIVE COMMENTS FROM DR. YEADON ON IVERMECTIN (on infertility) What is the truth? – READ, Dr Yeadon (source unknown) – WATCH, Dr Altman followup – READ

• August 20, 2024 – Dr. Lawrie has challenged Dr. Yeadon to debate this astounding claim – READ

August 16, 2024 – Dr Tess Lawrie Substack: Is ivermectin really a genocidal tool of the globalists? – READ, CREDIT

March 6, 2024 – Pierre Kory’s Substack: The Last of The “Big Seven” Fraudulent Ivermectin Trials Has Finally Been Published – READ, C19 group analysis on ivermectin trials – HERE, World Council for Health statement – READ

• re Oxford’s PRINCIPLE trial the same study investigator, Prof Chris Butler who also carried out the Molnupiravir PANORAMIC unprecedented 25,000 participant, randomised, within 2 days of symptoms, clinical trial – REF
• “Oxford’s long delayed PRINCIPLE trial just set a new record for ivermectin research fraud when they silently published it as a negative study despite their data showing profoundly positive impacts.”
• Butler designed the trial to use a low dose of ivermectin with short treatment duration and started late in mild patients yet still achieved a positive 2 day earlier recovery which is not negative and according to Dr Kory “must be viewed as the minimum of what ivermectin can achieve”

February 29, 2024 – Journal of Infection: Ivermectin for COVID-19 in adults in the community (PRINCIPLE): an open, randomised, controlled, adaptive platform trial of short- and longer-term outcomes by Hayward et al – READ, Dr Kory’s comments – READ

• “Significantly improved recovery and significantly lower risk of long COVID with ivermectin, despite very late treatment, low-risk patients, and poor administration.” …The efficacy seen for ivermectin here is despite the trial being the most clearly designed to fail trial, with major bias in design, operation, analysis, and reporting. This trial is a great example of bias in clinical trials…”- C19 analysis – READ
• This paper quitely appeared in the 7th ranked journal of infectious disease (why not a top ranking journal with more exposure?)
• The editor in Chief of the Journal, Dr. Robert Read, was also the chair of the Steering Committee for the COV-Boost trial which studied the effects of 7 different mRNA boosters (Astra Zeneca, Moderna, Pfizer, Janssen, Novavax etc) – REF, who are sponsored by Oxford – REF, COV-Boost – ARCHIVE

2023

November 30, 2023 – Dr Byram Bridle Substack: Home of Evidence-Based Medicine Says Ivermectin is Effective Against COVID-19 – McMaster Uni – READ

• A doctor forced to be “re-educated” for treating COVID-19 patients with ivermectin finds the McMaster University re-education platforms highlights 2021 ivermectin systematic review supports the use of ivermectin!

…evidence finds that large reductions in COVID-19 deaths are possible using ivermectin. Using ivermectin early in the clinical course may reduce numbers progressing to severe disease. The apparent safety and low cost suggest that ivermectin is likely to have a significant impact on the SARS-CoV-2 pandemic globally.“

October 9, 2023 – Senator Malcolm Roberts Qld: TGA is Risking Your Health to Act as a Sales Agent for Big Pharma – READ , WATCH, Ivermectin in Australia STROMECTOL – READ

“…a drug, a medicine or a product that is on the ARTG is there for a specific indication. In this case, the specific indication for ivermectin—for which there’s been a dossier provided, evaluated by the TGA as robust, good clinical science—is that it is useful for the treatment of certain parasitic illnesses, be they gastrointestinal or skin based. No evidence has been presented to the TGA by the sponsor to demonstrate in any way, shape or form that ivermectin is useful in treating COVID-19. If the sponsor would like to do so, we’d be happy to consider that, because that’s the only way that the TGA is able to expand that indication.”

Health Products Regulation Group (HPRG) Chief Medical Adviser – Adj Prof Robyn Langham

• It would seem these same rules DO NOT apply to vaccines, which public health appear to recommend off-lable.

The TGA did not remove ivermectin from the market place. The TGA restricted off-label prescribing of ivermectin. To ensure there was drug available to those with relevant diseases that needed it…it was ordered from a safety perspective [after broad consultation]

…I can’t speak to what it was that encouraged the Indian government to use it.

Adj Prof Robyn Langham

• Ivermectin restrictions were removed because most Australian’s were vaccinated and thus “protected for covid” – EXCERPT [yet they needed boosters, so how could they be “protected”] –

August 17, 2023 – The Highwire Ep 333: INESCAPABLE – FULL, The Jaxen Report: FDA Backtracks on Ivermectin – WATCH

• MONTAGE looking back at the war on ivermectin- WATCH
• August 8, 2023 Hearing – FDA representatives stated doctors DO have the authority to use ivermectin to treat COVID-19, that “the FDA was not regulating the use of off-label drugs”, which is contrary to the persuasive letters the FDA sent to Federation of State Medical Boards and Pharmacist Boards! – LISTEN

August 16, 2023 – Geoff Pain Substack: Pfizer knew Ivermectin protects against its deliberately added Endotoxin Jab Harms- Pfizer acquired Wyeth for $68 billion in 2009 as part of its plan to become the dominant player in Jabbing. What is the connection to Ivermectin? – READ

• Pfizer Trial Subject (C459100112314898) in Argentina contracted pneumonia 17 days after his second (placebo) shot (Sept 16, 2020) and was rescued with drugs that included ivermectin

August 14, 2023 – Kim Iversen: Peer Reviewed and Published, Too Little Too Late, Ivermectin Worked Against Covid-19 – WATCH, Vigilant Fox: “Ivermectin Worked!”: Peer-Reviewed Study Finds 74% Reduction in Excess Deaths – READ

• A now peer reviewed and published study shows Ivermectin reduced Covid deaths by 14 fold in areas of intense usage in Peru. – STUDY

August 8, 2023 – Cureus: COVID-19 Excess Deaths in Peru’s 25 States in 2020: Nationwide Trends, Confounding Factors, and Correlations With the Extent of Ivermectin Treatment by State – by Chamie et al – READ, Dr Kory – it took 2 years for peer review – GETTR, TWEET

• “The natural experiment that was put into motion with the authorization of IVM use for COVID-19 in Peru in May 2020, as analysed using data on excess deaths by locality and by state from Peruvian national health sources, resulted in strong evidence for the drug’s effectiveness….”
• “Coauthors of the 2022 TOGETHER Trial, which reported a negative conclusion for IVM treatment of COVID-19, repeatedly refused to disclose four per-protocol outcomes of paramount interest, two each for deaths and hospitalizations…”

July 30, 2023 – FLCCC Alliance Substack: Reader’s share personal experiences with FLCCC protocols – Testimonials – READ

July 27, 2023 – Meryl Nass Substack: Treating COVID-19 in 2023 and update on HCQ & Ivermectin – READ

May 31, 2023 – FLCCC: Gary Atkins, Who Has Been Quadraplegic for 46 Years, Has Been a Fan of Dr. Kory and the FLCCC Since The Beginning – used ivermectin and not jabbed – WATCH

May 3, 2023 – TGA: Removal of prescribing restrictions on ivermectin – READ, ARCHIVE, TIMELINE

February 21, 2023 – Dr. John Littell testified before the Sarasota County Public Hospital Board, claiming that ivermectin was effective in treating COVID-19, then gets ushered out – TWEET, AP “factcheck” – READ

• Dr Little official website – HERE
• Dr John Littell speaking with Mel K – WATCH

January 5, 2023 – PRESS RELEASE: MedinCell announces positive results for the SAIVE clinical study in prevention of Covid-19 infection in a contact-based population – READ, ClinicalTrials.gov – READ, Trial Site News – READ

• “The undeniably positive trial results for Ivermectin, with no unexpected side effects, should have quickly caught the attention of the FDA, CDC, WHO, and others as significantly as it did Dr. Kory. Especially given the high standards of the trial—it was a parallel-group, double-blinded, randomized, and placebo-controlled trial with little that could be done to improve the rigor of the design.” – UncoverDC – REF

January 3, 2023 – Courageous Discourse Substack | John Leake: Ivermectin’s Mechanism of Action Against SARS-CoV-2 Described – SHAME on the hospital systems that systematically denied patients (and their begging families) this FDA-approved, Nobel prize winning, wonder drug – READ

• “The systematic lying about hydroxychloroquine to suppress its use in the outpatient setting was infuriating. However, for me, the most upsetting stories were about people who died in hospital after being systematically denied ivermectin.”
• “Drs. Pierre Kory, Paul Marik, and Tess Lawrie were on the front line of fighting for ivermectin in the hospital setting.”
• From in vitro and prior studies it was known that ivermectin had demonstrated potent anti-viral activity, but precise mode of action was unknown. Until Dec 7, 2022 – STUDY

2022

December 7, 2022 – International Journal of Molecular Sciences: SARS-CoV-2 Spike Protein Induces Hemagglutination: Implications for COVID-19 Morbidities and Therapeutics and for Vaccine Adverse Effects – Boschi et al – READ, CREDIT, TIMELINE

• First understand that “SARS-CoV-2 Spike Protein Induces Hemagglutination—i.e., a reaction that causes clumping of red blood cells. A glycoprotein on the viral surface, namely hemagglutinin, interacts with red blood cells, leading to the clumping of red blood cells and the formation of a lattice.” – REF
• “IVERMECTIN blocked HEMAGGLUTINATION when added to RED BLOOD CELLS prior to spike protein and reversed HEMAGGLUTINATION when added afterward.” …”By reversing the clumping of red blood cells, ivermectin enabled the dying patient’s proper respiratory function to return, thereby generating his or her astonishing recovery.” REF

December 8, 2022 – Epoch Times: FDA Says Ivermectin Doesn’t Work Against COVID-19 but Points to Studies That Show It Does – READ

November 21, 2022 – Gateway Pundit: FTX Funded $18 Million Towards Research that Claimed that Ivermectin and Hydroxychloroquine Didn’t Work Against COVID – READ, The TOGETHER trials – READ

November 21, 2022 – Black Listed News: FDA Says Telling People Not to Take Ivermectin for COVID-19 Was Just a Recommendation – government lawyers argued during a recent hearing – READ, ARCHIVE

• Remember FDA Tweet Aug 21, 2021, Twitter post by the agency: “You are not a horse. You are not a cow. Seriously, y’all. Stop it.” – TWEET, FDA web page on “horse dewormer” – HERE

November 21, 2022 – Just The News: FDA social media posts on COVID under legal, medical scrutiny for misleading claims – READ, Sonia Elijah – TWEET

November 10, 2022 – The Highwire Ep 293: CONTROVERSIAL DRUG KEY TO FIGHTING RSV? – Ivermectin shown in vitro to be effective against RSV’s, RSV’s are increasing in children since the C19 vax – WATCH

October 27, 2022 – Biz News: Ivermectin, supported by evidence-based medicine, was cast aside during Covid at great cost – READ

• “This week we published the Totality of Evidence-Based Medicine (T-EBM) wheel on TrialSite News for the first time. By totality, we mean both the totality of the types of reports and the totality of reports for a given type.”
• “In a pandemic situation, double-blinded randomised controlled clinical trials on already approved therapeutics are neither cost-effective, nor required since the safety profile and mechanisms of action are already known. Therefore, allowing health providers to prescribe such medications off-label should be the first response, and should be encouraged.”

October 19, 2022 – Epoch Times: Doctors Suing Food and Drug Administration Over Ivermectin – READ

October 6, 2022 – Dr Kory Substack: More Fraud Uncovered In The Lopez-Medina Ivermectin Trial Published In JAMA – Well after 100 doctors wrote an open letter to JAMA asking for a retraction based on the study’s innumerable flaws, Alexandros Marinos uncovered more brazenly corrupt actions by study investigators. – READ, Kory credits “Do Your Own Research” – SUBSTACK, possible SOURCE

October 5, 2022 – Dr John Campbell: Ivermectin clarification (A walk through the terms and conditions of what not to say online!) – WATCH, The PRINCIPLE trial – nothing reported for 16 month on the ivermectin trial! – LINK, Dr Kory “A master class in the exposure of regulatory, academic, and media capture” – GETTR

October 1, 2022 – Global Newswire: The FDA Misled the Public About Ivermectin and Should Be Accountable in Court, Argues the Association of American Physicians and Surgeons (AAPS) – READ

September 17, 2022 – Trial Site News: Civil Karachi Hospital 423-Patient Study: Ivermectin + SOC Cohort Does Significantly Better Treatment for COVID-19 than Standard of Care Alone – READ

September 10, 2022 – America Out Loud with Dr McCullough: Hunting for Dr. Stone – Ivermectin administration started on 8th August, 2020 and hospitals cleared – READ & LISTEN, GETTR, Trial Site News – ARTICLE

September 5, 2022 – OANN: Calif. backs medical tyranny with Bill AB 2098, bans doctors from discussing Ivermectin with their patients – WATCH & READ

September 3, 2022 – Vigilant Fox Substack: Ivermectin Comeback: Peer-Reviewed Paper Shows 92 PERCENT REDUCTION in Mortality – The Highwire – READ, WATCH

September 3, 2022 – Blaze: Ivermectin reduces COVID death risk by 92%, peer-reviewed study finds – A new peer-reviewed study found that regular use of ivermectin reduced the risk of dying from COVID-19 by 92%. – READ

August 31, 2022 – Cureus: Regular Use of Ivermectin as Prophylaxis for COVID-19 Led Up to a 92% Reduction in COVID-19 Mortality Rate in a Dose-Response Manner: Results of a Prospective Observational Study of a Strictly Controlled Population of 88,012 Subjects – Kerr et al – STUDY

August 12, 2022 – Dr Pierre Kory Substack: The Miracle Not-Heard Around The World: The Success of Uttar Pradesh – Part 1 – READ
The north Indian state of 231 million people eradicated COVID with an ivermectin treatment program, representing one of the greatest public health achievements in history. It was kept a global secret.

July 22, 2022 – Steve Kirsch Substack – New study shows ivermectin can reduce chance of death by 92% – But the WHO, NIH, and FDA all recommend that you avoid using it. – READ

STUDY: Regular use of ivermectin as prophylaxis for COVID-19 led up to 92% reduction in COVID-19 mortality rate in a dose-response manner: results of a prospective observational study of a strictly controlled population of 88,012 subjects among 223,128 participants – READ

NIH: “The Panel recommends against the use of ivermectin for the treatment of COVID-19, except in clinical trials” & “Ivermectin is not approved by the FDA for the treatment of any viral infection.” – READ, ARCHIVE

July 2, 2022 – Stop the War on Doctors by Dr Pierre Kory – READ

June 20, 2022 – World Council for Health | General Assembly #45: Scientific Misconduct uncovered in the TOGETHER Ivermectin Trial – presentation by Dr Edmund Fordham – WATCH, FULL

May 5, 2022 – The TOGETHER trial aimed at studying the effectiveness of ivermectin to treat COVID-19 – [The trial is set up to fail!] – Effect of Early Treatment with Ivermectin among Patients with Covid-19 – READ

These flawed trials are used by the mainstream media to [falsely] discredit ivermectin. – EXAMPLE
To push their “vaccines-above-all-else strategy” they need treatments to appear to fail – so much for “evidence-based medicine!”

April 29, 2022 – NEJM published Ivermectin paper on a RCT concluding no clinical benefit BUT they neglected: “Patient Attrition Bias Explains The Latest NEJM Ivermectin Study” by Dr James Lyons-Weiler – SUBSTACK, NEJM

April 26, 2022 – Brownstone Institute: Revamping Our Dysfunctional Drug Approval Process – Big Pharma and other well-financed interests sponsor purportedly “impartial” medical trials aimed at discrediting cheaper generic alternatives. (Ivermectin study designed to fail! to support a narrative) – READ

March 14, 2022 – Pierre Kory Substack: The Global Disinformation Campaign Against Ivermectin, “The Fix” – Chapter 1 – The “narrative” that all positive ivermectin studies were small, low quality, fraudulent & could not be trusted was achieved via capture of the world’s leading ivermectin researcher, Dr. Andrew Hill. – READ

March 6, 2022 – Igor Chudov Substack: Not using Ivermectin killed about 688,000 Americans – new study – READ

2021

October 27, 2021 – Hal Turner Radio Show: Japan drops vax rollout, goes to Ivermectin, ENDS COVID almost overnight – ARCHIVE – Be sure to check-in with the fact checkers!

• “Japan pulls Moderna vax, ends nationwide vax drive after “magnetic” “metals” found to contaminate jabs” – READ
• Associated Press: Vaccines, masks? Japan puzzling over sudden virus success – Oct 18, 2021 –READ, ARCHIVE

October 18, 2021 – AIER: The FDA’s War Against the Truth on Ivermectin – READ

October 8, 2021 – Blitz: COVID cases in Indian Uttar Pradesh drops by 97.1 percent because of Ivermectin use – READ, CONTEXT

• “The strategy of trace, test & treat yields results.” The health officials went door-to-door in the state of 230 million residents, providing a test and treat program with medicine kits.

September 24, 2021 – The New Daily: Experts hit back at ‘cherrypicking’ of Australian Ivermectin research – READ

September 10, 2021 – Australia TGA: New restrictions on prescribing ivermectin for COVID-19 – READ, TWEET, Guardian: Australian regulator bans drug as Covid treatment after sharp rise in prescriptions – READ

September 10, 2021 – Colleen Huber NMD Substack: Ivermectin is safe and effective: The evidence – Decades of use with nearly four billion doses to humans preceded recent use with COVID patients. From the chapter ‘Ivermectin sends COVID to lockdown,’ in my book The Defeat Of COVID – READ

September 7, 2021 -The JD Rucker Show: Dr Sabine Hazan: How Big Tech is Keeping Ivermectin Researchers From Doing Clinical Trials – WATCH

• Dr Sabine Hazan is founder of Ventura Clinical Trials, and has been Principal Investigator and Sub Investigator in over 150 clinical trials. She is also the creator of ProgenaBiome, a state-of-the-art genetic research sequencing laboratory.

September 5, 2021 – PJ Media: ‘Rolling Stone’ Caught Peddling Fake News About Ivermectin ‘Horse Dewormer’ Overdoses Overwhelming ERs – READ, Rolling Stone Sept 3 article – ARCHIVE

September 3, 2021 – Pharmacy Times: Pharmacy Groups Call for Immediate End to Prescribing, Dispensing Ivermectin for COVID-19 Outside of Clinical Trials – READ

September 2, 2021 – The New Daily: CMO warns Australians not to take Ivermectin after overdose at Westmead – Australia’s chief medical officer has pleaded with citizens not to self-medicate with Ivermectin. FDA & TGA dewormer warning! – READ

September 1, 2021 – The Pulse: Westmead Hospital toxicologist warns: “Don’t rely on online sham cures for COVID-19” – Ivermectin is an anti-parasitic medication mainly used for farm animals that has not been proven to treat COVID-19, and like all medicines, can be dangerous if used incorrectly. – READ, TWEET

September 2021 – New Microbes and New Infections: Ivermectin: a multifaceted drug of Nobel prize-honoured distinction with indicated efficacy against a new global scourge, COVID-19 by Santin, McCullough & Borody et al – READ

August 24, 2021 – Blaze Media: Horowitz: The unmistakable ivermectin miracle in the Indian state of Uttar Pradesh – India’s 240m Populated Largest State – READ

August 23, 2021 – TGA: Ivermectin is a prescription medicine that is not approved in Australia (or in other OECD countries) to prevent or treat COVID-19 disease, and should not be imported for this indication – READ

• “The TGA strongly discourages self-medication and self-dosing with Ivermectin for COVID-19 as it may be dangerous to your health. There is insufficient evidence to validate the use of Ivermectin in patients with COVID-19.
• Ivermectin is indicated in the management and treatment of infections caused by parasites, such as mites and worms. In Australia, Ivermectin has been approved for the treatment of roundworm infections, scabies and inflammatory rosacea.
• Antiviral efficacy against COVID-19 and improvement to clinical outcomes from Ivermectin have not been proven.”
• [Its all about label “indications” – does COVID-19 vaccine labels specifically state preventing infection or transmission of SARS-CoV-2 (the virus)? No, they they refer to the COVID-19 “disease” i.e. the symptoms]

August 21, 2021 – FDA: “You are not a horse. You are not a cow. Seriously, y’all. Stop it.” – TWEET, ARCHIVE, PIC
FDA press release – READ – Just ahead of US full vaccine authorisation – ARTICLE

August 20, 2021: TGA: COVID-19 treatments: Information for consumers and health professionals – READ

• “Ivermectin has not received regulatory approval in Australia or by other comparable countries for use as an anti-viral treatment. Although there are some studies published either on unreferenced websites or in lower-tier medical journals, the consensus view of major regulators and in top-tier international medical journals [the gatekeepers] is that the evidence for the clinical efficacy and safety of ivermectin for the treatment or prevention of COVID-19 is not strong at this stage.

• The National COVID-19 Clinical Evidence Taskforce (NCCET) consisting of a large group of independent Australian clinical experts, is continuously updating treatment recommendations based on the best available evidence. They are not recommending the use of ivermectin for COVID-19 treatment outside of clinical trials with appropriate ethical approval.”

August 23, 2021 – TGA: Risks of importing Ivermectin for treatment of COVID-19 – READ

August 4, 2021 – Senator Malcolm Roberts – Why isn’t Ivermectin available in Australia? – WATCH

• August 17, 2022 – COVID Inquiry 2.0 – OFFICIAL
• March 23, 2022 – COVID UNDER QUESTION – OFFICIAL

July 28, 2021 – Cochrane Systematic Review: Ivermectin for preventing and treating COVID‐19 – Popp et al (referenced by TGA stating “This review found no evidence to support the use of Ivermectin for treating or preventing COVID-19 infection, and noted that the evidence base is limited”) – READ

July 28, 2021 – WSJ | Opinion: Why Is the FDA Attacking a Safe, Effective Drug? – Ivermectin is a promising Covid treatment and prophylaxis, but the agency is denigrating it. – READ, ARCHIVE

July 17, 2021 – The Spectator: Hunt goes off script with ivermectin – READ

• In Australia, one of the few doctors brave enough to use the drug to treat patients and save lives, Dr Mark Hobart, was reported AHPRA
• “Federal Health Minister Greg Hunt wrote to one of the doctors in Australia who prescribes ivermectin confirming that he was aware that some physicians are prescribing ivermectin off-label for Covid and that they were quite within their rights as the practice of prescribing registered medicines outside of their approved indications is not regulated or controlled by the Therapeutic Goods Administration (TGA), it is at the discretion of the prescribing physician.“

June 23, 2021 – BBC: Covid: Ivermectin to be studied as possible treatment in UK Oxford PRINCIPLE trial to compare those given the drug to patients receiving the usual NHS care – READ, Feb 2024 analysis of the trial – HERE

• Oxford PRINCIPLE Press Release: Ivermectin to be investigated in adults aged 18+ as a possible treatment for COVID-19 in the PRINCIPLE trial – READ, ARCHIVE
• Platform Randomised Trial of Treatments in the Community for Epidemic and Pandemic Illnesses (PRINCIPLE)

Ivermectin is readily available globally, has been in wide use for many other infectious conditions so it’s a well-known medicine with a good safety profile, and because of the early promising results in some studies it is already being widely used to treat COVID-19 in several countries.

Prof Chris Butler, from the University Oxford’s Nuffield Department of Primary Care Health Sciences, Joint Chief Investigator of the PRINCIPLE trial

June 21, 2021 – Am J Ther. | Meta Analysis: Ivermectin for prevention and treatment of COVID-19 infection: A systematic review, meta-analysis, and trial sequential analysis to inform clinical guidelines. American Journal of Therapeutics – by Bryant , Lawrie et al – READ, McMaster Health Evidence – ARCHIVE, CREDIT

March 10, 2021 – THE JAPANESE JOURNAL OF ANTIBIOTICS: Global trends in clinical studies of ivermectin in COVID-19 by Satoshi Omura et al – PDF, Dr Kory – WATCH

“Kitasato University, based on the judgment that it is necessary to examine the clinical effect of ivermectin to prevent the spread of uncertain COVID-19, asked Merck & Co., Inc. to conduct clinical trials of ivermectin for COVID-19 in Japan. … However, the company said that it had no intention of conducting clinical trials. As a result, Kitasato University decided to conduct a doctorinitiated clinical trial, the decision of which was published on the 12th of May

Satoshi Omura et al

• “…looking closely at the protocols of the trials in these developing countries, all of them are doctor-initiated. The scales of the trials are small due to a lack of funds. Even if the target patients could be randomized, complete blinding would not be possible due to a shortage of manpower.”

March 5, 2021 – FDA: Why You Should Not Use Ivermectin to Treat or Prevent COVID-19 – ARCHIVE, LIVE, “You are not a horse. You are not a cow. Seriously, y’all. Stop it.” Aug 2021 – TWEET

February 4, 2021 – Merck Statement on Ivermectin use During the COVID-19 Pandemic – READ, ARCHIVE, Dr Kory – WATCH

January 12, 2021 – SSRN: Sharp Reductions in COVID-19 Case Fatalities and Excess Deaths in Peru in Close Time Conjunction, State-By-State, with Ivermectin Treatments – Chamie-Quintero et al – Peru – READ, CREDIT

• “On May 8, 2020, Peru’s Ministry of Health approved ivermectin (IVM) for the treatment of COVID-19. A drug of Nobel Prize-honored distinction, IVM has been safely distributed in 3.7 billion doses worldwide since 1987.”

January 29, 2021 – Mectizan Expert Committee Statement on Mectizan Use During the COVID-19 Pandemic – READ

• The MEC reminds country partners that Mectizan [Ivermectin] is donated only for the elimination of onchocerciasis (river blindness) and lymphatic filariasis (elephantiasis).

2020

October 12, 2020 – CHEST Journal: Use of Ivermectin Is Associated With Lower Mortality in Hospitalized Patients With Coronavirus Disease 2019: The Ivermectin in COVID Nineteen Study (ICON) – Cepelowicz Rajter et al – READ, CREDIT

• “Many patients who were fortunate enough to prevail in court and receive ivermectin enjoyed an astonishing improvement of their condition within 24 hours of receiving their first dose—a recovery that struck family members as miraculous.” – REF

May 12, 2020 – Japan to start clinical trials with ivermectin for COVID-19 – ARCHIVE, REF

• “Kitasato University will soon begin a clinical trial to confirm the efficacy of the antiparasitic drug “stromectol” (generic name ivermectin) against new coronavirus infections.
• “We have confirmed the effectiveness against the new coronavirus in in vitro experiments (in an artificial environment such as in a test tube). I decided to start a doctor-initiated clinical trial because I thought it was necessary to scientifically verify its clinical efficacy.”
• “Computer-based simulations have reported that ivermectin has a binding affinity for the main protease of the new coronavirus. The main protease is an enzyme that cleaves proteins translated from the viral genome and functions. Therefore, it is thought that ivermectin can suppress viral replication by inhibiting the main protease.”
• “It is also known that ivermectin inhibits proteins in host cells called importins. Importins are proteins that have the function of transporting various proteins into the (cell) nucleus. Therefore, it is thought that ivermectin binds to the importin and inactivates it, thereby inhibiting the entry of the virus into the nucleus.” .
• “We are consulting with Maruho (Osaka City), the distributor of the drug, regarding securing the investigational drug. (Merck’s Japanese subsidiary) MSD will apply for approval, so we are in contact with MSD.”

April 3, 2020 – Monash University: Lab experiments show anti-parasitic drug, Ivermectin, eliminates SARS-CoV-2 in cells in 48 hours – Dr Kylie Wagstaff – READ

• “According to Hanaki, “Ivermectin has been reported to suppress the growth (replication) of various viruses since 2012.” “Based on those reports, an Australian research team confirmed in vitro experiments in April 2020 that ivermectin suppressed the growth of the new coronavirus” – REF (translated)

2015

October 5, 2015 – Nobel Prize in Physiology or Medicine awarded to 2 scientist for discovery of Ivermectin – READ

• William C. Campbell and Satoshi Ōmura discovered a new drug, Avermectin, which was subsequently chemically modified to a more effective compound called Ivermectin.

2013

October 30, 2013 – TGA: Product information for AusPAR Stromectol Ivermectin Merck Sharp Dohme (Australia) Pty Ltd PM-2012-01113-3-2 Final (ivermectin 3 mg) – PDF, ARCHIVE

1999

October 22, 1999 – WHO: WEEKLY EPIDEMIOLOGICAL RECORD, No. 42 – praise for ivermectin! – PDF

1987

October 2987 -The Task Force for Child Survival and Development | Mectizan® Donation Program: Merck donates ivermectin, a “very safe” drug, to help combat river blindness. – READ, TIMELINE

• this act ushered in the era known as “pharmacophilanthropy”
• January 29, 2021 – Mectizan Expert Committee Statement on Mectizan Use During the COVID-19 Pandemic – READ

1974

1974 – In 1974, Distinguished Professor Omura discovered that avermectin, a compound produced by actinomycetes living in soil, had antiparasitic properties. Merck later modified it to create ivermectin. – REF (translated using google)

• Ivermectin is an anti-parasitic drug developed through joint research between Kitasato University Professor Emeritus Satoshi Omura, who won the Nobel Prize in Physiology or Medicine in 2015, and pharmaceutical giant Merck”.
• Merck launched ivermectin as a veterinary drug in 1981. Since 1987, it has been provided free of charge as a human drug to regions where river blindness is prevalent. In Japan, it was approved as a drug for “intestinal nematode disease” in 2002, and “scabies” was added in 2006.

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