Can “vaccine” modified RNA impact human DNA?

Is there the potential for modified RNA, the “active substance” in the new synthetic gene technology products refered to as COVID-19 “vaccines”, able to interfer with or incorprate into human DNA?

So many questions:

• Is the potential for genetic interference simply discounted without the right studies being done? Or discrediting studies that suggest the possibility?
• If this occurs would it turn the human into a chimeric organism?
• What are the consequences for “ownership” if a person’s DNA becomes tagged with the incorporation of a patented genetic sequence permanently embeded in thier genome.
• What does that mean for the next generation should the foreign code get incorporated into the germ-line cells?
• Did the regulators miss the genotoxic evaluation because these products were assessed as a “vaccine” and not a “gene therapy” drug product?

This page is a place to gather emerging science and articles that pose questions and counter arguments, which reveal the potential mechanisms with which the new synthetic mRNA active substances wreak havock on our DNA including affecting the DNA’s normal function.

The media & authorities flat-out deny the possibility

Based on the fact that “RNA-based vaccines lack reverse transcriptase, politicians and mass media worldwide have denied, and still deny, that administered RNA can be reverse transcribed and integrated into the human genome.” [1] Several controversial lab studies have demonstrated the potential for RNA integration into DNA.

Given that these vaccines were considered “gene therapy” products in March 2019, why is this possibility flat out denied by “authorities”? Examples: GAVI, Dept Health AUST, CDC etc.

More information can be found by exploring the EXPERTS such as Dr Malone, Dr McCullough, Dr Rose, Dr Cole just to point out a few who have talked about the affect of this technology on DNA.

Links in reverse chronological order

Content is continuously being added

2023

March 9, 2023 – Anandamide Substack: Pfizer and Moderna bivalent vaccines contain 20-35% expression vector and are transformation competent in E.coli – READ

• “Given the near equimolar contamination, studies evaluating the reverse transcriptase [RT] capacity of LINE-1 should be reconsidered. If each injection provides trillions of dsDNA contaminants, LINE-1 RT activity is not a necessary step for genome integration….”
• “The critiques of Alden et al focused primarily on the fact that LINE-1 is predominantly expressed in cancer cells lines and that the LINE-1 observation shouldn’t be extrapolated to patients. The vaccines are providing trillions of dsDNAs containing a potentially leaky T7 promoter encoding a spike protein with a Kozak consensus sequence. With these levels of contamination, RT activity from LINE-1 is not a prerequisite for genome integration.”

January 19, 2023 – Biomedical Research & Environmental Sciences: Do COVID-19 RNA-Injections Affect Male Fertility? Latest Facts and Perspective – Bergholz and Steger – READ, CREDIT

• “High levels of LINE1 have been demonstrated… in sperm”, LINE1 can act as an endogenous reverse transcriptase!
• “This modRNA (modified RNA) comprises a 7-methylguanosine CAP and an UTR (UnTranslated Region) at the 5´end, as well as an UTR and a poly-A tail at the 3´ end, the latter of which is also known to play a vital role in LINE1 mediated retroposition“
• “Due to the presence of a furin cleavage site, subunit-1 of the spike protein can split off and leave the cell via exocytosis.” Subsequently the foreign spike protein can be distributed throughout the body by the circulatory system.”
• “While our current knowledge is based on results obtained in cell cultures [in vitro], it is important to prove whether vaccine-derived RNA will indeed integrate into the genome of a vaccinated individual and, even more important, into the germ cells genome.”

2022

September 1, 2022 – Authorea | Preprint: Potential Mechanisms for Human Genome Integration of Genetic Code from SARS-CoV-2 mRNA Vaccination – Kyriakopoulos, McCullough, Seneff et al – READ

• “Further toxicity evaluations are urgently needed to quantify potential emergence of interference with canonical DNA processes that could detrimentally impact the mRNA-vaccinated population”

March 4, 2022 – The Highwire – NEW STUDY: MRNA VACCINES MAY ALTER HUMAN DNA – WATCH, Feb 25, 2022 Intracellular Reverse Transcription– PAPER

• After nearly two years of fact-checkers promising mRNA Covid shots do not alter the human genome, new research is coming out to possibly contradict this point.
• Since no genotoxicity investigations were required or done prior to the Covid shot rollout, the public is left to wonder where the truth lies.

March 4, 2022 – ABC NEWS: Anti-vaxxers [pejorative] say a new study claims mRNA vaccines can alter your DNA. Here’s why experts say that’s bunkum – “No, mRNA jabs aren’t ‘genotoxic'” – READ

• “Claims that COVID-19 jabs can alter human DNA resurfaced this week as vaccine sceptics across social media seized upon the results of a new study to suggest that people receiving the vaccine risked changing or even poisoning their genes”
• “Not according to three experts consulted by Fact Check, who separately described the latest study as “regrettably weak”, “[not] very robust” and “very limited” in its findings.”
• “Claims of mRNA vaccines altering human DNA have persisted throughout the pandemic, despite being debunked by fact checkers at Reuters, PolitiFact and AFP” [Who gave fact checkers credibility?]

February 25, 2022 – Current Issues in Molecular Bioolgy: Intracellular Reverse Transcription of Pfizer BioNTech COVID-19 mRNA Vaccine BNT162b2 In Vitro in Human Liver Cell Line – Alden et al (Sweden) – READ, ARCHIVE

• Alden et al “demonstrated that COVID-19 mRNA vaccine BNT162b2 is able to enter human Huh7 liver cells and will be reverse transcribed into DNA as fast as six hours following exposure.
• Immunohistochemistry with an antibody against LINE1 ORFp1 (Open Reading Frame RNA-binding protein-1) revealed increased LINE1 nuclear distribution and PCR on genomic DNA amplified the DNA sequence unique to BNT162b2.” – REF
• The first demonstration in a human cell line where the synthetic RNA reverse transcribes DNA into the human genome – WATCH, FULL
• Note: paper’s ref #34: World Health Organization Messenger RNA Encoding the Full-Length SARS-CoV-2 Spike Glycoprotein. 2020 – HERE
• The synthetic mRNA uses pseudouridine and not natural uridine. This prevents the mRNA from breaking down! As for how long it actually lasts – they’ve not tested that step yet.

2021

November 11, 2021 – The Highwire Ep 241 – Sins of Science – FULL, IS SPIKE PROTEIN CAUSING CATASTROPHIC DAMAGE TO DNA? – WATCH, BACKUP, How DNA repairs itself 2011 TedTalk – WATCH
[The Swedish paper reference has since been retracted even though it was peer reviewd, but follow Jeffery Jaxen’s logic to potential link to the “up tick” in cancers that has been observed]

• The Swedish researchers analyzed “key checkpoint proteins” in the BRCA1 and 53BP1 (Guardian of the Genome) regeneration pathways and “found that the spike protein markedly inhibited both BRCA1 and 53BP1 foci formation.” – CREDIT
• Jan 2019 – 53BP1: A key player of DNA damage response with critical functions in cancer – PAPER
  • ““It has been extensively demonstrated that aberrant expression of 53BP1 contributes to tumor occurrence and development.”
• “The two major pathways for repair of DNA double-strand breaks (DSBs) are homologous recombination (HR) and nonhomologous end joining (NHEJ)” – 2008 PAPER

October 13, 2021 – Viruses: SARS–CoV–2 Spike Impairs DNA Damage Repair and Inhibits V(D)J Recombination In Vitro – Jiang & Mei (Sweden)- READ, RETRACTED May 10, 2022, another paper retracted after peer review!

• November 5, 2021 – Dr Been Medical Lectures: Spike Protein Goes to Nucleus and Impairs DNA Repair (In-Vitro Study – Not Possible In-Vivo) – WATCH

June 19, 2021 – COSMOS: Technically no longer human’ – can mRNA COVID-19 vaccines meld with your DNA? – READ, ARCHIVE

• In an AusSMC Expert Reaction, Professor Nigel McMillan from Griffith University suggests that the process of RNA being inserted into human DNA does happen in the case of some other viruses.”

June 18, 2021 – Scimex |Aust NZ Science News | Opinion: EXPERT REACTION: Can mRNA from COVID-19 vaccines be integrated into human DNA? – READ [Fodder for the press to cite] i.e COSMOS – READ

“The scientific consensus is that this work [from Zhang et al] is preliminary, not proven, and likely an artifact of the experimental process rather than a real finding. The claims have not been replicated by other researchers at this stage.”

Professor Nigel McMillan, Griffith University

“There have now been at least two studies [HERE & HERE] presenting evidence that the very detection technology used [by Zhang et al] could be to blame for the generation of hybrid human-viral sequences during the analysis, rather than events that had occurred in the cells.“

Professor Thomas Preiss, Australian National University

May 6, 2021 – Science: Further evidence supports controversial claim that SARS-CoV-2 genes can integrate with human DNA- After being challenged, research team provides more data to back its controversial hypothesis but the relevance to human health is unclear – READ

May 6, 2021 – Proceedings of the National Academy of Science (PNAS): Reverse-transcribed SARS-CoV-2 RNA can integrate into the genome of cultured human cells and can be expressed in patient-derived tissues – Zhang L & Rudolf Jaenisch, et al – READ, ARCHIVE

• They demonstrate that SARS-CoV-2 RNA can be reverse-transcribed without reverse transcriptase and DNA copies can integrate into the genome of infected human HEK293T cells and thus be “expressed as chimeric transcripts fusing viral with cellular sequences.”
• “Authors reported target site duplications fl anking the viral sequences and consensus LINE1 (Long Interspersed Nuclear Element-1) endonuclease recognition sequences at the integration sites suggesting a LINE1-mediated retroposition mechanism.” LINE1 can act as an endogenous reverse transcriptase – REF

April 14, 2021 – Reuters: Fact Check-mRNA vaccines do not turn humans into ‘hybrids’ or alter recipients’ DNA – READ, referenced HERE

• The PNAS paper “played into the hands of vaccine skeptics spreading false claims about the newly authorized mRNA vaccines”

March 5, 2021 – bioRziv preprint: SARS-CoV-2-host chimeric RNA-sequencing reads do not necessarily signify virus integration into the host DNA – Kazachenka et al – READ, published Frontiers in Microbiology June 2, 2021 – READ, Referenced – HERE to discount Zhang et al

February 17, 2021 BioRxiv Preprint: Host-Virus Chimeric Events in SARS-CoV-2-Infected Cells Are Infrequent and Artifactual – Yan et al – READ, Published July 12, 2021 in Journal Virology – READ, [Funded by NIAID who invested in Moderna’s mRNA vaccine] Referenced HERE to discount Zheng et al

• “Here we investigated the presence of HVC [host-virus chimeric] events in a large number of currently available RNA-sequencing samples from SARS-CoV2 infected cells and patients with COVID-19”

February 16, 2021 – Project Veritas: Facebook CEO Mark Zuckerberg Takes ‘Anti-Vax’ Stance in Violation of His Own Platform’s New Policy … ‘I Share Some Caution on this [Vaccine] Because We Just Don’t Know the Long-Term Side Effects of Basically Modifying People’s DNA and RNA’ – READ

January 4, 2021 – CDC: Facts about COVID-19 Vaccines: Will a COVID-19 vaccine alter my DNA? – ARCHIVE

• Note the CDC talk about “immunity” and protection “from getting infected” in the “future” if the natural virus gets into our bodies – well that didn’t age well!

2020

December 21, 2020 – Nebraska Medicine: You asked, we answered: Can mRNA vaccines alter human DNA? – READ, ARCHIVE

• “No, the vaccines cannot change your DNA “says James Lawler MD
• “mRNA is very fragile, and it’s very quickly degraded once inside the body” – [That is true for natural mRNA, but NOT for modified RNA in the “vaccines”, it is designed to evade breakdown…propaganda in action!]

December 16, 2020 – Science: The coronavirus may sometimes slip its genetic material into human chromosomes—but what does that mean? – Unexpected evidence that SARS-CoV-2 can integrate its genetic material could explain puzzling diagnostic tests in recovered COVID-19 patients – READ, ARCHIVE

• Referencing pre-print posted December 13, 2020 and subsequently peer reviewed and publishe May 2021 in PNAS

December 13, 2020 – Pre Print BioRxiv : SARS-CoV-2 RNA reverse-transcribed and 1 integrated into the human genome – Zhang, Rudolf Jaenisch et al – ARCHIVE, [The controversial paper released just as the new mRNA vaccines were starting to roll out], Marius Walter critique – THREAD

• “Prolonged SARS-CoV-2 RNA shedding and recurrence of PCR-positive tests have been widely reported in patients after recovery, yet these patients most commonly are non-infectious”
• “Here we investigated the possibility that SARS-CoV-2 RNAs can be reverse-transcribed and integrated into the human genome and that transcription of the integrated sequences might account for PCR-positive tests.”

July 16, 2020 – Facebook insider leaks video ofs Mark Zuckerberg from July 2020 – (Released Feb 2021) WATCH, in November 2020 he reversed his “view” when speaking with Fauci

“But I do just want to make sure that I share some caution on this [vaccine] because we just don’t know the long-term side effects of basically modifying people’s DNA and RNA…basically the ability to produce those antibodies and whether that causes other mutations or other risks downstream. So, there’s work on both paths of vaccine development.”

Mark Zuckerberg, July 16, 2020

July 7, 2020 [v1]- Research Square preprint: Exogenous coronavirus interacts with endogenous retrotransposon in human cells – Yin et al – READ, Published Frontiers in Cellular and Infection Microbiology Feb 25, 2021 – READ, Referenced – HERE

• We “observed that infection of these [SARS, MERS & COVID-19] coronaviruses all induced increase of retrotransposon expression with upregulation of TET [Ten-eleven translocation enzymes] genes”…”Retrotransposon upregulation may lead to increased genome instability…” “Therefore, people with higher basal level of retrotransposon such as cancer patients and aged people may have increased risk of symptomatic infection.”
• “We also observed chimeric transcripts of retrotransposon and SARS-CoV-2 RNA for potential human genome invasion of viral fragments, with the front and the rear part of SARS-CoV-2 genome being easier to form chimeric RNA.”
• “LINE-1 is the mostly well-studied autonomous retrotransposon. Most LINE-1 elements are inactivated in somatic cells, but some escape variously evolved silencing mechanisms…”
• “..upregulation of retrotransposon seems to be a common event induced by coronavirus infection, possibly through enhancing global DNA demethylation activity.”
• “we propose our hypothesis that coronavirus infection may increase retrotransposon expression through modulating TET activity to reduce global DNA methylation. Increased retrotransposon RNA may further form chimeric transcripts with coronavirus RNA, and integrate viral genomic fragments into human genome.”

2004

March 25, 2004 – PNAS: Long-term reinfection of the human genome by endogenous retroviruses – READ, ARCHIVE

• Human Endogenous retroviruses (HERVs) comprise between 5 to 8% of the human genome – meaning the germ-line was once invaded by exogenous [from the outside] viruses which became incorporated into the permanent genetic code

2001

February 15, 2001 – Nature: Initial sequencing and analysis of the human genome – International Human Genome Sequencing Consortium – READ, ARCHVIE, Human Genome Project – TIMELINE

• “There appear to be about 30,000–40,000 protein-coding genes in the human genome—only about twice as many as in worm or fly. However, the genes are more complex, with more alternative splicing generating a larger number of protein products”
  • This eventually reduced to the human genome comprising only 20,000 genes – it is more complex than they expected
  • Twenty years later, in 2020 humans begin potentially disrupting the natrual order of the human genome by mass administering a synthetic RNA product, refered to as “vaccine”, without testing the petential genetic consequeces