[Sept 2024 – Note that this page was not started as a timeline, unlike other pages, so many of the pre 2023 data points are not complete but are still being populated. This Sept 9,2024 article HERE , provides an excellent summary of what happened with HCQ, along with comments by Dr Malone HERE]

So why is hydroxychloroquine suddenly “dangerous”?

Some facts to consider about HCQ:

• Chloroquine and HCQ are listed as an essential medicine by the WHO.
• HCQ is relatively less “toxic” than Chloroquine when you look at the potential side effect profile.
• The patents for both Chloroquine and it’s derivative HCQ have expired, which means they can be manufactured generically, which in turn means cheaply.
• Hydroxychloroquine has been on the FDA’s list of approved drugs since 1955
• In 2005 an in vitro study of Chloroquine on SARS virus showed prohibitive viral properties when used early.
  August 22, 2005 – Viroolgy Journal: Chloroquine is a potent inhibitor of SARS coronavirus infection and spread – Vincent et al – READ
• In malaria prone countries, HCQ can be bought over the counter – no doctor’s script necessary.  In CDC fact sheet they recommend purchase before and deems it safe for adults and children, except those prone to psoriasis.
• HCQ acts as an ionophore, meaning it opens up a transport channel for zinc to enter the cell and it is the zinc that stops viral replication.
• A 200mg oral dose of hydroxychloroquine has a half life of 537 hours or 22.4 days in blood, longer in plasma.
• Experts agree that “chloroquine has a small toxic to therapeutic margin“, meaning the right dose is effective, too high and it is toxic, even fatal.
• In Taiwan December 2020 a manufacturing plant that makes the precursor to HCQ was damaged, and in May 2020, possibly 2 other plants that also make or store magnesium stearate were also damaged.  Coincidence?
• Since 1968 very few deaths attributed to hydroxychloroquine

Fact, if an effective early treatment was “found” for COVID-19:

• The pandemic would be over
• States of Emergency would no longer be ‘justifiable’
• Experimental vaccine’s would not be necessary or justifiable
• Emergency Use Authorisation or Provisional Registrations of vaccines would need to be stopped
• Vaccine manufacturers would loose hundreds of billions of dollars in profits.

Other questions to consider:

• Is HCQ a potential, broadspectrum anti-viral, in particular when used in combination with zinc?
• If HCQ is safe for adults, children and pregnant women for weekly treatment for malaria, they why is the same/similar dose suddenly “dangerous” in the middle of a pandemic, as a demonstrated effective early treatment measure?
• Why did health authorities design clinical trials for HCQ in late stage, hospitalised patients only, and at rates in excess of that used by frontline doctors for early treatment?
• If a broad spectrum anti-viral medication was “discovered” what would this do to the profitability of the vaccine industry?
• What would happen to the childhood vaccination program?
• Do you think Big Pharma and it’s “soldiers” would do everything they can to stop such information from coming to light?
• What tools do Big Pharma have to control the narrative?  Media? Lobby groups? Health authorities? Grant funding? Medical journal funding?

These are all questions to ponder as you dive into this controversial topic.  The greater number of people who know this information, the quicker a corrections can be made – assuming they do something about it!

HCQ and COVID-19

As the COVID-19 pandemic took hold in early 2020, some key doctors highlighted the life saving benefits of the HCQ drug for treating the symptoms of COVID-19 as well as potentially reducing the replication of the disease agent SARS-CoV-2.

We’ve capture their story here, along with the science and the mode of action this drug has against this virus.  We’ll also look at the focus of the clinical trials that the “expert medical authorities” conducted using HCQ, and how they determined that the drug failed to be beneficial and was deemed to be potentially dangerous.  There is so much to unravel for this drug and its controversy.

In the mean time if you want an excellent summary read this article from Jun 2020:  How a False Hydroxychloroquine Narrative Was Created

HCQ Timeline

In March 2020, Australia’s Clive Palmer through his foundation donated 32,900,000 doses of HCQ to the people of Australia, because of the positive information coming from independent doctors, virologists and scientists.

For an excellent timeline of event surrounding HCQ the Palmer Foundation website has been keeping track of since April 2020, below we’ll share our own discoveries of which there will be overlaps.  It appears the general public is not aware of much of this information.

This web page will be updated, it is set up to build the story in chronological order.

Scroll to the bottom of this page for the most recent videos

Dr Vladimir Zelenko’s Story

Zelenko “discovers” HCQ combination as an effective treatment for COVID-19

This story is a movie in the making.  Dr Vladimir Zelenko is a family doctor for around 30,000 residents in New York area.  He himself was suffering with cancer, undergoing treatment and surgery during the pandemic.  He claims to have never worn a mask while with his patients (many coming to him with COVID-19 symptoms) and he takes his prophylaxis treatment daily to protect himself against contracting the disease – by late 2020 he as yet hasn’t contracted COVID-19 but has assisted many hundreds of patients through the disease process, with only 2 hospitalisations, and 2 deaths, one with late stage cancer (as of end 2020).

It is highly recommended you listen to his story (below) yourself as he shares how he discovered HCQ + Zinc + Azithromycin combination for the treatment of his patients who came to him presenting with COVID-19 symptoms.  Listen to what he says and compare that to trials the “authorities” designed that  “proved” the drug to be “ineffective”.

Since the media won’t show you this, you’ll have to discover it for yourself.

Dr Zelenko share’s his treatment protocol for COVID-19

This video was first aired 2 July 2020 on The Highwire  which has since been deleted from YouTube.  Below is a part of this episode that features Dr Zelenko.

The Zelenko Protocol

Zelenco Protocol information with publication links and links to more videos

The Zelenko Protocol

Find the Zelenko Protocol here, the whole purpose is to prevent symptoms from escalating and preventing hospitalisation.

Dr Zelenko mentions virologist Professor Didier Raoult from France.  Over time as these two doctors communicated and they refined their treatment, Dr Raoult started to use zinc in combination, and thus decreased his dosage of hydroxychloroquine.

Watch Medcram episode 34 explaining the mechanisms of zinc with an ionophore such as choloroquine, referenced by Dr Z.

www.VladamirZelenkoMD.com

Dr Zelenko’s Letter to President Trump

In March 2020 Dr Zelenko wrote a letter to President Trump to inform him about his success with the hydroxychloroquine combination treatment protocol for the COVID-19 pandemic.  Just as an aside it was claimed by the media that Trump owned shares in Sanofi, one of the companies that makes the generic drug, but that was taken out of context and thus fake news.

Video has been removed:
President Trump On Using Dr. Vladimir Zelenko’s Hydroxychloroquine Protocol
https://www.youtube.com/watch?v=92pDKwloEEk

What the media didn’t tell you

An informative interview with Dr Zelenko

Dr Zelenko’s interview with the Corona Investigation Committee July22, 2021 – Session 62

Interesting statement by Dr Zelenko: “I’ve noticed, what ever the FDA decides, the rest of the world follows”.   Why this is interesting is that our TGA does refer to international regulatory bodies to assist in making recommendations and decisions.

He talks about how HCQ went from being available to everyone under Executive Order to being thwarted by FDA/HHS EUA for use in hospital settings only – the one setting it was never going to work in based on existing experience!

“In America, any drug that’s FDA approved can be used off-label for any reason” stated Dr Zelenco (within registered dose rates)

Combination treatment has provided the best results

The combination of HCQ with Zinc, is more effective than either used alone.  Zinc needs an ionophore to help it get into the cells, once in there it works to block the replication of the virus by inhibiting an enzyme called RNA-dependent RNA polymerase also called RNA replicase (see video below).
In addition, HCQ has multiple modes of action (see Dr Shiva video below) but when used in combination with zinc there is a synergistic effect.  Zinc is the bullet, HCQ (an ionophore) is the gun or the delivery tool.

Alternative Ionophores

If HCQ is not available Quercetin and EGCG (green tea extract) are also efficient zinc ionophores as discussed by Dr Zelenko.  All the front line doctors have stated, you need to get in early, the moment symptoms appear.

How Zinc and an ionophore work together

The paper referenced in this video: “Zn(2+) inhibits coronavirus and arterivirus RNA polymerase activity in vitro and zinc ionophores block the replication of these viruses in cell culture”.

Early treatment is key to the success with HCQ

The medical establishment (clinical trials) and media choose ONLY TO FOCUS  on advanced disease (hospitalisation) where HCQ  has demonstrated to offers little if any benefit based on front line experience.  The trials are designed to fail from the outset – timing, dose, used alone, not in combination.  This is not conspiracy, this is fact.

Early treatment is where all the front line doctors are having success in preventing hospitalisation.  But strangely this information is being censored.

The health establishment are doing garbage science.

April 16, 2020 – Unbreaking Science with Dr James Lyons-Weiler: Coronavirus: Mortality Rates, Hidden Information, Witheld Drugs w/ Meryl Nass, MD – withholding hydroxychloroqine early treatment – WATCH

HCQ: How It Works, benefits and side effects

Dr Shiva extracts the information from the scientific literature

Multiple mechanisms of action of hydryoxychloroqine against coronavirus:

1. Inhibits virus entry into the cell by inhibiting the viral particle binding to ACE2 receptor, this leads to reduced viral entry into the cell (Vincent et. al. 2005 CDC)
2. Inhibits viral replication of RNA via inhibition of RdRP in coronavirus.
3. Inhibits viral assembly
4. Inhibits new particle transport out of the cell
5. It acts as an ionophore for zinc, allowing zinc access into the cell, which in turn stops viral replication.

(note: Remdezivir, which is still under patent and costs around USD $3000 per dose, only inhibits viral replication, meaning one mode of action)

Mode of Action and Side Effects of HCQ

Dr Zelenko discusses COVID-19 outpatient management with Dr Been

American Front Line Doctor’s Summit

The summit videos were deleted from YouTube and web host provide deleted their site within 24 hours!

Massive censorship of Frontline Doctors led by Dr Simone Gold, where she and many other front line professionals shared their experience and treatment success stories along with other literature based presentations to help get the word out about all things COVID-19 related.  Their YouTube video’s and website was taken down by the hosting company (Square.com) within 24 hours of the summit – unheard of censorship.

But they have a new site here.  With their COVID-19 treatment’s page here and video page here including their Summit on July 27, 2020 covering many topics including hydroxychloroquine.

Doctor’s experience with HCQ:

Dr Anthony Cardillo explains that in his ER, they’ve found that HCQ really only works in combination with zinc.

Dr Zelenko has published his studies to share with everyone.  This was on the original Frontline Doctors website

Dr Simone Gold – White Paper on HCQ

The heart of the “problem”

Cardiologist at Mayo Clinic in March 2020 claim QT issues with hydroxychloroquine.  Why wait for now to raise this issue, when the drug has been handed out effectively like candy for malaria prevention to adults and children? Why now?

Then comes the VA Study

On 21st April 2020, the paper titled “Outcomes of hydroxychloroquine usage in United States veterans hospitalized with Covid-19” was published.  This is refereed to as the VA Study.

The media then grabbed hold of it’s conclusions and began to shout higher mortality rates with hydroxychloroquine (1, 2) or Fox news claiming HCQ has no benefit.  Though what they don’t tell you is it is an observational study who’s conclusions have not been put into context.

That is HCQ was use on patients who’s immune system was already shot, they were hospitalised in ICU on ventilators, it was not a randomised trial, the study didn’t report the doses of the drugs used, plus 30% of the control group received a treatment that itself could help reduce mortality.  Plus one of the authors Scott Sutton received funding from the Remdezivir manufacture Gilead.  So a case of bad science, conflicts of interest and another attack on a drug that still has potential as an early treatment!

Then on 24th April 2020, the FDA cautioned the use of HCQ due to the risk of heart rhythm problems – but only for COVID-19 suspected patients, not for Lupus or RA or for malaria treatment!

French virologist, Dr Didier Raoult responds to the flawed VA study here.

Del Bigtree unpacks the FDA and the two factions of the HCQ

(that YouTube deleted)

Laura Ingram on US Fox News reports on this VA study

Dr Raoult’s study

Dr Patrice Harris the President of the American Medical Association claimed on CNN in April 2020 that there was no evidence to support the use of hydroxychloroquine for COVID-19.  Understanding at this time, the front line doctors were successfully accumulating thousands of case studies, they’re using rates that are commonly used for malaria, they’re using it at the first sign of symptoms for at risk patients, and they are successfully preventing patients from having to go to hospital.

Fraudulent Peer Reviewed Lancet Study

Published on 22nd May 2020, the Lancet published a damning paper looking at 96,000 patients, and concluding the HCQ group were dying at high rates and with more heart related complications! –

The “…study did not examine the QT interval but instead directly analysed the risk of clinically significant ventricular arrythmias. We showed an independent association of the use of either hydroxychloroquine or chloroquine with the occurrence of de-novo ventricular arrhythmias. We also note that the hazard of de-novo ventricular arrhythmias increased when the drugs were used in combination with a macrolide” [such as azithromyicin].

On 25 May 2020, this lancet study gave justification for the World Health Organisation to temporarily pause it’s SOLIDARTY trials on HCQ.  A fraudulent, supposedly peer reviewed study caused the WHO, in the middle of a pandemic, to stop trials because of the heart problems supposedly caused by hydroxychloroquine.

But then two weeks later on the 4th June, 2020 after doctors and scientist started questioning this peer reviewed scientific paper it was retracted by The Lancet  and the US based company Surgisphere [1] that allegedly collected the data for this study from all over the world, including Australia, was completely fake!

WHO then resumed it’s study of HCQ.

Then on 15th June 2020 the FDA revokes the EUA for the use of HCQ and CQ to treat COVID-19 and referenced the already retracted lanced paper and refers to it as evidence for their decision!  So the FDA reference fraudulent science as evidence to not use a potentially life saving early treatment drug.

A second paper associated with Surgisphere has also been retracted from another peer review journal.

Australia’s TGA used Lancet study as a reason to restrict hydroxychloroquine in Australia

How much damage did these fraudulent study do to the HCQ treatment narrative?

Who else has lost faith in the “authorities”?

Clinical trials appear set-up to fail

Must read overview by Dr Meryl Ness “WHO and UK trials use potentially lethal hydroxychloroquine dose–according to WHO consultant” – HERE

August 13, 2020 – Unbreaking Science: Dr. Meryl Nass on lethal doses used in the HCQ trials – 2400 mg (2.4 mg) of HCQ is a lethal dose. So why did key studies of HCQ use 6 times the normal dose and when 35% increase mortality occur in hospitalized (late-stage) patients did the cease the trial instead of reduce the dose? – WATCH

All HCQ clinical trials designed by “medical experts” focused on late stage COVID-19, contrary to what was experienced in the field.

The key to HCQ’s success is treating the patient early and using the drug in low dose, with zinc.  Yet the international “safety and efficacy” clinical trails were designed to use the drug as a stand alone (without zinc), and in exceedingly high doses plus only in hospitalised patients.  In this setting the virus has finished its replication, and the symptoms have escalated, beyond what the drug could hope to benefit. This is contrary to the way the front line doctors are using the drug, and are achieving a high degree of success.

This is shown when you read the paper from the RECOVERY trial published November 2020 where it states in the discussion “Hydroxychloroquine has been proposed as a treatment for Covid-19 largely on the basis of its in vitro SARS-CoV-2 antiviral activity and on data from observational studies reporting effective reduction in viral loads.”

If these health officials that designed the large scale international clinical trials heard the doctors in the field they would know that the antiviral affects of HCQ have been shown not to be enough when used alone, that it is when used with zinc that the best results are had.

Its almost as though the trials were designed to fail!

The dose rate between therapeutically effective and that of being toxic, is small for chloroquine, and likely too hydroxychloroquine.  In the frail and already sick and weakened hospitalised COVID-19 patients, how would these trial doses of HCQ make them fair?

This graph below shows the relative dose of HCQ between various treatments up to 10 days of use based on the table above.   As you can see the early treatment protocol dosage is within the common Malaria and Arthritis treatment rates, where as two of the trials conducted in sick hospitalised patients were at toxic and possibly lethal doses!

HCQ Key clinical trials list:

• WHO – SOLIDARITY trial protocol
  Published – interim
• Oxford University – the RECOVERY trial
  Published here
• NIH – ORCHID study
  Published here
• Henry Ford Health System HCQ study
  Published here

Compare this to early treatment protocol doses

•  Zelenko Protocol, Out-patient (not hospital) for only moderate to high risk patients – combination treatment zinc, azitromycin + HCC
  (200mg x twice daily for 5-7 days = 400mg in first 24 hrs, cummulative 2000mg – 2800mg in 5 to 7 days respectively, max 400mg/day)

These studies above have been highlighted because these are what the Australian Therapeutic Goods Administration specifically referred to when they claimed the data shows “ no more effective than standard care in treating patients with COVID-19″.  Standard care should start at the GP’s office and not in hospital!  HCQ has performed poorly in clinical trials because it was used too late, in high doses and alone, not as a combination drug treatment.

Further still, based on these late stage clinical trials, the health officials and regulatory agencies deemed all use of HCQ ineffective and potentially dangerous!
If an early treatment was found the pandemic would be over and a vaccine would not be necessary, or at least mandating couldn’t be justified.

Australia’s TGA’s position on HCQ

The TGA claim use restrictions due to supply issues, yet the Palmer Foundation stocked us up in April 2020 with nearly 33 million doses, on top of what we already had in stock.

24 March 2020 – New restrictions on prescribing hydroxychloroquine for COVID-19

26 August 2020 – Amendments to the new restrictions on prescribing hydroxychloroquine for COVID-19

In this amemdment the National COVID-19 Clinical Evidence Taskforce  (NCCET) recommended against the use of hydroxychloroquine for the treatment of COVID-19.

Their media release states: “Taskforce Executive Director, Associate Professor Julian Elliott said the evidence indicates that hydroxychloroquine is potentially harmful and no more effective than standard care in treating patients with COVID-19.”  further “The pooled results show the drug does not reduce mortality, or shorten the amount of time a sick person spends in hospital. It also exposes them to side effects including cardiactoxicity.”

We are more than a year into this pandemic and they have not completed an early combination treatment study with HCQ, zinc and azithromycin or similar broad spectrum antibiotic.  “There are ongoing prevention trials investigating the use of hydroxychloroquine to reduce the risk of contracting COVID-19″ and they’ll get back to us.  Will they be in combination, and why so long?

Update: Dr Fauci’s emails have been sourced under FOI request

Dr Anthony Fauci, head of US NIAID in late May 2021 had about 3,200 of his January to June 2020 emails released under the Freedom of Information Act (FOIA), and they reveal much about what he knew.

On February 29, 2020 he was copied in on a high priority email to the vice president regarding the potential use of the cheap drug hydroxychloroquine to prophylax high risk patients.  The email even quoted the safe use rate of up to 6.5 mg/kg, a rate which Fauci’s NIH clinical trials exceeded, they used a one-dose-fits-all rate, but more importantly they used it in hospitalised patients when it was too late to be effective, and they knew it.

This is important for Australia, because our TGA referenced Fauci’s NIH ORCHID study as a “supporting” reason for them to make a blanket statement to NOT recommend hydroxychloroquine here in Australia even for it’s demonstrated benefit of early use with zinc.

Read Fauci’s email from February 2020

Articles and websites relating to HCQ

Medical Misinformation, Part 1: Hydroxychloroquine, 30 April 2020

NY Doctor Proved Everyone Wrong About Hydroxychloroquine – article by State of the Nation, a retrospective look at Dr Zelenko’s plea for truth

Tracking: HCQ studies for COVID-19: Real-time meta analysis for 245 studies and counting, and CV19-HCQ

WHO SOLIDARITY and UK RECOVERY trials use potentially lethal hydroxychloroquine dose, article by Meryl Nass, MD

COVID-19 and Coronavirus Resource Center

Countries in RED: DO NOT use or have LIMITED use of HCQ

More from Dr Zelenko and other doctors on HCQ

For the record.

April 2021 Part 1 of 4

Part 2 of 4
Part 3 of 4
Part 4 of 4

Interview with Dr Mercola

July 16, 2021

Dr Zelenko Interviewed by the Corona Investigation Committee

July 22, 2021

https://youtube.com/watch?v=XO4BmDEE8zw%3Fstart%3D18252

Corona Investigation committee interview – Session 62 Watch @4:45:50

Dr Zelenko nominated for the Presidential Medal of Freedom & Nobel Prize

August 2021

August 14, 2021 – Stew Peters: Dr. Zev Zelenko SLAYS Globalists, Exposes “Global Genocidal Event” – WATCH,

September 2, 2021 – Stew Peters: Dr. Zev Zelenko COVID Genocide “Very Nefarious, Sinister Purpose” WATCH

Dr Zelenko exposes how Dr Rick Bright (BARDA) sabotaged early COVID-19 treatment with HCQ, killing masses

September 2021 – Dr Zelenko exposes how Dr Rick Bright’s Very Bad move sabotaged early Covid treatment killing masses – WATCH

Hydroxychloroquine data points in reverse chronological order

Note this timeline is not complete and only started in this format approx 202. It continues to be updated.

2024

September 24, 2024 – PLOS Medicine: Evaluation of hydroxychloroquine or chloroquine for the prevention of COVID-19 (COPCOV): A double-blind, randomised, placebo-controlled trial – Schilling et al – READ, Craig Kelly – CREDIT, University of Oxford ClinicalTrials.gov NCT04303507

• “In this large placebo-controlled, double-blind randomised trial, HCQ and CQ were safe and well tolerated in COVID-19 chemoprevention, and there was evidence of moderate protective benefit in a meta-analysis including this trial and similar RCTs. ….. they [Hydroxychloroquine & Chloroquine] could have been deployed with benefit earlier, and they might have value in future pandemics…

September 9, 2024 – Brownstone Institute: Trump’s 63 Million Doses of Hydroxychloroquine Could Have Been Great for America by David Gortler, Pharm. D – READ

• Dr Robert Malone: What Happened to Trump’s 63 Million Doses of Hydroxychloroquine? – CREDIT

June 4, 2024 – Gateway Pundit: KILLER FAUCI: On March 16, 2020, Dr. Fauci Received Email Cheering Hydroxychloroquine Treatment of COVID in China – 4 Days Later He Publicly Rebuked President Trump at WH Presser For Suggesting It a Valid COVID Treatment – READ

March 31, 2024 – Meryl Nass: “How a false hydroxychloroquine narrative was created, and more”–republishing because we must never forget this evidence of a terrible crime – our-de-force paper on the 50+ ways HCQ was suppressed during 2020 – READ

March 26, 2024 – Broken Truth: Didier Raoult Francesoir Interview – Woodcock and Q Fever Treatment – WATCH, An explosive interview with Dr Didier Raoult reveals a possible motive behind the FDA acting commissioner’s refusal to discuss Coxiella Burnetti. READ

February 20, 2024 – Broken Truth presents documentary: Epidemic of Fraud – the coverup story of hydroxychloroquine – WATCH, READ, Press READ

February 2024 – Biomedicine & Pharmacotherapy: Deaths induced by compassionate use of hydroxychloroquine during the first COVID-19 wave: an estimate by Pradelle et al – READ

• The Latest Attempts to Discredit Hydroxychloroquine as a Treatment for COVID-19 – READ

I challenge the authors of this study to send me 1 out of the supposed 17000 people who died from HCQ…

We are all tired of Egocentric maniacs running our lives and allowing articles like this one with a conclusion that says “ Although our “estimates are limited by their imprecision” Who in their right mind published a conclusion like this? I give this paper a ZERO.

Dr Sabine Hazen

January 16, 2024 – Meryl Nass Substack: Here is the evidence (from 2004-2014) that our governments tried to kill us by restricting HCQ. WHY? Hydroxychloroquine doesn’t kill people unless you overdose. But it does kill coronaviruses.
This is critically important evidence that our governments deliberately harmed us by suppressing this drug. – READ

January 4, 2024 – Politico: Hydroxychloroquine could have caused 17,000 deaths during Covid, study finds – ARCHIVE, CREDIT

• “Nearly 17,000 people may have died after taking hydroxycholoroquine during the first wave of Covid-19, according to a study by French researchers.” – [Another HCQ “study” retracted[
• RETRACTED Biomedicine & Pharmacotherapy: Deaths induced by compassionate use of hydroxychloroquine during the first COVID-19 wave: An estimate by Pradelle et al – READ, ARCHIVE, RETRACTED – READ

2023

December 15, 2023 – Bannons War Room: Episode 3251: Censorship In Peer Review Journals w/ Dr Steven Hatfill – a COVID-19 pandemic advisor to the Trump Administration – WATCH, EXCERPT

• December 2023 – Journal of American Physicians and Surgeions: The COVID Debacle: Merging Criminal Law and Medical Science for Accountability by Steven Hatfill – READ, PDF, EXCERPT
• Robert Kadlac helped acquire 62 million doses of hydroxychloroquine, FDA’s Janet Woodcock thwarted it’s use – EXCERPT
• mRNA vaccines should not have happened because there were safe early treatment options – EXCERPT

November 3, 2023 – Epoch Times: Hydroxychloroquine Associated With Lower COVID-19 Mortality: Study – The French study included 30,202 patients – READ, Vigilant Fox – CREDIT

• People who received hydroxychloroquine were less likely to die than those who did not – 0.8% vs 4.8%

“This study represents the largest single-center study evaluating HCQ-AZ in the treatment of COVID-19. Similarly, to other large observational studies, it concludes that HCQ would have saved lives,”

Dr. Didier Raoult

September 24, 2023 – Gateway Pundit: Mayo Clinic Website Now Says Hydroxychloroquine CAN Be Used to Treat COVID-19 Patients, Previously Claimed It Was Not Effective – READ

• May Sep 2023: “Hydroxychloroquine may be used to treat coronavirus (COVID-19) in certain hospitalized patients.” – ARCHIVE,
  • The webpage was deleted in 2 days – HERE, but has been live since 2014! – ARCHIVES

• Mayo Oct 2021: “Using this medicine alone or with other medicines (eg, azithromycin) may increase your risk of heart rhythm problems (eg, QT prolongation, ventricular fibrillation, ventricular tachycardia). Hydroxychloroquine should only be used for COVID-19 in a hospital or during clinical trials. Do not take any medicine that contains hydroxychloroquine unless prescribed by your doctor“.- ARCHIVE, Also READ

July 27, 2023 – Meryl Nass Substack: Treating COVID-19 in 2023 and update on HCQ & Ivermectin – READ

April 4, 2023 – Pre Print: Early Treatment with Hydroxychloroquine and Azithromycin: A ‘Real-Life’ Monocentric Retrospective Cohort Study of 30,423 COVID-19 Patients – Million & Didier Raoult et al – READ

• “retrospective study from France (30,000+ patients) has found that HCQ + Azithromycin was REDUCING DEATHS by 71% when given early and by 45% when given in hospital – before they banned it” CREDIT SpeedOfScience in comments

March 15, 2023 – United Australia Party (UAP) hosts Australian Covid Vaccines & Effects Tour – Clive Palmer introduction and speaks about his HCQ donation to Australia – WATCH, Palmer’s HCQ donation to Australia – TIMELINE

2022

2021

June 13, 2021 – Hydroxychloroquine: Just the facts and a Follow the Money investigation by Sharyl Attkisson – READ

• “…two new studies that show the inexpensive drug works. A new study in MedRxiv found that hydroxychloroquine and zinc increased Covid-19 survival by almost three times. And a recent study published in the Journal of The Association of Physicians of India also found hydroxychloroquine is an effective treatment for Covid-19.”

June 10, 2021 – The US Sun: Hydroxychloroquine drug touted by Trump as Covid treatment can increase survival rates by 200%, study finds – READ

June 10, 2021 – Fox News | Ingraham Angle: Ingraham: Fauci ‘routinely’ acted against science – “Study: 100K lives could have been saved” with using HCQ – WATCH, FULL

June 9, 2021 – The Washington Times: Follow the money: Big Pharma, Dr. Fauci and the death of hydroxychloroquine – The $2.45 million Gilead spent in the first quarter of 2020 lobbying the federal government was well spent – READ

• “HCQ is cheap (costing under $10 for the course of a COVID-19 treatment), well-understood by physicians having been prescribed for more than 80 years, and can be taken orally. Yet, Dr. Anthony Fauci and others at the National Health Institute of Allergy and Infectious Diseases preferred remdesivir, a proprietary, intravenous drug manufactured by Gilead Sciences, costing about $3,500 per treatment, with unknown side effects.”

June 1, 2021 – Fox News | The Ingraham Angle – Dr Stephen Smith, Fauci on variants nad Dr Scott Atlas – ARCHIVE, We could have saved 100K lives – EXCERPT

April 13, 2021 – Rounding the Earth w/ Mathew Crawford: How to Rig Research: Surgisphere Part I – READ

A lot of the observations that took Surgisphere down were me emailing other people, or writing in forums, under names other than my own.

Mathew Crawford – REF

February 26, 2021 – The Lancet: Hydroxychloroquine with or without azithromycin for treatment of early SARS-CoV-2 infection among high-risk outpatient adults: A randomized clinical trial – Johnson et al – READ [NO ZINC?, ], Clinical Trial # NCT04354428 – READ, trial HISTORY

• “The COVID-19 Early Treatment Study was funded by the Bill & Melinda Gates Foundation (INV-017062) through the COVID-19 Therapeutics Accelerator….”
• “placebo” was vitamin C (1000mg/day1, then 500mg/day) and folic acid – so not inert placebo! -clinical trial – ARCHIVE
• HCQ 400 mg orally twice on Day 1 [800mg total], followed by 200 mg orally twice daily [400mg/day] ( for an additional 9 days

February 22, 2021 – The Guardian: Melbourne doctors under review for promoting discredited Covid treatment – Covid Medical Network doctors – READ,

• References peer reviewd paper in Reviews in Cardiovascular Medicine: Multifaceted highly targeted sequential multidrug treatment of early ambulatory high-risk SARS-CoV-2 infection (COVID-19) by McCullough et al – ARCHIVE, READ

2020

December 30, 2020 – Reviews in Cardiovascular Medicine: Multifaceted highly targeted sequential multidrug treatment of early ambulatory high-risk SARS-CoV-2 infection (COVID-19) by McCullough et al – ARCHIVE, READ (and image source)

December 20, 2020 – Taiwan News: Pharmaceutical factory on fire after explosion: 2 injured – makers of HCQ precursor – READ, worlds second largest HCQ supplier – SOURCE

• “Liberty Times reported that the factory produces hydroxychloroquine APIs, and is the world’s second largest HCQ raw material supplier.“

December 2020 – International Journal of Antimicrobial Agents: COVID-19 outpatients: early risk-stratified treatment with zinc plus low-dose hydroxychloroquine and azithromycin: a retrospective case series study – by Derwand, Zelenko et al – READ, TWEET

October 1, 2020 – The Scientist: The Surgisphere Scandal: What Went Wrong? – READ, CREDIT

August 30, 2020 – COVID-19 Real-Time Learning Network (sponsored by CDC grant): Hydroxychloroquine – information for doctors, links to “evidence” – ARCHIVE

• Explore the many references to clinical trials in HOSPITAL settings
• “One RCT suggests increased risk of QT prolongation among patients treated with HCQ+AZ compared to those not receiving HCQ” still hospitalised – July 23, 2020 – READ

July 2, 2020: Science: One U.K. trial is transforming COVID-19 treatment. Why haven’t others delivered more results? – trial design (hospital use in large doses) rules out HCQ by authorities – READ

June 17, 2020 – WHO: World Health Organization announces it was dropping hydroxychloroquine from the Solidarity trial – REF

• “Update (June 18): The World Health Organization announced yesterday that it was dropping hydroxychloroquine from the Solidarity trial after new data suggest the drug is ineffective as a COVID-19 treatment or prophylaxis.” – REF

June 17, 2020 – CNN: US stockpile stuck with 63 million doses of hydroxychloroquine …now that the US Food and Drug Administration has revoked permission for the drug to be distributed to treat coronavirus patients – READ, CREDIT

June 15, 2020 – CNN: FDA revokes authorization of drug Trump touted – ARCHIVE

• “Doctors can continue to legally prescribe the drugs off-label, as they can with any drug that’s approved for other conditions. The FDA’s emergency use authorization for hydroxychloroquine and chloroquine was narrow in scope, applying only to hospitalized Covid-19 patients and only to drugs donated to the Strategic National Stockpile.” !

June 15, 2020 – FDA: FDA cautions against use of hydroxychloroquine or chloroquine for COVID-19 outside of the hospital setting or a clinical trial due to risk of heart rhythm problems – Does not affect FDA-approved uses for malaria, lupus, and rheumatoid arthritis [!!!] – READ, CNN- CREDIT

• FDA July 1, 2020 Update: “A summary of the FDA review of safety issues with the use of hydroxychloroquine and chloroquine to treat hospitalized patients with COVID-19 is now available.” – PDF

June 15, 2020 – FDA LETTER from Denise M. Hinton, Chief Scientists FDA to Gary Disbrow, Deputy Assistant Secretary of BARDA – PDF, ARCHIVE, CNN – CREDIT

• This letter in response to BARDA requesting the FDA “revoke the Emergency Use Authorization (EUA) for emergency use of oral formulations of chloroquine phosphate (CQ) and hydroxychloroquine sulfate (HCQ) to be distributed from the Strategic National Stockpile (SNS) issued on March 28, 2020”
• Letter has “Attachment: Memorandum Explaining Basis for Revocation of Emergency Use Authorization for Emergency Use of Chloroquine Phosphate and Hydroxychloroquine Sulfate”

June 15, 2020 – FDA: Coronavirus (COVID-19) Update: FDA Revokes Emergency Use Authorization for Chloroquine and Hydroxychloroquine [but the product is still licensed!]- READ, ARCHIVE, FDA letter – PDF, Wired – ARTICLE

• “…the FDA determined that chloroquine and hydroxychloroquine are unlikely to be effective in treating COVID-19 for the authorized uses in the EUA.” – off-label use (which is legal) does not require EUA for a licensed product!
• “Additionally, in light of ongoing serious cardiac adverse events and other potential serious side effects, the known and potential benefits of chloroquine and hydroxychloroquine no longer outweigh the known and potential risks for the authorized use. This is the statutory standard for issuance of an EUA.”
• The Emergency Use Authorization (EUA) for HCQ was issued on March 28, 2020
• “Today’s request to revoke is based on new information, including clinical trial data results, that have led BARDA to conclude that this drug may not be effective to treat COVID-19 [Coronavirus Disease 2019] and that the drug’s potential benefits for such use do not outweigh its known and potential risks.”
• CNN: FDA revokes authorization of drug Trump touted – ARCHIVE

June 13, 2020 – The Lancet | Comment: Expression of concern: Hydroxychloroquine or chloroquine with or without a macrolide for treatment of COVID-19: a multinational registry analysis – by The Lancet Editors – READ

• To “alert readers to the fact that serious scientific questions have been brought to our attention. We will update this notice as soon as we have further information.”

June 8, 2020 – Science: Who’s to blame? These three scientists are at the heart of the Surgisphere COVID-19 scandal – Author partnership on coronavirus papers is “completely bizarre” and should have been a red flag, former journal editor says – READ (presents overview of authors) – Regading the RETRACTED Lancet Study

• Mehra “provided the kind of gravitas that can fast-track papers to leading journals.”
• Amit Patel (co-author) had introduced Mehra to Sapan Desai, a vascular surgeon and founder of Surgisphere, the tiny company that supplied the data.
• Mehra received compensation from Triple-Gene [3GTx.com], a gene therapy company Patel co-founded [and Clinical Director] to develop cardiovascular treatments.
  • “Triple-Gene LLC is a clinical stage cardiovascular gene therapy company and majority owned subsidiary of Precigen Inc. (NASDAQ: PGEN).” – REF

June 7, 2020 – STAT News: Researcher involved in retracted Lancet study has faculty appointment terminated, as details in scandal emerge – READ, Amit Patel – TWEET, The only author to be “punished” – CREDIT

• University of Utah has “mutually agreed” to terminate the [unpaid adjunct appointment with the Department of Biomedical Engineering] faculty appointment of Amit Patel,..who appears to have played a key role in involving a little-known company that has ignited a firestorm of controversy.”

June 5, 2020 – Oxford University RECOVERY Trial: PRESS Statement from the Chief Investigators of the Randomised Evaluation of COVid-19 thERapY (RECOVERY) Trial on hydroxychloroquine : No clinical benefit from use of hydroxychloroquine in hospitalised patients with COVID-19 – READ, This statement was used by WHO to help justify shutting down HCQ – CREDIT

• “‘On Thursday 4 June, in response to a request from the UK Medicines and Healthcare Products Regulatory Agency (MHRA), the independent Data Monitoring Committee conducted a further review of the data. Last night, the Committee recommended the chief investigators review the unblinded data on the hydroxychloroquine arm of the trial.
• ‘We have concluded that there is no beneficial effect of hydroxychloroquine in patients hospitalised with COVID-19. We have therefore decided to stop enrolling participants to the hydroxychloroquine arm of the RECOVERY Trial with immediate effect. We are now releasing the preliminary results as they have important implications for patient care and public health. “
• Trial primary endpoint was 28-day mortality for hospitalised COVID-19 patients. “There was also no evidence of beneficial effects on hospital stay duration or other outcomes.”…‘These data convincingly rule out any meaningful mortality benefit of hydroxychloroquine in patients hospitalised with COVID-19″

‘Hydroxychloroquine and chloroquine have received a lot of attention and have been used very widely to treat COVID patients despite the absence of any good evidence. The RECOVERY Trial has shown that hydroxychloroquine is not an effective treatment in patients hospitalised with COVID-19. Although it is disappointing that this treatment has been shown to be ineffective, it does allow us to focus care and research on more promising drugs.” [remdesivir?]

Peter Horby, Professor of Emerging Infectious Diseases and Global Health in the Nuffield Department of Medicine, University of Oxford, and Chief Investigator for the RECOVERY HCQ trial

June 4, 2020 – MedScape: Two Journals Retract Studies on HCQ, Heart Disease in COVID-19 – READ, TIMELINE

• “The Lancet announced today [June 4, 2020] that it has retracted a highly cited study that suggested hydroxychloroquine may cause more harm than benefit in patients with COVID-19. Hours later, the New England Journal of Medicine announced that it had retracted a second article by some of the same authors, also on heart disease and COVID-19.”

June 4, 2020 – NY Times: Two Huge Covid-19 Studies Are Retracted After Scientists Sound Alarms -The reports, published in two leading journals, were retracted after authors could not verify an enormous database of medical records – READ (Hydroxychloroquine is not mentioned in the title, read down to find it!), Med City News – READ

• “Both studies were led by a professor at Harvard, and both depended on a huge international database of patient medical records that few experts had ever heard of.”
• “On Wednesday, after the journals [NEJM & The Lancet] noted concerns about the studies, the World Health Organization announced that it would resume trials of the medications”!

“It is now clear to me that in my hope to contribute to this research during a time of great need, I did not do enough to ensure that the data source was appropriate for this use…For that, and for all the disruptions — both directly and indirectly — I am truly sorry.”

Dr. Mandeep Mehra, lead author of the two studies, said in a statement to The New York Times.

June 4, 2020 – The Guardian: Surgisphere: governments and WHO changed Covid-19 policy based on suspect data from tiny US company – READ

• “Surgisphere, whose employees appear to include a sci-fi writer and adult content model, provided database behind Lancet and New England Journal of Medicine hydroxychloroquine studies”

June 4, 2020 – Med City News: Randomized trial shows hydroxychloroquine doesn’t prevent Covid-19 as questions arise about earlier study – A randomized, placebo-controlled trial published in NEJM found the malaria drug was not effective as a post-exposure prophylaxis against coronavirus disease. However, questions have arisen about data used in a large observational study about the drug published last month – READ

• Uni Minnesota trial “data showed that 11.8% of participants who received hydroxychloroquine developed Covid-19, compared with 14.3% who received a vitamin pill as a placebo….the result did not reach statistical significance…there is no way to rule out whether the result was due to chance alone.” Thus it was concluded no difference.
• Note COVID-19 was self reported by patient and not PCR confirmed [as far as I can tell] the trial objective was to “to prevent disease” i.e. any symptoms, not hospitalisation or death!
• “The study provides the most definitive evidence yet that hydroxychloroquine is not effective against Covid-19.”

June 3, 2020 – University of Minnesota: University of Minnesota Trial Shows Hydroxychloroquine Has No Benefit Over Placebo in Preventing COVID-19 – READ, ARCHIVE, CREDIT, Trial used by WHO to stop HCQ – REF

• June 3, 2020 – NEJM: A Randomized Trial of Hydroxychloroquine as Postexposure Prophylaxis for Covid-19 – Boulware et al – READ, Clinical Trial NCT04308668 – READ [No PCR confirmatory testing done, huge doses used]
  • “We conducted a randomized, double-blind, placebo-controlled trial across the United States and parts of Canada testing hydroxychloroquine as postexposure prophylaxis….We enrolled 821 asymptomatic participants”
  • Treatment dose “hydroxychloroquine (800 mg once, followed by 600 mg in 6 to 8 hours, then 600 mg daily for 4 additional days)” [High dose rate and without zinc, contrary to those finding success]. “The primary outcome was the incidence of either laboratory-confirmed Covid-19 or illness compatible with Covid-19 within 14 days.”
  • “The incidence of new illness compatible with Covid-19 did not differ significantly between participants…” [So they DIDN’T PCR test to confirm that an “illness” was COVID-19???] BUT
• “40% of trial participants taking hydroxychloroquine developed non-serious side effects — predominantly nausea, upset stomach or diarrhea.” [Maybe because to the excessive dosage they prescribed!! Normal dose 200-400mg/day, they gave a huge dose of 1400mg on day 1, and 3 times normal daily dose (200mg) on days 2-5]
• “However, the trial [even with excessive doses] found no serious side effects or cardiac complications from taking hydroxychloroquine”
• The WHO use this Boulware et al study to further justify dropping HCQ from their clinical trials because” the study found “the drug did not prevent people exposed to SARS-CoV-2 from becoming sick” [yet the study looked at COVID-19 (self assessed symptoms) not SARS-CoV-2 (the virus, which would require PCR confirmatory testing)] – The Scientist – REF

May 30, 2020 – The Scientist: Disputed Hydroxychloroquine Study Brings Scrutiny to Surgisphere – READ, CREDIT

• “Scientists have raised questions about the dataset published in The Lancet last week that triggered the suspension of clinical trials around the world—and about Surgisphere Corporation, the company behind the study.”

May 28, 2020 – The Guaridan: Questions raised over hydroxychloroquine study which caused WHO to halt trials for Covid-19 – Exclusive: Australian researchers query origin of data used for Lancet study, but stress there is no evidence drug is a safe or effective treatment – READ

May 28, 2020 – Zenodo: An open letter to Mehra et al and The Lancet (Richard Horton (editor) – Concerns regarding the statistical analysis and data integrity – by James Watson on behalf of 201 signatories – READ, PDF, CREDIT

• “This impact has led many researchers around the world to scrutinize in detail the [Lancet] publication in question. This scrutiny has raised both methodological and data integrity concerns.” – 10 concerns listed

May 27, 2020 – CNN: Fauci: Science shows hydroxychloroquine is not effective as a coronavirus treatment – ARCHIVE

“The scientific data is really quite evident now about the lack of efficacy for it,”…[ there’s likelihood of] “adverse events with regard to cardiovascular.”

Dr Anthony Fauci told CNN’s Jim Sciutto on “Newsroom”

• “Fauci.. is the first Trump administration official to say the drug is not effective in treating the virus based on scientific data.” [in hospitalised patients, not where the drug is being used by frontline doctors!]

May 27, 2020 – CNN: France halts use of hydroxychloroquine on Covid-19 patients – READ

• “French Health Ministry revoked its authorization for the drug to be given to those with coronavirus…suggest a link between the use of hydroxychloroquine and “cardiac toxicity,” particularly when used in combination with the azithromycin…”
• “Some context: The announcement comes after the World Health Organization (WHO) on Monday said it had temporarily halted the study of hydroxychloroquine as a potential Covid-19 treatment in its Solidarity Trial, due to safety concerns” [Based on The Lancet, soon-after RETRACTED fraudulent paper]

Our data has very convincingly shown that across the world in a real-world population that this drug combination, whichever way you slice it or dice it, does not show any evidence of benefit, and in fact is immutably showing a signal of grave harm

Dr. Mandeep Mehra, CNN passed this off as a direct quote – REF, more powerful than that quoted by TIME –HERE (See May 22, 2020)

May 27, 2020 – The Scientist: WHO Halts Hydroxychloroquine Testing Over Safety Concerns – based on The Lancet study – READ,

May 26, 2020 – The Guardian: Australian hydroxychloroquine trial to treat Covid-19 under review after WHO safety concern – READ

• “The AustralaSian Covid-19 trial (Ascot) has been recruiting patients in more than 70 hospitals in every state and territory, and 11 hospitals in New Zealand.”
• “Meanwhile, the Therapeutic Goods Administration granted former federal politician Clive Palmer a contract to import 1m doses of the drug [hydroxychloroquine] to add to the national medical stockpile.”

May 26, 2020 – The Guaridian: WHO halts hydroxychloroquine trial for coronavirus amid safety fears- READ

May 25, 2020 – Medical News: Zero benefit of Hydroxychloroquine or Chloroquine in COVID-19, says extensive study – READ

May 25, 2020 – CNN: WHO temporarily pauses hydroxychloroquine study due to safety concerns – READ

• WHO Director-General Tedros Adhanom Ghebreyesus said during a media briefing in Geneva – the decision was made after The Lancet observational study was published where the “authors reported that among patients receiving the drug, when used alone or with a macrolide, they estimated a higher mortality rate”

May 25, 2020 – WHO Director-General’s opening remarks at the media briefing on COVID-19 – 25 May 2020 – READ, ARCHIVE

• “The Executive Group has implemented a temporary pause of the hydroxychloroquine arm within the Solidarity Trial while the data is reviewed by the Data Safety Monitoring Board.”…”I wish to reiterate that these drugs [HCQ & CQ] are accepted as generally safe for use in patients with autoimmune diseases or malaria”

May 22, 2020 – CNN: Sales of drug touted by Trump have been soaring – READ,

• “Amid the growing public attention on the medication, its sales doubled from March 2019 to more than $50 million in March [2020]”
• Following FDA’s “caution”…more than 830,000 prescriptions for the drug were filled for the generic and name-brand version of the drug, Plaquenil, in March – up from roughly 460,000 prescriptions written during the same time last year….The IQVIA data did not yet include April figures and did not capture prescriptions administered to patients in nursing homes through long-term care pharmacies or at hospitals.”
• FDA aware of reports of “serious heart-related adverse events and death in patients with COVID-19” taking HCQ or CQ. [Why are all the arthritis (adults and children up to 400mg/day) and malaria (400mg/week) patients taking the drug on a daily basis, not suffring the same alleged concern?]

May 22, 2020 – Forbes: All The Times Trump Has Promoted Hydroxychloroquine – A TIMELINE- (NOTE this article references The Lancet study, but they’ve not updated their article since then to reflect the The Lancet RETRACTED that fraudulent paper) – READ, ARCHIVE

May 22, 2020 – Time Magazine: Large Study Finds No Benefit — and Potential Harm — in Using Hydroxychloroquine for COVID-19 – ARCHIVE, MD Edge – READ,

• “…scientists in the U.S. and Switzerland report on an analysis of more than 96,000 people hospitalized with confirmed COVID-19 in 671 hospitals on six continents. Nearly 15,000 patients were treated…”
• ““However we sliced and diced the data, the results were identical,” says Dr. Mandeep Mehra, chair of cardiovascular medicine at Brigham and Women’s Hospital and professor of medicine at Harvard Medical School, who led the study. “There was no evidence of benefit, and a consistent signal of harm — and in particular, harm linked to heart rhythm disturbances.”…“Why would you risk harm when there is so much consistent data showing lack of benefit [with hydroxychloroquine]?”
• “In fact, as the evidence continues to suggest that hydroxychloroquine may not provide much benefit, and instead might increase the risk of harm to the heart, Mehra says doctors may shift from considering hydroxychloroquine to other drugs being studied as COVID-19 treatments, like remdesivir. Studies indicate that remdesivir, an antiviral that has not yet been approved to treat any disease, may help people with COVID-19 to recover faster..”

May 22, 2020 – The Lancet: Hydroxychloroquine or chloroquine with or without a macrolide for treatment of COVID-19: a multinational registry analysis by Prof Mandeep Mehra (Brigham and Women’s Hospital & Harvard), Sapan Desai (founder and chief executive of Surgisphere Corporation, Chicago, IL, USA) et al – ARCHIVE, now RETRACTED – READ, Brigham’s PRESS RELEASE – READ

“However we sliced and diced the data, the results were identical,… “There was no evidence of benefit, and a consistent signal of harm — and in particular, harm linked to heart rhythm disturbances.””

Dr. Mandeep Mehra, chair of cardiovascular medicine at Brigham and Women’s Hospital and professor of medicine at Harvard Medical School, who led the study

• “The data [a mammoth private database of patient medical records] came from a company called Surgisphere, which claims to have granular patient-level information shared by 1,200 hospitals and health facilities on six continents.” – REF
• “Critics were quick to point out anomalies in both pieces of research, including implausible findings that should have been detected during the peer review process — like the registry’s apparent inclusion of a large number of Covid-19 cases very early on in the pandemic, even in Africa, where few hospitals have electronic health records….Many researchers were astonished to find out that such a database could exist, or that the gathering and analysis of tens of thousands of medical records on multiple continents could have been carried out so quickly.” – REF
• “Dr. Desai vigorously defended the Surgisphere database, saying that he was “all for transparency” but was bound to secrecy by contractual agreements with the hundreds of hospitals that are his clients, and therefore could not show anyone the raw data from his registry..”…”until February, [2020, Desai] worked as a vascular surgeon at Northwest Community Hospital in Arlington Heights, Ill.” – REF
• June 8, 2020 – Science: Who’s to blame? These three scientists are at the heart of the Surgisphere COVID-19 scandal -Author partnership on coronavirus papers is “completely bizarre” and should have been a red flag, former journal editor says – READ

May 19, 2020 – FDA: Pharmacovigilance Memorandum for Hydroxychloroquine and Chloroquine for All adverse events in the setting of COVID-19 from the FDA Adverse Event Reporting System (FAERS) – PDF, an “uncharacteristically brief 15-page safety review memorandum of HCQ” – CREDIT

• Brownstone: “a methodologically questionable report criticizing HCQ’s safety. The FDA’s narrative was based on preliminary and time-compartmentalized findings, and not a reflection of historical safety or based on the appropriate clinical use of HCQ dosing, prescribing, timing, and duration. The FDA then seemed to label its findings as conclusive, figuratively slamming the door shut on the consideration of new findings.” – REF
• “According to its uncharacteristically brief 15-page safety review memorandum of HCQ published on May 19, 2020, the FDA considered data from the National Poison Data System (NPDS) which means it seems to have included the use of non-pharmaceutical-grade and/or self-administered HCQ and/or overdose data in its clinical evaluation. “
• “…Table 6 only contained around 256 applicable adverse event reports [possibly associated with HCQ/CQ] over a five-month period in the entire world when administered for Covid-19″ With doses “anywhere from 2x to 6x the recommended maximum maintenance dose of HCQ for any clinical indication per FDA and manufacturer’s dosing recommendations.” Also “it did not appear to investigate or report patient weights”
• “92 of the 109 serious cardiac cases (84%) reported concomitant use of at least one other medication that prolongs the QT interval.”…”In other words, the FDA included well-known, clinically unsound, long-established, drug-drug interactions, contraindicated uses, and/or prescribing errors in denigrating HCQ’s safety.”
• And so many more oversights by this FDA’s report – REF

May 19, 2020 – CNN: Trump says he is taking hydroxychloroquine though health experts question its effectiveness – ARCHIVE

• Trump consulted his Whitehouse doctor
• “The admission was a dramatic development in Trump’s attempts to promote hydroxychloroquine as a treatment for coronavirus, which began earlier in the outbreak and has been met with resistance from medical professionals”

May 18, 2020 – Med City News: Report: VA still using hydroxychloroquine for Covid-19; mounting data indicate no effect …Meanwhile, two large studies from hospitals in the New York City area indicated that the drug did not improve rates of mortality among hospitalized patient – READ

May 16, 2020 – AP: VA says it won’t stop use of unproven drug on vets for now – READ, CREDIT

May 14, 2020 – The Guardian: Drug imported for Covid-19 trials won’t be given to Australians who need it for other conditions – Clive Palmer bought millions of doses of hydroxychloroquine – READ, Palmer Foundation – READ

• 33 million doses of hydroxichloroquine imported by Palmer and made freely available to Australias national stockpile – TIMELINE
• Clive Palmer’s donation – WATCH, he tells his story 2024 – WATCH

May 11, 2020 – Politico: Hydroxychloroquine shows no benefit against coronavirus in N.Y. study – READ, CNN – ARCHIVE, The JAMA STUDY

• “University at Albany looked at 1,438 patients with coronavirus who were admitted to 25 New York City area hospitals.” [Not pre-hospitalisation!]
• HCQ+azithromycin “…the patients who took the drug combination were more than twice as likely to suffer cardiac arrest during the course of the study. Heart issues are a known side effect of hydroxychloroquine.”

May 11, 2020 – JAMA: Association of Treatment With Hydroxychloroquine or Azithromycin With In-Hospital Mortality in Patients With COVID-19 in New York State by Rosenberg et al – PAPER, READ

May 7, 2020 – NEJM: Observational Study of Hydroxychloroquine in Hospitalized Patients with Covid-19 – Geleris et al – READ, Large study finds no benefit from hydroxychloroquine in Covid-19- CREDIT

• Study in New York-Presbyterian Hospital—Columbia University Irving Medical Center, – Of 1446 consecutive patients, 70 patients were intubated, died, or discharged within 24 hours after presentation and were excluded from the analysis.
• Hydroxychloroquine dose – 600mg twice on day 1 (total 1200mg), then 400 mg daily for a median of 5 days. Started 24-48 hrs upon admittance to hospital. “Hydroxychloroquine-treated patients were more severely ill at baseline than those who did not receive hydroxychloroquine”

May 6, 2020 – Med City News: The eye-popping allegations in ousted BARDA Director Rick Bright’s whistleblower complaint – READ

• “In the complaint, Bright alleges that he faced retaliation after resisting efforts to promote broad use of hydroxychloroquine and chloroquine on the basis of their safety problems and lack of scientific support for such use…”
• April 23, 2020 – Ex-BARDA director says he was ousted for questioning hydroxychloroquine for Covid-19 – READ

May 5, 2020 – Washington Post: Ousted vaccine official alleges he was demoted for prioritizing ‘science and safety’ – Rick Bright says in a whistleblower complaint that he resisted pressure from HHS leaders to make ‘potentially harmful’ antimalarial drugs more widely available – READ, COMPLAINT

• Biomedical Advanced Research and Development Authority (BARDA) Director Rick Bright alleged he was demoted due to his resistance to Trump’s promotion of the unproven drug

May 1, 2020 – FDA issued EUA for the patented, more expensive competitor drug remdesivir – REF

April 30, 2020 – The Highwire Ep 161: CORONAVIRUS: A NATION DIVIDED – segment on Chloroquine vs. Remdesivir – WATCH, FULL

April 28, 2020 – James Todaro MD on Twitter: The Italian Society of Rheumatology studied 65,000 patients on longterm hydroxychloroquine for RA and Lupus. – Only 20 patients tested positive for COVID-19, No ICU, no deaths – This is a 90% reduction in infection rate compared to the rest of Italy – No Archive, READ, Gateway Pundit – READ The Highwire – WATCH

April 28, 2020 The Italian – ARTICLE

• “primary care doctors and general practitioners contacted during this research, many have admitted – under their breath – to use the drug [hydroxychloroquine] as a “prophylaxis”, …Health professionals who are in close contact with contagious patients take the drug in advance, precisely to decrease the probability of contracting the infection.”
• Italian Society of Rheumatology (SIR) questioned 1,200 rheumatologists throughout Italy to collect statistics on infections. Out of 65,000 chronic rheumatoid patients (Lupus and Rheumatoid Arthritis), who systematically take Plaquenil / hydroxychloroquine, only 20 patients tested positive for the virus. Nobody died, nobody is in intensive care, according to the data collected so far.

April 28, 2020 – Fox News: Ingraham Angle: Infectious disease expert slams study that panned hydroxychloroquine as COVID-19 treatment: ‘It’s a sham‘ – WATCH

• Dr. Stephen Smith – the study published last week indicating the antimalarial drug hydroxychloroquine showed no benefit [and potentially harmful] for coronavirus patients in U.S. veterans hospitals was a “sham.” [the VA STUDY]
• A New study by French doctor Didier Raoult show correct way to use HCQ

April 24, 2020 – PRESS RELEASE: FDA cautions against use of hydroxychloroquine or chloroquine for COVID-19 outside of the hospital setting or a clinical trail due to risk of heart rhythm problems – Does not affect FDA-approved used for malaria, lupus and rheumatoid arthritis – READ, ARCHIVE, The Highwire – WATCH

April 22, 2020 – Fox News: COVID-19 treatment hydroxychloroquine showed no benefit, more deaths in VA virus study – READ (see paper below)

April 21, 2020 – University of Melbourne: Clinical trial into two potential COVID-19 treatments commences – AustralaSian COVID-19 Trial (ASCOT) – READ, CREDIT

• “Laboratory tests have shown that lopinavir/ritonavir, which is currently used to treat HIV, and hydroxychloroquine, used to treat arthritis and prevent and treat malaria, can stop SARS-CoV-2, the virus that causes COVID-19, in its tracks.”
• “A clinical trial aimed at testing the effectiveness and safety of two existing drugs in patients hospitalised with COVID-19 has opened at the first site, the Royal Melbourne Hospital.
• “The aim of ASCOT is to test whether using these drugs will prevent patients deteriorating to the point of needing a ventilator in the intensive care unit (ICU),” said Associate Professor Steven Tong

April 21, 2020 – PrePrint : Outcomes of hydroxychloroquine usage in United States veterans hospitalized with Covid-19 by Magagnoli et al – READ, PDF , The Highwire – WATCH

• This was NOT a randomised study, and had other flaws such administering the drug to only the severely ill and those ventilated – too late to be effective, yet they concluded it increased mortality!
• The dosages for either drug are NOT even listed!
• 31% of the “control” group received azithromycin!
• Dr Stephen Smith calls this study “a sham”!
• Pharma-backed mainstream media picked up on this studies “conclusions” and used it to disqualify HCQ as a treatment, and the unsuspecting public, and healthcare community simply believe them

April 17, 2020 – Int J of Antimicrobial Agents: Can post-exposure prophylaxis for COVID-19 be considered as one of outbreak response strategies in long-term care hospitals? by Lee et al – READ
Post-exposure prophylaxis using hydroxychloroquine was provided to 211 persons, Disease development was successfully prevented without severe adverse events.

April 2, 2020 – Fox News | Ingraham Angle: Dr. Stephen Smith on effectiveness of hydroxychloroquine: ‘I think this is the beginning of the end of the pandemic’ – WATCH

March 31, 2020 – Washington Post: FDA authorizes widespread use of unproven drugs to treat coronavirus, saying possible benefit outweighs risk – READ

March 30, 2020: KHN: FDA Approves Emergency Use Of Malaria Drug Trump Touted Despite Scant Evidence That It Works – READ, and this on March 27 – HERE

March 29, 2020 – HHS: HHS accepts donations of medicine to Strategic National Stockpile as possible treatments for COVID-19 patients – 30 million doses of hydroxychloroquine sulfate donated by Sandoz and and one million doses donated by Bayer Pharmaceuticals – ARCHIVE

March 28, 2020 – The Register: Remember that clinical trial, promoted by President Trump, of a possible COVID-19 cure? So, so, so many questions… – Scientists pull coronavirus treatment study apart after rushed publication – ARCHIVE

March 28, 2020 – LA Times: Doctors and experts warn of the risks of using malaria drugs to treat COVID-19 – heart rhythm QT interval – READ, what is QT interval – READ

• “An article published this week in the Mayo Clinic Proceedings warns that both drugs could prompt dangerous and potentially deadly heart arrhythmias in the 3 million people worldwide who have a congenital cardiac condition — called long QT syndrome — that can cause the heart to beat erratically and lead to sudden death.” – Mayo Clinic preprint – PDF, Long QT syndrome – READ
• [Yet it’s ok to take for malaria!]

March 27, 2020 – Gateway Pundit: HUGE! Second French Study by Dr. Raoult finds Hydroxychloroquine and Azithromycin Helped EVERY PATIENT in Study Group of 80 Minus One – READ

March 27, 2020 – Fox News | The Ingraham Angle: Dr. Stephen Smith on effectiveness of hydroxychloroquine: ‘I think this is the beginning of the end of the pandemic’ – with Dr. Stephen Smith & Dr. Amesh Adalja – TRANSCRIPT

March 26, 2020: Newsday: Cuomo limits prescriptions for two drugs to active virus cases – READ, Dr Oz lift ban – READ

• An executive order issued by Gov. Andrew Cuomo limits prescriptions of hydroxychloroquine and chloroquine to only COVID-19 patients in state-approved clinical trials…

March 25, 2020 – Tech Startups: Doctor Vladimir Zelenko: I treated 350 coronavirus patients with 100% success using Hydroxychloroquine Sulfate – READ, Mar. 28, 2020 that number rose to 699 – READ

March 24, 2020 – FDA Drug Safety Communication on Hydroxychloroquine begins – READ

• FDA cautions against use of hydroxychloroquine or chloroquine for COVID-19 outside of the hospital setting or a clinical trial due to risk of heart rhythm problems – PDF

March 24, 2020 – NBC News: Man dies after taking chloroquine in an attempt to prevent coronavirus – A husband and wife in Arizona took chloroquine phosphate, an ingredient of fish parasite killers rather than the anti-malaria medication, following the President’s recommendation. The man died soon after ingesting the toxic chemical. His spouse was left in a critical condition. – READ

March 24, 2020 – Time Magazine: President Trump Called Hydroxychloroquine a ‘Game Changer,’ But Experts Warn Against Self-Medicating With the Drug. Here’s What You Need to Know – ORIGINAL, READ, Article archives – HERE

• “For the past few weeks President Trump has continually expressed great confidence in the promise of a new COVID-19 therapy involving two drugs—azithromycin and hydroxychloroquine”…
• “But in those few days, a few people [2, husband and wife who took fish tank cleaner – not hydroxychloroquine] who began self medicating with the drugs in an effort to prevent COVID-19 [misleading] have died, and others have been hospitalized. These tragedies have raised questions about the safety of the drug combo [from fish tank cleaner!!!], and how valid they are as a possible solution to treating COVID-19.”

“What do you have to lose? Take it,” … “I really think they should take it. But it’s their choice. And it’s their doctor’s choice or the doctors in the hospital. But hydroxychloroquine. Try it, if you’d like.”

President Trump – White House briefing April 4, 2020 (Time article updated, but not acknowledged in date)

March 23, 2020 – Time Magazine: Arizona Man Dies After Taking Chemical in Coronavirus Treatment Touted by President Trump – ARCHIVE

• “A Phoenix-area man has died and his wife was in critical condition after the couple took chloroquine phosphate, an additive used to clean fish tanks…It’s unclear if the couple took it specifically because of COVID-19″,
• Now Banner Poison and Drug Information Center “is warning everyone to avoid self-medicating”

March 21, 2020 – President Trump on Twitter re HYDROXYCHLOROQUINE & AZITHROMYCIN – TWEET, ARCHIVE

March 20, 2020 – AP FACT CHECK: Trump falsely claims drug approval for virus – READ

• “Technically, doctors can already prescribe the drug to patients with COVID-19, a practice known as off-label prescribing.”
• “Drug trials typically require hundreds or thousands of patients and, even when accelerated, take weeks or months to complete”
  • [This is deceptive, as HCQ has already gone through those safety trials before registration, and has an established 60 year risk profile for the doses used by the frontline doctors, so such huge trials “safety” trials are not required and is misleading to state this]
• “no FDA-approved therapeutics or drugs to treat, cure or prevent COVID-19”
• [Note during the pandemic the media the word “approved” instead of the correct phrase “Emeregency Use Authroised” – yet they attack Trump for saying apporved for and EUA “indication” approval – The drug is already registered – but BARDA got in and killed that EUA – WATCH]

March 20, 2020 – NBC News: Trump, promoting unproven drug treatments, insults NBC reporter at coronavirus briefing – READ

March 20, 2020 – ABC News: Chloroquine, an old malaria drug, may help treat novel coronavirus, doctors say – READ

• FDA approves compassionate use of chloroquine – President Donald Trump held a teleconference with state governors on Thursday at FEMA headquarters and discussed possible treatments for coronavirus.
• “The way that it worked against SARS was by preventing of the attachment of the virus to the cells. Chloroquine interfered with the attachment to that receptor on the cell membrane surface,” Horovitz said. “So it’s disrupting a lock and key kind of mechanism of attachment.”

March 20, 2020 – International Journal of Antimicrobial Agents: Hydroxychloroquine and azithromycin as a treatment of COVID-19: results of an open-label non-randomized clinical trial by Gautret and Didier Raoult et al – READ, Preprint – READ

• “However, [this] study was too small to be of significance, and there was no control group of patients to compare the outcome of the drugs.” – REF [reminder the FDA/ACIP considered 8 mice enough to justify injecting an experimental “vaccine”]

March 19, 2020 – President Trump mentions chloroquine/hydroxychloroquine as a potential treatment for COVID-19 based on feedback he had received from doctors using it on the frontline – WATCH,
Tony Fauci said “no” to being effective for COVID-19! – READ

March 18, 2020 – Cell Discovery: Hydroxychloroquine, a less toxic derivative of chloroquine, is effective in inhibiting SARS-CoV-2 infection in vitro – Liu et al – READ

March 11, 2020 – MedCram: Coronavirus Epidemic Update 34: US Cases Surge, Chloroquine & Zinc Treatment Combo, Italy Lockdown – WATCH, Korea using HCQ – EXCERPT

March 10, 2020 – J Critical Care: A systematic review on the efficacy and safety of chloroquine for the treatment of COVID-19 – Cortegiani et al – READ

• “There are more than 20 ongoing clinical trials in China and more scheduled to start in England, Thailand, South Korea and the United States” – REF

February 18, 2020 – Clinical Trials Arena: Coronavirus: Chloroquine yields positive data in covid-19 trial – Early data from clinical trials being performed in China has revealed that chloroquine phosphate could help treat the new coronavirus disease, Covid-19 – READ, WATCH

• Chloroquine was selected after screening thousands of existing drugs

February 11, 2020 (received as preprint) – International Journal of Antimicrobial Agents: Chloroquine for the 2019 novel coronavirus SARS-CoV-2 – Colson, Didier Raoult et al – READ, READ

2017

2019 – CDC: Medicines for the Prevention of Malaria While Traveling – Hydroxychloroquine (Plaquenil) – Brochure – PDF

• CDC promotes use of Hydroxychloroquine as safe and “a relatively well tolerated medicine.”
• The CDC in referencing the long-term use of HCQ for chronic disease treatments states “HCQ can be prescribed to adults and children of all ages. It can also be safely taken by pregnant women and nursing mothers.”

2014

October 1, 2014 – PLOS: Chloroquine is a zinc ionophore – Xue et al – READ, WATCH

2003

November 2003 – The Lancet | Infectious Disease: Effects of chloroquine on viral infections: an old drug against today’s diseases – Savarino et al – READ, CREDIT

• Chloroquine is a 9-aminoquinoline known since 1934…”Chloroquine/hydroxychloroquie can impair the replication of several viruses by interacting with the endosome-mediated viral entry or the late stages of replication of enveloped viruses”
• “Chloroquine has been shown to inhibit different viruses requiring a pH-dependent step for entry”
  • 2021- “Influenza hemagglutinin (HA) is a viral membrane bound protein that plays a critical role in the viral life cycle by mediating entry into target cells” – PAPER
  • May 2023 – pH-dependent endocytosis mechanisms for influenza A and SARS-coronavirus – PAPER
• “ Of particular interest for human pathology is the report that chloroquine inhibits uncoating of the hepatitis A virus, thus blocking its entire replication cycle”

October 30, 2003 – Antimicrobial Agents and Chemotherapy : Effect of zinc salts on respiratory syncytial virus replication by Suara et al – READ, The Highwire – CREDIT

1994

1994 – BOOK: Vaccines and world health : science, policy, and practice by Faul F. Basch (1994) – (Borrow online) – READ, Credit Dr Judy Wilyman – Vaccination – HERE

• “The Effect of Infection-Controlling Drugs on the Immune Response to Vaccines” – Chloroquine can inhibit the antibody production to vaccine antigens! – READ

The post Hydroxychloroquine first appeared on Totality of Evidence.

Budesonide works…since mid 2020!

To alleviate COVID-19 symptoms, and reduce hospitalisation by 90%

Symptoms of difficulty breathing were overcome using Budesonide

Those of us who have been following the COVID-19 trail from it’s inception have come across many front line doctors “screaming” out about about how they have successfully assisted their patients presenting with symptoms attributed to the disease called COVID-19. These EARLY intervention treatments have prevented the disease process from escalating and thus preventing hospitalisation.  Early treatment was focus of many front line emergency doctors and GP’s.

Finding an Early Treatment to Prevent Hospitalisation Means The Pandemic is OVER!

This is IMPORTANT because if a successful EARLY TREATMENT for COVID-19 is found then this “pandemic” is over!  How many COVID-19 patients died before they reached hospital?

Stabilising patients and preventing hospitalisation was the focus of front line doctors, where in the emergency room breathing issues was a consistent symptom Dr Bartlett came across.

So these doctors hit the books, prayed and searched for ways to relieve symptoms using existing tools to relieve symptoms, and Dr Bartlett found one.

The Budesonide story is one you need to know about

Nebulised Budesonide was “discovered” early in the pandemic (March 2020) to address the breathing issues that many patients presented with in the United States – the country that was said to be hardest hit by COVID-19 deaths!  If early symptoms weren’t addressed then patients could escalate to a cytokine storm of inflammatory chemicals leading to the need for ICU hosptilisation.

Budesonide is a 25 year old drug, it’s used by many millions of people every day to treat their asthma, its been used on babies through to fragile elderly without any trouble.

“When you use budesonide, it’s almost like putting a wet blanket over a fire.  It decreases the release of those inflammatory chemicals, and that buys time for the bodies immune system to kill off the virus.”
Dr Richard Bartlett, MD

Information about this potentially life saving, cheap and symptom reducing product was censored and belittled by the media and the “authorities”.  You really have to ask why?  This drug is a known product with a vast history of scientific literature and known potential side effects (which are few) – that appeared to remedy a problem in the beginning of a “pandemic”.

“…I am heartened that a relatively safe, widely available and well studied medicine such as an inhaled steroid [budesonide] could have an impact on the pressures we are experiencing during the pandemic.”
Professor Mona Bafadhel of Nuffield Department of Medicine, University of Oxford

Repurposing an existing, off-patent, cheap drug was not part of the “solution” they wanted us to know about.  Remember from the outset the “experts” said we won’t get out of this without a vaccine?  How did they know this?  Wasn’t this meant to be a new disease?

West Texas Doctor Richard Bartlett MD reported great success with his protocol in treating COVID-19 patients when treatment began early, rather than when patients start having difficulties. Early treatment is common in virtually all illnesses including common flu BUT no early treatment has been suggested as part of any protocol for COVID-19.  This should concern everyone.  Did this suggested avoidance of any early intervention by the “medical establishment” in the USA contribute to their “high” death numbers attributed to COVID-19?

Thankfully Front line doctors didn’t listen to everything their “medical experts” had to say!

Oxford University Clinical Trials Prove Budesonide Works

Well now, March 2021, there are clinical trials to prove that budesonide works to curb the symptoms of COVID-19, preventing hospitalisation and the escalation of the disease process.  According to Dr Bartlett, the emergency medicine doctor who “discovered” this treatment, the Oxford trials had to be cut short because the treated group (versus the control group with no budesonide) were clearly helped with the drug, they couldn’t ethically hold it back from the untreated group.  Imagine how many people struggling to breath over the past 10-12 months could have been assisted, prevented from hospitalisation and maybe saved?

You can read more about budesonide at this website budesonideworks.com and find links to the medical literature.
Click here to go direct to the early phase 2 study done by Oxford early 2021.
Click here for Case study Report by Dr Richard Bartlett and Alexandria Watkins

Dr Bartlett talks about the Oxford trial (March 2021)

Watch Video Testimony by Dr Richard Bartlett

Following is a collection of video’s about Budesonide.  These are not easy to find on YouTube, and may at some point get taken down.  We’ll try to put links to alternate channels below too in case these go down.

Following are some of the interviews that Dr Richard Bartlett an Emergency Medicine Doctor from Texas, gave early on in the pandemic to try to get this information out.  These are just a small segment of what is out there, at this stage they appear to still be up on YouTube.

Take the time to watch at least this first video.

July 2020 – Dr Bartlett’s Story of Budesonide Discovery

Panic Porn; Dr. Richard Bartlett; Independence Day Brilliance 7.2.20
YouTube Channel: America Can We Talk
Published: July 3, 2020

August 2020:  Dr. Richard Bartlett on inhaled steroid Budesonide and Covid-19

YouTube Channel: Drbeen Medical Lectures

June 2020:  The “Silver Bullet” For COVID-19 – Dr Richard Bartlett

July 2020: Dr. Richard Bartlett on inhaled steroid Budesonide and Covid-19

Trying Everything to get the word out

Dr Bartlett was getting heavily censored from the monopoly platforms, that he made contact with the Documentary creators of Out Of Shadows, and put a POWERFUL 9 minute, downloadable video on their homepage to help spread the word of hope.  In this video you will hear him describes how his interviews were heard by other hospital staff in other states and they employed the treatment strategy and emptied an ICU in 48 hours!

March 2021: Oxford Trial of Budesonide

Articles in reverse chronological order

2023

May 11, 2023 – The Highwire Ep 319: Awakening – Dr Richard Bartlett is back – ‘SILVER BULLET’ PROTOCOL FOR COVID VALIDATED TWO YEARS AFTER ATTACKED – WATCH, FULL

• With in hours of treatment people can breathe

April 18, 2023 – Med Express: Oral fluvoxamine plus budesonide found to cut severe disease in COVID-19 – PDF, Medical News – READ

• May 5, 2023 – McCullough Substack: Oral Fluvoxamine Plus Inhaled Budesonide Reduced Prolonged ER Stays or Hospitalization for Acute COVID-19 – Underpowered Multicenter Trial Confirms Expected Signal of Benefit Especially in Vaccinated Patients – READ

April 18, 2023 – Annals of Internatl Medicine: Oral Fluvoxamine With Inhaled Budesonide for Treatment of Early-Onset COVID-19 – A Randomized Platform Trial – Reis et al – READ

2021

August 10, 2021 – The Lancet – Inhaled budesonide for COVID-19 in people at high risk of complications in the community in the UK (PRINCIPLE): a randomised, controlled, open-label, adaptive platform trial – Yu et al (Oxford Uni trial) – READ, READ2, Dr Bartlett – WATCH,

• Science direct lists more budesonide trials – HERE

April 12, 2021 – Pre Print: Inhaled budesonide for COVID-19 in people at higher risk of adverse outcomes in the community: interim analyses from the PRINCIPLE trial – PRINCIPLE Collaborative Group – Yu et al – READ, REF, Published Aug 10, 2021 in The Lancet.

April 9, 2021 – The Lancet: Inhaled budesonide in the treatment of early COVID-19 (STOIC): a phase 2, open-label, randomised controlled trial – Ramakrishnan et al – READ

February 9, 2021 – Oxford University News: Common asthma treatment reduces need for hospitalisation in COVID-19 patients, study suggests – READ, BBC – READ, Yahoo – READ, Guardian – READ

• “The STOIC study found that inhaled budesonide given to patients with COVID-19 within seven days of the onset of symptoms also reduced recovery time.”
• “With at-home patients still often feeling seriously unwell, scientists from the University of Oxford found inhaling budesonide twice a day for two weeks speeds up an individual’s self-reported recovery by 72 hours.” – REF

February 8, 2021 – Preprint: Inhaled budesonide in the treatment of early COVID-19 illness: a randomised controlled trial – Oxford universtity authors – Ramakrishnan et al – READ, now published The Lancet – READ

• 90% of hospitalisations can be prevented – WATCH

2020

November 27, 2020 – The Oxford PRINCIPLE Trial: Inhaled corticosteroids to be investigated as a possible treatment for Covid-19 in national PRINCIPLE Trial – READ, ARCHIVE, Results – ARCHIVE, The Lancet – READ

• Platform Randomised trial of INterventions against COVID-19 In older peoPLE (PRINCIPLE) – ARCHIVE
• Inhaled budesonide is an inexpensive, safe and commonly prescribed treatment for asthma and COPD. It is the fourth medication to be tested in PRINCIPLE.
• “Led by the University of Oxford, the Platform Randomised trial of Interventions against Covid-19 In older peoPLE (PRINCIPLE) Trial is evaluating treatments that can help people aged over 50 recover more quickly from Covid-19 illness and prevent the need for hospital admission. The study has so far recruited more than 2100 volunteers from across the UK.”

2016

June 4, 2016 – BMC Pulmonary Medicine: Budesonide ameliorates lung injury induced by large volume ventilation – Ju et al – READ., CREDIT

• Cytokines are shut down with budesonide – REF

The post Budesonide first appeared on Totality of Evidence.