This page is a place to park information links relating to death data attributed to COVID-19, such as the 2020 changes to death certificate guidelines for COVID-19 and the financial incentives associated to COVID-19.

In March/April 2020 the U.S., Australia and the U.K. all changed how to fill in a death certificate specifically for COVID-19 – an unprecedented policy change!

“Diagnosing” COVID-19

Death have been classified as a COVID-19 even if they had not “symptoms” of COVID-19. How can that be?

In the US, all hospital admissions get PCR tested for COVID-19. When someone tests positive (which will likely occur if the PCR test is amplified to 35 cycles or more), then that person is labelled a COVID-19 case, whether they have symptoms or not. The person may have come to the hospital with a broken arm, or an asthma attack, or a post-jab side effect and upon a [false] positive PCR result, be rendered a COVID-19 patient! The moment they are PCR positive they are “diagnosed” with COVID-19 and become a hospital COVID-19 case. They then get funneled into a per-determined, one-size-fits-all, COVID-19 treatment protocol – all evidence-based medicine of course!!!

If that person then dies in hospital (which the remdesivir/ventilator COVID-19 protocol has a high chance of achieving) then their death certificate will be marked as a COVID-19 death.

PCR Test -> Diagnosis -> One-Size-Fits-All “Treatment” Protocol -> Death

At any time if a doctor “assumes” [US, AUS, UK] the person died of, with, or from COVID-19 – they can “legally” go ahead and mark the death certificate with cause-of-death as COVID-19 – no questions asked!

Why would doctor’s do this? Excellent question. Likely for a range of compounding reasons: absolute belief in the medical system, indoctrination, fear of loss of license, the comfort of a pay cheque, because the NIH said so – all these things have been proposed – which the links below attempt to capture.

Consider nearly 70% doctors in the US are employed by a corporate hospital system, which the hospital administrators dictated what treatments can and can’t be used. Only 30% of doctors are independent. It would seem many doctors and nurses are just doing what they are told, following protocol. Or fear they will lose their job and be struck off the medical register if they do speak out – as has happened to many.

It’s a complicated web of data points!

Hospital incentives fuel the statistics

US hospitals get bonus government payments for 1) all COVID-19 designated patients, 2) patients who receive remdesivir, and 3) patients who are ventilated.

The hospitals are incentivised to “treat” every patient the same by strictly following the NIH protocol, coupled with altered death certificate guidelines. Hospital administrators tell doctors how to treat their patients!

Hospitalised patients designated “unvaccinated” may have received jabbed

Since December 2020 to early 2021 the COVID-19 vaccines began roll-out around the world, starting with the UK on December 2, 2020. Hospital admissions have been littered with breakthrough COVID-19 infections (the vaccine didn’t stop infection) and vaccine injury (though not officially acknowledged), all of which added to “COVID-19” case numbers.

How many people were vaccine injured, went to hospital, were PCR positive [false or breakthrough] upon admission, but had only received one jab, or less than 2 weeks post-second jab? All these people would be counted as “unvaccinated COVID-19″ cases. Remember, the CDC changed the definition of “vaccinated”.

Once the COVID-19 vaccines rolled out, SARS-CoV-2 variant emergence accelerated (coincidence?). Scientific papers have shown that the new technology genetic vaccines interfere with a person’s immune system, rendering them more susceptible to getting sick with COVID-19 (breakthrough case) and taking longer to recover. Which in turn provided more COVID-19 “client$” for hospitals! and fuel for the government and media “COVID-19” death stats fear narrative.

How many COVID-19 deaths could have been avoided?

The frontline doctors have proven through their personal experience and by reading the historical and emerging scientific literature, that SARS-CoV-2 virus and the associated symptoms are treatable, if you do it early which shockingly the National Institute of Health COVID-19 protocol is to do nothing until the patient can’t breath!

The elderly and those with underlying health conditions are at most risk to an adverse outcome and children have minimal to no risk, but in all cases early treatment saves lives, a doctors such as Dr Byran Tyson, Dr Pierre Kory, Dr Paul Marik and the late Dr Zelenko have been practicing and preached since early 2020.

Geert Vanden Bossche has been warning the world about the potential catastrophic consequences of vaccinating during a pandemic. Dr Robert Malone and Dr Ryan Cole has been warning about the immune-consequences of the genetic injections and Dr Peter McCullough, besides highlighting early treatment options (which render’s the jabs mute and inappropriate), has tracked and reported the emerging science of COVID-19 from mid 2020 – so many deaths attributed to COVID-19 could have been avoided. Warnings have have come from many experts.

Deaths attributed to COVID-19

This page is an attempt to capture general discussion on the topic of died with COVID-19 , died from COVID-19 or assumed to have died of COVID-19, along with relevant public health measures that have supported the “padded” COVID-19 death statistics.

• See also John Beaudoin’s FOIA’d death certificate analysis – HERE

Links in reverse chronological order

This page is continuously being added to.

2024

April 15, 2024 – Wood House 76 by Jessica Hockett: The F Word -What I mean when I say I believe the New York City 2020 death curve is fraudulent – READ

• Six Kinds of Fraud (What a Fraudulent Death Curve Could Include or Involve):
  • Made-Up/Fabricated Deaths
  • Moved Deaths
  • Held-Back Deaths
  • Reclassified/Stolen Deaths
  • Double-Counted Deaths
  • Displaced Deaths
• “It’s hard to deny that without the New York City event, there would have been no selling Americans – or the rest of the world – on the WHO Pandemic Declaration or the story of a *Novel Spreading Virus in Need of New Treatments and a Dedicated Shot.*“

March 11, 2024 – Jessica Hockett | Woodhouse76 Substack: Did Strategic Chemical Poisoning & Orders to EMS Trigger New York City’s Spring 2020 Home Death Event? – Talking with Mark Kulacz about NYC’s disturbing home death & ambulance dispatch data – READ, WATCH,

• More reports on New York Death Spike – HERE e.g.:
  • The key claim about the spring 2020 mass casualty event in NYC’s healthcare system is hard to believe – READ
  • The spring 2020 daily death curves of Bergamo province, New York, and Chicago raise questions about whether the events can be reasonably blamed on sudden spread of the same pathogen – READ
  • New York City Public Hospital Agency Refuses to Release 2017-2019 Death Data (what are they hiding?) – READ
  • Why Did the New York City Medical Examiner Process 11,000 Deaths in Three Days? – READ

January 10, 2024 – New Hampshire Senate Health and Human Services Committee: Powerful testimony from John Beaudoin regarding analysis of ~1million FOIA’d death certificates – EXCERPT, WATCH, FULL, CREDIT

• …as soon as the vaccines rolled out, the cause of death on the death certificates changed: “blood and circulatory deaths all of a sudden started going up. They didn’t go up when COVID was around in 2020. They all of a sudden started going up in 2021.”
• They’re hiding vaccine injury “they turned off the software” that finds the words on death certificates. CDC has software [TRANSlation of Axis (TRANSAX) & ACME READ] that automatically reads death certificate words and converts it into ICD codes. “Those codes are the only way that the public knows what’s going on…”…”this is felony federal fraud”
• John has found deaths that immediately followed COVID-19 vaccination is being listed as COVID-19 on death certificates which hides the vaccine fatality and fraudulently bolsters COVID-19 death numbers.

2023

November 15, 2023 – Jessica Hockett | Woodhouse76 Substack: Why Did the New York City Medical Examiner Process 11,000 Deaths in Three Days? – READ

• The New York City Office of the Medical Examiner (OCME) processed 11,049 deaths between April 28-30th, 2020 including 6,533 in a single day

November 6, 2023 – First Principles with Dr Sheftall Substack: How Many People Died in the US during 2020, 2021 and 2022 because of (=”From”) Covid? – Our government and Johns Hopkins claimed 1.1 million – Take a closer look! – READ

• How Many Actually Died FROM (not merely “with”) COVID in the United States?…”The lion’s share of the difference is because we exaggerated our deaths in the U.S. Our government gave perverse monetary incentives to call a death a “COVID death” when a 40 cycle PCR was positive as Dr. Ezike pointed out so bravely, “Even when there was a clear alternative cause of death, if they tested positive for COVID, it was recorded as a COVID death”.”
• “…the large number of vulnerable after the weak flu season the year before caused Sweden’s death toll to be inflated…”

November 1, 2023 – PANDA: Does New York City 2020 Make Any Sense? – READ, Eight reasons to doubt the official NY data – READ

• Eight reasons why the data surrounding NY City spring 2020 mortality Spike might be incorrect:

1. It is unlikely that Covid combined with iatrogenic and other factors could have caused a wave of mortality as recorded.
2. It is implausible that every age category should experience a spike in deaths simultaneously.
3. It is improbable that deaths occurred simultaneously independent of place of death.
4. The magnitude and steepness of the spike in deaths is indicative of an unparalleled non-natural mass casualty event. But no such event has been detected.
5. Records of hospital visits and ambulance transports do not correlate with what would be expected had the massive wave of mortality happened as stated.
6. Occupancy levels of hospital and ICU beds are not what one would expect if such a wave of death happened.
7. What happened in NYC is significantly worse than similar cities in the U.S..
8. Far too many younger people are reported to have died in a very short time frame, and to have died from Covid.

October 18, 2023 – World Data Snapshot: COVID-19 cases vs death in comparison – Breakthrough cases – DATA

September 14, 2023 – The Highwire Ep 337: – FULL, How did Tanzania outperform the West on COVID?- WATCH

• “After shunning COVID vaccines during the early pandemic response, Tanzania became a natural experiment for all-cause mortality rates. Compared to large U.S. states like Texas and California, Tanzania, with one of the lowest COVID vaccination rates in the world, succeeded in having one of the lowest all-cause mortality rates on earth, through the worst of the pandemic.”

September 16, 2023 – COVID Chronicles Substack: Canada’s Christmas Miracle – 11,793 Canadians Resurrected from COVID Deaths – “very odd Canadian statistics” – READ

• “Most people are used to seeing death statistics reported on an annual basis, so some may consider this [cummulative graph over 3.75 years!] a method to exaggerate the perceived harm….
  • These data [method] don’t reveal the fact that COVID-19 has become less lethal over time”
  • Nor does this graph reveal that the majority of deaths occurred in people with frail health. People who died often had three or more additional serious chronic illnesses, and these were often associated with immunosuppression, which would make anyone susceptible to potentially serious illness from [ANY] infectious disease“
  • COVID-19 was no more lethal than several other common causes of death, including things like traffic accidents…”

August 28, 2023 – NY Post: 99% of new COVID-19 deaths reported by CDC not just due to virus: data – READ, Daily Mail – READ, Bannon War Room – CREDIT (Failing to justify another lockdown)

• “According to the CDC’s COVID-19 dashboard, just 1.7% of the 324 coronavirus deaths logged in the week ending Aug. 19 had the virus listed as the primary cause of death.” That’s 99% deaths not caused by the virus!”
• “While the CDC has not reported what the primary cause of death was in cases where Covid was the secondary factor…the largest cause of death in the US has been cancer, followed by diseases of the heart.”
• “The spike came as a new variant — dubbed EG.5, or Eris — emerged as the dominant strain, causing about 17% of COVID cases nationwide.” – TIMELINE,
  • “New variants EG.5, or Eris, and BA.8.26, or Pirola, have been detected in several countries around the globe and in the US recently.”

August 20, 2023 – Trust the Evidence Substack by Carl Heneghan and Tom Jefferson: Synchronicity of Deaths in the Pandemic – Analysing the simultaneous occurrence of deaths – READ

• “There was no unusually deadly virus, just a deadly reaction to an ordinary one” Joel Smalley – READ

August 15, 2023 – Doc Malik: John Beaudoin Talks To Me About The Fraud Behind Labelling “Covid” Deaths And Hiding Vaccine Deaths – WATCH, Coquin de Chien’s Newsletter by John – READ

July 27, 2023 – Ask Dr Drew Show: John Beaudoin, Sr: Death Certificates “Fraudulently Omitted” mRNA Vaccine Reactions – WATCH

July 25, 2023 – UnHerd: Did the New York Times just admit Covid deaths were overcounted? – READ, NYTimes: A Positive Covid Milestone (Jul 17, 2023) – READ

• “The official number is probably an exaggeration because it includes some people who had the virus when they died even though it was not the underlying cause of death,”
• A statement that “was verboten until not too long ago: throughout the pandemic, claims that the official number of Covid-19 hospitalisations and deaths was likely to be inflated — due to the use of very questionable statistical methods — were dismissed as groundless conspiracy theories. “

July 24, 2023 – Australian Senator Gerard Rennick: W.H.O. told governments to code deaths as Covid ones, even without the virus present – READ, Dr Malone – CREDIT

July 3, 2023 – Brownstone Institute: CDC Altered Minnesota Death Certificates that List a Covid Vaccine as a Cause of Death – READ, Warroom: Aaron Hertzberg And John Paul Beaudoin Sr. Explain How The CDC Lied About Vaccine Deaths – WATCH, TWEET, Leading Report –READ, Ed Dowd – CREDIT

• The death certificates for every death that took place in Minnesota between 2015 and the present – Anonymous FOIA applicant
• Revealing “7 death certificates from Minnesota that identify a covid vaccine as a cause of death where the CDC omitted the corresponding ICD 10 code identifying a vaccine side effect when the CDC assigned ICD codes to the death certificates.”
• The reports are for 61 to 92 years of age – those meant to be “protected” by the “vaccine”!
• There are two ICD 10 codes for vaccine side effects that can be broadly used for the covid vaccines – T88.1 (Other complications following immunization, not elsewhere classified) and Y59.0 (Viral vaccines)
  • UCoD (Underlying Cause of Death) refers to “the disease or injury that initiated the train of events leading directly to death, or the circumstances of the accident or violence which produced the fatal injury.”
  • MCoD (Multiple Causes of Death) refers to “the immediate cause of death and all other intermediate and contributory conditions listed on the death certificate.”

June 16, 2023 – John Beaudoin @Twitter: Testimony in Massachusetts this week re vaccine deaths – WATCH, Ed Dowd – CREDIT

May 11, 2023 – PANDA: What the Diamond Princess tells us about NYC in Spring 2020 – Did the Covid case and death numbers on the Diamond Princess cruise ship add up to a “novel deadly virus” that required “shutting down the world”? This forms part of our ongoing inquiry into the drivers of excess deaths. – READ

• “The first wave of putative Covid deaths in Spring 2020 demonstrated extremely unusual characteristics in some areas – including New York City and Bergamo, Italy….”

May 11, 2023 – MSN: Most COVID-19 Deaths May Be The Result of a Completely Different Infection – READ, ARCHIVE

• A new analysis suggests that a high percentage of people who required help from a ventilator due to a COVID-19 infection also developed secondary bacterial pneumonia.

April 27, 2023 – Journal of Clinical Investigation: Machine learning links unresolving secondary pneumonia to mortality in patients with severe pneumonia, including COVID-19 – Gao et al – READ

• May 5, 2023 – North Western Medicine: Secondary Bacterial Pneumonia Drove Many COVID-19 Deaths – Machine learning finds no evidence of cytokine storm in critically ill patients with COVID-19 – READ
  • high percentage of people who required help from a ventilator due to a COVID-19 infection also developed secondary bacterial pneumonia
• MSN: Most COVID-19 Deaths May Be The Result of a Completely Different Infection – READ, ARCHIVE, CREDIT

March 21, 2023 – ICAN: CDC Admits it Has No Idea How Many People Are Hospitalized for COVID – READ

• ICAN, through its attorneys, recently asked the CDC for all data reflecting the number of people hospitalized due to COVID-19 and the number admitted to a hospital for reasons other than COVID-19 (but who tested positive after being admitted)
• CDC’s RESPONSE:“The way that our data guidance defines COVID admission does not enable us to make a distinction between hospital admissions due to COVID-19 vs. hospital admissions for reasons other than COVID-19.”
• The “CDC is making no effort to provide accurate and important data to the public despite knowing that its inaccurate data continues to be used to impose restrictions, including mask requirements on children”

March 8, 2023 – Daily Mail: Covid vaccines couldn’t have been fast-tracked any quicker because the virus wasn’t deadly enough, Sir Chris Whitty claimed in leaked WhatsApps – “Chief medical officer said virus did not kill enough to warrant rushing jab trials” – READ, ARCHIVE, The Telegraph – READ, [How would you make a virus “appear” more deadly? – MAYBE]

• “Prof Sir Chris Whitty told Matt Hancock and others that diseases with a mortality rate in the range of 1 per cent would need a “very safe” vaccine and that the necessary clinical trials would be a “rate limiting step”.” – REF

January 20, 2023 – Real America : Dan Ball W/ Alex Stein, Alex Says Mother Died From COVID Protocols – WATCH

January 13, 2023 – Washington Post Opinion: We are overcounting covid deaths and hospitalizations. That’s a problem – READ, ARCHIVE

• “Understanding this distinction [dying from covid or with covid] is crucial to putting the continuing toll of the coronavirus into perspective. Determining how likely an infection will result in hospitalization or death helps people weigh their own risk.”

• [Dr. Leana Wen trying to get ahead of the narrative] “Here she is trying to lay down a paper trail for when the hearings start by finally acknowledging what was known (and called conspiracy theory) two years ago. That COVID deaths and hospitalizations are grossly overstated.” – Milo Mac – GETTR
• Flashback Sept 10, 2021 – CNN’s Dr Wen “The Unvaccinated Should Not Be Allowed To Leave Their Homes” – READ

2022

November 4, 2022 – SLAY: Massive Pandemic Data Fraud Exposed: 40% of ‘Covid Deaths’ Were Fabricated – READ, GETTR

November 2, 2022 – CHD | The Defender: Risk of Dying From COVID Always Was ‘Miniscule,’ Regardless of Age – Based on a new preprint analysis by professor John Ioannidis, there’s no reason for anyone to live in fear anymore – READ

March 25 2022 – UK government guidance for doctor’s completing medical certificates of cause of death COVID-19 (Official record) When someone dies, a doctor involved in their care has to complete a medical certificate of cause of death (MCCD), which the family take to the register office to register the death. – READ

Historical pages where you can download the guidance PDF

• March 25, 2022 – ARCHIVE, PDF
• April 1, 2020 – ARCHIVE, PDF
• March 31, 2020 – No Archive
• September 25, 2018 – ARCHIVE, PDF

March 11, 2022 – Medical News Today: How are COVID-19 deaths counted and what does this mean? – READ

• “The U.K. records any death that occurs within 28 days of a positive PCR test for SARS-CoV-2 as a COVID-19 death.”

March 10, 2022 – The Telegraph: Britain’s Covid death rate compared with rest of world is not as bad as feared – Lancet study calculates excess death rates for 191 countries, with UK roughly in middle in 102nd place – READ

March 10, 2022 – Massachusett’s Gov: Department of Public Health updates COVID-19 death definition – READ, ARCHIVE

• ” Currently, the COVID death definition includes anyone who has COVID listed as a cause of death on their death certificate, and any individual who has had a COVID-19 diagnosis within 60 days but does not have COVID listed as a cause of death on their death certificate.”
• “The revision follows the recommendation of the Council of State and Territorial Epidemiologists (CSTE), in collaboration with the US Centers for Disease Control and Prevention (CDC), to create a standardized approach for states to use for counting COVID-19 deaths.” – CSTE – HERE
• “We are adopting the new definition because we support the need to standardize the way COVID-19-associated deaths are counted…Prior to the CSTE definition, states did not have a nationally recommended definition for COVID-19 deaths and, as such, have been using a variety of processes and definitions to count their deaths” [Two years after Pandemic declared in 2020!]

2021

December 29, 2021 – Fauci Admits COVID Hospitalization Numbers Are Bogus – WATCH,
FAUCI ADMITS Hospitalized With COVID-19 is NOT Hospitalized From COVID-19 – TIMELINE

• “From the beginning, in March, 2020, Dr. James Lyons-Weiler has informed the public that CDC’s use of PCR to diagnose COVID is fundamentally flawed. He broke the new that their use of the universal Cycle Threshold would lead to massive numbers of false positives if mass testing was done. Now, even Fauci admits that “Hospitalized With” is NOT “Hospitalized From” – for children. Same for adults. Same for “Died With” vs. “Died From”. Same for “PCR+” vs. “COVID-19 Disease”. – REF

December 22, 2021 – Council of State and Territorial Epidemiologists (CSTE): Interim Guidance for Public Health Surveillance Programs for Classification of COVID-19-associated Deaths among COVID-19 Cases – PDF, ARCHIVE

October 12, 2021 – Epoch Times: Oregon Senators Call for Investigation Into Alleged COVID-19 Statistical Manipulation – READ, News Rescue – READ,

• “Thatcher and Linthicum submitted the petition in a letter on Aug. 16 after gathering signatures from 1,718 Oregonians and 53,032 Americans.” – LETTER
• Stand for Health Freedom (SHF), a non-profit organization that helped with the petition… cited a March 2020 study alleging that the CDC over-emphasized COVID-19 as the cause of death in compiling its statistics while “circumvent[ing] multiple federal laws” in the process” – STUDY PDF

October 12, 2020 – IPAK PHPI: COVID-19 Data Collection, Comorbidity & Federal Law: A Historical Retrospective by Ealy et al – PDF, This is what the “fact checkers” think – READ,

September 17, 2021 – CHD | The Defencer: Oregon Senators File Grand Jury Petition Alleging CDC, FDA Violated Federal Law by Inflating COVID Death Data – READ, Epoch Times

September 16, 2021 – Stand for Freedom | PRESS RELEASE: Oregon Senators File Formal Grand Jury Petition Calling for Investigation into CDC’s Willful Misconduct to Hyperinflate COVID-19 Data Following Federal Law Violations – READ, ARCHIVE

July 14, 2021 (air date unknown) – “Complete Hoax And A Farce”: Whistleblower Funeral Director Exposes The “Blatant” Covid Agenda – All patients immediately designated COVID-19 – WATCH, CREDIT

2020

November 8, 2020 – Daily Mail – Official data is ‘exaggerating’ the risk of Covid and talk of a second wave is ‘misleading’, 500 academics tell Boris Johnson in open letter attacking lockdown – letter by Dr Charlotte R Bell, Dr Rosamond Jones, and Keith Willison. ‘The management of the crisis has become disproportionate and is now causing more harm than good.” – READ

November 2, 2020 – The Critic UK: The Covid Physician’s true coronavirus timeline – READ

• “What was even odder to witness was the surreal lock-stepped, global lockdown that began around March 2020. Same language, same procedure, same time, no independent engagement of resource nor intelligence, no bespoke solutions. All but Sweden appeared to fall into a blind panic.”

Frankly, if it had not been for mainstream media and the government, I would not have even noticed there were a pandemic. I experienced no excessive dying, and no excessive becoming seriously ill.

“Clinical experience is as equally relevant as the statistical manipulation and science. My experience is no one but the government and mainstream media are sharing apocalyptic Covid-19 death experiences with me. I don’t see it in my clinical practice as a simple GP”

• “Up to my last time of asking in September 2020 there had been many well Covid-19 “swab positives”, and only 5 deaths “with” a Covid-19 “swab positive”. Those 5 deaths were all white, over 60 years, with other co-morbidities.”
• “Given my older patients were to be left at home to sink or swim, I concluded that the very safe hydroxychloroquine, zinc and azithromycin combination was worth trying in the best interests of those marooned patients.”
• “…how many are still dying of perfectly treatable, potentially fatal illness?” and delayed cancer diagnosis and treatment. “Look at section 11 of the unbelievably quickly drafted Coronavirus Act 2020 on medical indemnity during coronavirus.”
• Guidance changes to death certificate where doctors no longer “had to be that sure to write COVID-19 on a death certificate” was “highly irregular”.

July 18, 2020 – Fox 35 Investigates: FOX 35 INVESTIGATES: Questions raised after fatal motorcycle crash listed as COVID-19 death – READ, CREDIT

May 28, 2020 – RT: I’ve signed death certificates during Covid-19. Here’s why you can’t trust any of the statistics on the number of victims [UK NHS doctor] – READ

May 21, 2020 – The Atlantic: ‘How Could the CDC Make That Mistake?’ – READ

• The [seemingly incompetent disease agency] CDC is “combining test results that diagnose current coronavirus infections (PCR test)with test results that measure whether someone has ever had the virus” (antibody test), thus conflating the statistics and “compromising a few crucial metrics that governors depend on to reopen their economies”.
• The public-radio station WLRN, in Miami, first reported that the CDC was mixing viral and antibody test results.

May 20, 2020 – WLRN 91.3 FM | Miami: CDC’s National Dashboard Includes COVID-19 Data That Expert Says Mixes ‘Apples To Oranges’ – READ, CDC viral testing – ARCHIVE, Antibody testin – ARCHIVE

May 6, 2020 – Fox News | Laura Ingraham: It’s Ridiculous! Dr Scott Jensen On Broad COVID-19 Death Count Guidelines & Financial Incentives – WATCH

May 5, 2020 – Whitehouse Briefing | Deborah Birx “If someone dies with COVID-19, we’re counting that as a COVID-19 death” – EXCERPT

April 29, 2020 – Fee Stories: Physicians Say Hospitals Are Pressuring ER Docs to List COVID-19 on Death Certificates. Here’s Why – The economic incentive to add COVID-19 to diagnostic lists and death certificates is clear and does not require any conspiracy – READ, CERDIT

• The CARES Act increases Medicare payments to hospitals treating COVID-19 victims – READ
• “We aren’t pressured to test for flu,” Dr. Erickson said during his press conference. “Why are we being pressured to add Covid?”

April 24, 2020 – USA Today: Fact check: Hospitals get paid more if patients listed as COVID-19, on ventilators – READ

April 24, 2020 – Director of Illinois Department of Public Health: Dr. Ngozi Ezike is telling you that the numbers are wrong – ANYONE who tests PCR [false] positive for SARS-CoV-2 infection and then dies in hospital is designated a COVID-19 death – WATCH,

Everyone who’s listed as a COVID death, that doesn’t mean that that was the cause of the death but they had COVID at the time of death [!!!! note NO symptoms is a “symptom” of COVID-19!]

Dr Ngozi Ezike, Director of Illinois Department of Public Health

April 21, 2020 – UK updates Death Certificate guidelines for COVID-19 – TIMELINE

April 21, 2022 – NY Post: NY issues do-not-resuscitate guideline for cardiac patients amid coronavirus – READ, The Highwire Ep 161 – [~1hr] WATCH

• “drastic new guideline urging emergency services workers not to bother trying to revive anyone without a pulse when they get to a scene, amid an overload of coronavirus patients.”

April 21, 2020? – American Hospital Association: Coronavirus Update: CMS Releases Guidance Implementing CARES Act Provisions – READ, ARCHIVE, Guidance – PDF

• The Centers for Medicare & Medicaid Services (CMS) released new guidance implementing several provisions included in the Coronavirus Aid, Relief, and Economic Security (CARES) Act.

April 21, 2020 – FactCheck.org: Hospital Payments and the COVID-19 Death Count – READ, CREDIT

• “The figures cited by [Dr] Jensen generally square with estimated Medicare payments for COVID-19 hospitalizations, based on average Medicare payments for patients with similar diagnoses.”
• Dr Jensens figures for hospital payouts – REF
  • Patient admitted with “garden-variety pneumonia” – $5000
  • COVID-19 pneumonia – $13,000
  • COVID-19 pneumonia plus ventilator – $39,000

April 20, 2020 – WHO: INTERNATIONAL GUIDELINES FOR CERTIFICATION AND CLASSIFICATION (CODING) OF COVID-19 AS CAUSE OF DEATH Based on ICD – International Statistical Classification of Diseases – PDF

• W.H.O. told governments to code deaths as Covid ones, even without the virus present – CREDIT

April 14, 2020 – RT: ‘Presumed Covid-19’: NYC corona deaths suddenly soar past 10,000 after more than 3,700 victims added to list on PROBABLE grounds – READ, Dr Scott Jensen – TWEET, Presumed COVID-19 counted as a death statistic caused by the virus – TWEET, NY Times – READ

April 13, 2020 – KFF Health News: Furor Erupts: Billions Going To Hospitals Based On Medicare Billings, Not COVID-19 – READ

April 13, 2020 – Dr Brownstein: Fake COVID-19 Death Numbers and There Still Is Good News – ARCHIVE

• “Recall last week, the CDC stated that COVID can be a valid diagnosis of the death of someone whether there is positive testing or not for COVID. If the doctor suspects COVID is part of the reason why the patient died, COVID can and should be listed as the cause of death. That only serves to inflate the death numbers of COVID.”
• “Keep in mind that for every 1% uptick in the unemployment rate, there are estimates of up to 30,000 deaths from suicide, alcoholism and depression….studies have found that for every 1% rise in unemployment rate raises the risk of dying the next year by 6%.”

April 10, 2020 – Greatagameindia: Whistleblower: How CDC Is Manipulating The COVID-19 Death Toll – WATCH, READ, InfoWars – (backup video) – ARCHIVE, Jenna McCarthy – CREDIT

• Dr. Annie Bukacek of Montana exposed the inflated COVID hospitalization and mortality rates as well as the CDC’s manipulation of Coronavirus death certificates
• “Bukacek refers to a March 24, 2020 CDC memo from Steven Schwartz, director of the Division of Vital Statistics for the National Center for Health Statistics, titled “COVID-19 Alert No. 2.” – REF, CDC Memo: COVID-19 Alert No. 2 -New ICD code introduced for COVID-19 deaths – PFD

The assumption of COVID-19 death, can be made even without testing. Based on assumption alone the death can be reported to the public as another COVID-19 casualty….the rules for coding and selection of the underlying cause of death are expected to result in COVID-19 being the underlying cause more often than not.

The real number of COVID-19 deaths are not what most people are told and what they then think…How many people have actually died from COVID-19 is anyone’s guess… but based on how death certificates are being filled out, you can be certain the number is substantially lower than what we are being told. Based on inaccurate, incomplete data people are being terrorized by fear-mongers into relinquishing cherished freedoms.”

Dr. Annie Bukacek, PDF

April 9, 2020 – Daily Mail: Are doctors HARMING patients by ventilating them too soon? As 80% of NYC coronavirus patients on ventilators die – and doctors search for other ways to help them breathe – 40% and 50% of patients with severe respiratory distress die while on ventilators, up to 80% in New York City – READ

April 9, 2020 – Gateway Pundit: HUGE! MN Senator and Doctor: Hospitals Get Paid More to List Patients as COVID-19 and Three Times as Much if the Patient Goes on Ventilator –READ, Dr. Scott Jensen from Minnesota went on The Ingraham Angle – WATCH, TWEET, April 8, 2020 – Dr Jensen- ARTICLE2

• Dr Jensen reported “he received a 7-page document coaching him to fill out death certificates with a COVID-19 diagnosis without a lab test to confirm the patient actually had the virus.” – DOCUMENT, TWEET

“Right now Medicare is determining that if you have a COVID-19 admission to the hospital you get $13,000. If that COVID-19 patient goes on a ventilator you get $39,000, three times as much. Nobody can tell me after 35 years in the world of medicine that sometimes those kinds of things impact on what we do.“

Dr Scott Jensen

April 8, 2020 – KX4: How Honest is the COVID Fatality Count ? Dr. Scott Jensen is a Physician & Minnesota State Senator – WATCH

April 8, 2020 – PrePrint: Population-level COVID-19 mortality risk for non-elderly individuals overall and for non-elderly individuals without underlying diseases in pandemic epicenters by John Ioannidis et al – READ, CREDIT

• “The study found individuals less than 65 years old accounted for 5-9% of all COVID-19 deaths in 8 European epicenters and approached 30% in US hotbed locations. Compared to those over 65 years old, people less than 65 years old had a 13-15x lower risk in New York City, Louisiana and Michigan. The researchers also found that the COVID-19 death risk in people less than 65 years old is equivalent to the risk of dying from a car accident during a daily commute. The highest risk (in New York City) corresponds to the risk of dying in a traffic accident while travelling daily from Manhattan to Baltimore round trip for 25 days. Those 40 years and younger have almost no risk at all of dying.” – REF

April , 2020 – Kaiser Family Foundation: Estimated Cost of Treating the Uninsured Hospitalized with COVID-19 – READ, ARCHIVE

April 3, 2020 – CDC: Vital Statistics Reporting Guidance: Guidance for Certifying Deaths Due to Coronavirus Disease 2019 (COVID–19) – PDF, ARCHIVE

April 2, 2020 – The Highwire Ep 157: DATA OR DECEIT? : THE COVID-19 PEAK – WATCH

• “Is the panic surrounding death rates justified, or is it blown out of proportion? The only way to answer this question is to dig into the real numbers.”

March 25, 2020 – Australian ABS changes Death Certificate guidelines – TIMELINE

March 25, 2020 – The Undercover Economist | More or Less – Statistical national treasure Professor Sir David Spiegelhalter put the [age related] risks of Covid-19 into perspective. – LISTEN

March 24, 2020 – National Vital Statistics System: COVID-19 Alert No. 2: New ICD code introduced for COVID-19 deaths – PDF, BACKUP, Archive – PDF

• The new ICD code for Coronavirus Disease 2019 (COVID-19) is U07.1
• “NCHS is not planning to implement U07.2 for mortality statistics” as supplied by WHO
• “If the death certificate reports terms such as “probable COVID-19” or “likely COVID-19,” these terms would be assigned the new ICD code [U07.1]. It Is not likely that NCHS will follow up on these cases.”
• “COVID-19 should be reported on the death certificate for all decedents where the disease caused or is assumed to have caused or contributed to death… If the decedent had other chronic conditions such as COPD or asthma that may have also contributed, these conditions can be reported in Part II.”

• “The CDC published guidelines on March 24, 2020 that substantially altered how cause of death is recorded exclusively for COVID-19. This change was enacted apparently without public opportunity for comment or peer-review. As a result, a capricious alteration to data collection has compromised the accuracy, quality, objectivity, utility, and integrity of their published data, leading to a significant increase in COVID-19 fatalities.” – REF, SOURCE

March 23, 2020 – Off Guardian: Italy: Only 12% of “Covid19 deaths” list Covid19 as cause Report shows up to 88% of Italy’s alleged Covid19 deaths could be misattributed – READ, ARCHIVE, Italy’s translated REPORT, Italian Civil Protection Service press briefing (protezionecivile.gov.it) – ARCHIVE

“I want you to remember these people died WITH the coronavirus and not FROM the coronavirus”

Italian Civil Protection Service – YouTube deleted the Italian government briefing video!

March 22, 2020 – KSAT: First COVID-19 death reported in San Antonio – READ, ARCHIVE, Fox – READ

• A woman in her 80s died at an area hospice facility in San Antonio after she was infected with COVID-19, She was previously treated at Brooke Army Medical Center, she had a history of underlying health issues…

March 20, 2020 – The Telegraph: Why have so many coronavirus patients died in Italy? – The country’s high death toll is due to an ageing population, overstretched health system and the way fatalities are reported – READ, ARCHIVE, WATCH

“On re-evaluation by the National Institute of Health, only 12% of death certificates have shown a direct causality from coronavirus, while 88 per cent of patients who have died have at least one pre-morbidity – many had two or three,”

Prof Walter Ricciardi, Scientific Advisor to Italy’s Ministry of Health

March 20, 2020 – Italian report translated to English: “Characteristics of COVID-19 patients dying in Italy Report based on available data on March 20th, 2020” – PDF, SOURCE

May 19, 2020 – Scientific Magazine: How COVID-19 Deaths Are Counted- READ

• “Death certificates can be signed by a physician who was responsible for a patient who died in a hospital, which accounts for many COVID-19 deaths. They can also be signed by medical examiners or coroners, who are independent officials who work for individual counties or cities…”

March 19, 2020 – UK Government: COVID-19 is no longer considered to be a high consequence infectious disease (HCID) in the UK – MERS & SARS are still on the list – ARCHIVE, LIVE, 2019, TIMELINE

March 4, 2020 – National Vital Statistics System: Guidance for Certifying COVID-19 Deaths – US CDC changes Death Certificate guidelines – PDF, PDF2, ARCHIVE, TIMELINE,

• August 2004 insturction Instructions for Completing the Cause-of-Death Section of the Death Certificate – READ

January 11, 2020 – Aljazeera: China reports first death from mysterious outbreak in Wuhan – Death comes as Beijing announced that 41 people have been diagnosed with pathogen linked to a new type of coronavirus. – “61-year-old man has died from pneumonia in the central Chinese city of Wuhan” – READ, TIMELINE

January 8, 2020 [date of woman’s death]- Japanese SoHu news : An American woman died of coronavirus! [Google translate] – ARCHIVE, CREDIT

• “On February 26 [2020], the US KJCT8 News Network reported that a woman recently told the media that her sister Lola Short died on January 8 (Wednesday), and that one of the causes of death was infection with the coronavirus.
• Almeta Stone, a woman living in the Montrose area [Colorado, USA], said sadly to reporters: “My sister passed away on January 8. I was determined to let her go quietly and take care of her aftermath. But when I got the death certificate , I was confused for a moment. The hospital kept assuring me that my sister died of common flu, but the death certificate clearly stated the word coronavirus.””
• The first official novel coronavirus case was January 29, 2020 – TIMELINE

2010

January 4, 2010 – CDC Mortality Medical Data System – ARCHIVE, TODAY, John Beaudoin read the death certificates to reveal the CDC is hiding vaccine injury – CREDIT

• The National Center for Health Statistics (NCHS) began to develop the Mortality Medical Data System in 1967 to automate the entry, classification, and retrieval of cause-of-death information reported on death certificates. Mortality medical data is processed through four basic programs: Super-MICAR Data Entry, MICAR200, ACME, and TRANSAX
  • MICAR200 (Mortality Medical Indexing, Classification, and Retrieval) Automates the multiple cause coding rules and assigns ICD codes to each numeric entity reference number.
  • ACME (Automated Classification of Medical Entities) Automates the underlying cause-of-death coding rules with the multiple cause-of-death codes (ICD) assigned to each entity listed on cause-of-death certifications, preserving the location and order as reported by the certifier. ACME then applies the World Health Organization (WHO) rules to the ICD codes and selects an underlying cause of death.
  • TRANSAX (TRANSlation of Axis) Converts the ACME output data into fixed format and translates the data into a more desirable statistical form…from an entity basis to a record basis.

The post Cause of Death: COVID-19 – With, From or Assumed! first appeared on Totality of Evidence.

The S protein binds to ACE2 through the receptor binding domain (RBD) region of the S1 subunit, mediating viral attachment to host cells in the form of a trimer. ACE2 is distributed mainly in the lung, intestine, heart, and kidney, and alveolar epithelial type II cells are the major expressing cells – REF

All of the COVID-19 vaccines are based on the SARS-CoV-2 spike (S) protein from the initial Wuhan strain, then later in 2022 the Omicron strain spike subvariant was added. Spike is just one of 29 proteins that make up the SARS-CoV-2 virus particle.

The new gene technology “vaccines” work by tricking the body into making this foreign spike protein within the human cells, in what we now know to be an unknown quantity of spike and from any cell in the body that the lipid nanoparticles (in the case of the mRNA products) travel to. Add to this the manufactured spike protein does not stay on the cells surface, it gets into the bloodstream and circulates through out the body.

Spike Protein is toxic

On May 28, 2021 Canadian vaccinologist Dr Byram Bridle stated that the emerging scientific publications are revealing that the spike protein is toxic, and it is circulating in the bloodstream, getting to all parts of the human body. It is toxic because it damages cells.

Autopsy findings reveal that spike protein can be found in organs through-out the body. It does not remain in the deltoid muscle. Embalmers are finding peculiar white fibrous strands that are blocking the circulatory system in the deceases – it is unclear what this is and if it is associated with the spike protein or other contents in the injectables.

Spike protein fits the definition of a biological weapon – (Karen Kingston presentation to Florida commissioners Feb 14, 2023) – EXCERPT

Spike Protein-Induced Diseases

“On October 14-16, 2022, over 300 physicians, and other healthcare providers gathered for the inaugural FLCCC conference titled “Understanding and Treating Spike Protein-Induced Diseases.” With an aim of gathering a deeper understanding and expertise about what presenters referred to as the adverse effects of the vaccine’s spike protein, one key topic was the persistence of spike-induced diseases persisting in patients.” – REF

Spike Protein Detox Guide

World Council for Health – Spike Protein Detox Guide – An “evolving guide with emerging information on how to clear viral and vaccine-induced spike proteins from the body” – HERE

The World Council for Health state: “Many people have been unable to find help for spike protein related illness (also called spikopathy) through existing healthcare services. This information is relevant if you have experienced adverse reactions after a jab, have Long Covid, or have post Covid-Injection Syndrome (pCoIS).”

This page will collect articles and interviews regarding specifically the “spike protein” and the suggested new “Spike Protein-Induced Disease“. It is not complete but a snap-shot of the topic. The page will continuously be added to.

• NextStrain.org – SARS-CoV-2 – HERE
• 2023 – FLCCC Educational Confernces: Emerging Approaches to Treating Spike Protein-Induced Diseases – FREE, PORTAL

Spike Protein links in reverse chronological order

2024

July 7, 2024 – Dr Sabine Hazan: “A concept that no one talks about is the fact that the spike is possibly airborne.” – TWEET

March 24, 2024 – Preprint: Persistence of S1 Spike Protein in CD16+ Monocytes up to 245 Days in SARS-CoV-2 Negative Post COVID-19 Vaccination Individuals with Post-Acute Sequalae of COVID-19 (PASC)-Like Symptoms – Patterson et al – READ, Kevin McKernan/Clare Craig – CREDIT

• “Paper from Bruce Pattersons lab – Spike protein and even mutated Spike Protein found in the Long-Vax patients 245 days later. Mutated Spike is a sign of Translational fidelity issues. N1-methyl-PseudoU is gumming up the works and making the ribosomes mumble.”

Febraury 26, 2024 – Bannons War Room Episode 3419: Michael Nehls MD Warns Of The Dangers Of Spike Proteins – Book ‘The Indoctrinated Brain‘ – EXCERPT, WATCH, FULL

• The human mind is attacked by the spike protein – it destroys memory and our personality.

January 11, 2024 – The Highwire Episode 354: INDOCTRINATED Author Michael Nehls, M.D., Ph.D of ‘The Indoctrinated Brain’ Gives you tools to combat the attack on our Medical Freedom

2023

December 6, 2023 – Nature: N1-methylpseudouridylation of mRNA causes +1 ribosomal frameshifting – by Mulroney et al – READ

• Dec 7, 2023 – Igor’s Substack: Covid Vaccines Produce Random Junk Proteins Thanks to an “Invention” Which Coincidentally Won the Nobel Prize – A Quarter of Vaccinated Subjects Produce Random Junk Proteins due to vaccine “Read Errors” and even get immunity to them, study finds – READ
• Dec 8, 2023 – Dr Naomi Wolf on Bannons War Room “The injections have an ingredient in them that is causing frameshifting” – WATCH, censored – READ
• Dec 10, 2023 – Kevin McKernan Substack: FrameShiting Slippery Sequence – The Shift is about to hit the Fan – READ

September 21, 2023 – The Highwire Ep 338: Turbo Trouble – FULL, ARE THE VACCINATED HARBORING DANGEROUS SPIKE PROTEINS? – WATCH

September 7, 2023 – The Highwire Ep 336: Tinderbox – FULL, NEW REPORT: Spike protein worsens neurodegenerative diseases –WATCH

September 1, 2023 – Preprint: SARS-CoV-2 Spike amyloid fibrils specifically and selectively accelerates amyloid fibril formation of human prion protein and the amyloid β peptide – Larsson et al – READ

• “The spike protein may have the capacity to accelerate amyloid plaque formation in those susceptible to prion diseases, such as Alzheimer’s disease (AD) and Creutzfeldt-Jakob disease (CJD).” – REF

August 15, 2023 – Wiley Online: Detection of recombinant Spike protein in the blood of individuals vaccinated againts SARS-CoV-2: Possible molecular mechanism – Brogna et al – READ

• Sept 1, 2023 – Igor’s Substack: Half of Vaccinated People Never Stop Producing Spike Protein, Study Found – READ
• ~50% of the vaccinated produce the synthetic spike protein, some for as long as 187 days (6 month) post-vaccination – REF

April 8, 2023 – German study: Spike proteins from viruses and vaccines cause brain cells to die – “A recently published German study indicates that the spike proteins from Covid-19 and the Covid vaccines cause brain cell death” – (German) READ, Dr Malone SUBSTACK

• April 5, 2023 – PrePrint: SARS-CoV-2 Spike Protein Accumulation in the Skull-Meninges-Brain Axis: Potential Implications for Long-Term Neurological Complications in post-COVID-19 – Rong et al – READ
  • “”Injection of the spike protein alone resulted in cell death in the brain, indicating a direct effect on brain tissue. We observed the presence of spike protein in the skulls of deceased individuals long after their COVID-19 infection, suggesting that spike protein persistence may contribute to long-term neurological symptoms.”

March 23, 2023 – Courageous Discourse substack | Dr McCullough: Prescription and Over-the-Counter Treatments for Post-COVID Syndrome – Long List of Possibilities with Early Data Published – READ, Daily Clout – READ, PAPER

• Those vaccinated have been additionally loaded with Spike, so may have even a worse course with prolonged symptoms including fatigue, lethargy, brain fog, muscle loss, skin and hair changes, sleeplessness, and effort intolerance.

March 16, 2023 – preprint: Strategies for the Management of Spike Protein-Related Pathology – Halma, Tess Lawrie et al – READ

March 14, 2023 – Circulation: Circulating Spike Protein Detected in Post–COVID-19 mRNA Vaccine Myocarditis by Yonker et al – READ

• DrBeen Medical Lectures:Vaccine Generated Spike in the Blood of Children with Myocarditis – WATCH
  • “”Somehow these vaccine generated spike proteins behaved very similarly to the spike proteins in MIS-C…Damage is caused by the spike protein and the inflammation is caused by the innate arm of the immune system instead of the acquired arm.” – TWEET

February 21, 2023 – Dr McCullough Substack: Dissolution of Spike Protein by Nattokinase – COVID-19 Vaccine Detoxification – for the vaccine injured – READ

• “The mRNA and adenoviral DNA products were rolled out with no idea on how or when the body would ever breakdown the genetic code.”
  • The synthetic mRNA carried by LNP “appears to be resistant to breakdown by human ribonuclases by design…it is a big problem when the protein is the pathogenic SARS-CoV-2 Spike.”
  • The adenoviral DNA (Janssen) should broken down by deoxyribonuclease, however this has not be exhaustively studied.”
• “Nattokinase is an enzyme is produced by fermenting soybeans with bacteria Bacillus subtilis var. natto and has been available as an oral supplement.
  • It degrades fibrinogen, factor VII, cytokines, and factor VIII and has been studied for its cardiovascular benefits…. among all the proposed detoxification agents, I believe nattokinase and related peptides hold the greatest promise for patients at this time.”
  • Nattokinase is dosed in fibrinolytic units (FU) per gram and can vary according to purity.
• August 24, 2022 – Molecules: Degradative Effect of Nattokinase on Spike Protein of SARS-CoV-2 – Tanikawa et al – READ
• Based on Kurasawa et al 2015 – “an empiric starting dose [of nattokinase] could be 2000 FU twice a day.” Read for safety and contraindications.
• “Based on these findings, nattokinase and similar products such as serrapeptase should undergo well-funded, accelerated preclinical and clinical development programs.” …”It will take up to 20 years to have a fully developed pharmaceutical profile to characterize the safety and efficacy of nattokinase in the treatment of vaccine injury and post-COVID syndromes.”!!

February 14, 2023 – Florida’s Collier County Commission re “10.A. & 11.A. COVID-19 Farmworker Grant”: Karen Kingston presentation, expanding on surgeon general Lapado’s assessment of the mRNA vaccine and more (technically edited version) – WATCH, Collier TV – source – FULL, Substack: Letter sent to commissioners – READ

• Spike protein fits the definition of a biological weapon – EXCERPT

January 29, 2023 – APMIS: SARS‐CoV‐2 spike mRNA vaccine sequences circulate in blood up to 28 days after COVID‐19 vaccination by Alfredo et al – READ, CREDIT

• “In 10 of 108 HCV patient samples, full‐length or traces of SARS‐CoV‐2 spike mRNA vaccine sequences were found in blood up to 28 days after COVID‐19 vaccination.”

January 12, 2023 – Dr Alexander Substack: ‘Spike protein in blood of adolescents & young adults who developed post-mRNA vaccine myocarditis‘; have we found the myocarditis smoking gun? Yonker et al. now say so but WE always knew this! – READ,

• January 4, 2023 – Circulation: Circulating Spike Protein Detected in Post–COVID-19 mRNA Vaccine Myocarditis – Yonker et al – READ

2022

December 15, 2022 – Ask Dr. Drew w/ Dr Kelly Victory: Dr. David Wiseman [Ex J&J Scientist & Drug Developer] Examines mRNA Vaccine Spike Proteins & Molnupiravir – WATCH, YouTube, READ

December 2022 – Cureus: Mitogen Activated Protein Kinase (MAPK) Activation, p53, and Autophagy Inhibition Characterize the Severe Acute Respiratory Syndrome Coronavirus 2 (SARS-CoV-2) Spike Protein Induced Neurotoxicity by Kyriakopoulos, McCullough, Seneff et al – READ

• “Spike protein produced within the CNS after delivery via LNP is the biologic basis for neurological deterioration after taking it in the arm with repeated exposures over time.” Dr McCullough – GETTR

December 12, 2022 – NextStrain: SARS-CoV-2 strain – screenshot showing the evolution boom once vaccines began! – The original (Vaccine) virus (and spike protein) are extinct! – LINK

November 30, 2022 – Science Advances: SARS-CoV-2 spike protein binds and modulates estrogen receptors – Solis et al – STUDY, Medical Xpress – ARTICLE

• This “may lead to the severe coagulopathy observed in patients with COVID-19 and a minority of subjects receiving the SARS-CoV-2 vaccine” -[except it’s a COVID-19 vaccine, and define “minority”] – REF

November 22, 2022 – Expose News: Dr. Russell Blaylock: How Vaccine-Induced Spike Proteins Damage the Brain and Cause Cancer – READ

November 17, 2022 – CHD | ‘Doctors And Scientists’ With Brian Hooker Ep 34: ‘Sickness Behavior’ + the Effect of Spike Proteins on the Body with Dr Russell Blaylock – WATCH, READ

November 1, 2022 – Trial Site News: Physician Conference: FLCCC Teaches Remedies to Reverse “Spike Protein-Induced Diseases” – READ, FLCCC – WEBSITE

November 1, 2022 – Nebraska MED: How long do mRNA and spike proteins last in the body? – READ

• “There is no evidence that any mRNA or protein accumulates in any organ.” [because they haven’t done the studies due to “warp speed”]
• “The spike protein is unique to SARS-CoV-2 – it doesn’t look like other proteins your body makes. So antibodies created against the spike protein won’t harm your body, they will only target coronavirus.”
  • [Prof Angus Dalgeleish in early 2020 showed the epitopes of coronavirus spike are similar to blood (thus result in clotting) and mylin (thus nerve cell attack) so autoimmune and other issues were expected earlier than June 2020, but were ignored]
• “the mRNA is quickly degraded (within a few days)” [not true, pseudouridine means it is not normal mRNA, and causes it to persist for months]
• “…Infectious Disease Society of America (IDSA) estimates that the spike proteins that were generated by COVID-19 vaccines last up to a few weeks, like other proteins made by the body.” [no ref on page indicated!]

October 21, 2022 – CHD | Friday Roundtable: Worrying Developments With Michael Palmer, M.D. + Sucharit Bhadki, M.D – a dive deep into the connection between heart and brain damage and COVID vaccines (with slides) – WATCH, Dr Palmer discusses autopsy findings – spike in heart and brain tissue – EXCERPT

“Every injected mRNA “vaccine” will cause severe damage in our body and must be forbidden”

Dr Bhakdi

October 14, 2022 – Boston lab creates a Wuhan-Omicron chimeric virus, killing 80% of humanised lab mice -coding for Omicron BA.1 spike protein – TIMELINE

August 24, 2022 – Molecules: Degradative Effect of Nattokinase on Spike Protein of SARS-CoV-2 – Tanikawa et al – READ, Dr McCullough – READ

• “In the first experiment they demonstrated that Spike was degraded in a time and dose dependent manner in a cell lysate preparation that could be analogous to a vaccine recipient.” – REF
• “The second experiment demonstrated that nattokinase degraded the Spike protein in SARS-CoV-2 infected cells”..reproducing Oba et al study from 2021 – REF

August 19, 2022 – Doctors 4 Covid Ethics: Vascular and organ damage induced by mRNA vaccines: irrefutable proof of causality by Michael Palmer, MD and Sucharit Bhakdi, MD – READ

August 5, 2022 – Jonathan Weissman: Spike as a Superantigen – WATCH, MORE

July 30, 2022 – Arkmedic Substack: Welcome to Gilead – A scientific scandal with huge implications for women’s health is brewing and you weren’t going to hear about it – until now – Women’s cancer to accelerate – READ, Jikky Kjj -(archive) THREAD

• “…if my suspicions are correct the paper that I’m going to discuss shows that women in every developed country are at risk of a tsunami of women’s cancers.” – the Jiang study “Spike Impairs DNA Damage Repair” has just been RETRACTED!
• “…the BRCA gene is really important. It is part of the “homologous recombination DNA repair pathway”. Which is one of the mechanisms that the body uses to stop your cells turning cancerous in response to environmental stress, and which is why women with BRCA mutations are at much higher risk of breast and ovarian cancer than those without.”…One of the most important components of this pathway is p53 (or TP53) which is commonly called the “guardian of the genome”.”
• “Of all the proteins produced by the SARS-CoV-2 virus, one of them – the spike protein – obliterated the DNA repair mechanism in lymphocytes”

July 25, 2022 – World Council for Health | General Assembly meeting #50 Vaccine Injury Tx Pathways: FULL
Dr. Ryan Cole: Health & Wellness: We Have Been Badly Spiked!, – WATCH
Dr. Pierre Kory (USA) – Unspiking: The New Trend – WATCH

“We’re playing whac-a-mole with a shot, with viruses that constantly mutate and we will never keep up. And we know the harms of a lipid nanoparticle plus a gene sequence..its not just the shots a wrong, this platform is wrong…it needs to be expunged from society…”

Lipid nanoparticles can’t be controlled – they go everywhere…
The gene-sequence makes your body a toxin-factory for that spike

Dr Ryan Cole

• Downregulation of Toll Like Receptors 3, 4, 7 & 8 – TLR 7, 8 increases laten viruses (Herpes, Zoster’s EBV, RSV, HPV etc)

June 2022 – Food & Chemical Toxicology: Innate immune suppression by SARS-CoV-2 mRNA vaccinations: The role of G-quadruplexes, exosomes, and MicroRNAs – Seneff, McCullough et al – READ

May 17, 2022 – American Chemical Society: Amyloidogenesis of SARS-CoV-2 Spike Protein – Nystrom & Hammarstrom – READ, SOURCE

April 19, 2022 – Pre-Print – SARS-CoV-2 spike protein disrupts lipid metabolism resulting in liver, heart & kidney damage – Nguyen et al – READ, ARTICLE, reference SOURCE

April 17, 2022 – Dr Been Medical Lectures: Summary – Vaccine Generated Spike Proteins Circulate in The Blood on Exosomes (Study) – WATCH

April 4, 2022 – NIH RECOVER initiative to find answers for “Long COVID” – TIMELINE

• Is long COVID associated with spike protein, and if so is it “dose” dependent and/or time exposed to spike?

February 24, 2022 – Merogenomics Update 32: Spike protein in nucleus “NEWS” – COVID-19 vaccines – WATCH, COVID Medical Network letter pg 11 – CREDIT

• Dr Mikolaj Raszek, geneticist and biochemist, explains, how scientific evidence from Pfizer’s own documents “Nonclinical Evaluation Report”, presented to the Australian government, TGA for provisional registration of their COVID-19 mRNA “vaccine” , confirming the possible entry of the spike protein into the cell nuclei.
• From Section 2.3 Expression of Antigens

February 23, 2022 – Biochemical Journal: A central role for amyloid fibrin microclots in long COVID/PASC: origins and therapeutic implications – Kell, Pretorius et al – READ, SOURCE

February 15, 2022 – Clinical Infectious Diseases: Circulating SARS-CoV-2 Vaccine Antigen [Spike Protein] Detected in the Plasma of mRNA-1273 Vaccine Recipients -by Ogata et al – READ, UncoverDC – ARTICLE

February 8, 2022 – Science Translational Medicine: A human antibody reveals a conserved site on beta-coronavirus spike proteins and confers protection against SARS-CoV-2 infection – Zhou et al – READ

February 7, 2022 – J. Biological Chemistry: The spike protein of SARS-CoV-2 induces endothelial inflammation through integrin α5β1 and NF-κB signaling – Robles et al – READ

January 24, 2022 – Study published in Cell reveals that the spike protein antigen and mRNA persist in lymph nodes for up to 2 month – possibly longer – TIMELINE, STUDY

January 5, 2022 – Omicron: poor at infecting deep lung and will likely escape vaccines – TIMELINE, Nature ARTICLE

• Mutations in spike protein affect how effective it is at infecting cells (regions in the body) plus it’s likelihood at escaping any vaccine-induced immunity

2021

December 15, 2021 – International Journal of Biological Macromolecules: SARS-CoV-2 spike protein causes blood coagulation and thrombosis by competitive binding to heparan sulfate – Zheng et al – READ

December 7, 2021 – A paper predicted the spike protein mutations – “[N]atural selection is the dominating mechanism of SARS-CoV-2 evolution, which favors mutations that strengthen viral infectivity” [due to mass vaccination pressures?]. – TIMELINE, PAPER

November 15, 2021 – The Highwire: IS SPIKE PROTEIN CAUSING CATASTROPHIC DAMAGE TO DNA? – WATCH

November 8, 2021- Circulation: Abstract 10712: Observational Findings of PULS Cardiac Test Findings for Inflammatory Markers in Patients Receiving mRNA Vaccines – Gundy – READ, reference SOURCE

October 30, 2021 – Trial Site News: Dr. Robert Malone, Inventor of mRNA technology discusses the Spike Protein | Interview – WATCH, EXCERPT

October 13, 2021– Study shows SARS-CoV-2 spike protein enters the nucleus and impairs the normal damage-repair function of the DNA. – TIMELINE, The Highwire – WATCH [There has been a massive rise in cancer since the vaccine rollout – see Dr Ryan Cole]

October 13, 2021 – SARS–CoV–2 Spike Impairs DNA Damage Repair and Inhibits V(D)J Recombination In Vitro by Jiang et al, READ, (another paper retracted, May 10, 2022!) – The Highwire – WATCH, EXCERPT

September 23, 2021 – Natural News: WORLD BOMBSHELL: Leaked DARPA document, DRASTIC analysis confirms attack on humanity using aerosolized, skin-penetrating nanoparticle spike proteins – i.e. an aerosolized vaccine! – READ

September 17, 2021 – Biochemical and Biophysical Research Communications: Natto extract, a Japanese fermented soybean food, directly inhibits viral infections including SARS-CoV-2 in vitro – Oba et al – READ, Dr McCullough: Nattokinase – READ

August 23, 2021 – Cardiovascular Diabetology: Persistent clotting protein pathology in Long COVID/Post-Acute Sequelae of COVID-19 (PASC) is accompanied by increased levels of antiplasmin – Pretorius et al – READ, reference – SOURCE

Following removal of platelets from plasma, and adding just the S1 subunit of spike into that plasma the proteins will clump – this is unusual in the absence of platelets – “this is why we’re seeing these very resistant micro-clots” says Dr Cole – REF

August 20, 2021 – Bioscience Reports: SARS-CoV-2 spike protein S1 induces fibrin(ogen) resistant to fibrinolysis: implications for microclot formation in COVID-19 – Grobbelaar et al – READ, WCH reference – SOURCE, AMD Substack – READ

August 10, 2021 – Lung Cellular & Molecular Physiology: The SARS-CoV-2 spike protein subunit S1 induces COVID-19-like acute lung injury in K18-hACE2 transgenic mice and barrier dysfunction in human endothelial cells – Colunga Biancatelli et al – READ, reference SOURCE

• Just the spike alone without the rest of the virus components present, can cause all of the same damage in pulmonary tissues!

June 24, 2021 – The Highwire: mRNA PIONEER RAISES COVID VACCINE CONCERNS – an interview with Dr Malone – WATCH References to spike! Dr Robert Malone – MORE

June 21, 2021 – Orthomolecular News: Resolving “Long-Haul COVID” and Vaccine Toxicity: Neutralizing the Spike Protein by Thomas Levy – READ

“spike protein syndromes” can occur in three situations:

1. active SARS-CoV-2 infection
2. during long-haul COVID syndrome
3. in response to spikes protein-laden vaccine in most organ systems through out the body

Much of the rationale of the protocols is based on what is known about the spike protein and how it appears to inflict its harm.

June 13, 2021 – Dark Horse Podcast: Spike protein is very dangerous, it’s cytotoxic (Robert Malone, Steve Kirsch, Bret Weinstein) – ARCHIVE, YouTube, BACKUP, Spike protein is dangerous – EXCERPT

June 4, 2021 – The Highwire: TROUBLING SCIENCE EMERGING ON SPIKE PROTEIN – Byron Bridle PhD, brings forth evidence, suggesting the toxic protein in the shot distributes all over the body within as little as 15 minutes. – WATCH

June 3, 2021 – Dr. Malcolm Kendrick: COVID19 – the spike protein and blood clotting – READ

June 2021 – Canadian COVID-19 Care Alliance: Why Parents, Teens, and Children Should Question the COVID-19 Vaccine – PDF

• Recent studies indicate the spike protein, itself, may potentially be harmful
• The toxicity studies conducted with the Pfizer BioNTech vaccine do not allow for a safety assessment of the spike protein

May 28, 2021 – FOI request shows vaccine Lipid Nanoparticles (LNP) do NOT stay at the injection site as athorities stated – TIMELINE (see below)

May 28, 2021 – On Point with Alex Pierson: New peer reviewed study on COVID-19 vaccines suggests why heart inflammation, blood clots and other dangerous side effects occur – with Dr Byram Bridle – ARCHIVE, BACKUP, Uncover DC – ARTICLE, Dr Byram Bridle – HERE

“We have known for a long time that the spike protein is a pathogenic protein. It is a toxin that can cause damage in our body if it gets into circulation. Now, we have clear-cut evidence that the vaccines that make the cells in our deltoid muscles manufacture this protein, [we now know] the vaccine itself plus the protein gets into blood circulation...”

Dr Byram Bridle

May 28, 2021 – The Highwire: PRO-VAX DOC: “I CAN NO LONGER RECOMMEND THE VACCINE TO ANY INDIVIDUAL” – Dr McCullough – comments on spike protein – WATCH

May 26, 2021 – Preprint: “Vaccine-Induced Covid-19 Mimicry” Syndrome:Splice reactions within the SARS-CoV-2 Spike open reading frame result in Spike protein variants that may cause thromboembolic events in patients immunized with vector-based vaccines by Kowarz et al – READ

May 20, 2021 – Paper shows how vaccine spike protein gets into blood stream – TIMELINE, Ogata – PAPER, Daily Skeptic – ARTICLE

May 20, 2021 – Clinical Infectious Diseases: Circulating Severe Acute Respiratory Syndrome Coronavirus 2 (SARS-CoV-2) Vaccine Antigen Detected in the Plasma of mRNA-1273 Vaccine Recipients – Ogata et al – READ

• “…the detection of spike protein in the plasma of 3 of 13 young healthcare workers following vaccination with Moderna’s mRNA-1273 vaccine. In one of the workers, the spike protein circulated for 29 days.” Further investigation needed – REF

May 12, 2021 – The Highwire: IS COVID-19 A BIO-WEAPON? Discussion with Dr Richard Fleming – WATCH

May 10, 2021 – PolyBio Seminar Series: Dr. Resia Pretorius presents: “Consequences of coagulation in COVID-19 and LongCovid/PACS.” – WATCH, Can fibrin, platelet and red blood cell dysfunction be attributed to Spike Protein? – EXCERPT

• spike protein immediately caused platelet hyper-activation and spontaneous clot-let formation

May 6, 2021 – PrePrint: The BNT162b2 mRNA vaccine against SARS-CoV-2 reprograms both adaptive and innate immune responses – Fohse et al – READ, reference SOURCE

• The innate immune system is altered, and we don’t know for how long! Which makes you prone to other infections.
• “The response of innate immune cells to TLR4 [Toll-like receptor 4] and TLR7/8 ligands was lower after BNT162b2 vaccination,…the mRNA BNT162b2 vaccine induces complex functional reprogramming of innate immune responses, which should be considered in the development and use of this new class of vaccines.” –

April 30, 2021 – Salk Institute: The novel coronavirus’ spike protein plays additional key role in illness – Salk researchers and collaborators show how the protein damages cells, confirming COVID-19 as a primarily vascular disease – READ, Dr Malone – TWEET

April 20, 2021 – Dr Palevsky on Spike Protein Shedding – WATCH

@2:15: We know that spike protein via natural SARS-CoV-2 viral infection has been shown to cause:

• brain inflammation and neurological damage
• heart attacks
• lung, liver and kidney diseases
• Interacting with male and female reproductive systems
• Affects ability of oxygen to bind to blood and blood clotting

Thus the vaccine, forcing the body to make spike protein, is setting up these same potential illnesses! It is the types for adverse events which VAERS is capturing!

March 31, 2021 – Paper reveals how spike protein damages cells (cytotoxic), confirming COVID-19 is a vascular disease and not a respiratory disease – TIMELINE, PAPER

February 9, 2021 – David Martin World – Butterfly of the Week, 8 Feb 21: Selective Spike Proteins and Other Statistical Wonders (links under video) – WATCH

January 2021 – Vaccines (Basel): SARS-CoV-2 Spike Protein Elicits Cell Signaling in Human Host Cells: Implications for Possible Consequences of COVID-19 Vaccines – Suzuk et al – READ, CCCA – SOURCE

January 7, 2021 – Dr Been Medical Lectures: Will the vaccine continue to make spike proteins? overwhelming the immune system? – WATCH (links in description)

• There are millions of ribosomes in each cell – READ
• Discussion on mRNA decay

January 4, 2021 – New VOC (Beta) escapes vaccine “immune protection”, starts talk of booster shots for a vaccine that only is less than a month in the UK population!!! – spike protein mutations – TIMELINE

2020

December 18, 2020 – Study: Vaccine-induced antibody actually increases infectivity of SARS-CoV-2 (Pathogenic Priming) – TIMELINE, Japanese PAPER, @40min – WATCH

December 18, 2020 – UK Alpha variant is designated – TIMELINE

• “B.1.1.7 has an unusually large number of genetic changes, particularly in the spike protein. Three of these mutations have potential biological effects…As of 15th December, there are 1623 genomes in the B.1.1.7 lineage.”

December 14, 2020 – UK SARS-CoV-2 variant has 17 spike protein mutations – Alpha variant – TIMELINE

• The COVID-19 vaccine was rolled out in the UK – Authorised Dec 2, 2020 – TIMELINE

December 11, 2020 – Journal of Respiration: SARS-CoV-2 Spike Protein and Lung Vascular Cells – Suresh & Suzuki – READ, CCCA – SOURCE

December 4, 2020 – Signal Transduction & Targeted Therapy: CD147-spike protein is a novel route for SARS-CoV-2 infection to host cells – Wang et al – READ

• Interestingly ivermectin competes at the same spike binding site and can displace the spike from the CD147 cell surface receptor, which is important for reversing clotting mechanisms – REF
• CD147 is experssed on Platelets, RBCs, endothelial cells, lymphocytes, macrophages, fibroblasts etc. Plus it is upregulated on many cancer cells – Spike S1 and ivermectin binds to CD147!

December 4, 2020 – PrePrint: SARS-CoV-2 Spike Protein Impairs Endothelial Function via Downregulation of ACE2 by Lei et al – READ, ARTICLE, Stew Peters – WATCH, Dr Ryan Cole – WATCH

December 1, 2020 – Doctors petition EMA to stop vax trials – serous concerns – TIMELINE

• Possible Infertility issues: Syncytin-1 is a prerequisite for a successful human pregnancy and is also found in “homologous form in the spike proteins of SARS viruses”, it could be possible anti-spike antibodies could also act as anti-Syncytin-1 antibodies thus a vaccinated woman could be rendered infertile for an unknown duration. – [vaccine “spike protein antigen” could set up auto-immune attack on placenta – it needs investigation, massive contraindication to pregnancy and women of child bearing age]
• [Syncytin-1 and its receptor is present in human gametes – READ]

October 28, 2020 – eLife: Escape from neutralizing antibodies by SARS-CoV-2 spike protein variants – Weisblum et al – READ

• “SARS-CoV-2 spike protein was already evolving immunity to the antibodies directed towards it from natural immunity which raised early questions about the long term viability of pharmaceuticals directed against the original spike protein” – REF

September 4, 2020 – J. Henatology & Oncology: SARS-CoV-2 binds platelet ACE2 to enhance thrombosis in COVID-19 – Zhang et al – “SARS-CoV-2 Spike protein enhances thrombosis potential in vivo” – READ, CCCA – SOURCE

August 3, 2020 – Nature: Structural and functional properties of SARS-CoV-2 spike protein: potential antivirus drug development for COVID-19 by Huang et al – READ

July 29, 2020 – Preprint: Prevalence of amyloid blood clots in COVID-19 plasma – Pretorius et al – READ, now published Nov 2020 – HERE

July 12, 2020 – NIAID – COVID-19 Prevention Network: The Science of COVID-19 Vaccines and Antibodies – ARCHIVE

A vaccine is a substance that teaches your body to recognize a foreign invader, such as a virus, sound an alarm to activate your immune system, and instruct your fighter cells and proteins to go to work to fight the virus.

The goal of a vaccine is to eliminate or control the virus in your body, which could prevent infection, or control an infection from developing into disease.

The vaccine causes the immune system to respond by looking as much like the invading virus as possible without causing disease itself.

NIAID defines what a vaccine is and does – it is VERY B R O A D and vague

• Vaccine Antibodies vs. SARS-CoV-2 Infection Antibodies – READ
• Vaccine Basics – Simplified Immune Response: How We Develop Immunity. A graphic that outlines how vaccines can help the body learn to identify a new virus, and help the body remember how to fight the virus if a person is exposed to it in the future – ARCHIVE

June 2020 – The Evidence which Suggests that This Is No Naturally Evolved Virus: A Reconstructed Historical Aetiology of the SARS-CoV-2 Spike by B. Sørensen, A. Dalgleish, A. Susrud – READ, PDF [Updated May 26, 2021 – READ] ,

• Minerva – The evidence which suggests that this is no naturally evolved virus (article uploaded to Minerva, Norway) – READ, CREDIT, Prof Angus Dalgleish – MORE

June 17, 2020 – CHD: Robert F. Kennedy, Jr.: Q & A with Dr. Theresa Deisher – ARCHIVE, YouTube

“The people getting COVID-19 disease are not making antibodies to the spike protein unless they have severe disease.”

Dr Theresa Deisher [@44:45]

May 5, 2020 – NY Post: Study shows new coronavirus mutation appears stronger, more contagious – READ, April 30, 2020 – STUDY

May 5, 2020 – LA Times: Scientists say a now-dominant strain of the coronavirus could be more contagious than original – READ, April 30, 2020 – STUDY (see date below) – TIMELINE

• “Scientists … told The Times that they are pinning their hopes on initial evidence that the virus is stable and not likely to mutate the way the influenza virus does, requiring a new vaccine every year. The Los Alamos report could upend that assumption.” [All coronaviruses readily mutate!]
• Brenner noted that the study did not show the mutation makes people sicker, but found more of the virus present in sick people, “suggesting that it replicates better.” – [More transmissible (due to high viral load) and better ability to infect cells (replicate virus faster) does not necessarily mean people become sicker – mutations in the spike have huge consequences for a vaccine!]

May 1, 2020 – Frontiers: Reduction and Functional Exhaustion of T Cells in Patients With Coronavirus Disease 2019 (COVID-19) – Diao et al – READ, SOURCE

• Spike protein shown to be the cause of CD4, CD8 T Cell dysregulation

April 30, 2020 – PrePrint BioRxiv: Spike mutation pipeline reveals the emergence of a more transmissible form of SARS-CoV-2 – Korber et al – READ , Aug 2020, peer reviewed and published in Cell: Tracking Changes in SARS-CoV-2 Spike: Evidence that D614G Increases Infectivity of the COVID-19 Virus – READ, TIMELINE

• [Clearly it was known in April 2020 that the spike protein mutated, yet all COVID-19 vaccines used the spike protein as the target “antigen” genetic code – “leaky vaccine”!]
• Spike protein already has 14 mutations (G614) first identified February 2020
• G614 is associated with lower RT PCR Cycle thesholds (Cts), suggestive of higher viral loads in patients
• “scientists said they felt an “urgent need for an early warning” so that vaccines being created around the world to combat COVID-19 will be effective against the newer, stronger strain.” – NY Post – ARTICLE

April 2020 – Antiviral Research: The spike glycoprotein of the new coronavirus 2019-nCoV contains a furin-like cleavage site absent in CoV of the same clade by Coutard et al – READ

March 9, 2020 – Cell: Structure, Function, and Antigenicity of the SARS-CoV-2 Spike Glycoprotein by Walls et al – READ

March 3, 2020 – NIH: Novel coronavirus structure reveals targets for vaccines and treatments – READ, ARCHIVE, Study funded by NIAID, Results were published on February 19, 2020, in Science (see below).

• A collaborative team including scientists from Dr. Jason McLellan’s lab at the University of Texas at Austin and the NIAID Vaccine Research Center (VRC) isolated a piece of the genome predicted to encode for its spike protein based on sequences of related coronaviruses. The team then used cultured cells to produce large quantities of the protein for analysis.
• The researchers used a technique called cryo-electron microscopy to take detailed pictures of the structure of the spike protein. This involves freezing virus particles and firing a stream of high-energy electrons through the sample to create tens of thousands of images. These images are then combined to yield a detailed 3D view of the virus.”
• The researchers found that the SARS-CoV-2 spike was 10 to 20 times more likely to bind ACE2 on human cells than the spike from the SARS virus from 2002. This may enable SARS-CoV-2 to spread more easily from person to person than the earlier virus.
• [Only] 3 different antibodies against the 2002 SARS virus could not successfully bind to the SARS-CoV-2 spike protein. This suggests that potential vaccine and antibody-based treatment strategies will need to be unique to the new virus.” [Natural infection by SARS-CoV-1 surely has more than 3 potential antibodies!]

“We hope these findings will aid in the design of candidate vaccines and the development of treatments for COVID-19,”

Dr. Barney Graham, Deputy Director NIAID Vaccine Research Center (VRC)

February 19, 2020 – UT scientists produce first 3-D map of new coronavirus, the Trimeric spike glycoprotein becomes the target for novel vaccines – TIMELINE, Science Wrapp et al – Structure of the nCoV trimeric spike – PAPER

• This schematic [below] shows the 3-D atomic-scale map, or molecular structure, of the SARS-CoV-2 spike protein. The protein takes on two different shapes, called conformations – one before it infects a host cell, and another during infection. This structure [B on left] represents the spike protein before it infects a cell, called the prefusion conformation – REF

February 19, 2020 – Science: Cryo-EM structure of the 2019-nCoV spike in the prefusion conformation – Wrapp et al – READ, ARCHIVE

• “Because of the indispensable function of the S protein, it represents a target for antibody-mediated neutralization, and characterization of the prefusion S structure would provide atomic-level information to guide vaccine design and development.”

February 19, 2020 – NIAID: NIH Scientists Identify Atomic Structure of Novel Coronavirus Protein – ” the findings will aid in the design of candidate vaccines and the development of treatments for COVID-19″ – READ, ARCHIVE (see paper above) – As cited by Moderna –HERE

January 13, 2020 – Moderna finalised their spike-protein vaccine mRNA sequence – TIMELINE

2019

February 21, 2019 – JCI insight – Anti-spike IgG causes severe acute lung injury by skewing macrophage responses during acute SARS-CoV infection – Liu et al READ

• IgG antibody against coronavirus spike protein causes massive issues – Study findings reveal a mechanism responsible for virus-mediated acute lung injury (ALI) which can be fatal.

2018

February 6, 2018 – US Patent: US9884895B2: Methods and compositions for chimeric coronavirus spike proteins – Ralph Baric et al – READ, Applied March 20, 2014

2015

June 25, 2015 – Nature: Scientific Reports: A single-dose of oral nattokinase potentiates thrombolysis and anticoagulation profiles – Kurosawa et al – PDF, Dr McCullough – READ

June 10, 2015 – Study published reveals only 2 bat coronavirus spike protein mutations necessary for the virus to infect human cells – TIMELINE, PAPER – See more Lab or Animal Origin

2010

June 22, 2010 – China & Australia study SARS-CoV potential to infect bat species, call for more surveillance – TIMELINE

• They looked at 7 additional bat species and “tested their interactions with human SARS-CoV spike protein using both HIV-based pseudotype and live SARS-CoV infection assays. …Further, the alteration of several key residues either decreased or enhanced bat ACE2 receptor efficiency.”

2005

August 2005 – Published study show RNA can evade the innate immune system if the code is altered to pseudouridine – TIMELINE, PAPER, [The 2020 mRNA vaccine spike protein code has pseudouridine]

The post The Spike Protein first appeared on Totality of Evidence.

Long term symptoms following a SARS-like infection is known to occur in both SARS and MERS, so this persistence of symptoms is not new.

Are the “long COVID” symptoms experienced in 2020 the same as those from 2021 – following the rollout of the COVID-19 vaccines? How much of the symptoms are due to the toxic effects of the non-defined dose of spike protein? How many cases are the result of delayed early treatment. The official US treatment guidelines is to DO NOTHING until hospitalisation is required! How much virus was allowed to simply build up in a persons body, and did this have flow on health issues?

Is the same spike protein coded by the vaccines also resulting in on-going health issues – the same symptoms as long COVID? Are all long COVID cases pigeon-holed to be the result of only post-COVID-19 infection? The vaccine induced spike-protein, or pathogenic priming are not even officially considered as a potential causal age of long COVID.

Define Long COVID

At a White House press briefing on February 3, 2022 Dr Anthony Fauci stated that the NIH initiated the RECOVER study in collaboration with other agencies looking at the incidence, prevalence and hopefully understanding the pathogenic mechanisms of Long COVID – WATCH,

He defined “long COVID” as the following:

Long COVID means the persistence of signs and symptoms that are not explainable by any readily recognisable pathogenic process following the recovery from the acute infection [of SARS-CoV-2].

Dr Anthony Fauci – White House press briefing

He goes on to state:

“There have been some suggestions that it is an aberrant inflammatory response, perhaps some element of autoimmunity, perhaps some element of persistence of nucleotide fragments of the virus. All of these now are being actively perused. But before we can make any definitive statements we need to learn a lot more about it. But the ultimate goal of figuring out how me might be able to mitigate or prevent some of those symptoms”

[no mention of pathogenic priming from the COVID-19vaccines!]

Resource links:

• CDC on Long COVID or Post-COVID conditions – HERE, ARCHIVE
• July 2021 – HHS recognise Long COVID as a DISABILITY
  
• Patient led COVID-19 research group – ARCHIVE, HERE, PRESS
  
• NIH RECOVER website – HERE, ARCHIVES
  
• NIH website search for “Long COVID” articles – HERE

Long COVID treatment protocols – unofficial!

For informational purposes only. Not medical advice

The Front line COVID Critical Care Alliance (FLCCC), doctors headed by Dr Paul Marik & Dr Pierre Kory have been treating long COVID (long haul COVID-19) since the pandemic began, they have their treatment protocols available for the world to use. You will find more information by reading their website and listening to their interviews:

• Dr Paul Marik – HERE
• Dr Pierre Kory – HERE
• FLCCC: I-RECOVER – Long COVID Treatment – HERE, ARCHIVE
• FLCCC: I-RECOVER – Post-Vaccine Treatment Protocol – HERE
• Dr Been’s “Long Story Short” updates on FLCCC Alliance Channel – HERE

Long COVID links in reverse chronological order

2024

June 18, 2024 – ABC News: Months after being diagnosed with COVID-19, one in five people are still suffering from symptoms, new research finds – READ

• JAMA: Epidemiologic Features of Recovery From SARS-CoV-2 Infection by Oelsner et al – READ

April 16, 2024 – Malone Substack: mRNA Pseudo-Vaccines: Current Research – A newly published peer reviewed journal article documents more damages done – READ, ARCHIVE

• PLOS Study showed “people with long COVID had much worse outcomes when “vaccinated” (after developing long COVID) than those who didn’t receive a vaccine, and that these bad outcomes persisted for at least a year after “vaccination.”

April 2024 – Royal Australian College of General Practitioners (RACGP): Long COVID: Sufferers can take heart by Robert Tindle – READ, ARCHIVE – This paper reportedly sent it to all GPs with “Stunning revelations from an entity that originally pushed the Covid injections…Key paragraphs buried in middle of their paper” – Malcolm Roberts TWEET

• “Millions worldwide experience post-acute sequelae of COVID-19 (PASC or long COVID), according to the World Health Organization (WHO), European Union and the UK and US governments…”
• “…Because COVID-19 vaccines were approved without long-term safety data and might cause immune dysfunction, it is perhaps premature to assume that past SARS-CoV-2 infection is the sole common factor in long COVID.”…There is concern that COVID-19 vaccination per se might contribute to long COVID, giving rise to the colloquial term ‘Long Vax(x)’. [Yet Dr Kory & Dr Marik has been saying that ~2yrs]
  • [Public health in South Australia are “nudging” health care to get COVID-19 and flu jabs or sign a declaration of refusal! – WATCH]

March 31, 2024 – “Long covid takes toll” [gaslighting the public] – Dr Ian Brighthope – READ

• Letter from Hon. Mark Buttler MP stating Australian gov. official position:
  • Of 14 deaths linked to vaccination none are in children, and none since 2022!
  • “COVID-19 vaccination is highly effective against COVID-19 mortality among older adults although effectiveness wanes with time since the last dose.” Keep on boosting! – Government funded Liu et al paper in Lancet – STUDY?
• Australia has high sick leave rate in the young – blamed on “long covid”

March 7, 2024 – The Hill | Op-Ed: Is it Long COVID or Long Vax? Does the Government want to Know? Kory & Marik – READ, FLCCC substack – CREDIT

• Re Dr Harlan Krumholz recent study at the Yale School of Medicine | Preprint: Post-Vaccination Syndrome: A Descriptive Analysis of Reported Symptoms and Patient Experiences After Covid-19 Immunization – READ
• “America’s health agencies need to snap into action to help study this problem so we can better understand and treat these conditions. Unfortunately, there doesn’t seem to be much hope of this happening…
• … Our health agencies have been coopted by industry and political forces, leaving millions of people vulnerable to injury, suffering and death, in many cases without any recourse.”

February 21, 2024 – FLCCC: Lingering Long COVID and Long Vax: FLCCC Weekly Update w/ Dr Marik and Scott Marsland FNP-C – Presentation by Dr Marik WATCH, FULL, Dr Kory talking with TND with Jan Jeffcoat – EXCERPT

• Getting a steady steam of patients (who’ve been sick for at least 1.5yrs, following a journey through “the system” before they find Dr Kory) – long-vax (~70%) is far more common than long-covid, and long-vax is far sicker and improve less with time – Dr Kory – EXCERPT
• Official long covid clinics offer very little care, and have little understanding of the disaese, their patients feel aboandoned – according to Dr Kory
• Although it has a new name, it’s not a new disease. Its already known as Myalgic Encephalomyelitis/Chronic fatigue syndrome (ME/CFS) – all symptoms temporarily associated right after their COVID-19 vaccine shot
  • Diagnosis is founded on 3 main symptoms:
    • 1) A new debilitating fatigue
    • 2) Post-exertional malaise
    • 3) Brain fog
    • 4) plus a whole side list of symptoms!
• The patients who are really sick have micro-bloodclotting problems

January 18, 2024 – Senate Health Committee: Addressing Long COVID: Advancing Research and Improving Patient Care – READ,

• This hearing “simply was not a serious effort” to address long COVID says Marik and Kory – REF

January 14, 2024 – Bangkok Post: Long Covid, vaccines may cause disease and death: Chula, Rangsit – warning from Prof Dr Thiravat Hemachudha – READ

2023

December 12, 2023 – ABC News Australia: Long COVID cases will likely increase with each new wave, so why are we closing clinics? 23 clinics established in Australia, five have closed or scaled back operations after cuts to funding – READ

• A parliamentary inquiry into long COVID estimated that between 200,000 and 2 million Australians have some form of long COVID, which can include more than 200 symptoms.

September 28, 2023 – FLCCC Long (COVID) Story Short Episode 72 w/ Dr Been: Cardiac Cell Mitochondrial Damage by the Spike Protein – WATCH, FLCCC Substack – CREDIT

• Discuss “a first-of-its-kind study from Taiwan that demonstrates mitochondrial damage in cardiac pericyte cells when presented with the S1 part of the spike protein.”
• March 2023 – Cell Journal: Spike Protein Impairs Mitochondrial Function in Human Cardiomyocytes: Mechanisms Underlying Cardiac Injury in COVID-19 by Huynh et al – READ

September 9, 2023 – Courageious Discourse: Vaccination Makes Long-COVID Syndrome Worse and Last Longer
Lancet Paper Inadvertently Discloses Data on Vaccination Worsening Long-COVID Symptomatology – READ

September 8, 2023 – Dr Ian Brighthope Substack: Long COVID maims doctors – Doctors have been damaged in many ways by their chosen profession, Covid is only one. – READ

• July 4, 2023 – British Medical Association ( BMA): First major survey of doctors with Long Covid reveals debilitating impact on health, life and work- READ
  • One in Five Doctors With Long COVID Can No Longer Work: Survey
• January 13, 2023 – Nature Reviews Microbiology: Long COVID: major findings, mechanisms and recommendations – Davis et al – READ
  • Long Covid affects more than 65 million people worldwide – an epidemic!
• CDC Long COVID – Household Pulse Survey – READ
  • Approximately 1 in 10 people infected with the virus develop long-term symptoms.

August 26-27, 2023 – Vejon Health w/ Dr Philip McMillan | Post Vax/Long Covid Congress – The Silent Disaster: Access slides and watch – Day 1 – HERE, Day 2- HERE

• The SARS-CoV-2 Spike Protein: An Engineered PRION like Incapacitating Agent by Kevin McCairn PhD – EXCERPT

April 27, 2023 – Umbrella News: Diagnosing long COVID: ‘We Still Don’t Really Know What It Is’ – READ, Dystopian Down Under Substack – READ

• “In the fourth year of the pandemic, long COVID is emerging as a major public health concern. However, the medical community is yet to arrive at a clear understanding of what the condition is, what causes it, and how to treat it.” [Hint – brand new medical intervention widely used from Dec 2020?]

April 24, 2023 – ABC News Australia: $50 million boost for long COVID research as parliamentary inquiry hands down Long COVID report – READ, Dept Health Long COVID- READ [Note officially the “19” has been dropped!!!]

• Aust. Govt PRESS RELEASE: Sick and tired: Long COVID inquiry report released – READ

April 23, 2023 – Australian Inquiry into Long COVID and Repeated COVID Infections – READ, release report – READ

• Terms of reference – NOT even looking at toxic spike protein from vaccination – READ

March 24, 2023 – American Thought Leaders: Dr. Sabine Hazan: The Gut Bacteria That’s Missing in People Who Get Severe COVID – WATCH, LISTEN

January 24, 2023 – NY Times: Long Covid Is Keeping Significant Numbers of People Out of Work, Study Finds – analysis of workers’ compensation claims in New York State – READ

• NYSIF – SHINING A LIGHT ON LONG COVID: An Analysis of Workers’ Compensation Data (referenced) – REPORT
• “…during the first two years of the pandemic, about 71 percent of people the fund classified as experiencing long Covid either required continuing medical treatment or were unable to work for six months or more.”

January 14, 2023 – Milo Mac: CDC’s National Center for Health Statistics (NCHS) on the mortality associated with Long COVID released on Dec 14, 2022 – GETTR, CDC report – PDF

• “The CDC says that only 3,544 people died from Long COVID from January 2020 to June 2022 and the vast majority of those deaths occurred in the 65+ age group”
• CDC’s “own data blows away the narrative that excess deaths are caused by Long COVID” [Ed Dowd comment re Long Covid – WATCH]

2022

December 15, 2022 – Ask Dr Drew: Help For COVID Long Haulers: Dr. Ram Yogendra & Dr. Bruce Patterson Reveal Research – WATCH

December 14, 2022 – NIAID: NIAID Pandemic Autopsy Study Fosters Long COVID Treatment Trial – READ

• Autopsies of 44 people who died from COVID-19 in the first year of the pandemic showed researchers that disease-causing SARS-CoV-2 virus spread throughout the body – beyond just a respiratory disease – and remained in tissue for months.
• The work also supported the rationale for an upcoming clinical trial evaluating the antiviral drug Paxlovid for the treatment of post-acute sequelae of COVID-19, also known as Long COVID. – Clinical Trial – READ

December 14, 2022 – Just The News: CDC claims 3,500 Americans dead from ‘Long Covid’ – Poorly understood set of symptoms has received much media attention – READ, CDC report – PDF, GETTR

December 2022 – CDC | NVSS vital statistics rapid release #25: Identification of deaths with post-acute sequelae of COVID-19 from death certificate literal text: United States, January 1, 2020–June 30, 2022 – READ
[changing death certificates from COVID-19 (potential vaccine injury) to Long COVID???]

December 12, 2022 – Expose News: Authorities ignore published science proving Covid injections are Dangerous and “long Covid” doesn’t exist – READ

December 6, 2022 – Vinay Prasad: Cross Sectional Studies FAIL For LONG COVID | Amazing new Lancet Paper! – WATCH, Long COVID in Children and Young Adults – A new paper blows up the NARRATIVE – SUBSTACK, the paper – HERE

Dec 4, 2022 – The Lancet: Natural course of health and well-being in non-hospitalised children and young people after testing for SARS-CoV-2: A prospective follow-up study over 12 months by Pereira et al – READ

November 3, 2022 – Science News: Where are the (more than 400) long COVID clinics? USA – READ

October 28, 2022 – Steve Kirsch Substack: Early treatment reliably prevents long-haul COVID symptoms (PACS) – It will take the medical community at least 10 years to figure this out, even though it was published in the peer-reviewed medical literature more than a year ago. Here’s why. – READ

October 25, 2022 – American Thought Leaders: Dr. Paul Marik: Spike-Related Diseases, Gaslighting of the Vaccine Injured, and the Suppression of Early Treatment – WATCH

October 13, 2022 – The Highwire Ep 289: ‘COVID-19: THE LONG HAUL’ DOCTORS PANEL FROM FREEDOM FEST – with Dr. Pierre Kory, Dr. Robert Malone, and Dr. Richard Urso – WATCH, FULL

September 1, 2022 – AUSTRALIA: Referral for Long COVID inquiry from the Minister for Health and Aged Care, the Hon Mark Butler MP, the House Standing Committee on Health, Aged Care and Sport inquired into and reported on Long COVID and Repeated COVID Infections. – REF

• Inquiry completed April 24, 2023 – published its report Sick and tired: Casting a long shadow – REPORT

July 20, 2022 – Conservative Review with Daniel Horowitz: How to Heal Your Body from Jab Injury and Long COVID with Dr Henry Ealy – LISTEN

July 6, 2022 – STAT News: Estimates of long Covid are startlingly high. Here’s how to understand them – READ

• Recent CDC analysis implies that “a fifth of people infected with Covid — have at least one lingering post-infection symptom that is seriously affecting their daily life.”

~June 30, 2022 – Royal Australian College of General Practitioners: Guidelines for “caring for patients with post–COVID-19 conditions” – READ, ARCHIVE, Royal Australian College of General Practitioners (RACGP): Defining post–COVID-19 conditions – READ

May 24, 2022 – CDC | MMWR: Post–COVID Conditions Among Adult COVID-19 Survivors Aged 18–64 and ≥65 Years — United States, March 2020–November 2021 – READ, ARTICLE

• 1 in 5 adults may have long COVID – that’s tens of millions of Americans are potentially DISABLED – [no wonder they don’t want to even consider at spike protein/vaccine injury]

May 23, 2022 – A Neighbor’s Choice: The Science: Dr. Pierre Kory, Where Do We Go From Here? Why are government-prescribed drugs failing in the pandemic? Is there an overlap between those suffering from long COVID and the vaccine-injured? and more… – WATCH

March 6, 2022 – Startacus Substack: COVID-19 Deep Dive Part I: Pathophysiology – The first in a series of articles exploring each aspect of the pandemic in detail – READ

• The media acted like this so-called “Long COVID” was something mysterious. It is not. It is a well-established aspect of SARS-like viruses and has been recognized by the scientific literature for over a decade. – PAPER
• “Maybe, just maybe, there are some very evil people out there who want to keep this crisis going forever. Maybe they don’t want this disease to actually be treated successfully.”

February 23, 2022 – Epoch Times: Early Treatment and Proper Hydration Key to Preventing Long COVID Symptoms: Dr. Keith Berkowitz – READ

“Most of the people that have had early treatment, we’re seeing much less incidence of long COVID in that group,”

Berkowitz told The Epoch Times

• The National Institutes of Health (NIH) says there is insufficient evidence to recommend for or against the use of ivermectin for COVID-19…Governmental health authorities have been slow to recommend early treatment for COVID-19 as they continue with the same messaging for people who test positive for the disease: self-monitor at home, keep hydrated, and only go to the ER when breathing becomes difficult.
• Only January 2022 did CDC promote treat early…after patented drugs received Emergency Use Authorisation!- TWEET, ARCHIVE, CDC website – HERE

Febraury 23, 2022 – Biochemical Journal: A central role for amyloid fibrin microclots in long COVID/PASC: origins and therapeutic implications by Kell et al – READ, CREDIT

February 2, 2022 – FLCCC Weekly Webinar: Long COVID and the I-RECOVER Protocol – Dr. Keith Berkowitz and Dr. Mobeen Syed join Dr. Paul Marik to discuss long COVID and how to treat it with the I-RECOVER protocol. – WATCH

January 9, 2022 – European Journal of Pediatrics: Long COVID symptoms and duration in SARS-CoV-2 positive children — a nationwide cohort study – Borch et al – READ “Conclusions: Long COVID in children is rare and mainly of short duration.”

• In children younger than 18, long COVID is “rare and mainly of short duration,” according to the largest nationwide cohort study, involving 37,522 children with COVID-19 and a control group of over 78,000 children. Epoch Times- REF

2021

October 6, 2021 – WHO: A clinical case definition of post COVID-19 condition by a Delphi consensus – READ, ARCHIVE

• “WHO has developed a clinical case definition of post COVID-19 condition by Delphi methodology that includes 12 domains, available for use in all settings….”
• “Post COVID-19 condition occurs in individuals with a history of probable or confirmed SARS CoV-2 infection, usually 3 months from the onset of COVID-19 with symptoms and that last for at least 2 months and cannot be explained by an alternative diagnosis. Common symptoms include fatigue, shortness of breath, cognitive dysfunction but also others and generally have an impact on everyday functioning. Symptoms may be new onset following initial recovery from an acute COVID-19 episode or persist from the initial illness. Symptoms may also fluctuate or relapse over time.“

September 14, 2021 – NIH Blog by Francis Collins: Breakthrough Infections in Vaccinated People Less Likely to Cause ‘Long COVID’ – READ

July 12, 2021 – CDC: Post-COVID Conditions – ARCHIVE

• As of July 2021, “long COVID,” also known as post-COVID conditions, can be considered a disability under the Americans with Disabilities Act (ADA) – READ, SOURCE

June 21, 2021 – Orthomolecular Medicine News: Resolving “Long-Haul COVID” and Vaccine Toxicity: Neutralizing the Spike Protein by Dr Thomas Levy – READ

June 16, 2021 – FLCCC: I-RECOVER Protocol for Long Haul COVID Syndrome – Version 1 – ARCHIVE, [note this protocol has been updated by FLCCC – HERE]

April 8, 2021 – CDC: Post-COVID Conditions: Information for Healthcare Providers (with references) – ARCHIVE, READ

• “Long COVID encompasses a wide range of symptoms and clinical findings that can occur in people with varying degrees of illness from acute SARS-CoV-2 infection, including patients who had mild or asymptomatic SARS-CoV-2 infection.” [Not a single mention of vaccine or vaccination]

March 1, 2021 – NIH: PASC Technical Assistance Workshop – SLIDES, SOURCE

February 2021 – NIH launched the RECOVER (Researching COVID to Enhance Recovery) initiative in February 2021 – ARCHIVE, READ

• Post-Acute Sequelae of SARS-CoV-2 infection (PASC)
• The research effort is working to identify the causes and the means to prevent and treat PASC, including what is commonly called Long COVID or long-haul COVID.
• “[S]ymptoms can include fatigue, shortness of breath, “brain fog,” sleep problems, fever, anxiety, and depression. These and other long-term effects of COVID-19 are collectively referred to by the broad research term post-acute sequelae of SARS-CoV-2 infection (PASC)”

February 23, 2021 – NIH Director Francis Collins: NIH launches new initiative to study “Long COVID” – READ, ARCHIVE

• “In some cases, new symptoms arise well after the time of infection or evolve over time” [potential vaccine injury, pathogenic priming is not a consideration!]
• Congress provided $1.15 billion in funding over four years for NIH to support research into the prolonged health consequences of SARS-CoV-2 infection

January 21, 2021 – NY Times Magazine: My ‘Long Covid’ Nightmare: Still Sick After 6 Months – A Times reporter caught the coronavirus – first time was April 17, 2020, second time June 22, 2020 – severe chest pain, elevated D-dimer, inflammation – READ

January 21, 2021 – ABC Action News: USF doctor warns COVID can severely damage lungs, even in those without symptoms – Dr. Gaetane Michaud, a pulmonologist with USF – READ

• “The X-rays and scans she’s seeing show worse damage post-COVID than in those who have smoked for years. The damage is seen even in some patients who never saw a symptom.”

January 19, 2021 – BMJ: The elephant and the blind men: the children of long covid – Rapid Response: Vaccinating children to prevent Long Covid? Much more caution needed in interpreting current epidemiological data – READ

January 19, 2021 – Dr Francis Collins Blog -Trying to Make Sense of Long COVID Syndrome – ARCHIVE, READ

• “…new results from the largest global study of this emerging “Long COVID syndrome” highlight just how real and pressing this public health concern really is. The study, reported recently as a pre-print on medRxiv, is based on survey results from more than 3,700 self-described COVID “Long Haulers” in 56 countries” – From surveys distribution via online COVID-19 support groups and social media – STUDY
• “They show nearly half couldn’t work full time six months after unexpectedly developing prolonged symptoms of COVID-19.”

January 15, 2021 – CBS News: Post-COVID lungs worse than the worst smokers’ lungs, surgeon says – Dr. Brittany Bankhead-Kendall tweeted, “Post-COVID lungs look worse than any type of terrible smoker’s lung we’ve ever seen – READ, TWEET, CNN Wire – READ, Mirror – READ, East Mojo – READ, Boston 25 News “no one’s talking about it…” – READ

• Dr Milton Wolf, a radiologist comments on her x-rays as “wildly misreported as “Post Covid Lungs.” …she’s flat out wrong” – READ

January 8, 2021 – NY Times: 6 Months After Leaving the Hospital, Covid Survivors Still Face Lingering Health Issues – A large study of [1,733] patients from a Wuhan, China hospital showed that a half-year later, three-quarters were struggling with problems like fatigue, depression and diminished lung function – READ

• This is one of the first publications which describes longer-term outcomes from COVID-19 infection – 63% patients experienced ongoing exhaustion or muscle weakness, ~25% difficulty sleeping and 23% experienced anxiety or depression

January 8, 2021 – The Lancet: 6-month consequences of COVID-19 in patients discharged from hospital: a cohort study [China] – Huang et al – ARCHIVE, READ

January 2021 – Clinical Medicine London: Long-term sequelae following previous coronavirus epidemics – O’Sullivan – READ, CREDIT

• SARS & MERS epidemics both “left survivors with fatigue, persistent shortness of breath, reduced quality of life and a significant burden of mental health problems.”

2020

December 27, 2020 – Medrxiv – Characterizing Long COVID in an international cohort: 7 months of symptoms and their impact . David HE et al – PDF, CREDIT

December 18, 2020 – National Institute for Health and Care Excellence (NICE) UK | NG188: COVID-19 rapid guideline: managing the long-term effects of COVID-19 – READ, ARCHIVE

December 3, 2020 – NIH: Workshop on Post-Acute Sequelae of COVID-19 – “to summarize existing knowledge on post-acute manifestations of COVID-19 and to identify key knowledge gaps” – ARCHIVE, WATCH

September 3, 2020 – NIH Directors Blog: Citizen Scientists Take on the Challenge of Long-Haul COVID-19 – READ, Re online Body Politic COVID-19 Support Group, the Patient-led Research for COVID-19 – WEBSITE

July 10, 2020: BMJ Opinion: Patients’ experiences of “longcovid” are missing from the NHS narrative – READ, ARCHIVE

June 4, 2020 – The Atlantic: COVID-19 Can Last for Several Months – The disease’s “long-haulers” have endured relentless waves of debilitating symptoms—and disbelief from doctors and friends – ARCHIVE

June 2020 – COVID-19 Longhauler Advocacy Project (C19LAP) was founded in June of 2020 – WEBSITE, CREDIT

• Long COVID (LC) is a patient coined term describing the sequela of symptoms post-COVID infection, lasting at least 12 weeks, The CDC refers to Long COVID as “Post COVID Syndrome” (PCS) and the NIH refers to it as “Post Acute Sequela of COVID-19” (PASC). – REF
• The website has NO reference to post-vaccination potential for the chronic dis-ease. Both the virus and the COVID-19 vaccines ALL have the toxic spike protein in common.

The post Long COVID first appeared on Totality of Evidence.

End of Life Protocols

Patients with “moderate to severe” COVID-19 may have difficulty breathing, so why would “public health” recommend products that make breathing more difficult?

• “Midazolam is a short-acting injectable benzodiazepine with rapid onset that is commonly used in seizures, anesthesia and anxiety disorders.” – REF. Midazolam is also known under the brand name Versed. It is most frequently used before surgeries or procedures to decrease anxiety, cause drowsiness, and help with anesthesia in patients who need tubes or machines to help them breathe. – REF
  A side effect of the drug is abnormally slow breathing, respiratory depression and respiratory arrest! – REF

• “Morphine is an opioid agonist used for the relief of moderate to severe acute and chronic pain.” – REF A side effect of morphine can be breathing problems – REF

This page is an attempt to capture links relating to midazolam and morphine for COVID-19 patients, and also includes the treatment of the elderly, setting up the conditions/justifications to give them these drugs according to “protocol”.

Links in reverse chronological order

2024

February 15, 2024 – Medical and Clinical Research: Excess Deaths in the United Kingdom: Midazolam and Euthanasia in the COVID-19 Pandemic by Wilson Sy (Aust) –READ, READ, now peer reviewed, CREDIT, Dr John Campbell walks through the paper looking at the many graphs – WATCH

February 22, 2024- Hearts of Oak: The Week According To . . . Wayne Cunnington – Vaccine Injuries and Midazolam Murders – WATCH

2023

July 20, 2023 – Jikkyleaks: Iatrogenic murder scandal “How did they get away with it? Nurse Elena Vlaica aleges murder of her husband Stuart 18 months ago – TWEET

March 7, 2023 – JikkyLeaks via Twitter: Re Statista data: Care home occupancy rate in the United Kingdom 2006-2021 – April 2020 : 10% immediate drop in care home occupancy. – 55,000 deaths – 11-sigma – TWEET

March 4, 2023 – The Daily Beagle Substack: The Death Penalty Drugs Used By Care Homes – “digging through prescription datasets, BNF codes, documentation, forms, procedures, dosage limits, MHRA authorisations and more, and we come bearing blood-soaked receipts that it was indeed a Mass Murder of the Elderly” – READ, CREDIT

One question to ask: was COVID-19 used as a cover story for killing off a large quantity of the elderly in care homes?

• Midazolam Is Literally Used For Lethal Injection, and dose Exceeds That Used In Death Penalty – dosage for execution using midazolam is 50mg with 50mg of hydromorphone – UK palliative care homes in 2015 recommend 10-60mg for agitation!
• MHRA advised no more than 3.5mg total for the over 60s, yet orders for 10mg doses spiked in April 2020, 2mg and 5mg dose are availble. Morphine also spiked at the same time.
• “Assisted dying ” drugs spiked in 2020, and the know rates are Midazolam = 10mg (“care” homes used 10-60mg!), also Morphine = 15mg-3g- REF
• Anti-inflammatory drug orders dived around the same time – why?
• According to UK ONS “17 316 patients died in England in April, 2020, with “dementia and Alzheimer’s disease” recorded on their death certificate”, 3 times more than expected, compared with the 5-year mean for April” – REF
• “On April 8, 1,447 deaths involving Covid-19 occurred in the UK, more than on any other day in the pandemic so far. During April there were 21 consecutive days when the number of Covid-19 deaths in the UK was over 1,000.”…Up to Dec 18, 2020 in the UK 82,957 deaths involved COVID-19 on their death certificate with 19,568 deaths in care homes clustered around April 2020 – ARTICLE
• Midazolam has appeared in “End of Life” documents since October 2012, yet MHRA didn’t give marketing authorisation for Midazolam until September 7, 2020! for ICU sedation etc. – PDF

February 27, 2023 – The Daily Beagle Substack: Mass Murdering Of The Elderly – “Midazolam depresses respiration and it hastens death. It changes end-of-life care into euthanasia.” – Professor Patrick Pullicino – READ

Feb 8, 2023 – Jikkyleaks via Twitter: HOLY CRAP – This is the data for midazolam prescribing from the UKs official GP prescriber database – TWEET, Not Hospital/ICU use, – TWEET, This looks to be solely for use in nursing homes and at home – TWEET, Open Prescribing GP data – HERE

The “spike in midazolam prescription (on this *GP* database) was driven almost entirely by injectable 10mg/2ml doses (1501041T0), This was not the anxiolytic oral form. It’s a euthanasia injection.” – TWEET, DATA

2022

October 23, 2022 – Radical w/Maajid Nawaz #27 – On Midazolam, ‘End of Life “Care” Pathways’ & the Nursing Code of Conduct – with Kate Shemirani, Natural Nurse & founder of the British Nursing Alliance – WATCH

• Discussion and need for investigation on has the “Liverpool Care Pathway” using Midazolam & Morphine been replaced in name only with the ‘End of Life “Care” Pathways which also uses Midazolam & Morphine?

November 11, 2022 – Expose News: ‘Midazolam Matt’ Hancock orchestrated the Genocide of the Elderly & Vulnerable & we can prove it; He should be in Prison, not in the Jungle on National TV – READ

November 9, 2022 – IMT: Accord Healthcare launch Midazolam – Accord Healthcare is delighted to announce the launch of Midazolam 1mg/ml solution for injection/infusion, the first in their Liberandum® range which comes in a twist box containing 1 x 5ml pre-filled syringe. – READ

October 23, 2022 – Radical w/Maajid Nawaz #27: On Midazolam, ‘End of Life “Care” Pathways’ & the Nursing Code of Conduct – with Kate Shemirani – WATCH

August 14, 2022 – Radical w/Maajid Nawaz #17: On Midazolam & End of Life “Care” Pathways – A recap on previous episode and then feature medical researcher Stuart Wilkie who presents some up to date findings into End of Life Care Pathways – WATCH, Exercise Cygnus Report – ARCHIVE

July 31, 2022 – Joel Smalley Substack: We talked about Midazolam – Another perspective from Dr Pierre Kory, on the front line – READ

July 29, 2022 – Joel Smalley Substack: We need to talk about Midazolam. – My friend, Dr Mike Yeadon is very well placed to tell us. Perhaps, Matt Hancock would like to respond? – WATCH & READ

May 29, 2022 – Radical w/Maajid Nawaz #6: On Allegations of Involuntary State Euthanasia Using Midazolam – Interviews with Freelance Investigative Journalist Jacqui Deevoy, Health Scientist Dr Kevin Corbett Phd, Retired Nurse Celia Jones who is a witness and widow to Brian Boulton, Practising Nurse Elena Anamaria who is a witness and widow to Stuart Nisbet and Medical Researcher Stuart Wilkie – WATCH

January 25, 2022 – Europe Reloaded: UK Lawyer Clare Wills Harrison: Midazolam Orders and The Liverpool Care Pathway – Part 3 of 3 – READ

January 23, 2022 – Expose News: Clare Wills Harrison: Midazolam Orders and The Liverpool Care Pathway – READ

2021

August 14, 2021 – Cairns News: Are hospitals worldwide running a euthanasia program against our elderly people with the drug midazolam? – READ

August 2, 2021 – Expose News: Midazolam was used to end the lives of thousands who you were told had died of Covid-19 & an NHS document proves Staff were ordered to do it – READ

• “NHS staff were told in ‘clinical guidance for symptom control for patients with Covid-19‘ that excessive doses of morphine and midazolam should be given to ease the symptoms of Covid-19.”
• NHS: Clinical Guideline for Symptom Control for patients with COVID-19 – PDF
• “Confidential NHS documents [REF] clearly show that the elderly and vulnerable were to be denied treatment and put on the end of life pathway in response to a pandemic, and the evidence clearly shows this was put into practice.”

July 30, 2021 [First archive date] – AUSTRALIA: NSW government: End of life and palliative care medication prescribing – “Stat dose Morphine 2.5mg subcut injection plus Midazolam 2.5mg subcut injection….” – READ, ARCHIVE, CREDIT

• Morphine + Midazolam has been used for years for manageing BREATHLESSNESS in the last days of life (dated April 2017) – PDF from Archive page above

July 30, 2021 – The Telegraph: NHS made secret pandemic plan to deny care to elderly – Strategy drawn up by NHS England following 2016 pandemic planning exercise was designed to stop hospitals being overwhelmed – READ, Pandemic NHS triage and social care briefing papers – READ

July 26, 2021 – EU Times: UK ‘Treated’ The COVID-19 Elderly Patients with Midazolam, a Drug which CHOKES YOU and STOPS YOUR BREATHING – READ

July 14, 2021 – Unity News Network: MIDAZOLAM- The scandal that cannot be ignored by Jacqui Deevoy – READ, MIRROR

• “Extensive research reveals that the Liverpool Care Pathway, which was abandoned in 2014 after being deemed inhumane, was brought back in at the start of the pandemic in early 2020 and is being implemented in hospitals and care homes across the UK.”

June 16, 2021 – The Globe and Mail: Quebec nursing home often gave morphine rather than treat COVID-19 patients, inquest told – READ

June 13, 2021 – SGT REport: DEATH MERCHANTS: MORE SHOCKING EVIDENCE OF THE DEPOP AGENDA – “UK Truth journalist Jacqui Deevoy, who has had her work published by the mainstream media for more than two decades, is finding it increasingly difficult to get her articles published regarding this topic: More shocking evidence of the global depopulation agenda.”- WATCH

June 13, 2021 – Expose News: The Evidence – ‘You stayed at home, to protect the NHS, but they gave Midazolam to the Elderly and told you they were Covid Deaths’ – READ, EU Times – MIRROR

“In March 2020 the British people were told that they must “stay at home” in order to “protect the NHS” and “save lives”. They were also told that the authorities needed just “three weeks to flatten the curve”.” -WHAT IF THAT WAS A LIE!?!

June 9, 2021 – We Are News Now: interview with Jacqui Deevoy on Midazolam – WATCH

June 9, 2021 – Discerning Consciousness Podcast: Midazolam & State Sponsored Euthanasia of The Elderly: Special Guest Jacqui Deevoy – Jacqui reveals the shocking truth, gained from personal testimonies, about the misappropriate use of the drug since the start of the Covid pandemic last March. She also shares information about The Liverpool Care Pathway and how it appears to have been secretly reinstated without the consent of patients and their families. – ARCHIVE, OTHER

June 8, 2021 – Expose News: Midazolam: A story of euthanasia… #WeNeedToTalkAboutMidazolam – READ

June 7, 2021 – Daily Expose: Matt Hancock confirming the mass purchase of Midazolam in UK – WATCH

June 5, 2021 – Expose News: The Liverpool Care Pathway – #WeNeedToTalkAboutMidazolam – READ

• “The Liverpool Care Pathway (LCP) was a scheme that we’re told intended to improve the quality of care in the final hours or days of a patient’s life.”

June 4, 2021 – BREAKING NEWS!! RIGHT NOW with Gareth Icke – Episode 8: Journalist Jacqui Deevoy has an explosive story, a story of state Euthanasia that she has taken to 28 editors, which non have had the courage to publish it!! – WATCH, BACKUP

June 4, 2021 – Lawyer Clare Wills Harrison describes the horrific happenings in one ‘care’ home amid the ‘Covid’ cull of the elderly – WATCH

March 18, 2021 – The Telegraph: Care home residents put on ‘do not resuscitate’ orders without consent – More than 500 residents made subject to such orders, Care Quality Commission [CQC] says, but true number likely to be much higher – READ, ARCHIVE

2020

December 11, 2020 – FDA approved an abbreviated new drug application for midazolam injection – READ

December 9, 2020 – David Icke: The premeditated mass murder of old people worldwide – David Icke talks with real journalist Jacqui Deevoy – WATCH

December 3, 2020 – The Telegraph: Care homes using ‘do not resuscitate’ orders without consent of patients and families, report finds – Watchdog [Care Quality Commission] says ‘unlawful’ blanket orders were placed on residents at height of Covid crisis and some may still be in place – ARCHIVE

October 12, 2020 – The Telegraph: Watchdog [CQC] investigates claims of blanket Do Not Resuscitate orders in care homes -= Move follows concerns that orders were applied to groups such as residents in some care homes during first coronavirus peak – READ

• Compassion In Dying has been calling for an inquiry into the use of Do Not Attempt Resuscitation (DNAR) and Do Not Attempt Cardiopulmonary Resuscitation (DNACPR) orders during the Covid crisis.”

August 23, 2020 – The Telegraph: Care homes ‘were bullied into accepting patients with coronavirus’ [During March-April 2020] – Research also found that homes were refused treatment for residents by hospitals at the height of the pandemic – READ

August 23, 2020 – The Telegraph: NHS asked care homes to place ‘Do Not Resuscitate’ orders on all residents at height of pandemic – One in 10 staff members changed DNR plans without discussion with family members, nursing staff, or residents – ARCHIVE

• Care homes were asked by NHS managers and GPs to place blanket ‘Do not resuscitate’ (DNR) orders on all their residents at the height of the coronavirus pandemic to keep hospital beds free, a new report has found.”

August 22, 2020 – MD Linx: Critical drug shortages caused by COVID-19 – READ

August 18, 2021 – Reuters: Fact Check-UK coroner said Wayne Smith died of COVID-19 – READ

August 10, 2020 – The Centre for Evidence-Based Medicine (CEBM): Covid-19: Guidelines for Community Palliative Care – which is the ‘Best in Show’? – READ “For anxiety/agitation it recommends oral lorazepam or midazolam”

August 2, 2020 – The Telegraph: Government ‘drops pledge to test everyone in care homes for coronavirus’ [The most vulnerable population] – The decision would roll back on a promise to test more than two million residents and staff in care homes – READ

July 12, 2020 – Daily Mail – Did care homes use powerful sedatives to speed Covid deaths? Number of prescriptions for the drug midazolam doubled during height of the pandemic – READ, CREDIT

July 12, 2020 – The Sun: DRUG SCANDAL Care homes accused of using powerful sedatives to make coronavirus victims die more quickly as use rocketed 100% – READ

July 3, 2020 – The Telegraph: Covid cases were linked to patients moving from hospitals to care homes, Government report admits – The ONS separately released data showing that nearly 20,000 residents in England and Wales have died with coronavirus in their care home – READ

• “Discharging hospital patients back into care homes was an ‘important source’ of infection, government experts have admitted, as new figures show that more than half of care homes have had a confirmed case of Covid-19.”

June 29, 2020 – The Telegraph: Thousands may have died in care homes after families were ‘blocked from discharging them’ – READ

May 19, 2020 – Pharmaceutical Journal: Supplies of sedative used for COVID-19 patients diverted from France to avoid potential shortages – READ

April 25, 2020 – The Lancet: Sedating ventilated COVID-19 patients with inhalational anesthetic drugs – Orser et al – READ

April 21, 2020 – ABC News: Doctors: Execution drugs could help COVID-19 patients – A group of medical professionals is asking death penalty states for medications used both for lethal injections and to help coronavirus patients who are on ventilators – ARCHIVE, CREDIT

• “doctors asked states with the death penalty to release any stockpiles they might have of execution drugs to health care facilities.”
• “Drugs being requested include the sedative midazolam, the paralytic vecuronium bromide and the opioid fentanyl.”- putting patients on ventilators with out these drugs would be “torture”.

April 17, 2020 – “Matt Hancock, the UK health secretary, told the House of Commons Health and Social Care Select Committee on 17 April 2020 that intensive therapy unit medicines — including midazolam — are part of “a delicate supply chain” as they “are made in a relatively small number of factories around the world”” – REF, House of Commons – PDF

April 13, 2020 – The Hill: Doctors ask for death penalty drugs to treat coronavirus patients – READ, The LETTER

April 9, 2020 – CBS News: Amid rush to secure ventilators, doctors warn of shortage of crucial drugs – READ

April 6, 2020 – The Telegraph: Older people pressured into signing documents leaving them exempt from receiving CPR, charities warn – The charities said it in a statement that ‘it is crucial that we continue to protect people’s fundamental human rights’ – READ

April 3, 2020 – National Institute for Health and Care Excellence (NICE) UK: COVID-19 rapid guideline: managing symptoms (including at the end of life) in the community – NICE guideline [NG163] – ARCHIVE, Jikky Leaks- CREDIT

April 2, 2020 – Royal Collage of Anaesthetists: Guidance on potential changes to anaesthetic drug usage and administration during pandemic emergency pressures – READ

April 2, 2020 – Regulatory Focus: FDA reports shortage of sedation drug used for putting COVID-19 patients on ventilators – READ

March 31, 2020 – Stat News: A new Covid-19 problem: Shortages of medicines needed for placing patients on ventilators – READ

• “There has been a 51% increase in demand so far this month for half a dozen different sedatives and anesthetics: propofol, dexmedetomidine, etomidate, ketamine, lorazepam, and midazolam.”

March 28, 2020 – The Telegraph: Exclusive: Exercise Cygnus warned the NHS could not cope with pandemic three years ago but ‘terrifying’ results were kept secret – Ministers were informed three years ago that Britain would be quickly overwhelmed by a severe outbreak – READ, Exercise Cygnus uncovered: the pandemic warnings buried by the government  – READ

March 21, 2020 – Braun, an International Healthcare products provider in the UK – supplied 10,000 doses of the sedative midazolam to Italy “for the mechanical ventilation of thousands of COVID-19 patients who needed help breathing”…”hospitals suddenly needed three or four times the normal amount of this drug.” – READ, ARCHIVE, CREDIT

2018

2018 – WHO Guide: Integrating palliative care and symptom relief into the response to humanitarian emergencies and crises – PDF

2015

June 29, 2015 – Live Science: How Does Execution Drug Midazolam Work? – “States can still use the sedative drug midazolam in lethal injections, according to today’s Supreme Court decision.” – READ, CREDIT

2014

May 1, 2014 – Forbes: The Drugs Used In Execution By Lethal Injection – READ

• “midazolam has no analgesic, or painkilling, activity on its own. In fact, the combination of midazolam, fentanyl, and propofol are used together for what’s commonly called “conscious sedation,” a type of incomplete anesthesia that works for short, outpatient surgical procedures or changing dressings for burn patients.” – [i.e. Surgeries are not a feature of care homes- REF]

1999

1999 – American Medical Association: “Through an educational grant from the Robert Wood Johnson Foundation, the AMA Institute for Ethics’ Educating Physicians on End-of-Life Care project provides training to practicing physicians on the core skills needed to provide quality end-of-life care” – REF, AMA – TIMELINE

The post Midazolam & Morphine first appeared on Totality of Evidence.

Dr Bryan Ardis in early 2020 looked into remdesivir, on the back of losing his father-in-law to this very drug in February 2020, and revealed to the world that the NIH’s promotion of remdesivir as the only allowed hospital treatment for COVID-19 was in fact increasing mortality – a death that was certified as a COVID-19 death! Dr Ardis provides his overview of remdesivir findings at the Grand Jury inquiry – HERE.

Australia’s TGA granted provisional registration for remdesivir (Veklury) in early 2020. [1]

Giliead Sciences – the company that makes remdesivir:

• Gilead Sciences website – HERE, ARCHIVES
• Gilead Press Release – 2020 ARCHIVES
• Gilead Sciences Ongoing Response To COVID-19 – ARCHIVES
• Gilead Remdesivir Emergency Use Fact Sheets – ARCHIVE
• Remdesivir Clinical Trials – April 2020 – ARCHIVE
  • Gilead study in patients with moderate disease: NCT04292730
  • Gilead study in patients with severe disease: NCT04292899
  • NIAID study: NCT04280705
  • INSERM study: 2020-000936-23
  • China study in patient with mild/moderate disease: NCT04252664
  • China study in patients with severe disease: NCT04257656
• NASDAQ Gilead stock – HERE

Hospital Protocols force remdesivir onto patients – what hospitals are doing and how to protect yourself and your loved ones

• Death by Hospital PROTOCOL! – HERE, CREDIT
• Remdesivir stories at protocolkills.com – HERE

Following are links to aid with your own research into Remdesivir

2024

October 4, 2024 – Gateway Pundit: EXCLUSIVE: Military Whistleblower Shares his Motivation for Releasing the Explosive “The Remdesivir Papers” Report – READ under the pseudonym Daniel LeMay

October 4, 2024 – Gateway Pundit: The Remdesivir Papers: Did Service Members Deserve to Die? – READ, Remdesivir Paper – PDF

• “Data derived from the Department of Defense Joint Trauma System (JTS) by a military whistleblower offers a stark contrast to the results of multiple clinical trials involving the liberal usage of remdesivir in military treatment facilities and other civilian facilities, as well as its potential contribution to, at minimum, hundreds of untimely deaths.”
• “service members and veterans participated in at least four Phase 3 Adaptive COVID19 Treatment Trials (ACTT) between February 2020 and June 2021, to include NCT04280705 [ACTT-1], NCT04401579 [ACTT-2], NCT04492475 [ACTT-3], and NCT04640168 [ACTT-4]. Each of these trials was sponsored by the National Institute of Allergy and Infectious Diseases (NIAID).”…Another trial (NCT04302766) was sponsored by U.S. Army Medical Research and Development Command (USAMRDC). – REF
• “A true placebo, like saline, wasn’t used other than in circumstances where there were limitations on matching placebo supplies.” – both the treatment and “placebo” received remdesivir! – REF,
• “Why has the USAMRDC not published data on the number of deaths from participants in NCT04302766 nor the number of deaths of those who may not have been part of the trial itself but were treated with remdesivir in dozens of MTFs around the country?”

• September 24, 2024 – Gateway Pundit FOIA request – PDF
• “Four years later, it has been clearly determined that the use of remdesivir can result in many potential organ-based adverse effects.”
• “were deaths during remdesivir treatment trials wrongly attributed to COVID-19 when they could/should have been attributed to the use of the controversial drug?”

September 23, 2024 – Newsweek: COVID Treatment Recall Issued After Glass Found in Drug – READ

• The affected lot, identified as 47035CFA, was distributed nationwide in the United States beginning July 16, 2024.
• September 26, 2024 – CHD: Glass Particles Prompt Another Recall of Remdesivir, the Controversial Drug Hospitals Used to Treat COVID Patients – READ, CREDIT

September 20, 2024 – FDA: Gilead Issues Voluntary Nationwide Recall of One Lot of Veklury (Remdesivir) for Injection 100 mg/vial Due to the Presence of a Glass Particle – READ, CREDIT

June 2, 2024 – Arkmedic Substack: GileadGate Exposed – Rebekah Barnett’s bombshell FOIA investigation uncovers a web of vested interests in the cover-up of an identified cancer risk related to specific COVID vaccines. – READ

March 9, 2024 – Geoff Pain Substack: Remdesivir Deaths – was Endotoxin a factor? – READ

• Chemical structure of Remdesivir has organophosphate and cyanide groups but looking at symptoms, could Endotoxin contamination, as found in India, be the caused deaths?

February 2, 2024 – CHD Bus Stories: “They’re Still Killing With Remdesivir” – Nancy Wilson was “forced” to get the COVID-19 shot under mandates, she then tested positive while in hospital, multiple staff asked her to take remdesivir. She declined and took ivermectin instead. Find out how the doctors reacted – WATCH

Jan-Feb 2024 – CHD Bus Stories: Loved one’s killed by COVID-19 hospital protocols, usually involving remdesivir (a small collection of stories):

• My Wife Was Killed By Hospital Covid Protocol – Clyde “Rick” Stephenson – WATCH
• They Killed My Wife In The Hospital She Worked At – Mark Hartshorn’s wife, Jill – WATCH
• My Wife Survived Covid Hospital Protocol – Richard‘s story – WATCH
• My Daughter Snuck Ivermectin Into The Hospital – Micheal Murphy‘s story – WATCH
• Dennis tells the story of his friend, Daniel Freeman, who passed away in the hospital while being treated for the virus – WATCH
• My Husband Was Killed By Hospital Covid Protocol – Juliana‘s story – WATCH
• My Mother Died In Hospital During Covid – Kelly warning – WATCH
• My Husband Was Killed by Covid Hospital Protocol – Cynthia‘s recounts the heart-wrenching details – WATCH
• They Tried To Kill Me – WATCH
• My Momma Was Killed By Hospital Covid Protocol – Kristina Croft – WATCH
• They Killed My Healthy Husband – Jill Smith obtained over 6,000 pages of records, 60 of which listed drugs he was administered – WATCH
• My Husband Survived Hospital Covid Protocol – Robyn‘s story – WATCH
• Michelle Mixa cousin cousin die in the hospital – WATCH
• My 30 Year Old Daughter Chasity Anderson Was Killed By A Hospital Chasit – She was put on remdesivir, labeled ‘DNR,’ isolated from family and put on a ventilator, she did not make it out of the hospital alive – WATCH
• They Killed My Mom With Remdesivir – Crystal shares how her mum went to hospital with abroken hip, they tested for COVID-19 it was positive, she then fell victim to “hospital protocol” for positive test!!! – he mum had “no symptoms, whatsoever,”- WATCH
• I Survived The Hospital Covid Protocol – Valerie‘s story, more than just a lack of informed consent. While a patient, she made known her wishes about treatment and end-of-life care by writing them on her arm, yet Valerie still felt an “overwhelming fear” about her situation – WATCH
• Hospital Covid Protocol Death – In August 2021, when his parents tested positive for COVID. While his vaccinated mother was sent home, his father, who had received no COVID shots, was admitted to the hospital to receive “separate treatment.” – Wayne and Mary‘s story – WATCH
• My Dad Was Killed By Remdesivir – story of Renee’s father – WATCH
• My Husband Ray Was Killed By Covid Hospital Protocol – WATCH
• My Husband Survived Hospital Protocol – as an employee of the pharmaceutical industry she was shocked and surprised – WATCH
• My Dad Was Killed By Hospital Protocol –Andy‘s story – WATCH
• Hospital Hostage Rescue – Within hours of being admitted, Gail Seiler remembers being told by a doctor that she was going to die but that “the only hope” she had for survival “was remdesivir and a vent.” – WATCH
• They Killed My Mom – Elizabeth Kucker‘s story – WATCH
• My Mom Was Killed By Covid Hospital Protocol after 53 days – Genny Rodriguez‘s story, find out what she uncovered from the medical records after the fact. – WATCH
• My Husband Was Killed By Hospital Protocol – Liz recounts Kevin’s tragic death – WATCH
• They Killed My Husband – Vanessa Tilley speaks out – WATCH
• Covid Hospital Protocol Killed My Husband – Lisa Butler shares her husband’s medical records – WATCH

2023

October 18, 2023 – Daily Clout c/ Dr Naomi Wolf: Grace’s Dad (Scott Schara) Tells Heartbreaking Story of His Daughter’s Murder at Hospital – WATCH

• He and his family lost their lovely, ebullient, formerly perfectly healthy 19-year-old daughter Grace at Ascension Hospital after she was admitted with COVID and an unlawful “Do Not Resuscitate” notification was placed, against her family’s will, in her records.

August 9, 2023 – The Dossier Substack by Jordan Schachtel: Fauci successor at NIAID peddled dangerous Remdesivir drug as ‘silver bullet’ against Covid-19-Dr. Jeanne Marrazzo tried to use unsafe antiviral IV drug on every covid hospitalized patient at UAB. – READ

August 9, 2023 – Rounding the Earth Substack: BOMBSHELL: New FOIA Documents Reveal the COVID Pandemic Was a DoD Operation Dating Back to Obama – Jeanne Marrazzo has been queened to replace Fauci as head of NIAID – insights – READ

• July 2020, Marrazzo at University of Alabama called using HCQ as “irresponsible and despicable” – she is funded by Gilead pharma for remdesivir trials!

July 28, 2023 – American Thinker: ‘It’s Murder’: Remdesivir Victims Decry FDA’s Shocking New Move by Stella Paul – READ, CREDIT

• “Remdesivir may be the most despised drug in American history, earning the nickname ‘Run Death Is Near’ for its lethal record during COVID.””

July 24, 2020 – Testimonial – Remdesivir’s typical trail of destruction, knocked out kidneys in 9 days – TWEET , So sorry for your loss Dawn.

July 10, 2023 – Ethical Skeptic: Those who have made arguments that Remdesivir was deadly, have a data to back their contention as a hypothesis. – THREAD

• Non-Alcohol related Liver Mortality did not arrive with Covid, it arrived with Remdesivir. Now this ICD set has recovered fully to PFE-baseline

May 30, 2023 – Brownstone Institute: Why Are Hospitals Still Using Remdesivir? – Two smoking guns – READ

• “Alas, the federal government insisted that if hospitals wanted to get paid, they had to treat Covid patients with Remdesivir. The fact that this drug was made by their good friends at Gilead Science and everybody was getting rich from the deals they cut had absolutely nothing to do with it, of course. It was all done for love of the people. But just to make sure that Remdesivir could attain its current billion-dollar status, the feds incentivized hospitals with a 20 percent boost to the entire hospital bill of patients treated with Remdesivir. “

• CMS.gov – still paying on Veklury (remdesivir) til September 30, 2023, even though emergency officially ended – ARCHIVE, [January 21, 2022 – FDA granted supplemetal approval remdesivir for COVID-19, April 25, 2022 EUA revoked

• “The 20 largest hospitals enjoyed a 62 percent increase in their combined net assets during those glorious Covid years, providing many top executives with a $10 million salary or more.” Open Books – READ

May 26, 2023 – CHD Th Peoples Testament: COVID Vaccine Injured Police Officer Killed by Remdesivir – guest Karlyn Swoap – WATCH

May 7, 2023 – C’s Newsletter Substack by Charles Wright: The Duality of Steve Kirsch – Remdesivir and Vaccine Adverse Events. – READ

• Steve Kirsch established Covid Early Treatment Fund (CETF) in April 2020,
• He let Rockefeller Philanthropy Advisors manage the fund
• Kirsch’s CETF funded research on several chemical compounds, including Remdesivir.
• Mr. Kirsch also reported on Twitter that he had a friend at Gilead, the patent holder of Remdesivir.
• [Reserve your judgement of Steve Kirsch based on his funding of this product at this point in time (April 2020) I’d suggest he was just trying to find an answer, he explains his early journey on June 2021 podcast with Bret Wienstien and Dr Robert Malone. I place this information here to capture the big picture. Everyone is on a journey of “discovery”!]

March 15, 2023 – The Expose: Remdesivir estimated to have killed 100,000 Americans – READ

2022

October 27, 2022 – The Highwire Ep 291 – REMDESIVIR NIGHTMARE: “I ABSOLUTELY BLAME THE HOSPITAL FOR HIS DEATH” – interview with two widows whose husbands lost their lives while on the same COVID-19 treatment protocol at Beaumont Hospital in Michigan – WATCH, FULL

October 18, 2022 – Nature Communications: Effect of remdesivir post hospitalization for COVID-19 infection from the randomized SOLIDARITY Finland trial – Nevalainen et al – READ

September 26, 2022 – Vigilant Fox: Incentivized to KILL: Prescribe Remdesivir, and We’ll Give You a 20% Bonus – EXCERPT, WATCH, Interview with Steve Kirsch – SOURCE, More Dr Marik – HERE

“The hospital bill, the average, is about $400,000 to $500,000 per COVID patient — PER COVID patient.”
[So that’s an $80,000 to $100,000 BONUS]

Dr Paul Marik

September 22, 2022 – The Highwire Ep 286 – LAWYERS SUE HOSPITALS FOR REMDESIVIR DEATHS [ALARMING] – WATCH, FULL

• The Fauci promoted NIH Remdesivir RCT clinical trail started Feb 21, 2020 enrolling 1100 individuals, it concluded that patients had a “31% better chance of recovering and getting out of the hospital”
• They changed the trial endpoints from reduced mortality, to days in hospital. They unblinded patient and discharged treatment group from hospital early!
• Anyone who came to a hospital and “diagnosed” with COVID-19 were put on remdesivir. Hospitals incentivised, patients restrained to beds with cable ties, drugged with morphine, starved, dehydrated, phone remove and isolated from their family – the average time to death on remdesivir is 9 days! = torture
• Patients threatened if they leave hospital against medical advice, insurance won’t cover hospital cost = blackmail
• Lawyers have thousands of alarmingly similar testimonies across 32 states.
• Some clients received 30-40 different drugs, many contraindicated with remdesivir!

September 7, 2022 – Towards The Light: Remdesivir deaths press conference – Fresno, California – WATCH

August 16, 2022 – Gilead PRESS RELEASE: Veklury® (Remdesivir) Demonstrates Continued In Vitro Antiviral Activity Against Omicron Subvariants, Including BA.4 and BA.5 – READ, ARCHIVE

July 30, 2022 – Arkmedic Substack: Welcome to Gilead – A scientific scandal with huge implications for women’s health is brewing and you weren’t going to hear about it – until now – Women’s cancer to accelerate – READ

• Another paper “Spike Impairs DNA Damage Repair” RETRACTED! [peer review or peer pressure!]
• “…if my suspicions are correct the paper that I’m going to discuss shows that women in every developed country are at risk of a tsunami of women’s cancers.”

July 15, 2022 – Vaccine Safety Research Foundation Episode #38: The Tragedy of Remdesivir – WATCH

April 22, 2022 – WHO now recomends remdesivir – READ, CREDIT

• “On 22 April 2022, following publication of new data from a clinical trial looking at the outcome of admission to hospital, WHO now suggests the use of remdesivir in mild or moderate COVID-19 patients who are at high risk of hospitalization.”

April 21, 2022 – Gilead Statement on WHO Recommendation of Veklury® (Remdesivir) and Acceleration of Prequalification Submission – READ, ARCHIVE

• “World Health Organization’s (WHO) Therapeutics and COVID-19: living guideline, which now conditionally recommends Veklury® (remdesivir) for use in the treatment of patients with non-severe COVID-19 at the highest risk of hospitalization.” – WHO document – ARCHIVE
• “The revised recommendation is based on evidence from our Phase 3 double-blind, placebo-controlled trial (PINETREE) demonstrating that a three-day course of Veklury treatment significantly reduced the risk of hospitalization for non-hospitalized patients at high risk of disease progression.” [They’re testing remdesivir as EARLY treatment – finally!!! – so like Hydroxychloroquine but remdesivir is highly TOXIC]

February 23, 2022 – Stew Peters: REMDESIVIR HAS BEEN AUTHORIZED FOR USE IN INFANTS – w/ Ali Shultz – infants separated from parents and force remdesivir – WATCH, CREDIT

February 5, 2022 – TGAustralia: TGA approves provisional determination for Gilead Sciences Pty Ltd for COVID-19 treatment, VEKLURY (remdesivir), for proposed use in children and adults who are at risk of progressing to severe COVID-19 – ARCHIVE

February 2, 2022 – The Water Cooler w/ David Brody: Dr. Paul Marik Calls Remdesivir Policy an “Absolute Disgrace” – WATCH, CREDIT

January 21, 2022 – The David Knight Show: HHS Targets Kids, Ends Adult Data Collection – on EUA of Remdesivir for children – WATCH, CREDIT,

• David Knight summarizes the history of Veklury® (remdesivir) and raises the issue of data manipulation regarding the health of children

January 21, 2022 – FDA PRESS RELEASE: FDA Takes Actions to Expand Use of Treatment for Outpatients with Mild-to-Moderate COVID-19 and to pediatric population down to 3.5kg weight! – READ Three days later monoclonal antibodies were removed as an early treatment option!

January 21, 2022 – Gilead PRESS RELEASE: FDA Approves Veklury® (Remdesivir) for the Treatment of Non-Hospitalized Patients at High Risk for COVID-19 Disease Progression – READ

• “Approval Based on Phase 3 Data Showing Veklury Significantly Reduced Risk of Hospitalization By 87% Compared with Placebo”
• NIH Guidelines Recommend Veklury for the Treatment of Non-Hospitalized Patients at High Risk
• FDA Expands Pediatric Emergency Use Authorization (EUA) to Include Treatment of Non-Hospitalized Pediatric Patients at High Risk

January 27, 2022- NEJM – Early Remdesivir to Prevent Progression to Severe COVID-19 in Outpatients (3-day course remdesivir) – READ

2021

November 17, 2021 – Association of American Physicians and Surgeons (AAPS): Biden’s Bounty on Your Life: Hospitals’ Incentive Payments for COVID-19 – READ

• The ‘Coronavirus Aid, Relief, and Economic Security Act’’ or the ‘‘CARES Act’’ March 27, 2020 allowed for these incentives

• “A 20 percent “boost” bonus payment from Medicare on the entire hospital bill for use of remdesivir instead of medicines such as Ivermectin.”

October 18, 2021 – The Blaze: Horowitz: The $cience of remdesivir vs. ivermectin: A tale of two drugs – READ, ARCHIVE

• “A tale of two drugs. One has become the standard of care at an astronomical cost despite studies showing negative efficacy, despite causing severe renal failure and liver damage, and despite zero use outpatient. The other has been safely administered to billions for river blindness and now hundreds of millions for COVID throughout the world and has turned around people at death’s doorstep for pennies on the dollar.”

October 13, 2021 – Cardiovascular Toxicity: Potential cardiotoxic effects of remdesivir on cardiovascular system: a literature review. (Remdesivir is substantially more cardio-toxic than chloroquine) – READ, WATCH

~August 27, 2021 – Awaken America tour: Dr Brian Ardis warns about remdesivir – WATCH, CREDIT

July 15, 2021 – JAMA Network Open: Association of Remdesivir Treatment With Survival and Length of Hospital Stay Among US Veterans Hospitalized With COVID-19 – Ohl et al – READ, CREDIT [toxicity of remdesivir is revealed]

• “In this cohort study of US veterans hospitalized with COVID-19 at Veterans Affairs facilities, remdesivir treatment was associated with prolonged hospitalization but was not associated with improved survival.”

July 8, 2021 – In the US “COVID-19 Treatment Guidelines”, the NIH knows remdesivir is associated with renal toxicity – See Table 2e pg. 153 – HERE, ARCHIVE, WATCH The table is now referred to as Table 2f – HERE

April 22, 2021 – E Clinical Medicine: Efficacy of the TMPRSS2 inhibitor camostat mesilate in patients hospitalized with Covid-19-a double-blind randomized controlled trial – Gunst et al – PDF , FUNDING, ARCHIVE, Danish study – READ,

• In this comostat mesiliate trial “some patients received remdesivir and/or dexamethasone as standard of care”!! – CREDIT
  • ““Remdesivir was administered to 96 participants; 64 (47%) in the camostat group and 32 (47%) in the placebo group.”” The study had a total of 208 participants in total of which 46% received remdesivir!
• The study found “that 200 mg t.i.d. camostat mesilate is not an effective treatment for hospitalized patients with Covid-19”

April 17, 2021 – India – COVID-19: Remdesivir price slashed by nearly Rs 2000 post govt intervention – READ

April 2021 – Remdesivir and acute renal failure: a potential safety signal from disproportionality analysis of the WHO safety database. (Remdesivir was found to have a 20-fold higher renal failure rate compared to three comparable drugs: hydroxychloroquine, tocilizumab, and lopinavir/ritonavir) – READ, WATCH

May 10, 2021 – National Center for Global Health and Medicine (NCGM) JAPAN: Flowchart for the Treatment of COVID-19 in NCGM (adults) 3rd Edition – PDF, ARCHIVE, (NCGM date back to 1868! – PDF)

• NCGHM were intimately involved in the management of the Diamond Princess cruise ship and the early trials with Remdesivir.

March 18, 2021 – American Society of Microbiology: Remdesivir for COVID-19: Why Not Dose Higher? – READ, Funded by Steve Kirsh foundation – CREDIT

January 31, 2021 – Forbes: The Strange Story Of Remdesivir, A Covid Drug That Doesn’t Work – READ, ARCHIVE, CREDIT

• “After authorization, remdesivir quickly became the standard-of-care drug in the U.S. Despite evidence of limited efficacy and serious side effects, the U.S. government paid hospitals a 20% upcharge for following the remdesivir protocol, plus an additional bonus.”

January 4, 2021 – WCPO: A new study from the University of Cincinnati is raising concerns about the safety of the FDA approved COVID-19 treatment Remdesivir – WATCH, CREDIT

January 2, 2021 – Springer: Remdesivir in Coronavirus Disease 2019 (COVID-19) treatment: a review of evidence by Jaime Lin et al – READ

• “Remdesivir, an investigational broad-spectrum antiviral agent has previously demonstrated in vitro activity against Severe Acute Respiratory Syndrome Coronavirus 2 (SARS-CoV-2), and in vivo efficacy against other related coronaviruses in animal models.”

2020

November 20, 2020 – NBC News: Remdesivir shouldn’t be used on hospitalized COVID-19 patients, WHO advises (as there is no evidence it improves survival or reduces the need for ventilation). “Remdesivir has potential side-effects on the kidneys, according to data Gilead shared with the European Medicines Agency” – READ, ARCHIVE, READ2

November 20, 2020 – WHO: WHO recommends against the use of remdesivir in COVID-19 patients – ARCHIVE, CREDIT

• “WHO has issued a conditional recommendation against the use of remdesivir in hospitalized patients, regardless of disease severity, as there is currently no evidence that remdesivir improves survival and other outcomes in these patients.”
• “On 22 April 2022, following publication of new data from a clinical trial looking at the outcome of admission to hospital, WHO now suggests the use of remdesivir in mild or moderate COVID-19 patients who are at high risk of hospitalization” – REF

November 19, 2020 – BMJ: WHO Guideline Development Group advises against use of remdesivir for covid-19 – READ

November 5, 2020 – NEJM: Remdesivir for the Treatment of Covid-19 — Final Report by Beigel et al [NIH paper] – READ, CNN – this study was used to gain FDA approval – READ

Dr Alexander discussion re paper – SUBSTACK

• Study design tampering “they made a non patient important outcome (time to recovery), the primary outcome.”
• “the NIH highly touted and flaunted study that did not report or focus on patient-important objective outcomes and only on reduced time to recovery, was deeply flawed methodologically.” – REF

November 4, 2020 – Under it’s New COVID-19 Treatments Add-On Payment (NCTAP) US CMS.gov provides a 20% bonus payment on the entire hospital bill, just if they administer remdesivir. – LINK, LINK2, WATCH Compared to other treatments remdesivir is below inferior (look at cost of the drugs vs those approved!)!

October 29, 2020 – Pulitzer Center: The ‘Very, Very Bad Look’ of Remdesivir, the First FDA-Approved COVID-19 Drug – READ

• On October 15, 2020 “The World Health Organization’s (WHO’s) Solidarity trial showed that remdesivir does not reduce mortality or the time COVID-19 patients take to recover.”
• Science has learned that both FDA’s decision and the EU deal came about under unusual circumstances that gave the company important advantages.” The FDA did not consult their Antimicrobial Drugs Advisory Committee (ADAC).
• The European Union settle on the remdesivir pricing exactly 1 week before the disappointing Solidarity trial results came out – a $1 billion deal!

October 28, 2020 – Science Innsider: The ‘very, very bad look’ of remdesivir, the first FDA-approved COVID-19 drug – The Food and Drug Administration held no advisory meeting on antiviral, and the European Union signed contract without knowing of failed trial – READ

• Gilead Sciences, On 8 October, 2020 Gilead Sciences signed an agreement to supply the European Union with its drug remdesivir as a treatment for COVID-19—a deal potentially worth more than $1 billion. Two weeks later, on 22 October, the U.S. FDA approved remdesivir for hopitalised COVID-19 patients in the United States—the first drug to receive that status.

October 25, 2020 – Vox: The FDA approved remdesivir to treat Covid-19. Scientists are questioning the evidence – READ, CREDIT

October 23, 2020 – NBC News: FDA approves first drug for COVID-19: remdesivir. No other Covid-19 drugs have received FDA approval. – READ

October 22, 2020 – The Highwire Ep 186: FAUCI’S REMDESIVIR ‘FALLS FLAT’ – WATCH, BITCHUTE, FULL

• “In April, Dr. Fauci said the repurposed antiviral, Remdesivir, showed a “clear-cut, significant, positive effect in diminishing the time to recovery.” However, the WHO has now released the findings of its ‘Solidarity Trial,’ encompassing 400 hospitals around the world. Results indicate the drug has ‘fallen flat,’ prompting the WHO to declare it has “little to no effect” on hospitalized COVID-19 patients.”
• “This is just a drug looking for a purpose” says Del

October 22, 2020 – CNN: Remdesivir becomes first Covid-19 treatment to receive FDA approval – READ

October 22, 2020 – FDA: FDA Approves First Treatment for COVID-19 – READ, Label for Veklury – PDF

• Approved “antiviral drug Veklury (remdesivir) for use in adult and pediatric patients 12 years of age and older and weighing at least 40 kilograms (about 88 pounds) for the treatment of COVID-19 requiring hospitalization.

October 22, 2020 – FDA’s approval of Veklury (remdesivir) for the treatment of COVID-19—the science of safety and effectiveness – READ, REF, Gilead letter – PDF, Product label – PDF

• Approved for adult patients and children (12 years of age and older and weighing at least 40 kg) requiring hospitalization – “the first drug approved to treat COVID-19“
• “This approval does not include the entire population that had been authorized to use Veklury under a mechanism called emergency use authorization (EUA), which is not the same as approval.
• “FDA also revised the EUA for Veklury, originally issued on May 1, 2020, to permit the drug’s use for treatment of suspected or laboratory confirmed COVID-19 in hospitalized pediatric patients weighing 3.5 kg to less than 40 kg or hospitalized pediatric patients less than 12 years of age weighing at least 3.5 kg.”
• “Gilead submitted a study published in the New England Journal of Medicine that showed the drug shortened the course of illness from an average of 15 days to about 11 days in hospitalized patients.” – REF, Study not peer reviewd until Nov 2020 – STUDY – Time to recovery a poor primary endpoint – SUBSTACK

October 20, 2020 – Reuters: EU makes 1 billion-euro bet on Gilead’s COVID drug before trial results – The European Union agreed to pay > 1 billion euros (USD$1.2 billion) to Gilead for a six-month supply of its antiviral drug remdesivir, before the publication of final results of the biggest trial of the COVID-19 medication “The agency [WHO] is investigating remdesivir’s potential adverse effects on kidneys”. – READ

October 16, 2020 – Science: Remdesivir and interferon fall flat in WHO’s megastudy of COVID-19 treatments – READ, ALT

October 15, 2020 – PRESS RELEASE: Gilead Sciences Statement on the Solidarity Trial – READ, ARCHIVE

• “We are concerned that the data from this open-label global trial have not undergone the rigorous review required to allow for constructive scientific discussion, particularly given the limitations of the trial design.”

October 15, 2020 – NEJM: Repurposed antiviral drugs for COVID-19 –interim WHO SOLIDARITY trial results – READ, preprint date – READ2, WHO SOLIDARITY TRIAL COVID-19 core protocol – PDF

• WHO funded SOLIDARITY trial included: “405 hospitals in 30 countries, 11,330 adults underwent randomization; 2750 were assigned to receive remdesivir, 954 to hydroxychloroquine, 1411 to lopinavir (without interferon), 2063 to interferon (including 651 to interferon plus lopinavir), and 4088 to no trial drug.”
• ALL had “little or no effect on hospitalized patients with Covid-19, as indicated by overall mortality, initiation of ventilation, and duration of hospital stay.”
• The regimen for remdesivir (intravenous) was 200 mg on day 0 and 100 mg on days 1 through 9.
• [note: hydroxychloroquine was not being used in patients this late by the frontline doctors – MORE]

October 15, 2020 – HHS | Public Health Emergency: Veklury (remdesivir): ASPR’s Portfolio of COVID-19 Medical Countermeasures under Investigation – ARCHIVE, SOURCE, READ, Includes timeline, FAQ and distribution linkes for Veklury!

• “October 1, 2020: Updated EUA released; USG oversight of the allocation and distribution of Veklury (remdesivir) is no longer required as supply is greater than demand by U.S. hospitals….”
• About the Agreement with Gilead Science, Inc. and AmerisourceBergen (the sole distributor for remdesivir) – ARCHIVE [FYI these drug wholesaler merged in 2001 – REF]

October 3, 2020 – The Lancet correspondence: Remdesivir and COVID-19 – READ

September 16, 2020 – Infectious Diseases Society of America (IDSA) | COVID-19 Real-Time Learning Network – curated review of key information and literature about Remdesivir [cites research studies]- ARCHIVE

• IDSA funded by CDC grant number 6 NU50CK000477-04-01
  • American Hostital Association (AHA LLN) funded by same grant CDC grant number 6 NU50CK000477-04-01 – REF
  • CDC grant also for serological, antigen and molecular diagnostic testing studies – REF

• August 21, 2020 – Effect of Remdesivir vs Standard Care on Clinical Status at 11 Days in Patients With Moderate COVID-19: A Randomized Clinical Trial – Spinner et al – READ
• May 22, 2020 – NEJM (Preprint): Remdesivir for the Treatment of Covid-19 — Final Report by Beigel et al ACTT-1 Study Group Members – READ (Adaptive COVID-19 Treatment Trial (ACTT): An NIH-sponsored randomized, double-blind, placebo-controlled adaptive trial – TRIAL)
  • Trial protocol CHANGED mid trial! Originally had “death” on thier “7-point ordinal scale ” for primary outcome measure (Feb 21, 2020) – ARCHIVE, by April 27, 2020 they changed the trial design to be only “Time to recovery” as primary outcome measure – ARCHIVE [See Feb 21, 2020 below for screenshots]
• May 27, 2020 – SIMPLE-Severe Trial: Gilead-sponsored multinational, open-label trial of remdesivir in patients with severe COVID-19 – NEJM: Remdesivir for 5 or 10 Days in Patients with Severe Covid-19 by Goldman et al – READ, Clinical Trial protocol (Dec 31, 2019) – READ
• April 29, 2020 – The Lancet: Remdesivir in adults with severe COVID-19: a randomised, double-blind, placebo-controlled, multicentre trial – Wang et al – READ, ARCHIVE – In China “Due to under-enrollment, the trial was stopped early and was likely under-powered.”
• Other Remdesivir clinical trials – SEARCH, ARCHIVE

September 11, 2020 – HHS | Office of the Assistant Secretary for Preparedness and Response (ASPR): Update and Guidance on U.S . Government Allocation and Distribution of Remdesivir – Unclassified – SLIDES, ARCHIVE

• US govt received 940,000 “vials” DONATED by Gilead, HHS purchases 500,000 “treatment courses” from July-Sept 2020 – at 6.25 vials/ave course = 3,125,000 vials+ – SLIDE 6, As of Sept 10, 2020 the HHS has allocated 76,644 cases (3,065,760 vials or 490,522 treatment courses) -see Slide 10
• Hospitals report data into “HHS Protect” (SLIDE 11) – “HHS Protect is a secure decision-making and operations platform for the whole-of-government response to the COVID-19 pandemic.” – PDF

August 28, 2020 – PRESS RELEASE: Gilead’s Investigational Antiviral Veklury® (Remdesivir) Receives U.S. Food and Drug Administration Emergency Use Authorization for the Treatment of Patients With Moderate COVID-19 – Expands Previous Authorization of Veklury to Treat Hospitalized Patients with COVID-19 Regardless of Oxygen Status – READ, old READ

• A “submission of a New Drug Application (NDA) to the FDA for remdesivir under the name Veklury®”
• The Emergency use “authorization is temporary and may be revoked, and does not take the place of the formal new drug application submission, review and approval process.”

August 13, 2020- Clin. Epid. & Global Heath: Remdesivir and its antiviral activity against COVID-19: A systematic review – READ

July 10, 2020 – Nature Medicine: Extrapulmonary manifestations of COVID-19 – READ, WATCH

• These are all side effects of remdesivir, yet the study concludes they are attributed to the virus SARS-CoV-2:
  
  “Although COVID-19 is most well known for causing substantial respiratory pathology, it can also result in several extrapulmonary manifestations. These conditions include thrombotic complications, myocardial dysfunction and arrhythmia, acute coronary syndromes, acute kidney injury, gastrointestinal symptoms, hepatocellular injury, hyperglycemia and ketosis, neurologic illnesses, ocular symptoms, and dermatologic complications.”

June 30, 2020 – Case report study of the first five COVID-19 patients treated with remdesivir in France (the remdesivir treatment was interrupted in 4 out of 5 patients) – READ, WATCH

June 30, 2020 – The Guardian: US secures world stock of key Covid-19 drug remdesivir – No other country will be able to buy remdesivir, … – READ, CREDIT

June 28, 2020 – HHS signed a memorandum of agreement with Gilead Sciences, Inc – READ, SOURCE

June 11, 2020 – NEJM – Compassionate Use of Remdesivir for Patients with Severe COVID-19 (study by Gilead 10 days of drug of which 60% patients reported adverse events including acute kidney failure) – READ, WATCH

May 28, 2020 – The Lancet – Remdesivir in adults with severe COVID-19: a randomised, double-blind, placebo-controlled, multicentre trial by Wang et al – READ, PDF, (note this was in preprint April 29, 2020), Dr Alexander – SUBSTACK

• “In adult patients admitted to hospital for severe COVID-19, “remdesivir was not associated with statistically significant clinical benefits.”
• Furthermore, and very alarmingly, adverse events were reported in “102 (66%) of 155 remdesivir recipients versus 50 (64%) of 78 placebo recipients.” –REF

May 27, 2020 – NEJM: Remdesivir for 5 or 10 Days in Patients with Severe Covid-19 by Goldman et al – READ

• SIMPLE-Severe Trial: Gilead-sponsored multinational, open-label trial of remdesivir in patients with severe COVID-19 – SOURCE

May 26, 2020 – MedRxiv Preprint: Remdesivir use in patients with coronavirus COVID-19 disease: a systematic review and meta-analysis of the Chinese Lancet trial with the NIH trial – by Paul Alexander et al – READ, CREDIT

• Dr Alexander “when working for the World Health Organization (WHO) and the Pan American Health Organiization in Washington DC, published a paper in May 2020 that served to promote the use of Remdesivir. It was simply a review of 2 clinical trials that claimed a reduction in time to recovery and reduced risk of Serious Adverse Events” – REF

May 16, 2020 – The Lancet: Remdesivir in adults with severe COVID-19: a randomised, double-blind, placebo-controlled, multicentre trial – Wang et al (China study of remdesivir) – READ, CREDIT

• “No patients were enrolled after March 12 [2020], because of the control of the outbreak in Wuhan and on the basis of the termination criteria specified in the protocol, the data safety and monitoring board recommended that the study be terminated and data analysed on March 29.”
• “Remdesivir was stopped early because of adverse events in 18 (12%) patients versus four (5%) patients who stopped placebo early.” …[A]dverse events including gastrointestinal symptoms (anorexia, nausea, and vomiting), aminotransferase or bilirubin increases, and worsened cardiopulmonary status.

May 14, 2020 – Bloomberg: All eyes on Gilead – READ, ARCHIVE, Wikipedia – CREDIT, Comments from “Ken Kent, Gilead’s vice president in charge of chemical development and manufacturing…”

• “In mid-January [2020], Kent got a call from Reza Oliyai, senior vice president for Gilead’s pharmaceutical operations, telling him the company would need to make large quantities of remdesivir to fight the novel coronavirus.”
• “Remdesivir is tricky to produce—the monthslong process involves 70 raw materials, reagents, and catalysts”… and approximately “25 chemical steps in the production process. Most drugs require about half that number. Some of the steps are more delicate than others. An early one uses a reagent so flammable it will spontaneously combust if exposed to air. Another involves a poison called trimethylsilyl cyanide.” – REF
  • Symptoms of cyanide poisoning includes kidney failure, the same symptom remdesivir recipients often experience!
• “The original end-to-end manufacturing process required 9 to 12 months to go from raw materials at contract manufacturers to finished product, but after restarting production in January 2020, Gilead Sciences was able to find ways to reduce the production time to six months” – REF

May 7, 2020 – Japan approves Gilead Sciences’ remdesivir as COVID-19 drug – READ

May 7, 2020 – PRESS RELEASE: Gilead Announces Approval of Veklury® (remdesivir) in Japan for Patients With Severe COVID-19 – READ, ARCHIVE

May 4, 2020 – Dr Shiva Ayyadurai: Dr.SHIVA LIVE: The Truth About Remdesivir & Immune Health. A CytoSolve Analysis – presentation on viruses, the immune system and remdesivir – WATCH, What is Cytosolve? – EXCERPT, FULL, BACKUP –

• Remdesivir triphosphate (RDV-TP) (Gilead # GS-441524) inhibits the viral enzyme RNA-dependent RNA Polymerase (RDRP) – it mimics Adenine. RDRP is necessary for viral RNA replication in cells
• Gilead trial discussed – remdesivir – 71% (5 day tmt arm) and 74% (10 day tmt arm) people had ADVERSE EFFECTS!, [no placebo group], which included Acute Respiratory Failure & Liver dysfunction! – EXCERPT

May 1, 2020: FDA issued an Emergency Use Authorization (EUA) for the emergency use of Veklury® (remdesivir) for treatment of hospitalized patients with severe 2019 coronavirus disease (COVID-19) – PDF, ARCHIVES, Remdesivir – FDA

• On January 21, 2022 – the EUA was REVOKED

April 30, 2020 – The Highwire Ep 161: CORONAVIRUS: A NATION DIVIDED – segment on Chloroquine vs. Remdesivir – WATCH, FULL

April 29, 2020 – Time Magazine: Remdesivir Receives FDA Emergency Use Authorization After Promising Results as a Coronavirus Treatment – READ

April 29, 2020 – NY Post: Dr. Fauci praises remdesivir after breakthrough in coronavirus treatment – WATCH & READ, In the Whitehouse – EXCERPT

• “reduced coronavirus recovery time” – [the trial was not complete and the endpoint were changed after the trial was set]

April 29, 2020 – NY Post: Gilead says remdesivir shows ‘positive’ signs for coronavirus treatment – READ

• The firm teased an upcoming briefing by NIAID [Dr Fauci] that would offer “detailed information” about the results.
• “The company also announced its own study showed that 62% of patients treated early with remdesivir were discharged from the hospital, compared with 49% of patients who were treated late.”

April 29, 2020 – LA Times: Clinical trial of remdesivir may be a turning point in coronavirus fight – READ

• Government researches suggest antiviral medication remdesivir helped patients with advanced COVID-19 recover 31% faster than a placebo treatment. – 1,063 patients enrolled in trial

• “The early results, emerging from a large clinical trial sponsored by the National Institute of Allergy and Infectious Diseases, appears to position the drug as the standard therapy for hospitalized COVID-19 patients going forward.”
• “the benefits were so clear that researchers halted this portion of the trial early. As they move on to investigate other drugs against COVID-19, researchers will give all trial participants remdesivir and will make the antiviral the new standard against which other drugs are compared, Fauci said.”
• [Dr Marik comments the trial was fraudulent – WATCH]
• China study with remdesivir found “no significant difference in how sick patients became or how quickly they recovered” – The Lancet – STUDY

“What [the clinical trial] has proven is that a drug can block this virus,”…“This drug happens to be blocking an enzyme that the virus uses.”

Fauci said on Wednesday in the Oval Office of the White House

April 29, 2020 – Gilead PRESS RELEASE – Gilead Sciences Statement on Positive Data Emerging From National Institute of Allergy and Infectious Diseases’ Study of Investigational Antiviral Remdesivir for COVID-19 – READ, ARCHIVE

April 29, 2020 – Gilead PRESS RELEASE – Gilead Announces Results From Phase 3 Trial of Investigational Antiviral Remdesivir in Patients With Severe COVID-19 – Study Demonstrates Similar Efficacy with 5- and 10-Day Dosing Durations of Remdesivir – READ, ARCHIVE

April 29, 2020 – The Lancet: Remdesivir in adults with severe COVID-19: a randomised, double-blind, placebo-controlled, multicentre trial – Wang et al (CHINA) – READ, LA Times – ARTICLE

• Hospitalised patients – 158 received remdesivir (GS-5734) and 79 placebo
• the found “no significant difference in how sick patients became or how quickly they recovered” – ARTICLE
  [Yet the same day this was published Fauci announced remdesivir as the standard of care for COVID-19 in hospitals in the US]
• “Adverse events were reported in 102 (66%) of 155 remdesivir recipients versus 50 (64%) of 78 placebo recipients. Remdesivir was stopped early because of adverse events in 18 (12%) patients versus four (5%) patients who stopped placebo early.”
• [Note LA Times claimed remdesivir was “used effectively against Ebola” this is untrue, it was pulled from the ebola trials, it was increasing mortality!- ARTICLE]

April 26, 2020 – COVID-19 Early Treatment Fund: Entrepreneur and philanthropist Steve Kirsch founded CETF to fund outpatient clinical trials of repurposed drugs – Website first ARCHIVED, READ,

• “This site describes the fastest way to defeat the virus.” Early treatment FAQ – READ

• Remdesivir was top of the list! – ARCHIVE
• Clinical Trials @ Aug 2020 – ARCHIVE, now – READ

April 24, 2020 – CNBC: Coronavirus: Remdesivir had no effect on patients, according to leaked Gilead study on using Remdesivir to treat Covid-19 – Hannah Kuckler, Financial Times – WATCH, CREDIT

• WHO allegedly prematurely published results from the first RCT on Remdesivir conducted in China where 237 patients were enrolled of which 158 were given remdesivir (the study planned to enrol 453 but fell short!). Mortality at 28 days was 13.9% drug, 12.8% placebo control
• But Gilead believe the WHO’s post had ‘inappropriate characterization of the study’
• Note on Feb 2, 2020 – 50 Tons of Vitamin C was trucked into Wuhan for healthcare workers etc, and even IV vit C trials couldn’t enrol enough patients – HERE

April 21, 2020 – Defense Visual Information Distribution Service: Fort Detrick Installation Utilizes Whole of Government Approach to Tackle COVID-19 – READ, CREDIT

• “While USAMRDC scientists hope to have a vaccine available within 12-18 months, they are also utilizing their extensive laboratory capabilities to rapidly advance COVID-19 antiviral treatments. The U.S. Army Medical Research Institute of Infectious Diseases (USAMRIID), located on Fort Detrick, has consistently been at the forefront of the discovery and development of biodefense therapeutics, including remdesivir, mAB114 and ZMapp, which were used during the 2018-2020 Ebola virus disease outbreak in the Democratic Republic of Congo” [so they knew remdesivir’s high mortality rate]

April 19, 2020 – In Jan & Feb 2020 remdesivir trials for COVID-19 were conducted, on April 19, 2020 the last patient was enrolled in the NIH trial according to Dr Marik. Ten days later (April 29, 2020), before the study had terminated, Dr Fauci announced in the oval office the trial was “good news”! – WATCH

April 19, 2020 – Microbiology Notes: Remdesivir- Mechanism of Action, Uses, Synthesis & COVID-19 – ARCHIVE, Dr Shiva – CREDIT, Mode of Action – IMAGE

April 17, 2020 – NIH: Antiviral remdesivir prevents disease progression in monkeys with COVID-19 – Study supports clinical testing under way across U.S. – READ, CREDIT

April 15, 2020 – PRESS RELEASE: Gilead Provides Additional Information Regarding 2020 Annual Meeting of Stockholders Due to COVID-19 Precautions – READ, ARCHIVE

April 11, 2020 – Infectious Disease Society: Infectious Diseases Society of America Guidelines on the Treatment and Management of Patients with COVID-19 – ARCHIVE

• “The guideline panel suggests against remdesivir for routine treatment of patients with oxygen saturation >94% and no supplemental oxygen; however, strongly urges continued study through recruitment into RCTs”
  • The mode of action of remdesivir is only “acts by causing premature termination of viral RNA transcription” – [is viral replication even an issue in this stage of disease progression in hospitalised patients? Especially given the drugs “toxicity profile”.]
• “Patients receiving five days of remdesivir may experience fewer SAEs and adverse events leading to treatment discontinuation than patients receiving 10 days of remdesivir…”

April 10, 2020 – NEJM: Compassionate Use of Remdesivir for Patients with Severe Covid-19 – Grein et al (Gilead Sciences) – PDF

April 9, 2020 – Quartz: How the military secured a coronavirus drug that has yet to win FDA approval – READ, CREDIT

• “News of the military’s deal with Gilead was surprising, shining a light on the military’s unique ability to acquire medications before the FDA has signed off on the same drug for average Americans, if it ever does.””

April 8, 2020 – PRESS RELEASE: Gilead Announces $20 Million Philanthropic Fund to Support Nonprofit Organizations Impacted by the COVID-19 Crisis – READ, ARCHIVE

• “Gilead Sciences, Inc. (Nasdaq: GILD) announced the creation of the global Gilead CARES (COVID-19 Acute Relief and Emergency Support) Grantee Fund to provide financial support to current grantees facing an imminent closure or termination of vital services due to losses attributable to the COVID-19 pandemic. The fund will provide up to $20 million in donations to these nonprofit groups.”

April 5, 2020 – Motley Fool: Gilead Has Treated More Than 1,700 COVID-19 Patients With Remdesivir – READ

March 25, 2020 – National Center for Global Health & Medicine (Japan): NCGM Fights against COVID-19 – Lessons Learned (2nd Edition) – PDF, CREDIT, NCGM – HERE, ARCHIVE

• Reported investigator-initiated clinical trials were launched using Remdesivir, as part of “multi-regional clinical trials in collaboration with the NIH (National Institutes of Health, USA)”.

March 23, 2020 – NY Times: Coronavirus Patients in Limbo as Gilead Suspends Emergency Drug Access – ARCHIVE

• Six clinical trials of remdesivir are underway around the world

March 18, 2020 – STAT News: WHO to launch multinational trial to jumpstart search for coronavirus drugs – READ, CREDIT

• SOLIDARITY trial “…a multiarm, multicountry clinical trial for potential coronavirus therapies, part of an aggressive effort to jumpstart the global search for drugs to treat Covid-19.
• “The drugs to be tested are the antiviral drug remdesivir; a combination of two HIV drugs, lopinavir and ritonavir; lopinavir and ritonavir plus interferon beta; and the antimalarial drug chloroquine.

March 16, 2020 – STAT News: As the coronavirus spreads, a drug that once raised the world’s hopes is given a second shot – READ, CREDIT

March 11, 2020 – Military Times: Army signs agreement with drug giant Gilead on experimental COVID-19 treatment – READ

March 11, 2020 – U.S. Army Medical Materiel Development Activity: USAMMDA Announces Agreement with Gilead Sciences to Provide Investigational New Drug for Warfighters Exposed to Coronavirus Disease – READ, CREDIT

• USAMMDA, a subordinate command of the U.S. Army Medical Research and Development Command, announced ” it has entered into a Cooperative Research and Development Agreement [CRADA] with Gilead Sciences to provide Gilead’s investigational drug, remdesivir, for the treatment of Department of Defense personnel exposed to coronavirus disease 2019, known as COVID-19.”
• “In the CRADA, the USAMMDA Force Health Protection program will allow for the investigational use of remdesivir provided by Gilead, at no cost to the government, in the absence of any approved treatment options”
• Today’s announcement builds on a longstanding partnership between the DOD and Gilead Sciences to protect our Service Members….Gilead continues to test a collection of their antiviral molecules and remdesivir against other viral pathogens representing potential global health threats.

March 5, 2020 – US Department of Defense: Defense Department Press Briefing Investigating and Developing Vaccine Candidates Against COVID-19 – READ, CREDIT

• Army Brig. Gen. Michael J. Talley, commanding general of U.S. Army Medical Research and Development Command (USAMRDC) and Fort Detrick, revealed that “a cooperative research and development agreement with an industry partner is under review for the DOD to gain access to an antiviral drug for treatment use in our medical centers, our military treatment facilities.”

March 5, 2020 – NEJM: First Case of 2019 Novel Coronavirus in the United States – Holshue et al – READ

February 28, 2020 – Scientific America: A Promising Antiviral Is Being Tested for the Coronavirus—but Results Are Not Yet Out – READ, ARCHIVE

• The drug remdesivir is effective against many other viruses, and some experts are optimistic that it—or similar compounds—may work for the pathogen responsible for COVID-19
• …”and a malaria drug called chloroquine, which is not an antiviral but has shown some efficacy against COVID-19 in a lab dish. Yet experts say drugs that specifically target other pathogens are unlikely to work well enough.”
• “Timothy Patrick Sheahan, an assistant professor of epidemiology at the University of North Carolina Gillings School of Global Public Health, is among those in the U.S. working on antiviral drugs for COVID-19. Like De Clercq, he is skeptical that many of the antivirals already on the market would work.

“I’m doubtful that existing approved medications for other infectious diseases will have some magical property against this new coronavirus,”

Tim Sheahan

• [Note Sheahan has a conflict of interest in making this statement as he helped develop remdesivir otherwise known as GS-5734 ]
• “Sheahan and his colleagues have published several papers showing that remdesivir is effective against SARS, MERS and related bat coronaviruses, as well as some of the common cold coronaviruses.” – HERE & HERE
• “Lisa Gralinski, an assistant professor of epidemiology and colleague of Sheahan’s at the Gillings School,
• “I think it will probably be really effective” if you can get it to the patient within the first or second week… But “you’re not going to be able to come in and give this drug to someone who’s approaching end-stage lung disease and improve their outcome.” At that point, the lung damage is no longer being caused by viral replication but is happening because of the body’s own immune response—so an antiviral would likely not be effective. Yet if enough of the drug is available, Gralinski says, she would give it at the time of diagnosis.”
• “…if we already have something that’s mostly through development, like has luckily been the case with remdesivir, you can get it to people very rapidly.” Even if the drug proves to be effective, however, producing enough of it and distributing it to everyone in need is not guaranteed.”

February 26, 2020 – Senator Rand Paul’s wife Kelley buys stocks in Gilead – SOURCE

February 26, 2020 – PRESS RELEASE: Gilead Sciences Initiates Two Phase 3 Studies of Investigational Antiviral Remdesivir for the Treatment of COVID-19 – READ, ARCHIVE

• “Gilead’s trials will evaluate two dosing durations of the drug, which is given intravenously. The randomized, open-label, multicenter studies will enroll about 1,000 patients mostly in Asia, as well as in countries that have had high numbers of diagnosed cases. The trials are planned to start in March.
• These trials are on top of two clinical trials in China’s Hubei province led by the China-Japan Friendship Hospital and a recently launched trial in the U.S. led by the NIAID. Gilead donated the drug and provided scientific expertise for those trials. The China trial data is expected in April.” – REF
• “despite its deadly history – [remdesivir is] approved for use in clinical trials to evaluate its efficacy in the treatment of COVID-19. – READ

February 25, 2020 – NIAID: NIH Clinical Trial of Remdesivir to Treat COVID-19 Begins – Study Enrolling Hospitalized Adults with COVID-19 in Nebraska – READ, ARCHIVE

• Clinical Trial begun at the University of Nebraska Medical Center (UNMC) in Omaha – sponsored by NIAID – Clinical Trial NCT04280705 – HERE
• “UNMC’s National Quarantine Unit is supported by the office of the Assistant Secretary for Preparedness and Response (ASPR) at the Department of Health and Human Services. It has a 20-bed capacity and is in close proximity to the Nebraska Biocontainment Unit, should a higher level of care be needed. Clinical trial participants are cared for in the biocontainment unit.”

February 21, 2020 – ClinicalTrials.gov: Adaptive COVID-19 Treatment Trial – READ, ARCHIVE, That trial will be conducted at up to 50 sites around the world and will test remdesivir against a placebo. – SOURCE

• April 27, 2020 – NIAID changed clinical trial trial Primary Outcome Measure, to time to recovery and removing “death” from the criteria – ARCHIVE

February 18, 2020 – Gilead Sciences Update On The Company’s Ongoing Response To COVID-19 – ARCHIVE, LIVE, All ARCHIVES

• “Remdesivir is an investigational nucleotide analog with broad-spectrum antiviral activity – it is not approved anywhere globally for any use.”
• “This is an experimental medicine that has only been used in a small number of patients with COVID-19 to date, so Gilead does not have an appropriately robust understanding of the effect of this drug to warrant broad use at this time.”
• “Remdesivir has demonstrated in vitro and in vivo activity in animal models against the viral pathogens MERS and SARS, which are also coronaviruses and are structurally similar to COVID-19.” [so to did cheap Hydroxychloroquine, with a history and safety profile]
• To date “two studies are being coordinated by the China-Japan Friendship Hospital and are being conducted at multiple sites in Hubei province” China.
  • The study in patients with severe disease began enrolling patients on February 6, 2020 – TRIAL
  • The study in patients with moderate disease began enrolling patients on February 13, 2020

February 6, 2020 – ClinicalTrails. gov: Severe 2019-nCoV Remdesivir RCT – READ, ARCHIVE, SOURCE

February 6, 2020 – New York Times: China Begins Testing an Antiviral Drug [remdesivir] in Coronavirus Patients – READ

February 5, 2020 – ClinicalTrails. gov: Mild/Moderate 2019-nCoV Remdesivir RCT – READ, ARCHIVE

February 5, 2020 – Washington Times: Chinese scientists ask for patent on U.S. drug to fight virus – READ
Gilead, headquartered in Foster City, California, said it applied in 2016 for a Chinese patent on use of remdesivir against coronaviruses and is waiting for a decision.

January 31, 2020 – Gilead Sciences Statement on the Company’s Ongoing Response to the 2019 Novel Coronavirus (2019-nCoV) – READ, READ, CREDIT

• “While there are no antiviral data for remdesivir that show activity against 2019-nCoV at this time, available data in other coronaviruses give us hope. Remdesivir has demonstrated in vitro and in vivo activity in animal models against the viral pathogens MERS and SARS, which are coronaviruses that are structurally similar to 2019-nCoV. There are also limited clinical data available from the emergency use of remdesivir in the treatment of patients with Ebola virus infection.”
• Gilead is working closely with global health authorities..through the appropriate experimental use of our investigational compound remdesivir.:
  • U.S. Food and Drug Administration (FDA),
  • the U.S. Centers for Disease Control and Prevention (CDC), the U.S. Department of Health and Human Services (DHHS),
  • the U.S. Department of Defense (DoD) – CBRN Medical,
  • the China CDC and National Medical Product Administration (NMPA),
  • the World Health Organization (WHO),
  • and the U.S. National Institute of Allergies and Infectious Diseases (NIAID), and
  • along with individual researchers and clinicians

January 21, 2020 – The antiviral Remdesivir was used on the first COVID-19 patient in the US, given on the evening of day 7 of hospitalisation – TIMELINE, Daoyu15 Substack: Study of the USA-WA-1 case report… – READ, Also – READ

• But the patient had cleared the virus by day 3 of hospitalisation (as indicated by higher PCR cycles needed indicating viral titers dropped) and when pneumonia began to develop on the 6th day of hospitalization, was subjected to antibiotics treatment – REF
• Remdesivir given evening of hospitalisation day 7 at the same time the antibiotic Vancomycin was stopped, the next day the patient “clinical conditions improved”. Remdesivir was used after the virus had cleared! and used in conjunction with other treatments, yet this case study was justification for clinical trials!

January 2020 – “In mid-January, [Ken] Kent got a call from Reza Oliyai, senior vice president for Gilead’s pharmaceutical operations, telling him the company would need to make large quantities of remdesivir to fight the novel coronavirus.” – REF

2019

December 31, 2019 – Clinical Trials.gov | Gilead Sciences-sponsored : Study to Evaluate the Safety and Antiviral Activity of Remdesivir (GS-5734) in Participants With Severe Coronavirus Disease (COVID-19) – READ, ARCHIVE March 3, 2020 (Phase 3 Not yet recruiting) – ARCHIVE, Protocol – PDF, History of initial study changes – ARCHIVE

• May 27, 2020 – SIMPLE-Severe Trial: Gilead-sponsored multinational, open-label trial of remdesivir in patients with severe COVID-19 – NEJM: Remdesivir for 5 or 10 Days in Patients with Severe Covid-19 by Goldman et al – READ, SOURCE

December 24, 2019 – [Bloomberg: All eyes on Gilead – REF] – Tomas Cihlar, VP for discovery virology at Gilead Sciences Inc., received a email from a top infectious diseases expert at the University of Virginia.

• “There were cases of pneumonia suddenly emerging in Wuhan, China. Watch this one, the virologist warned. It might be a new coronavirus.”
• “Remdesivir was one of the few experimental medicines that had shown promise in lab studies against a wide variety of coronaviruses.” [i.e. in vitro like Chloroquine in 2005]
• Gilead started planning “on the assumption” the new virus would turn into a pandemic…”Within weeks, Chief Executive Officer Daniel O’Day formed a task force to study how to test remdesivir and, if it worked, mass-produce it”

December 12, 2019 – NEJM: A Randomized, Controlled Trial of Ebola Virus Disease Therapeutics – (monoclonal antibodies vs remdesivir), funded by NIAID. [The study showed 28 days of remdesivir increased mortality of 53.1% and pulled from the trial] – READ, PDF, WATCH, Dr Marik comments – WATCH,

• Remdesivir dropped from Ebola trial in DRC – increased risk of death & kidney failure- TIMELINE

November 27, 2019 – NEJM: A Randomized, Controlled Trial of Ebola Virus Disease Therapeutics – Malangu et al (PALM Consortium Study Team) – READ in Democratic Republic of Congo, ClinicalTrials.gov number NCT0371958

• November 27, 2019 – NIAID: Investigational Drugs Reduce Risk of Death from Ebola Virus Disease
  Study Leaders Publish Results from NIH-DRC-WHO Clinical Trial of Four Experimental Therapies – READ, ARCHIVE
• The clinical trial known as PALM, short for “Pamoja Tulinde Maisha,” a Kiswahili phrase that translates to “together save lives,” was organized by an international research consortium coordinated by the World Health Organization (WHO).
• “The mortality rate in the remdesivir treatment group, 53% (93/175), was similar to ZMapp” the highest mortality rate of all investigational drugs

September 2019 – Antiviral Research: Broad spectrum antiviral remdesivir inhibits human endemic and zoonotic deltacoronaviruses with a highly divergent RNA dependent RNA polymerase – Brown with Baric & Sheahan et al – READ, SOURCE

August 13, 2019 – Clinical Trials Arena: Preliminary findings from the Pamoja Tulinde Maisha (PALM) clinical trial have revealed that two monoclonal antibodies, REGN-EB3 and mAb114, produced a higher chance of survival in Ebola patients. (not remdesivir) – READ

• “Reuters noted that around 29% of subjects treated with REGN-EB3 and 34% in the mAb-114 arm died, compared to 49% of those on ZMapp and 53% who received remdesivir.”

August 12, 2019 – Science: Finally, some good news about Ebola: Two new treatments dramatically lower the death rate in a trial (not remdesivir!) – READ

August 12, 2019 – NIH: Independent Monitoring Board Recommends Early Termination of Ebola Therapeutics Trial in DRC Because of Favorable Results with Two of Four Candidates – Pamoja Tulinde Maisha (PALM) study – ARCHIVE

• The “study leaders halted the trial early, on August 9, 2019, as recommended by an independent data and safety monitoring board based on its review of preliminary data from 499 study patients.” – REF

August 9, 2019 – Remdesivir dropped from Ebola trial – TIMELINE

2018

March 6, 2018 – American Society of Microbiology: Coronavirus Susceptibility to the Antiviral Remdesivir (GS-5734) Is Mediated by the Viral Polymerase and the Proofreading Exoribonuclease – Agostini, with Baric & Sheahan et al – READ, SOURCE

2017

August 31, 2017 – Gillings School researchers receive $6M+ grant to fight infectious diseases – (Ralph Baric) – READ

• “In previous studies, Baric, Sheahan and colleagues found that GS-5734 prevents the development of severe acute respiratory syndrome coronavirus (SARS-CoV) in mice. The drug also was shown to inhibit MERS-CoV and multiple other coronaviruses (CoV), suggesting that it may actually inhibit all CoV.”
• Ralph S. Baric, PhD, professor, and Timothy Sheahan, PhD, research assistant professor, both in the Department of Epidemiology at the Gillings School

August 9, 2017 – NIH GRANT: Broad-spectrum antiviral GS-5734 to treat MERS-CoV and related emerging CoV – Baric & Sheahan – READ, CREDIT

• Awarded Up to $6M multiple Grants – READ

August 8, 2017 – US Patent #9,724,360 : Methods for treating Filoviridae virus infections – READ, CREDIT

• “Provided are compounds, methods, and pharmaceutical compositions for treating Filoviridae virus infections by administering ribosides, riboside phosphates and prodrugs thereof, of Formula IV: ##STR00001## The compounds, compositions, and methods provided are particularly useful for the treatment of Marburg virus, Ebola virus and Cueva virus infections.”

History of Gilead Sciences – LINK

2016

2016 – Warren, T., et al., (2016), “Therapeutic efficacy of the small molecule GS-5734 against Ebola virus in rhesus monkeys“, Nature, 531:381-5. – READ, Patent – CREDIT

• “The 2013–2016 outbreak of [Ebola virus (EBOV) disease] EVD in West Africa was the largest and most complex EBOV outbreak in the recorded history of the disease”…”No antiviral therapeutics have yet received regulatory approval or demonstrated clinical efficacy” for Ebola
• “Here we report the discovery of a novel small molecule GS-5734, a monophosphoramidate prodrug of an adenosine analogue, with antiviral activity against EBOV. GS-5734 exhibits antiviral activity against multiple variants of EBOV and other filoviruses in cell-based assays”
• The broad-spectrum antiviral activity of GS-5734 in vitro against other pathogenic RNA viruses, including filoviruses, arenaviruses, and coronaviruses, suggests the potential for wider medical use.”

1999

October 1999- Gilead and Roche announced that the FDA approved Tamiflu for the treatment of influenza A and B in adults – in time for the 1999-2000 flu season in the US. – ARCHIVE, ARCHIVE

• Tamiflu (oseltamivir phosphate) is the first flu pill from a new class of drugs called neuraminidase inhibitors that are designed to be active against all common strains of the influenza virus.
• Then in November 2000, Tamiflu was approved for the prevention of naturally occurring influenza A and B in adults and adolescents 13 years and older. In addition to the United States, Tamiflu is available in 26 countries worldwide.
• Some of the side effects from Tamiflu include suicide! “Sadly and predictably, using Tamiflu for treating the common flu will tend to increase the chances of creating super-viruses that will become immune to anti-viral drugs. It is almost as though this drug has the capacity to create thousands (or millions) of “terrorist cells” that could threaten the body (and the body politic).” – (2010 – How to create your own pandemic) READ

1997

1997 – Gilead and Roche announce positive Phase II results from a study of its influenza compound, GS 4104. In time will be called Tamiflu (oseltamivir phosphate)

1997 – Gilead names Donald H. Rumsfeld Chairman of Gilead Sciences Board of Directors, succeeding Michael L. Riordan, MD, former Chairman and President, and Gilead founder – REF, ARCHIVE, WIKI, CREDIT

• Rumsfeld remained chariman until 2001.
• Rumsfeld was appointed secretary of defense for a second time in January 2001 by President George W. Bush.
• September 10, 2001, the day before 9/11 attack – Donald Rumsfeld declared “We cannot track 2.3 TRILLION dollars” – WATCH

1996

1996 – Gilead’s receives FDA approval for it’s first commercial product, VISTIDE® (cidofovir injection), for the treatment of cytomegalovirus (CMV) retinitis in patients with AIDS. – REF

• Gilead ships VISTIDE to wholesaler and specialty distributors nationwide within hours of approval. VISTIDE is marketed in the United States by Gilead’s special sales force of Antiviral Specialists. – REF

• By 1997 is is available in both the United States (marketed by Gilead) and abroad (marketed by Pharmacia & Upjohn)

1996 – “Gilead and Hoffmann La-Roche agree to develop and market therapies to treat and prevent viral influenza. – REF

• Roche agrees to pay Gilead up to $50 million in milestone and licensing fees in exchange for worldwide rights to Gilead’s proprietary anti-influenza technology; Roche also funds development costs.
• Gilead announces the discovery of an orally active, highly potent compound that inhibits the replication of the influenza virus. Preclinical studies demonstrate promising antiviral activity against multiple strains of the influenza virus.”

1990

July 1990 – Gilead and Glaxo Wellcome form a five-year collaborative research agreement under which Gilead will conduct research with a goal of identifying code blocker compounds with potential application in the diagnosis, prevention and treatment of cancer.” – REF

1987

1987 – Gilead company is formed – ARCHIVE

• “Gilead is founded by Michael Riordan, MD. Our name was derived from an ancient region in the Middle East, presently part of the nation of Jordan. This region was recognized in antiquity as the source of a healing compound known as the “balm of Gilead.””

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